List of soft tissue tumors

The fifth edition (2020) WHO classification of soft tissue tumors categorizes soft tissue tumors by its histology.[1] Some new types have been introduced, based on their distinct biological behaviour, location, genetics and appearance.[2][3][4]

Soft tissue tumors  Family (class) | Type | Image

|
|

Adipocytic tumor[5] | Lipoma |
Lipomatosis |
Lipomatosis of nerve |
Lipoblastoma and lipoblastomatosis |
Angiolipoma |
Myolipoma of soft tissue |
Chondroid lipoma |
Spindle cell lipoma and pleomorphic lipoma |
Hibernoma |
Atypical spindle cell / pleomorphic lipomatous tumour |
Atypical lipomatous tumour / well-differentiated liposarcoma |
Dedifferentiated liposarcoma |
Myxoid liposarcoma |
Pleomorphic liposarcoma |
Myxoid pleomorphic liposarcoma |
Fibroblastic and myofibroblastic tumors | Nodular fasciitis |
Proliferative fasciitis and proliferative myositis |
Myositis ossificans and fibro-osseous pseudotumour of digits |
Ischemic fasciitis |
Elastofibroma |
Fibrous hamartoma of infancy |
Fibromatosis colli |
Juvenile hyaline fibromatosis |
Inclusion body fibromatosis |
Fibroma of tendon sheath |
Desmoplastic fibroblastoma Myofibroblastoma |
Calcifying aponeurotic fibroma |
EWSR1-SMAD3-positive fibroblastic tumour (emerging)  |
Angiomyofibroblastoma |
Cellular angiofibroma |
Angiofibroma of soft tissue |
Nuchal-type fibroma |
Acral fibromyxoma Gardner fibroma |
Palmar fibromatosis and plantar fibromatosis |
Desmoid fibromatosis |
Lipofibromatosis 96 Giant cell fibroblastoma |
Dermatofibrosarcoma protuberans |
Solitary fibrous tumour |
Inflammatory myofibroblastic tumour |
Low-grade myofibroblastic sarcoma |
Superficial CD34-positive fibroblastic tumour |
Myxoinflammatory fibroblastic sarcoma |
Fibrosarcoma; Infantile fibrosarcoma, adult fibrosarcoma  |
Myxofibrosarcoma  |
Low-grade fibromyxoid sarcoma |
Sclerosing epithelioid fibrosarcoma |
So-called fibrohistiocytic tumors | Tenosynovial giant cell tumor |
Deep fibrous histiocytoma |
Plexiform fibrohistiocytic tumor |
Giant cell tumor of soft tissue |
Vascular tumors | Haemangiomas (Synovial haemangioma, Intramuscular angioma, Arteriovenous malformation/haemangioma, Venous haemangioma)  |
Anastomosing haemangioma |
Epithelioid haemangioma |
Lymphangioma and lymphangiomatosis |
Tufted angioma and kaposiform haemangioendothelioma |
Retiform haemangioendothelioma |
Papillary intralymphatic angioendothelioma |
Composite haemangioendothelioma |
Kaposi sarcoma |
Pseudomyogenic haemangioendothelioma |
Epithelioid haemangioendothelioma |
Angiosarcoma |
Pericytic (perivascular) tumours | Glomus tumour |
Myopericytoma, including myofibroma |
Angioleiomyoma |
Smooth muscle tumors | Leiomyoma |
Leiomyosarcoma |
EBV-associated smooth muscle tumour[4] |
Inflammatory leiomyosarcoma |
Skeletal muscle tumours | Rhabdomyoma |
Embryonal rhabdomyosarcoma |
Alveolar rhabdomyosarcoma |
Pleomorphic rhabdomyosarcoma |
Spindle cell / sclerosing rhabdomyosarcoma  |
Ectomesenchymoma |
Gastrointestinal stromal tumour |  |
Chondro-osseous tumours | Soft tissue chondroma

Extraskeletal osteosarcoma

Peripheral nerve sheath tumours | Schwannoma

Neurofibroma

Perineurioma

Granular cell tumour

Dermal nerve sheath myxoma

Solitary circumscribed neuroma

Ectopic meningioma and meningothelial hamartoma

Benign triton tumour / neuromuscular choristoma

Hybrid nerve sheath tumour

Malignant peripheral nerve sheath tumour

Malignant melanotic nerve sheath tumour

Tumours of uncertain differentiation  |
Intramuscular myxoma |
Juxta-articular myxoma |
Deep (aggressive) angiomyxoma |
Atypical fibroxanthoma |
Angiomatoid fibrous histiocytoma |
Ossifying fibromyxoid tumour |
Myoepithelioma, myoepithelial carcinoma, and mixed tumour  |
Pleomorphic hyalinizing angiectatic tumour of soft parts |
Haemosiderotic fibrolipomatous tumour |
Phosphaturic mesenchymal tumour |
NTRK-rearranged spindle cell neoplasm (emerging)  |
Synovial sarcoma |
Epithelioid sarcoma |
Alveolar soft part sarcoma |
Clear cell sarcoma of soft tissue |
Extraskeletal myxoid chondrosarcoma |
Desmoplastic small round cell tumour |
Extrarenal rhabdoid tumour |
PEComa |
Intimal sarcoma |
Undifferentiated sarcoma |

## References[edit | edit source]

1. ↑ Bansal, Abhinav; Goyal, Surbhi; Goyal, Ankur; Jana, Manisha (October 2021). "WHO classification of soft tissue tumours 2020: An update and simplified approach for radiologists". European Journal of Radiology. 143: 109937. doi:10.1016/j.ejrad.2021.109937. ISSN 1872-7727. PMID 34547634. Archived from the original on 2022-07-01. Retrieved 2022-06-20.
2. ↑ WHO Classification of Tumours Editorial Board, ed. (2020). "1. Soft tissue tumors". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 1–320. ISBN 978-92-832-4503-2.
3. ↑ Houdek, Matthew T. (2023). "1. Approach to bone and soft tissue tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. ISBN 978-0-323-75871-0. Archived from the original on 2023-02-26. Retrieved 2023-06-13.
4. ↑ 4.0 4.1 Nobori, Alexander K.; Dry, Sarah M. (2023). "6. Smooth muscle tumors". In Folpe, Andrew L.; Nielsen, Gunnlaugur Petur (eds.). Bone and Soft Tissue Pathology: A Volume in the Foundations in Diagnostic Pathology Series (2nd ed.). Philadelphia: Elsevier. pp. 161–174. ISBN 978-0-323-75871-0. Archived from the original on 2023-07-09. Retrieved 2023-07-08.
5. ↑ Thway, Khin (January 2022). "What's new in adipocytic neoplasia?". Histopathology. 80 (1): 76–97. doi:10.1111/his.14548. ISSN 1365-2559. PMID 34958506. Archived from the original on 2023-02-25. Retrieved 2022-06-20.