Mir-124 microRNA precursor family

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miR-124 microRNA precursor family

Predicted secondary structure and sequence conservation of mir-124

Identifiers
Symbol| mir-124
Rfam| RF00239
miRBase| MI0000443
miRBase family| MIPF0000021
Other data
RNA type| Gene; miRNA
Domain(s)| Eukaryota
GO| 0035195 0035068
SO| 0001244
PDB structures| PDBe

The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373),[1] nematode worms (MI0000302),[2] mouse (MI0000150) and human (MI0000443).[3] The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3′ arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation.[4] However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation.[5][6]

## Contents

* 1 Targets of miR-124
* 2 Clinical medicine
* 3 References
* 4 External links

## Targets of miR-124

* Visvanathan et al. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).[7]
* Makeyev et al. showed that miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells.[8]
* Arrant et al. wrote that miR-124 changes glutamate receptor composition in the prefrontal cortex and can decrease social dysfunction in frontotemporal dementia.[9]

## Clinical medicine

Presence of the G allele, compared to the C allele, in SNP rs531564 in pri-miR-124-1, measured by PCR-RFLP in leukocyte DNA, is linked to a reduced risk of gastric cancer (e.g. GG v CC OR 0.34 95% CI 0.19-0.59, p<0.001).[10]

## References

1. ↑ "Computational identification of Drosophila microRNA genes". Genome Biology 4 (7): R42. 2003. doi:10.1186/gb-2003-4-7-r42. PMID 12844358.
2. ↑ "The microRNAs of Caenorhabditis elegans". Genes & Development 17 (8): 991–1008. April 2003. doi:10.1101/gad.1074403. PMID 12672692.
3. ↑ "Identification of tissue-specific microRNAs from mouse". Current Biology 12 (9): 735–739. April 2002. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
4. ↑ "A functional study of miR-124 in the developing neural tube". Genes & Development 21 (5): 531–536. March 2007. doi:10.1101/gad.1519207. PMID 17344415.
5. ↑ "MicroRNA-mediated switching of chromatin-remodelling complexes in neural development". Nature 460 (7255): 642–646. July 2009. doi:10.1038/nature08139. PMID 19561591. Bibcode: 2009Natur.460..642Y.
6. ↑ "MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression". The Journal of Biological Chemistry 289 (30): 20788–20801. July 2014. doi:10.1074/jbc.m113.525493. PMID 24878960.
7. ↑ "The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development". Genes & Development 21 (7): 744–749. April 2007. doi:10.1101/gad.1519107. PMID 17403776.
8. ↑ "The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing". Molecular Cell 27 (3): 435–448. August 2007. doi:10.1016/j.molcel.2007.07.015. PMID 17679093.
9. ↑ "MicroRNA-124 modulates social behavior in frontotemporal dementia". Nature Medicine 20 (12): 1381–1383. December 2014. doi:10.1038/nm.3768. PMID 25473917.
10. ↑ "Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility". British Journal of Biomedical Science 75 (4): 182–186. October 2018. doi:10.1080/09674845.2018.1492206. PMID 29938592.

## External links

*   * Page for miR-124 microRNA precursor family at Rfam
* miRBase family for miR-124

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miRNA precursor families

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