Blister

For other uses, see Blister (disambiguation).

"Vesiculation" redirects here. For vesiculation in geology, see Vesicular texture.

Blister

Other names: Vesicle, bullae[1]
Blisters from abrasive rubbing are common on the feet.
Specialty| Dermatology
Causes| Heat, cold, electricity, chemicals, friction, radiation

A blister is a well-defined, fluid-containing bump in the skin.[1] There may be one, many, or several merged to form a larger blister.[1] It can be irregular, grouped in clusters or scattered, or form in a line.[1] A blister may be firm or burst easily, and have one or several cavities.[1] A small blister is a vesicle, whereas bullae are large blisters.[1]

It is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma.[2] However, blisters can be filled with blood (known as "blood blisters") or with pus (for instance, if they become infected).[citation needed] To heal properly, a blister should not be popped unless medically necessary. If popped, the excess skin should not be removed because the skin underneath needs the top layer to heal properly.[3]

The word "blister" entered English in the 14th century. It came from the Middle Dutch "bluyster" and was a modification of the Old French "blostre", which meant a leprous nodule—a rise in the skin due to leprosy.

## Contents

* 1 Causes
* 1.1 Friction
* 1.2 Burning
* 1.3 Chemical exposure
* 1.4 Blood blister
* 1.5 Medical conditions
* 2 Pathophysiology
* 2.1 Friction blisters
* 3 Prevention
* 3.1 Friction blisters
* 3.2 Other
* 4 See also
* 5 References
* 6 External links

## Causes[edit | edit source]

Friction: various sized blisters on the sole of a foot Burning: two days after second-degree burn Chemical exposure: sulfur mustard agent

A blister may form when the skin has been damaged by friction or rubbing, heat, cold or chemical exposure. Fluid collects between the upper layers of skin (the epidermis) and the layers below (the dermis). This fluid cushions the tissue underneath, protecting it from further damage and allowing it to heal.

### Friction[edit | edit source]

Intense rubbing can cause a blister, as can any friction on the skin if continued long enough. This kind of blister is most common after walking long distances or by wearing old or poorly fitting shoes.[4][5][6] Blisters are most common on the hands and feet, as these extremities are susceptible while walking, running, or performing repetitive motions, such as joystick manipulation whilst playing certain video games, certain sports (e.g., baseball pitching), digging with a shovel, playing guitar or bass, etc. Blisters form more easily on damp skin than on dry or soaked skin,[7] and are more common in warm conditions. Less-aggressive rubbing over long periods of time may cause calluses to form rather than a blister. Both blisters and calluses can lead to more serious complications, such as foot ulceration and infection, particularly when sensation or circulation is impaired, as in the case of diabetes, neuropathy or peripheral artery disease (PAD).

### Burning[edit | edit source]

This type of blistering is one of the tools used to determine the degree of burns sustained. First and second degree burns may result in blistered skin; however, it is characteristic of second degree burns to blister immediately, whereas first degree burns can have blisters after a couple of days. Sunburn can also result in blisters.

Blisters can also form on the hands and feet as a result of tissue damage incurred by frostbite.[8]

### Chemical exposure[edit | edit source]

Sometimes, the skin will blister when it comes into contact with a cosmetic, detergent, solvent, or other chemical such as nickel sulfate, Balsam of Peru,[9] or urushiol (poison ivy, poison oak, poison sumac).[10] This is known as contact dermatitis. Blisters can also develop as a result of an allergic reaction to an insect bite or sting. Some chemical warfare agents, known as blister agents or vesicants, cause large, painful blisters wherever they contact skin; an example is mustard gas.

### Blood blister[edit | edit source]

A blood blister usually forms when a minute blood vessel close to the surface of the skin ruptures (breaks), and blood leaks into a tear between the layers of skin. This can happen if the skin is crushed, pinched or aggressively squeezed.

