Ukrain

Short description: Chemical compound

Ukrain

The chemical structure of ukrain claimed by the manufacturer could not be determined in independent studies.[1][2]

Clinical data
Other names| celandine
Dependence
liability| Low
Addiction
liability| Low
Routes of
administration| intravenous and intramuscular
Legal status
Legal status|

* US: Not FDA approved
* Not recommended for cancer treatment

Identifiers

IUPAC name

* Ukrain

CAS Number|

* 138069-52-0

PubChem CID|

* 13456988

ChemSpider|

* 140682

UNII|

* 6251Q9UK1S

Chemical and physical data
Formula| C66H75N6O18PS
Molar mass| 1303.38 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* C[N+]1(CC2=C(C=CC3=C2OCO3)C4C1C5=CC6=C(C=C5CC4O)OCO6)CCNP(=S)(NCC[N+]7(CC8=C(C=CC9=C8OCO9)C1C7C2=CC3=C(C=C2CC1O)OCO3)C)NCC[N+]1(CC2=C(C=CC3=C2OCO3)C2C1C1=CC3=C(C=C1CC2O)OCO3)C.[OH-].[OH-].[OH-]

InChI

* InChI=1S/C66H72N6O15PS.3H2O/c1-70(25-43-37(4-7-49-64(43)85-31-76-49)58-46(73)16-34-19-52-55(82-28-79-52)22-40(34)61(58)70)13-10-67-88(89,68-11-14-71(2)26-44-38(5-8-50-65(44)86-32-77-50)59-47(74)17-35-20-53-56(83-29-80-53)23-41(35)62(59)71)69-12-15-72(3)27-45-39(6-9-51-66(45)87-33-78-51)60-48(75)18-36-21-54-57(84-30-81-54)24-42(36)63(60)72;;;/h4-9,19-24,46-48,58-63,73-75H,10-18,25-33H2,1-3H3,(H3,67,68,69,89);3*1H2/q+3;;;/p-3

* Key:KIGCDEJCMKDBHU-UHFFFAOYSA-K

Ukrain (Ukrainian: Україн; also called celandine) is the trademarked name of a semi-synthetic substance derived from the plant Chelidonium majus and promoted as a drug to treat cancer and viral infections, including HIV and hepatitis.[3][4] It was created in 1978, by the famed Ukrainian chemist Vasyl Novytskyi (uk) (Ukrainian: Василь Новицький).[5] Ukrain is named after the nation of Ukraine and is produced by the Austrian company Nowicky Pharma.

According to the American Cancer Society and the Memorial Sloan-Kettering Cancer Center, there is no evidence that Ukrain is an effective cancer treatment.

## Contents

* 1 Evidence
* 2 Legal incidents
* 3 See also
* 4 References
* 5 External links

## Evidence

In 2005, Edzard Ernst led a review into evidence of the effectiveness of Ukrain. Although the review found evidence suggesting the drug was effective, it also concluded that "numerous caveats prevent a positive conclusion".[6] Commenting on the review some years later, Ernst wrote on his blog that the results they were examining had seemed "too good to be true" - and on investigation the trials were very small in size, often seemed to include Novytskyi himself, and had significant methodological flaws. However, despite the cautious conclusion given, "this article became much cited. ... [Novytskyi] must have been delighted".[4]

The Memorial Sloan-Kettering Cancer Center says that clinical trials have yet to prove safety and effectiveness of Ukrain.[7] The American Cancer Society stated that, as of 2013, "available scientific evidence does not support claims that celandine is effective in treating cancer in humans".[3] It may however be responsible for some adverse side-effects including hepatitis and allergic skin reactions.[3]

## Legal incidents

Ukrain is not approved by the US Food and Drug Administration.[7] On September 4, 2012, several people including Vasyl Novytskyi, the drug's developer, were arrested in Austria for distributing the drug under suspicion of commercial fraud.[4][8] Novytskyi appeared in Vienna regional court again in January 2015 for selling Ukrain, earning an estimated 1.1 million euros through fraud by changing labels on expired vials.[9] In March 2015, two co-defendants of Novytskyi were exonerated for commercial fraud, while legal proceedings continue for Novytskyi.[10]

From October 2013 to April 2014, a licensed naturopath in Tucson, Arizona, Michael Uzick, was using Ukrain in his practice to treat cancer patients. He was reported to the Arizona authorities by Britt Marie Hermes, who discovered while working for Uzick that the unapproved drug was being imported.[11] Uzick was given a letter of reprimand by the Arizona Naturopathic Physicians Medical Board.[11][12]

## See also

* List of ineffective cancer treatments
* Thiotepa \- a chemotherapeutic agent

## References

1. ↑ "Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway". BMC Cancer 6: 14. January 2006. doi:10.1186/1471-2407-6-14. PMID 16417634.
2. ↑ "Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure". Cancer Letters 160 (2): 237–41. November 2000. doi:10.1016/s0304-3835(00)00595-4. PMID 11053654.
3. ↑ 3.0 3.1 3.2 "Celandine". American Cancer Society. August 2011. http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/herbsvitaminsandminerals/celandine.
4. ↑ 4.0 4.1 4.2 Ernst, Edzard (14 October 2012). "A telling story about "alternative" cancer cures and their purveyors". http://edzardernst.com/2012/10/a-telling-story-about-alternative-cancer-cures-and-their-purveyors/.
5. ↑ "Українського винахідника ліків проти раку заарештували за шахрайство" (in uk). 2012-09-08. https://tsn.ua/ukrayina/ukrayinskogo-vinahidnika-likiv-proti-raku-zaareshtuvali-za-shahraystvo.html.
6. ↑ "Ukrain - a new cancer cure? A systematic review of randomised clinical trials". BMC Cancer 5: 69. July 2005. doi:10.1186/1471-2407-5-69. PMID 15992405.
7. ↑ 7.0 7.1 "Ukrain". Memorial Sloan-Kettering Cancer Center. September 2012. http://www.mskcc.org/cancer-care/herb/ukrain.
8. ↑ "Krebskranke getäuscht: Festnahmen" (in de). wien.orf.at. 4 September 2012. https://wien.orf.at/news/stories/2548611/.
9. ↑ "Ukrainian chemist lands in court for cancer 'cure'". The Local. 28 Jan 2015. http://www.thelocal.at/20150128/ukrainian-chemist-lands-in-court-for-cancer-cure.
10. ↑ "Mitangeklagte in Prozess um angebliches Krebs-Heilmittel freigesprochen". derStandard.at. 5 March 2015. http://derstandard.at/2000012542143/Mitangeklagte-Krebs-Heilmittel-verkauft-freigesprochen.
11. ↑ 11.0 11.1 Thielking, Megan (20 October 2016). "'Essentially witchcraft:' A former naturopath takes on the field". STAT. https://www.statnews.com/2016/10/20/naturopath-critic-britt-hermes/.
12. ↑ "Dr. Michael Uzick Disciplinary Actions". http://directorynd.az.gov/agency/pages/directorySearchDetail.asp?holderID=102.

## External links

* The official site from Nowicky Pharma about the drug Ukrain
* CAM-Cancer information page on Ukrain

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*[US]: United States
*[CID]: Compound ID