mir-101 microRNA precursor family

Predicted secondary structure and sequence conservation of mir-101

Identifiers
Symbol| mir-101
Rfam| RF00253
miRBase| MI0000103
miRBase family| MIPF0000046
Other data
RNA type| Gene; miRNA
Domain(s)| Eukaryota
GO| 0035195 0035068
SO| 0001244
PDB structures| PDBe

miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739)[1] and mouse (MI0000148).[2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.

Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.[3]

## References

1. ↑ "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes & Development 16 (6): 720–8. March 2002. doi:10.1101/gad.974702. PMID 11914277.
2. ↑ "Identification of tissue-specific microRNAs from mouse". Current Biology 12 (9): 735–9. April 2002. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
3. ↑ "miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients". Breast Cancer Research and Treatment 160 (3): 439–446. December 2016. doi:10.1007/s10549-016-4013-7. PMID 27744485.

## Further reading

* "Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth". The FEBS Journal 279 (22): 4201–12. November 2012. doi:10.1111/febs.12013. PMID 23013439.

## External links

*   * Page for mir-101 microRNA precursor family at Rfam
* miRBase family MIPF0000046

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miRNA precursor families

1-100|

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Other|

* BART1
* BART2
* BHRF1-1
* BHRF1-2
* BHRF1-3
* Let-7
* Lin-4
* Lsy-6

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