Urinary retention

Other names: Ischuria, bladder failure, bladder obstruction
Urinary retention with greatly enlarged bladder as seen by CT scan.
Specialty| Emergency medicine, urology
Symptoms| Sudden onset: Inability to urinate, low abdominal pain[1]
Long term: Frequent urination, loss of bladder control, urinary tract infection[1]
Types| Acute, chronic[1]
Causes| Blockage of the urethra, nerve problems, certain medications, weak bladder muscles[1]
Diagnostic method| Amount of urine in the bladder post urination[1]
Treatment| Catheter, urethral dilation, urethral stents, surgery[1]
Medication| Alpha blockers such as terazosin, 5α-reductase inhibitors such as finasteride[1]
Frequency| 6 per 1,000 per year (males > 40 years old)[1]

Urinary retention is an inability to completely empty the bladder.[1] Onset can be sudden or gradual.[1] When of sudden onset, symptoms include an inability to urinate and lower abdominal pain.[1] When of gradual onset, symptoms may include loss of bladder control, mild lower abdominal pain, and a weak urine stream.[1] Those with long-term problems are at risk of urinary tract infections.[1]

Causes include blockage of the urethra, nerve problems, certain medications, and weak bladder muscles.[1] Blockage can be caused by benign prostatic hyperplasia (BPH), urethral strictures, bladder stones, a cystocele, constipation, or tumors.[1] Nerve problems can occur from diabetes, trauma, spinal cord problems, stroke, or heavy metal poisoning.[1] Medications that can cause problems include anticholinergics, antihistamines, tricyclic antidepressants, decongestants, cyclobenzaprine, diazepam, NSAIDs, amphetamines, and opioids.[1] Diagnosis is typically based on measuring the amount of urine in the bladder after urinating.[1]

Treatment is typically with a catheter either through the urethra or lower abdomen.[1][2] Other treatments may include medication to decrease the size of the prostate, urethral dilation, a urethral stent, or surgery.[1] Males are more often affected than females.[1] In males over the age of 40 about 6 per 1,000 are affected a year.[1] Among males over 80 this increases 30%.[1]

## Contents

* 1 Signs and symptoms
* 2 Causes
* 2.1 Bladder
* 2.2 Prostate
* 2.3 Postoperative
* 2.4 Chronic
* 2.5 Other
* 3 Diagnosis
* 4 Treatment
* 4.1 Medication
* 4.2 Catheter
* 4.3 Surgery
* 4.4 Sitting position
* 5 Complications
* 6 Epidemiology
* 7 References
* 8 External links

## Signs and symptoms[edit | edit source]

Onset can be sudden or gradual.[1] When of sudden onset, symptoms include an inability to urinate and lower abdominal pain.[1] When of gradual onset, symptoms may include loss of bladder control, mild lower abdominal pain, and a weak urine stream.[1] Those with long-term problems are at risk of urinary tract infections.[1]

## Causes[edit | edit source]

### Bladder[edit | edit source]

* Detrusor sphincter dyssynergia
* Neurogenic bladder (commonly spinal cord damage, pelvic splanchic nerve damage, cauda equina syndrome, pontine micturition or storage center lesions, demyelinating diseases or Parkinson's disease)
* Iatrogenic (caused by medical treatment/procedure) scarring of the bladder neck (commonly from removal of indwelling catheters or cystoscopy operations)
* Damage to the bladder

### Prostate[edit | edit source]

* Benign prostatic hyperplasia (BPH)
* Prostate cancer and other pelvic malignancies
* Prostatitis

Penile urethra:

* Congenital urethral valves
* Phimosis or pinhole meatus
* Circumcision
* Obstruction in the urethra, for example a stricture (usually caused either by injury or STD), a metastasis or a precipitated pseudogout crystal in the urine
* STD lesions (gonorrhoea causes numerous strictures, leading to a "rosary bead" appearance, whereas chlamydia usually causes a single stricture)

### Postoperative[edit | edit source]

Risk factors include

* Age: Older people may have degeneration of neural pathways involved with bladder function and it can lead to an increased risk of postoperative urinary retention.[3] The risk of postoperative urinary retention increases up to 2.11 fold for people older than 60 years.[3]
* Medications: Anticholinergics and medications with anticholinergic properties, alpha-adrenergic agonists, opiates, nonsteroidal anti-inflammatories (NSAIDs), calcium-channel blockers and beta-adrenergic agonists, may increase the risk.[3]
* Anesthesia: General anesthetics during surgery may cause bladder atony by acting as a smooth muscle relaxant.[3] General anesthetics can directly interfere with autonomic regulation of detrusor tone and predispose people to bladder overdistention and subsequent retention.[3] Spinal anesthesia results in a blockade of the micturition reflex.[3] Spinal anesthesia shows a higher risk of postoperative urinary retention compared to general anesthesia.[3]
* Benign prostatic hyperplasia: Men with benign prostatic hyperplasia are at an increased risk of acute urinary retention.[3]
* Surgery related: Operative times longer than 2 hours may lead to an increased risk of postoperative urinary retention 3-fold.[3]

