SIR-Spheres

SIR-Spheres microspheres are used to treat patients with unresectable liver cancer. These are mostly patients with hepatocellular carcinoma (HCC), metastatic colorectal cancer (mCRC), or metastatic neuroendocrine tumours (mNET).[1] Therapy goals are local disease control, downstaging to resection, bridging to transplantation, and extended survival.[2]

## Contents

* 1 Description
* 2 Mode of action
* 3 See also
* 4 References
* 5 External links

## Description

SIR-Spheres microspheres contain resin based microspheres with an average diameter between 20 and 60 micrometre. The microspheres are impregnated with 90Y, a beta radiating isotope of yttrium with a half-life of 64.1 hours.[3]

## Mode of action

Once injected into the hepatic artery via a catheter by an interventional radiologist the microspheres will preferably lodge in the vasculature of the tumour. The radiation will lead to damage of tumour tissue and, in the best case to a complete elimination of the tumour. Due to the half-life almost all of the radiation is delivered within 2 weeks. After 1 month almost no radioactivity will remain.

The procedure is also known as selective internal radiation therapy (SIRT) or radioembolization.

## See also

* TheraSphere
* Sirtex

## References

1. ↑ J.I.Bilbao & M.F.Reiser: Liver Radioembolization with Yttrium-90 Microspheres, Springer 2008 ISBN 978-3-540-35421-5
2. ↑ R.Salem et al J.Vasc Intervent Radiol 2006; 17:1251-1278
3. ↑ http://www.sirtex.com/content.cfm?sec=usa&MenuID=1120

## External links

* Sirtex
* Insider Radiology

* v
* t
* e

Radiation oncology

* (ICD-9-CM V3 92.2-92.3
* ICD-10-PCS D)

Specific
therapies

| Teletherapy1|

| by photon|

* Superficial X-rays
* Orthovoltage X-rays
* Megavoltage X-rays
* Radiosurgery / Stereotactic radiation therapy
* Cyberknife
* Gamma Knife
* Cobalt therapy

|

by electron|

* Electron therapy

by hadron|

* Particle therapy
* fast neutron
* neutron-capture
* proton

Brachytherapy2|

* Prostate
* 125I
* 103Pd
* Plaque radiotherapy (125I)
* Selective internal radiation therapy / SIR-Spheres / TheraSphere (90Y)

Unsealed source
radiotherapy3

* Iobenguane (131I)
* 90Y
* Lexidronam (153Sm)
* 89Sr
* Radioimmunotherapy
* ibritumomab tiuxetan

Other|

* Intraoperative radiation therapy
* electron
* TARGIT
* Tomotherapy

Conditions|

* Radiation burn
* Radiation proctitis
* Radiation-induced lung injury

Features and
equipment

* BEAMnrc
* Bolus
* Bragg peak
* D50
* Dose profile
* Dose verification system
* Dose-volume histogram
* Dosimetry
* Isocenter
* Mobetron
* Monitor unit
* Multileaf collimator
* Nanoimpellers
* Neutron generator
* Oxygen enhancement ratio
* Pencil
* Pencil-beam scanning
* Percentage depth dose curve
* Radiation oncologist
* Radiation Therapist
* Radiation treatment planning
* Radiopharmacology
* Tissue to Air Ratio (TAR)

* 1 Also known as external-beam radiotherapy.
* 2 Also known as sealed-source radiation therapy.
* 3 Also known as systemic radioisotope therapy.

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