Indium (111In) capromab pendetide

Indium (111In) capromab pendetideMonoclonal antibody

Type| Whole antibody
Source| Mouse
Target| Glutamate carboxypeptidase II
Clinical data
Trade names| Prostascint
ATC code|

* V09IB04 (WHO)

Identifiers
CAS Number|

* 151763-64-3 N (capromab)
148805-91-8 (pendetide)

ChemSpider|

* none

UNII|

* 03MZ53X1YS

ChEMBL|

* ChEMBL1201579 N

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Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.[1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).[1]

Early trials with yttrium (90Y) capromab pendetide were also conducted.[3]

## References

1. ↑ 1.0 1.1 "Indium-111 capromab pendetide in the management of recurrent prostate cancer". Expert Review of Anticancer Therapy 8 (2): 175–81. February 2008. doi:10.1586/14737140.8.2.175. PMID 18279057.
2. ↑ WHO Drug Information
3. ↑ "A phase II study of [90Y] yttrium-capromab pendetide in the treatment of men with prostate cancer recurrence following radical prostatectomy". Cancer Biotherapy & Radiopharmaceuticals 14 (2): 99–111. April 1999. doi:10.1089/cbr.1999.14.99. PMID 10850293.

* v
* t
* e

Diagnostic radiopharmaceuticals (ATC: V09)

Central nervous system|

* 99mTc (Exametazime)
* 123I (Ioflupane
* Iofetamine
* Iomazenil)
* 18F (Florbetapir, Flutemetamol)

Skeletal system|

* 99mTc (Medronic acid)

Renal|

* 123I (Sodium iodohippurate)
* 64Cu (Cu-ETS2)

Gastrointestinal/Hepatic|

* 75Se (SeHCAT)

Respiratory system|

* 133Xe
* 81mKr
* 99mTc (99mTc-MAA)

Cardiovascular system|

* 99mTc (Sestamibi
* Tetrofosmin)
* 111In (Imciromab)
* 82Rb (Rubidium chloride)

Inflammation/infection|

* 99mTc (Exametazime
* Sulesomab
* Tilmanocept)
* 111In
* 67Ga

Tumor|

* 99mTc (Arcitumomab
* Votumumab
* Hynic-octreotide)
* 111In (Capromab pendetide
* Satumomab pendetide)
* 125I (Minretumomab)
* 123I / 131I (Iobenguane)
* 18F (Fluciclovine
* Fludeoxyglucose
* Fluoroethyltyrosine
* Sodium fluoride)

Adrenal cortex|

* 123I
* 125I / 131I (Iodocholesterol)

Radionuclides
(including tracers)|

| positron (PET list)|

* 11C ([11C]ME@HAPTHI
* 25B-NBOMe (Cimbi-36)
* Acetate
* Choline
* Carfentanil
* DASB
* DTBZ
* Flumazenil
* Methionine
* N-Methylspiperone
* Pittsburgh compound B
* Raclopride
* Verapamil)
* 13N (Ammonia)
* 15O (Water)
* 18F (Altanserin
* Desmethoxyfallypride
* FMISO
* Fallypride
* Florbetaben
* Florbetapir
* Flubatine
* Fluciclovine
* Fludeoxyglucose (18F) (FDG)-glucose analogue
* Flumazenil
* Fluorocholine
* Fluorodeoxysorbitol (FDS)
* Fluorodopa
* Fluorothymidine F-18
* Fluspidine
* Flutemetamol
* MPPF
* Mefway
* Nifene
* N-Methylspiperone
* FET
* Setoperone)
* 64Cu
* 68Ga
* 82Rb (Rubidium chloride)

|

gamma ray/photon (SPECT/scintigraphy)|

* 51Cr
* 57Co
* 67Ga
* 75Se
* 81mKr
* 99mTc
* 111In
* 123I
* 125I
* 131I
* 133Xe
* 153Sm
* 201Tl