### Chronic[edit | edit source]

Chronic urinary retention that is due to bladder blockage which can either be as a result of muscle damage or neurological damage.[4] If the retention is due to neurological damage, there is a disconnect between the brain to muscle communication, which can make it impossible to completely empty the bladder.[4] If the retention is due to muscle damage, it is likely that the muscles are not able to contract enough to completely empty the bladder.[4]

The most common cause of chronic urinary retention is BPH.[1] BPH is a result of the ongoing process of testosterone being converted to dihydrotestosterone which stimulates prostate growth.[5] Over a person's lifetime, the prostate experiences constant growth due to the conversion of testosterone to dihydrotestosterone.[5] This can cause the prostate to push on the urethra and block it, which can lead to urinary retention.[5]

### Other[edit | edit source]

* Tethered spinal cord syndrome
* Psychogenic causes (psychosocial stresses, fear associated with urination, paruresis ("shy bladder syndrome")- in extreme cases, urinary retention can result)
* Consumption of some psychoactive substances, mainly stimulants, such as MDMA and amphetamine.
* Use of NSAIDs or drugs with anticholinergic properties.
* Stones or metastases can theoretically appear anywhere along the urinary tract, but vary in frequency depending on anatomy
* Muscarinic antagonist such as atropine and scopolamine
* Malfunctioning artificial urinary sphincter

## Diagnosis[edit | edit source]

Analysis of urine flow may aid in establishing the type of micturition (urination) abnormality. Common findings, determined by ultrasound of the bladder, include a slow rate of flow, intermittent flow, and a large amount of urine retained in the bladder after urination. A normal test result should be 20-25 mL/s peak flow rate. A post-void residual urine greater than 50 ml is a significant amount of urine and increases the potential for recurring urinary tract infections. In adults older than 60 years, 50-100 ml of residual urine may remain after each voiding because of the decreased contractility of the detrusor muscle.[4] In chronic retention, ultrasound of the bladder may show massive increase in bladder capacity (normal capacity is 400-600 ml).

Non-neurogenic chronic urinary retention does not have a standardized definition; however, urine volumes >300mL can be used as an informal indicator.[4] Diagnosis of urinary retention is conducted over a period of 6 months, with 2 separate measurements of urine volume 6 months apart. Measurements should have a PVR (post-void residual) volume of >300mL.[4]

Determining the serum prostate-specific antigen (PSA) may help diagnose or rule out prostate cancer, though this is also raised in BPH and prostatitis. A TRUS biopsy of the prostate (trans-rectal ultra-sound guided) can distinguish between these prostate conditions. Serum urea and creatinine determinations may be necessary to rule out backflow kidney damage. Cystoscopy may be needed to explore the urinary passage and rule out blockages.

In acute cases of urinary retention where associated symptoms in the lumbar spine are present such as pain, numbness (saddle anesthesia), parasthesias, decreased anal sphincter tone, or altered deep tendon reflexes, an MRI of the lumbar spine should be considered to further assess cauda equina syndrome.

* As seen on axial CT

* Ultrasonography showing a trabeculated wall, seen as small irregularities mainly at left (superior part). This is strongly associated with urinary retention.[6]

## Treatment[edit | edit source]

Acute urinary retention is a medical emergency and requires prompt treatment. In acute urinary retention, urinary catheterization, placement of a prostatic stent, or suprapubic cystostomy relieves the retention. In the longer term, treatment depends on the cause. BPH may respond to alpha blocker and 5-alpha-reductase inhibitor therapy, or surgically with prostatectomy or transurethral resection of the prostate (TURP).

Use of alpha-blockers can provide relief of urinary retention following de-catheterization for both men and women.[7][8] In case, if catheter can't be negotiated, suprapubic puncture can be done with lumbar puncture needle.

### Medication[edit | edit source]

Some people with BPH are treated with medications. These include tamsulosin to relax smooth muscles in the bladder neck, and finasteride and dutasteride to decrease prostate enlargement. The drugs only work for mild cases of BPH but also have mild side effects. Some of the medications decrease libido and may cause dizziness, fatigue and lightheadedness.

### Catheter[edit | edit source]

Acute urinary retention is treated by placement of a urinary catheter (small thin flexible tube) into the bladder. This can be either an intermittent catheter or a Foley catheter that is placed with a small inflatable bulb that holds the catheter in place.

