Solute carrier family 30 member 10

Generic protein structure example

Solute carrier family 30 member 10 is a protein that in humans is encoded by the SLC30A10 gene. [1]

## Function

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].

## References

1. ↑ "Entrez Gene: Solute carrier family 30 member 10". https://www.ncbi.nlm.nih.gov/gene/55532.

## Further reading

* "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics 5 (1): 32. 2004. doi:10.1186/1471-2164-5-32. PMID 15154973.
* "Polymorphisms in mitochondrial genes and prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 17 (12): 3558–66. 2008. doi:10.1158/1055-9965.EPI-08-0434. PMID 19064571.
* "Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease". Am. J. Hum. Genet. 90 (3): 467–77. 2012. doi:10.1016/j.ajhg.2012.01.017. PMID 22341971.
* "Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man". Am. J. Hum. Genet. 90 (3): 457–66. 2012. doi:10.1016/j.ajhg.2012.01.018. PMID 22341972.
* "Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis". Metallomics 4 (8): 771–9. 2012. doi:10.1039/c2mt20088k. PMID 22706290.
* "Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations". Biochem. Biophys. Res. Commun. 432 (1): 1–4. 2013. doi:10.1016/j.bbrc.2013.01.058. PMID 23357421.
* "Inherited manganism". Clin Neurol Neurosurg 115 (8): 1536–8. 2013. doi:10.1016/j.clineuro.2012.12.032. PMID 23369405.
* "Altered expression of ZnT10 in Alzheimer's disease brain". PLOS ONE 8 (5): e65475. 2013. doi:10.1371/journal.pone.0065475. PMID 23741496. Bibcode: 2013PLoSO...865475B.
* "Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: implications of the up-regulation of ZIP14 and the down-regulation of ZnT10". Metallomics 6 (4): 944–9. 2014. doi:10.1039/c3mt00362k. PMID 24576911.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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