HEPBS

Names
Preferred IUPAC name

4-[4-(2-Hydroxyethyl)piperazin-1-yl]butane-1-sulfonic acid

Other names

HEPBS

Identifiers

CAS Number

* 161308-36-7

3D model (JSmol)

* Interactive image

PubChem CID

* 9965191

InChI

* InChI=1S/C10H22N2O4S/c13-9-8-12-6-4-11(5-7-12)3-1-2-10-17(14,15)16/h13H,1-10H2,(H,14,15,16)

Key: LOJNFONOHINEFI-UHFFFAOYSA-N

SMILES

* C1CN(CCN1CCCCS(=O)(=O)O)CCO

Properties

Chemical formula

| C10H22N2O4S
Molar mass | 266.356 g/mol
Appearance  | White crystalline powder
Density | 1.25 g/cm3 (predicted)
Melting point |  211–216 °C (412–421 °F; 484–489 K)
Acidity (pKa)  | 8.3
Hazards
Main hazards | Irritant
GHS Signal word | Warning

GHS hazard statements

| H315, H319, H335

GHS precautionary statements

| P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501
Flash point | Non-flammable

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

HEPBS (N-(2-Hydroxyethyl)piperazine-N'-(4-butanesulfonic acid)) is a zwitterionic organic chemical buffering agent; one of Good's buffers. HEPBS and HEPES have very similar structures and properties, HEPBS also having an acidity (pKa) in the physiological range (7.6-9.0 useful range). This makes it possible to use it for cell culture work.

HEPBS 1H NMR spectrum.

## References

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*[CID]: Compound ID
*[H315]: Causes skin irritation
*[H319]: Causes serious eye irritation
*[H335]: May cause respiratory irritation
*[P261]: Avoid breathing dust/fume/gas/mist/vapours/spray
*[P264]: Wash … thoroughly after handling
*[P271]: Use only outdoors or in a well-ventilated area
*[P280]: Wear protective gloves/protective clothing/eye protection/face protection
*[P302+352]: IF ON SKIN: Wash with soap and water
*[P304+340]: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
*[P305+351+338]: IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing
*[P312]: Call a POISON CENTER or doctor/physician if you feel unwell
*[P321]: Specific treatment (see … on this label)
*[P332+313]: If skin irritation occurs: Get medical advice/attention
*[P337+313]: Get medical advice/attention
*[P362]: Take off contaminated clothing and wash before reuse
*[P403+233]: Store in a well ventilated place. Keep container tightly closed
*[P405]: Store locked up
*[P501]: Dispose of contents/container to …