Biotinylated retinoids

Biotinylated retinoids are derivatives of retinol (vitamin A) carrying a biotin group for use in the isolation and purification of Retinol Binding Proteins involved in the visual cycle. The first biotinylated retinoid was synthesized in 2002 [1] and was used in the isolation and characterization of RPE65.[2]

## Notes and references

1. ↑ Nesnas, N.; Rando, R. R.; Nakanishi, K. (2002). "Synthesis of biotinylated retinoids for cross-linking and isolation of retinol binding proteins". Tetrahedron 58 (32): 6577. doi:10.1016/S0040-4020(02)00667-1. http://www.columbia.edu/cu/chemistry/groups/nakanishi/publication/712-Synthesis of Biotinylated Retinoids for Cross-Linking and Isolation of Retinol Binding Proteins.pdf.
2. ↑ Jahng, W. J.; David, C.; Nesnas, N.; Nakanishi, K.; Rando, R. R. (2003). "A Cleavable Affinity Biotinylating Agent Reveals a Retinoid Binding Role for RPE65†". Biochemistry 42 (20): 6159–6168. doi:10.1021/bi034002i. PMID 12755618.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Biotinylated retinoids. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Biotinylated_retinoids&oldid=901834"