* v
* t
* e

Monoclonal antibodies for tumors

Tumor
("-t(u[m])-")|

| Human ("-tumu-")|

* Adecatumumab§
* Ascrinvacumab§
* Cixutumumab§
* Conatumumab§
* Daratumumab
* Drozitumab§
* Duligotumab§
* Dusigitumab§
* Enfortumab vedotin†
* Enoticumab§
* Figitumumab§
* Ganitumab†
* Glembatumumab vedotin†
* Intetumumab§
* Ipilimumab
* Iratumumab§
* Istiratumab
* Icrucumab§
* Lexatumumab§
* Lucatumumab§
* Mapatumumab§
* Narnatumab§
* Necitumumab
* Nesvacumab§
* Nivolumab
* Ofatumumab
* Olaratumab†
* Panitumumab
* Patritumab§
* Pembrolizumab
* Pritumumab§
* Radretumab§
* Ramucirumab
* Rilotumumab†
* Robatumumab§
* Seribantumab§
* Tarextumab§
* Teprotumumab†
* Tovetumab§
* Vantictumab§
* Votumumab§
* Zalutumumab†

"-melu-" (melanoma)
Flanvotumab§

|

Mouse ("-tumo-")|

* Altumomab pentetate
* Anatumomab mafenatox
* Arcitumomab
* Bectumomab
* Blinatumomab
* Detumomab
* Ibritumomab tiuxetan
* Lilotomab
* Minretumomab
* Mitumomab
* Moxetumomab pasudotox†
* Naptumomab estafenatox
* Nofetumomab merpentan
* Pemtumomab†
* Pintumomab
* Racotumomab
* Satumomab pendetide
* Solitomab
* Taplitumomab paptox
* Tenatumomab
* Tositumomab
* 3F8

"-govo-" (ovarian tumor)
Abagovomab
Igovomab
Oregovomab

"-pro-" (prostate tumor)
Capromab pendetide

"-colo-" (colonic tumor)
Edrecolomab
Nacolomab tafenatox

Chimeric ("-tuxi-")|

* Amatuximab§
* Bavituximab§
* Brentuximab vedotin
* Carotuximab†
* Cetuximab
* Derlotuximab biotin§
* Dinutuximab
* Ensituximab§
* Futuximab§
* Girentuximab†
* Indatuximab ravtansine§
* Isatuximab†
* Loncastuximab tesirine
* Margetuximab†
* Rituximab#
* Siltuximab
* Ublituximab†
* IMAB362

"-mexi-" (melanoma): Ecromeximab§

Humanized ("-tuzu-")|

* Abituzumab§
* Alemtuzumab
* Bevacizumab
* Bivatuzumab mertansine§
* Brontictuzumab§
* Cantuzumab mertansine§
* Cantuzumab ravtansine§
* Cirmtuzumab
* Citatuzumab bogatox§
* Clivatuzumab tetraxetan
* Cofetuzumab pelidotin
* Dacetuzumab§
* Demcizumab§
* Dalotuzumab§
* Denintuzumab mafodotin§
* Elotuzumab
* Emactuzumab§
* Emibetuzumab§
* Enoblituzumab§
* Etaracizumab§
* Farletuzumab§
* Ficlatuzumab§
* Flotetuzumab§
* Gemtuzumab ozogamicin‡
* Imgatuzumab§
* Inotuzumab ozogamicin†
* Labetuzumab§
* Lifastuzumab vedotin§
* Lintuzumab§
* Lorvotuzumab mertansine§
* Lumretuzumab§
* Matuzumab§
* Milatuzumab§
* Nimotuzumab†
* Obinutuzumab
* Ocaratuzumab§
* Otlertuzumab§
* Onartuzumab§
* Oportuzumab monatox†
* Parsatuzumab§
* Pertuzumab
* Pinatuzumab vedotin§
* Polatuzumab vedotin†
* Rosmantuzumab
* Rovalpituzumab tesirine†
* Sacituzumab govitecan†
* Sibrotuzumab§
* Simtuzumab§
* Tacatuzumab tetraxetan§
* Tigatuzumab§
* Trastuzumab
* Tucotuzumab celmoleukin§
* Vandortuzumab vedotin§
* Vanucizumab§
* Veltuzumab§
* Vorsetuzumab mafodotin§
* CBR96-doxorubicin immunoconjugate
* PankoMab

"-gozu-" (ovarian tumor)
Sofituzumab vedotin§

Rat/mouse hybrid
("-tumaxo-")|

* Catumaxomab
* Ertumaxomab§

Chimeric + humanized
("-tuxizu-")|

* Depatuxizumab mafodotin†
* Duvortuxizumab
* Ontuxizumab§

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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