### Medical conditions[edit | edit source]

There are also a number of medical conditions that cause blisters. The most common are chickenpox, herpes, impetigo, and a form of eczema called dyshidrosis. Other, much rarer conditions that cause blisters include:

* Bullous pemphigoid: a skin disease that causes large, tightly filled blisters to develop, usually affecting people over the age of 60.
* Pemphigus: a serious skin disease in which blisters develop if pressure is applied to the skin; the blisters burst easily, leaving raw areas that can become infected.
* Dermatitis herpetiformis: a skin disease that causes intensely itchy blisters, usually on the elbows, knees, back and buttocks. The blisters usually develop in patches of the same shape and size on both sides of the body.
* Chronic bullous dermatosis: a disease that causes clusters of blisters on the face, mouth or genitals.
* Cutaneous radiation syndrome
* Epidermolysis bullosa[11]

## Pathophysiology[edit | edit source]

### Friction blisters[edit | edit source]

Friction blisters are caused by excess shear stress between the bottom and surface of the skin and the body. The strata of skin around the stratum spinosum are most susceptible to shear. As the stratum spinosum tears away from the connecting tissues below, plasma from the cells diffuses out. This plasma solution helps new cells divide and grow into new connective tissues and epidermal layers.

The clear fluid will be reabsorbed as new cells develop and the swollen appearance will subside. Painful blisters located on hands (palmar surface) and feet (plantar surface) are due to tissue shearing deeper in the epidermis, near nerve endings. Lower tissues are more susceptible to infection.

## Prevention[edit | edit source]

### Friction blisters[edit | edit source]

Friction blisters, caused by rubbing against the skin, can be prevented by reducing the friction to a level where blisters will not form.[4][5][6][12] This can be accomplished in a variety of ways.

Blisters on the feet can be prevented by wearing comfortable, well-fitting shoes and clean socks. Inherently ill-fitting or stiffer shoes, such as high heels and dress shoes, present a larger risk of blistering. Blisters are more likely to develop on skin that is moist, so socks that manage moisture or frequent sock changes will aid those with particularly sweaty feet. While exercising or playing sports, special sports socks can help keep feet drier and reduce the chance of blisters.[13] Before going for a long walk, it is also important to ensure that shoes or hiking boots have been properly broken in.

Even before a "hot" or irritated area on the foot is felt, taping a protective layer of padding or a friction-reducing interface between the affected area and the footwear can prevent the formation of a blister.[14] Bandages, moleskin and tapes generally must be applied to the foot daily, and most have a very high coefficient of friction (COF), but a friction-management patch applied to the shoe will remain in place much longer, throughout many changes of socks and insoles. This type of intervention may be used with footwear that is worn daily, with specialty shoes and boots like hockey skates, ice skates, inline skates, ski boots and cleats, or even with orthotic braces and splints. For periods of sustained use such as hiking and trail running, especially where water ingress or moisture build up in the shoe or boot can occur, moisture wicking liner socks can provide the required friction protection.

To avoid friction blisters on the hands, gloves should be worn when using tools such as a shovel or pickaxe, doing manual work such as gardening, or using sports equipment like golf clubs or baseball bats. Oars used for competitive rowing are known for causing frequent blisters on the hands of oarsmen. Weightlifters are also prone to blisters as are gymnasts from the friction developed by the rubbing against the bars. To further reduce the occurrence one can tape the hands, and there are also a number of products on the market that claim to reduce the occurrence of blisters. These are all intended to be worn as a liner underneath a glove. The majority of these offerings simply add padding, and create a layer that reduces the coefficient of friction between the skin and the glove.

A lubricant, typically talcum powder, can be used to reduce friction between skin and apparel in the short term. People put talcum powder inside gloves or shoes for this purpose, although this type of lubricant can actually increase the friction in the long term as it absorbs moisture. Increased friction makes blisters more likely.

### Other[edit | edit source]

Sunscreen and protective clothing should also be used during the hottest part of the day to avoid blisters from sunburn. Avoiding sunlight during midday is the best way to avoid blisters from sunburn. Protective gloves should be worn when handling detergents, cleaning products, solvents and other chemicals.

