Akt-PKB

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This editable Main Article is under development and subject to a disclaimer.

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Due to technical limitations, this article uses an unusual title. It should be called Akt/PKB.

The serine/threonine protein kinase B (PKB) family or Akt is an important downstream signaling component of tyrosine kinase growth factor and G-coupled receptors. Akt/PKB is activated by phosphorylation at two distinct amino acid residues, Threonin 308 and Serine 473.