Aerobactin

Aerobactin is a bacterial iron chelating agent (siderophore)[1] found in E. coli and other Enterobacteriaceae species.[2][3] It is a virulence factor enabling E. coli to sequester iron in iron-poor environments such as the urinary tract.[4]

Aerobactin is biosynthesized by the oxidation of lysine, catalyzed by the enzyme aerobactin synthase, which is then coupled to citric acid. The gene for this enzyme is found in the aerobactin operon, which is roughly 8 kilobases long and contains 5 or more genes in total.[5]

Yersinia pestis contains genes relating to aerobactin, but they have been inactivated by a frameshift mutation, thus Y. pestis is no longer able to synthesize aerobactin.[6]

## Other homologs

* Rhizobactin from Sinorhizobium[7]
* Alcaligin from Bordetella[7]

## References

1. ↑ J. B. Neilands (1995). "Siderophores: Structure and Function of Microbial Iron Transport Compounds". J. Biol. Chem. 270 (45): 26723–26726. doi:10.1074/jbc.270.45.26723. PMID 7592901.
2. ↑ "Aerobactin and other virulence factor genes among strains of Escherichia coli causing urosepsis: association with patient characteristics". Infect. Immun. 56 (2): 405–12. February 1988. doi:10.1128/iai.56.2.405-412.1988. PMID 2892793.
3. ↑ Russo, Thomas A.; Olson, Ruth; MacDonald, Ulrike; Beanan, Janet; Davidson, Bruce A. (2015). "Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Ex Vivo and In Vivo". Infection and Immunity 83 (8): 3325–3333. doi:10.1128/iai.00430-15. PMID 26056379.
4. ↑ Meyrier A (1999). "Urinary Tract Infection". Atlas of diseases of the kidney. 2. Oxford: Blackwell Science. ISBN 0-632-04387-3. http://www.kidneyatlas.org/book2/adk2_07.pdf.
5. ↑ "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". J. Bacteriol. 165 (2): 570–8. February 1986. doi:10.1128/jb.165.2.570-578.1986. PMID 2935523.
6. ↑ "Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis". Microbiology 153 (Pt 7): 2332–41. July 2007. doi:10.1099/mic.0.2006/004275-0. PMID 17600077.
7. ↑ 7.0 7.1 Cianciotto NP (June 2007). "Iron acquisition by Legionella pneumophila". Biometals 20 (3–4): 323–31. doi:10.1007/s10534-006-9057-4. PMID 17180462.

* v
* t
* e

Escherichia coli

Outbreaks|

* 1993 Jack in the Box
* 1996 Odwalla
* 2000 Walkerton
* 2005 South Wales (O157)
* 2006 North American (spinach; O157:H7)
* 2006 North American (multiple; O157:H7)
* 2009 United Kingdom
* 2011 Germany (O104:H4)
* 2015 United States

Genes|

* CPS operon
* DnaG
* Fis
* FNR regulon
* OmpT
* RecBCD
* RpoE
* RpoF
* RpoN
* RpoS

Strains|

* Enterohemorrhagic
* Enteroinvasive
* Enterotoxigenic
* O104:H21
* O104:H4
* O121
* O157:H7
* Verotoxin-producing

Related|

* Aerobactin
* Coliform index
* Long-term evolution experiment
* EcoCyc
* Enteroaggregative
* Molecular biology
* Hok/sok system
* LacUV5
* Min System
* Pathogenic
* EnvZ/OmpR
* Rho factor
* T4 rII system
* Theodor Escherich

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