15-oxoprostaglandin 13-oxidase

Short description: Class of enzymes

15-oxoprostaglandin 13-oxidase

Identifiers
EC number| 1.3.1.48
CAS number| 57406-74-3
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
| Search

PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a 15-oxoprostaglandin 13-oxidase (EC 1.3.1.48) is an enzyme that catalyzes the chemical reaction

(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+

The 3 substrates of this enzyme are (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate, NAD+, and NADP+, whereas its 4 products are (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprosta-13-enoate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase. Other names in common use include 15-oxo-Delta13-prostaglandin reductase, Delta13-15-ketoprostaglandin reductase, 15-ketoprostaglandin Delta13-reductase, prostaglandin Delta13-reductase, prostaglandin 13-reductase, and 15-ketoprostaglandin Delta13-reductase.

## Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1V3T, 1V3U, 1V3V, and 2DM6.

## References

* Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung. Methods in Enzymology. 86. 1982. pp. 156–63. doi:10.1016/0076-6879(82)86186-7.
* Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta. Methods in Enzymology. 86. 1982. pp. 163–7. doi:10.1016/0076-6879(82)86187-9.

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Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor|

* Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
* 7-Dehydrocholesterol reductase
* Biliverdin reductase
* 2,4 Dienoyl-CoA reductase
* Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor|

* Dihydroorotate dehydrogenase
* Coproporphyrinogen III oxidase
* Protoporphyrinogen oxidase
* Bilirubin oxidase
* Acyl-CoA oxidase
* Dihydrouracil oxidase
* Tetrahydroberberine oxidase
* Secologanin synthase
* Tryptophan alpha,beta-oxidase
* Pyrroloquinoline-quinone synthase
* L-galactonolactone oxidase

1.3.5: Quinone|

* Succinate dehydrogenase
* SDHA
* SDHB
* SDHC
* SDHD

1.3.99: Other acceptors|

* Fumarate reductase
* Butyryl-CoA dehydrogenase
* Acyl CoA dehydrogenase
* ACADSB
* ACADS
* 5α-reductase
* SRD5A1
* SRD5A2
* SRD5A3
* Glutaryl-CoA dehydrogenase
* Isovaleryl coenzyme A dehydrogenase
* 3-oxo-5beta-steroid 4-dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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Original source: https://en.wikipedia.org/wiki/15-oxoprostaglandin 13-oxidase. Read more

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