Iodine (125I) human albumin

Short description: Iodinated I-125 human serum albumin

Iodine (125I) human albuminClinical data

Trade names| Jeanatope
AHFS/Drugs.com| FDA Professional Drug Information
Routes of
administration| Intravenous injection
ATC code|

* V09GB02 (WHO)

Legal status
Legal status|

* US: ℞-only

Pharmacokinetic data
Elimination half-life| ~14 days
Excretion| via kidneys
Identifiers
PubChem SID|

* 17396952

DrugBank|

* DB09429

UNII|

* 68WQQ3N9TI

KEGG|

* D02794

Iodine (125I) human albumin (trade name Jeanatope) is human serum albumin iodinated with iodine-125, typically injected to aid in the determination of total blood and plasma volume.[1][2]

Iodine-131 iodinated albumin (trade name Volumex) is used for the same purposes.[3]

## Contents

* 1 Medical uses
* 2 Contraindications
* 3 Adverse effects
* 4 Pharmacokinetics
* 5 References

## Medical uses

Iodine (125I) human albumin is used to determine a person's blood volume. For this purpose, a defined amount of radioactivity in form of this drug is injected into a vein, and blood samples are drawn from a different body location after five and fifteen minutes. From the radioactivity of these samples, the original radioactivity per blood volume can be calculated; and knowing the total amount of radioactivity injected, one can calculate the total blood volume.[1]

It can also be used to calculate the blood plasma volume using a similar method. The main difference is that the drawn blood sample has to be centrifuged to separate the plasma from the blood cells.[1]

## Contraindications

The US Food and Drug Administration lists no contraindications for this drug.[1]

## Adverse effects

There is a theoretical possibility of allergic reactions after repeated use of this medication.[1]

## Pharmacokinetics

Iodine-125 is a radioactive isotope of iodine that decays by electron capture with a physical half-life of 60.14 days. The biological half-life in normal individuals for iodine (125I) human albumin has been reported to be approximately 14 days. Its radioactivity is excreted almost exclusively via the kidneys.[1]

## References

1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Jeanatope FDA Professional Drug Information. Accessed 21 April 2021.
2. ↑ DrugBank DB09429 . Accessed 21 April 2021.
3. ↑ Volumex Injection FDA Professional Drug Information. Accessed 21 April 2021.

* v
* t
* e

Diagnostic radiopharmaceuticals (ATC: V09)

Central nervous system|

* 99mTc (Exametazime)
* 123I (Ioflupane
* Iofetamine
* Iomazenil)
* 18F (Florbetapir, Flutemetamol)

Skeletal system|

* 99mTc (Medronic acid)

Renal|

* 123I (Sodium iodohippurate)
* 64Cu (Cu-ETS2)

Gastrointestinal/Hepatic|

* 75Se (SeHCAT)

Respiratory system|

* 133Xe
* 81mKr
* 99mTc (99mTc-MAA)

Cardiovascular system|

* 99mTc (Sestamibi
* Tetrofosmin)
* 111In (Imciromab)
* 82Rb (Rubidium chloride)

Inflammation/infection|

* 99mTc (Exametazime
* Sulesomab
* Tilmanocept)
* 111In
* 67Ga

Tumor|

* 99mTc (Arcitumomab
* Votumumab
* Hynic-octreotide)
* 111In (Capromab pendetide
* Satumomab pendetide)
* 125I (Minretumomab)
* 123I / 131I (Iobenguane)
* 18F (Fluciclovine
* Fludeoxyglucose
* Fluoroethyltyrosine
* Sodium fluoride)

Adrenal cortex|

* 123I
* 125I / 131I (Iodocholesterol)

Radionuclides
(including tracers)|

| positron (PET list)|

* 11C ([11C]ME@HAPTHI
* 25B-NBOMe (Cimbi-36)
* Acetate
* Choline
* Carfentanil
* DASB
* DTBZ
* Flumazenil
* Methionine
* N-Methylspiperone
* Pittsburgh compound B
* Raclopride
* Verapamil)
* 13N (Ammonia)
* 15O (Water)
* 18F (Altanserin
* Desmethoxyfallypride
* FMISO
* Fallypride
* Florbetaben
* Florbetapir
* Flubatine
* Fluciclovine
* Fludeoxyglucose (18F) (FDG)-glucose analogue
* Flumazenil
* Fluorocholine
* Fluorodeoxysorbitol (FDS)
* Fluorodopa
* Fluorothymidine F-18
* Fluspidine
* Flutemetamol
* MPPF
* Mefway
* Nifene
* N-Methylspiperone
* FET
* Setoperone)
* 64Cu
* 68Ga
* 82Rb (Rubidium chloride)

|

gamma ray/photon (SPECT/scintigraphy)|

* 51Cr
* 57Co
* 67Ga
* 75Se
* 81mKr
* 99mTc
* 111In
* 123I
* 125I
* 131I
* 133Xe
* 153Sm
* 201Tl

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