Succinate-semialdehyde dehydrogenase (acylating)

Identifiers
EC number| 1.2.1.76
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
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PMC| articles
PubMed| articles
NCBI| proteins

Succinate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating).[1][2][3] This enzyme catalyses the following chemical reaction

succinate semialdehyde + CoA + NADP+ ⇌ succinyl-CoA + NADPH + H+

Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.

## References

1. ↑ "Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri". European Journal of Biochemistry 212 (1): 121–7. February 1993. doi:10.1111/j.1432-1033.1993.tb17641.x. PMID 8444151.
2. ↑ "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp". Journal of Bacteriology 188 (24): 8551–9. December 2006. doi:10.1128/JB.00987-06. PMID 17041055. PMC 1698253. http://oceanrep.geomar.de/6268/1/J. Bacteriol.-2006-Alber-8551-9.pdf.
3. ↑ "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science 318 (5857): 1782–6. December 2007. doi:10.1126/science.1149976. PMID 18079405.

## External links

* Succinate-semialdehyde+dehydrogenase+(acylating) at the US National Library of Medicine Medical Subject Headings (MeSH)

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Aldehyde/oxo oxidoreductases (EC 1.2)

1.2.1: NAD or NADP|

* Aldehyde dehydrogenase
* Acetaldehyde dehydrogenase
* Long-chain-aldehyde dehydrogenase

1.2.2: cytochrome|

* Formate dehydrogenase (cytochrome)

1.2.3: oxygen|

* Aldehyde oxidase

1.2.4: disulfide|

* Oxoglutarate dehydrogenase complex
* Pyruvate dehydrogenase
* Branched-chain alpha-keto acid dehydrogenase complex
* BCKDHA
* BCKDHB
* DBT
* DLD

1.2.7: iron-sulfur protein|

* Pyruvate synthase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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