Mir-451 microRNA

mir-451

miR-451 microRNA secondary structure and sequence conservation

Identifiers
Symbol| mir-451
Rfam| RF00722
miRBase family| MIPF0000148
OMIM| 612071
Other data
RNA type| microRNA
Domain(s)| Eukaryota; Vertebrata
PDB structures| PDBe

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.[1]

## Applications

A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples.[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.[2]

## References

1. ↑ van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance.". The International Journal of Biochemistry & Cell Biology 42 (8): 1282–1290. doi:10.1016/j.biocel.2010.01.014. PMID 20083225.
2. ↑ 2.0 2.1 Courts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification.". Journal of Forensic Sciences 56 (6): 1464–1470. doi:10.1111/j.1556-4029.2011.01894.x. PMID 21827476.

## Further reading

* "Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.". Proc Natl Acad Sci U S A 107 (34): 15163–15168. 2010. doi:10.1073/pnas.1006432107. PMID 20699384. Bibcode: 2010PNAS..10715163Y.
* "miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.". Genes Dev 24 (15): 1620–1633. 2010. doi:10.1101/gad.1942110. PMID 20679398.
* "Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta.". Genes Dev 24 (15): 1614–1619. 2010. doi:10.1101/gad.1942810. PMID 20679397.
* "microRNA-451: A conditional switch controlling glioma cell proliferation and migration.". Cell Cycle 9 (14): 2742–2748. 2010. doi:10.4161/cc.9.14.12248. PMID 20647762.
* "Expression of microRNA-451 in normal and thalassemic erythropoiesis.". Ann Hematol 89 (10): 953–958. 2010. doi:10.1007/s00277-010-0980-7. PMID 20461517.
* "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.". Mol Cell 37 (5): 620–632. 2010. doi:10.1016/j.molcel.2010.02.018. PMID 20227367.
* "miR-451 enhances erythroid differentiation in K562 cells.". Leuk Lymphoma 51 (4): 686–693. 2010. doi:10.3109/10428191003629362. PMID 20218812.
* "MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells.". Nucleic Acids Res 37 (11): 3821–3827. 2009. doi:10.1093/nar/gkp255. PMID 19386621.
* "microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells.". Clin Cancer Res 15 (7): 2281–2290. 2009. doi:10.1158/1078-0432.CCR-08-1818. PMID 19318487.
* "miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.". Blood 113 (8): 1794–1804. 2009. doi:10.1182/blood-2008-05-155812. PMID 18849488.
* "MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells.". Biochem Biophys Res Commun 376 (1): 86–90. 2008. doi:10.1016/j.bbrc.2008.08.107. PMID 18765229.
* "Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.". Mol Cancer Ther 7 (7): 2152–2159. 2008. doi:10.1158/1535-7163.MCT-08-0021. PMID 18645025.
* "Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells.". Biochem Pharmacol 76 (5): 582–588. 2008. doi:10.1016/j.bcp.2008.06.007. PMID 18619946.

## External links

*   * Page for mir-451 microRNA precursor family at Rfam
* "MicroRNA MIR451 family (MIR451) Gene group". HUGO Gene Nomenclature Committee (HGNC). https://www.genenames.org/data/genegroup/#!/group/1727.

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miRNA precursor families

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* BART1
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* BHRF1-1
* BHRF1-2
* BHRF1-3
* Let-7
* Lin-4
* Lsy-6

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