Selective receptor modulator

Drug class

Tamoxifen, a SERM and a widely used drug in the treatment of breast cancer.

Class identifiers
Synonyms| SRM
Use| Various
Biological target| Steroid hormone receptor
Chemical class| Steroidal; Nonsteroidal

In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.[1] A SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.

## Classes

Classes of selective receptor modulators include:

* Selective androgen receptor modulator (SARM)
* Selective estrogen receptor modulator (SERM)
* Selective glucocorticoid receptor modulator (SEGRM)
* Selective progesterone receptor modulator (SPRM)
* Selective PPAR modulator (SPPARM) including SPPARMγ (affecting the PPARγ) and SPPARMα (PPARα)

## See also

* Agonist–antagonist
* Selective glucocorticoid receptor agonist (SEGRA)

## References

1. ↑ "Coregulator function: a key to understanding tissue specificity of selective receptor modulators". Endocr. Rev. 25 (1): 45–71. February 2004. doi:10.1210/er.2003-0023. PMID 14769827.

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*[SERM]: selective estrogen receptor modulator