Type II collagen

collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)

Identifiers
Symbol| COL2A1
Alt. symbols| SEDC
NCBI gene| 1280
HGNC| 2200
OMIM| 120140
RefSeq| NM_001844
UniProt| P02458
Other data
Locus| Chr. 12 q13.11-q13.2

Type II collagen is the basis for articular cartilage and hyaline cartilage, formed by homotrimers of collagen, type II, alpha 1 chains.

It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.

Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis.[1][2]

## See also

* Type I collagen
* Collagen, type III, alpha 1

## References

1. ↑ "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern Rheumatology 19 (6): 581–9. 2009. doi:10.1007/s10165-009-0210-0. PMID 19697097.
2. ↑ "Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial". The Eurasian Journal of Medicine 48 (2): 95–101. June 2016. doi:10.5152/eurasianjmed.2015.15030. PMID 27551171.

## External links

* Collagen+type+II at the US National Library of Medicine Medical Subject Headings (MeSH)

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