## See also[edit | edit source]

* List of dermatology terminology

## References[edit | edit source]

1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "2. Cutaneous signs and diagnosis". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Elsevier. p. 11\. ISBN 978-0-323-54753-6. Archived from the original on 2021-09-23. Retrieved 2021-10-03.
2. ↑ Uchinuma, E; Koganei, Y; Shioya, N; Yoshizato, K (1988). "Biological evaluation of burn blister fluid". Annals of Plastic Surgery. 20 (3): 225–30. doi:10.1097/00000637-198803000-00005. PMID 3358612.
3. ↑ "Blister Treatments and Prevention". WebMD. Archived from the original on 2017-05-19. Retrieved 2017-03-04.
4. ↑ 4.0 4.1 [Naylor PFD. "The Skin Surface and Friction," British Journal of Dermatology. 1955;67:239–248.]
5. ↑ 5.0 5.1 [Naylor PFD. "Experimental Friction Blisters," British Journal of Dermatology. 1955;67:327–342.]
6. ↑ 6.0 6.1 [Sulzberger MB, Cortese TA, Fishman L, Wiley HS. "Studies on Blisters Produced by Friction," Journal of Investigative Dermatology. 1966;47:456–465.]
7. ↑ [Carlson JM. "The Friction Factor," OrthoKinetic Review. Nov/Dec 2001;1(7):1–3.]
8. ↑ "First Degree Burns". Uuhsc.utah.edu. Archived from the original on 2012-02-18. Retrieved 2012-02-21.
9. ↑ "Conn's Current Therapy 2011". google.com. Archived from the original on 2020-02-20. Retrieved 2021-05-28.
10. ↑ Commissioner, Office of the. "Consumer Updates - Outsmarting Poison Ivy and Other Poisonous Plants". www.fda.gov. Archived from the original on 2010-07-16. Retrieved 2021-05-28.
11. ↑ Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter; Marshall, John F.; McGrath, John A.; Mellerio, Jemima E. (2020-09-24). "Epidermolysis bullosa". Nature Reviews Disease Primers. 6 (1): 1–27. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. Archived from the original on 2020-11-18. Retrieved 2021-05-28.
12. ↑ [Hanna T, Carlson JM. "Freedom from Friction," OrthoKinetic Review. Mar/Apr 2004;4(2):34–35.]
13. ↑ "Treatment Skin Blisters – Blister On Bottom Of Foot – Blister On Foot". Goengo.com. Archived from the original on 2012-03-12. Retrieved 2012-02-21.
14. ↑ "Adventure Medical Kit Blister Medic Gel - BackpackGearTest.org". backpackgeartest.org. Archived from the original on 2016-12-20. Retrieved 2021-05-28.

## External links[edit | edit source]

Classification|

* ICD-10: T14.0
* ICD-9-CM: 919.2
* MeSH: D001768
* DiseasesDB: 1777
* SNOMED CT: 339008

|

External resources|

* MedlinePlus: 003239

*   * The dictionary definition of blister at Wiktionary

* v
* t
* e

General wounds and injuries

Abrasions|

* Abrasion
* Avulsion

Blisters|

* Blood blister
* Coma blister
* Delayed blister
* Edema blister
* Fracture blister
* Friction blister
* Sucking blister

Bruises|

* Hematoma/Ecchymosis
* Battle's sign
* Raccoon eyes
* Black eye
* Subungual hematoma
* Cullen's sign
* Grey Turner's sign
* Retroperitoneal hemorrhage

Animal bites|

* Insect bite
* Spider bite
* Snakebite

Other:|

* Ballistic trauma
* Stab wound
* Blunt trauma/superficial/closed
* Penetrating trauma/open
* Aerosol burn
* Burn/Corrosion/Chemical burn
* Frostbite
* Occupational injuries
* Traumatic amputation

By region|

* Hand injury
* Head injury
* Chest trauma
* Abdominal trauma

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