Intermittent catheterization can be done by a health care professional or by the person themselves (clean intermittent self catheterization). Intermittent catheterization performed at the hospital is a sterile technique. Patients can be taught to use a self catheterization technique in one simple demonstration,[9] and that reduces the rate of infection from long-term Foley catheters. Self catheterization requires doing the procedure periodically during the day, the frequency depending on fluid intake and bladder capacity. If fluid intake/outflow is around 1.5 litres per day, this would typically be performed roughly three times per day, i.e. roughly every six to eight hours during the day, more frequently when fluid intake is higher and/or bladder capacity lower.

For acute urinary retention, treatment requires urgent placement of a urinary catheter. A permanent urinary catheter may cause discomfort and pain that can last several days.

Older people with ongoing problems may require continued intermittent self catheterization (CISC). CISC has a lower infection risk compared to catheterization techniques that stay within the body.[9] Challenges with CISC include compliance issues as some people may not be able to place the catheter themselves.[10]

### Surgery[edit | edit source]

The chronic form of urinary retention may require some type of surgical procedure. While both procedures are relatively safe, complications can occur.

In most patients with benign prostate hyperplasia (BPH), a procedure known as transurethral resection of the prostate (TURP) may be performed to relieve bladder obstruction.[11] Surgical complications from TURP include a bladder infection, bleeding from the prostate, scar formation, inability to hold urine, and inability to have an erection. The majority of these complications are short lived, and most individuals recover fully within 6–12 months.[12]

### Sitting position[edit | edit source]

A meta-analysis on the influence of voiding position on urodynamics in healthy males and males with LUTS showed that in the sitting position, the residual urine in the bladder was reduced. The other parameters, namely the maximum urinary flow and the voiding time were increased and decreased respectively. For healthy males, no influence was found on these parameters, meaning that they can urinate in either position.[13]

## Complications[edit | edit source]

The urinary bag of a person with post obstructive diuresis

Complications of untreated urinary retention include bladder damage and chronic kidney failure.[14] Urinary retention is a disorder treated in a hospital, and the quicker one seeks treatment, the fewer the complications.

Following treatment of urinary retention, postobstructive diuresis may occur. This is defined as more than 400 ml of urine production over 2 hours or 3 liters over 24 hours.[15]

In the longer term, obstruction of the urinary tract may cause:

* Bladder stones
* Atrophy of the detrusor muscle (atonic bladder is an extreme form)
* Hydronephrosis (congestion of the kidneys)
* Hypertrophy of the detrusor muscle (the muscle that squeezes the bladder to empty it during urination)
* Diverticula (formation of pouches) in the bladder wall (which can lead to stones and infection)

## Epidemiology[edit | edit source]

Urinary retention is a common disorder in elderly males. The most common cause of urinary retention is BPH. This disorder starts around age 50 and symptoms may appear after 10–15 years. BPH is a progressive disorder and narrows the neck of the bladder leading to urinary retention. By the age of 70, almost 10 percent of males have some degree of BPH and 33% have it by the eighth decade of life. While BPH rarely causes sudden urinary retention, the condition can become acute in the presence of certain medications (blood pressure pills, anti histamines, antiparkinson medications), after spinal anaesthesia or stroke.

In young males, the most common cause of urinary retention is infection of the prostate (acute prostatitis). The infection is acquired during sexual intercourse and presents with low back pain, penile discharge, low grade fever and an inability to pass urine. The exact numbers of individuals with acute prostatitis is unknown, because many do not seek treatment. In the US, at least 1-3 percent of males under the age of 40 develop urinary difficulty as a result of acute prostatitis. Most physicians and other health care professionals are aware of these disorders. Worldwide, both BPH and acute prostatitis have been found in males of all races and ethnic backgrounds. Cancers of the urinary tract can cause urinary obstruction but the process is more gradual. Cancer of the bladder, prostate or ureters can gradually obstruct urine output. Cancers often present with blood in the urine, weight loss, lower back pain or gradual distension in the flanks.[16]

Urinary retention in females is uncommon, occurring 1 in 100,000 every year, with a female-to-male incidence rate of 1:13. It is usually transient. The causes of UR in women can be multi-factorial, and can be postoperative and postpartum. Prompt urethral catheterization usually resolves the problem.[17]

## References[edit | edit source]

1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 "Urinary Retention". National Institute of Diabetes and Digestive and Kidney Diseases. Aug 2014. Archived from the original on 4 October 2017. Retrieved 24 October 2017.
2. ↑ Sliwinski, A; D'Arcy, FT; Sultana, R; Lawrentschuk, N (April 2016). "Acute urinary retention and the difficult catheterization: current emergency management". European Journal of Emergency Medicine. 23 (2): 80–8. doi:10.1097/MEJ.0000000000000334. PMID 26479738.
3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Kowalik, Urszula; Plante, Mark K. (June 2016). "Urinary Retention in Surgical Patients". The Surgical Clinics of North America. 96 (3): 453–467. doi:10.1016/j.suc.2016.02.004. ISSN 1558-3171. PMID 27261788.
4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Stoffel, JT (September 2017). "Non-neurogenic Chronic Urinary Retention: What Are We Treating?". Current Urology Reports. 18 (9): 74. doi:10.1007/s11934-017-0719-2. PMID 28730405.
5. ↑ 5.0 5.1 5.2 Herati, AS; Kohn, TP; Butler, PR; Lipshultz, LI (June 2017). "Effects of Testosterone on Benign and Malignant Conditions of the Prostate". Current Sexual Health Reports. 9 (2): 65–73. doi:10.1007/s11930-017-0104-7. PMC 5648355. PMID 29056882.
6. ↑ Page 306 Archived 2018-01-16 at the Wayback Machine in:Sam D. Graham, Thomas E. Keane, James Francis Glenn (2010). Glenn's Urologic Surgery. Lippincott Williams & Wilkins. ISBN 9780781791410.`{{cite book}}`: CS1 maint: multiple names: authors list (link)
7. ↑ Fisher, Euan; Subramonian, Kesavapillai; Omar, Muhammad Imran (2014-06-10). "The role of alpha blockers prior to removal of urethral catheter for acute urinary retention in men". The Cochrane Database of Systematic Reviews (6): CD006744. doi:10.1002/14651858.CD006744.pub3. ISSN 1469-493X. PMID 24913721.
8. ↑ Drake, MarcusJ; Mevcha, Amit (2010-04-01). "Etiology and management of urinary retention in women". Indian Journal of Urology. 26 (2): 230–5. doi:10.4103/0970-1591.65396. PMC 2938548. PMID 20877602. Archived from the original on 2018-06-01. Retrieved 2021-10-29.
9. ↑ 9.0 9.1 "Clean Intermittent Self-Catheterization". Archived from the original on 2017-07-16.
10. ↑ Seth, Jai H.; Haslam, Collette; Panicker, Jalesh N. (2014). "Ensuring patient adherence to clean intermittent self-catheterization". Patient Preference and Adherence. 8: 191–198. doi:10.2147/PPA.S49060. ISSN 1177-889X. PMC 3928402. PMID 24611001.
11. ↑ eMedicine Health. "Inability to urinate" Archived 2010-03-05 at the Wayback Machine 2010-02-10.
12. ↑ National kidney and urologic diseases information clearinghouse. "Urinary retention overview" Archived 2010-01-29 at the Wayback Machine 2010-02-10.
13. ↑ Phillips, Robert S.; de Jong, Ype; Pinckaers, Johannes Henricus Francisca Maria; ten Brinck, Robin Marco; Lycklama à Nijeholt, Augustinus Aizo Beent; Dekkers, Olaf Matthijs (2014). "Urinating Standing versus Sitting: Position Is of Influence in Men with Prostate Enlargement. A Systematic Review and Meta-Analysis". PLoS ONE. 9 (7): e101320. doi:10.1371/journal.pone.0101320. PMC 4106761. PMID 25051345.
14. ↑ General information on urinary retention Archived 2010-02-20 at the Wayback Machine 2010-02-10
15. ↑ "Management of Acute Urinary Retention in the Emergency Department | EB Medicine". www.ebmedicine.net. 23 (3). March 2021. Archived from the original on 16 April 2021. Retrieved 13 May 2021.
16. ↑ Urologic Emergencies Archived 2010-03-10 at the Wayback Machine Urology Channel portal. 2010-02-10
17. ↑ Özveren, B; Keskin, S (2016). "Presentation and prognosis of female acute urinary retention: Analysis of an unusual clinical condition in outpatients". Urology Annals. 8 (4): 444–448. doi:10.4103/0974-7796.192111. PMC 5100150. PMID 28057989.

## External links[edit | edit source]

Classification|

* ICD-10: R33
* ICD-9-CM: 788.2
* MeSH: D016055
* DiseasesDB: 13582

|

* v
* t
* e

Symptoms and signs relating to the urinary system

Pain|

* Dysuria
* Renal colic
* Costovertebral angle tenderness
* Vesical tenesmus

Control|

* Urinary incontinence
* Enuresis
* Diurnal enuresis
* Giggling
* Nocturnal enuresis
* Post-void dribbling
* Stress
* Urge
* Overflow
* Urinary retention

Volume|

* Oliguria
* Anuria
* Polyuria

Other|

* Lower urinary tract symptoms
* Nocturia
* urgency
* frequency
* Extravasation of urine
* Uremia

Eponymous|

* Addis count
* Brewer infarcts
* Lloyd's sign
* Mathe's sign

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