Hypertensive heart disease

Cross-section of the heart at the ventricular level; mild left ventricular hypertrophy, with no cavitary dilation

Hypertensive heart disease includes a number of complications of high blood pressure that affect the heart. While there are several definitions of hypertensive heart disease in the medical literature,[1][2][3] the term is most widely used in the context of the International Classification of Diseases (ICD) coding categories. The definition includes heart failure and other cardiac complications of hypertension when a causal relationship between the heart disease and hypertension is stated or implied on the death certificate. In 2013 hypertensive heart disease resulted in 1.07 million deaths as compared with 630,000 deaths in 1990.[4]

According to ICD-10, hypertensive heart disease (I11), and its subcategories: hypertensive heart disease with heart failure (I11.0) and hypertensive heart disease without heart failure (I11.9) are distinguished from chronic rheumatic heart diseases (I05-I09), other forms of heart disease (I30-I52) and ischemic heart diseases (I20-I25). However, since high blood pressure is a risk factor for atherosclerosis and ischemic heart disease,[5] death rates from hypertensive heart disease provide an incomplete measure of the burden of disease due to high blood pressure.

## Contents

* 1 Signs and symptoms
* 2 Cause
* 3 Diagnosis
* 3.1 Differential diagnosis
* 4 Prevention
* 4.1 Blood pressure goals
* 5 Treatment
* 6 Epidemiology
* 6.1 Sex differences
* 6.2 Ethnic differences
* 7 References
* 8 External links

## Signs and symptoms[edit | edit source]

The symptoms and signs of hypertensive heart disease will depend on whether or not it is accompanied by heart failure. In the absence of heart failure, hypertension, with or without enlargement of the heart (left ventricular hypertrophy) is usually symptomless.[citation needed]

Symptoms, signs and consequences of congestive heart failure can include:

* Fatigue
* Irregular pulse or palpitations
* Swelling of feet and ankles
* Weight gain
* Nausea
* Shortness of breath
* Difficulty sleeping flat in bed (orthopnea)
* Bloating and abdominal pain
* Greater need to urinate at night
* An enlarged heart (cardiomegaly)
* Left ventricular hypertrophy and left ventricular remodeling[5]
* Diminished coronary flow reserve and silent myocardial ischemia[5]
* Coronary heart disease and accelerated atherosclerosis[5]
* Heart failure with normal left ventricular ejection fraction (HFNEF),[6] often termed diastolic heart failure[5]
* Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac death[5]

Heart failure can develop insidiously over time or patients can present acutely with acute heart failure or acute decompensated heart failure and pulmonary edema due to sudden failure of pump function of the heart. Sudden failure can be precipitated by a variety of causes, including myocardial ischemia, marked increases in blood pressure, or cardiac arrhythmias.[citation needed]

## Cause[edit | edit source]

In terms of the etiology of Hypertensive heart disease we find that chronic high blood pressure is present above a certain range(systolic bp > 120 mm Hg or a diastolic pressure > 80mm Hg)[7]

## Diagnosis[edit | edit source]

Automated arm blood pressure meter showing arterial hypertension (shown a systolic blood pressure 158 mmHg, diastolic blood pressure 99 mmHg and heart rate of 80 beats per minute) Stages of elevated BP and hypertension[8] Category | Systolic BP (mm Hg) | Diastolic BP (mm Hg)

|
|

Normal | < 120 | < 80
Elevated | 120–129 and | <80
Stage I | 130–139 or | 80–89
Stage II | at least 140 or | at least 90

### Differential diagnosis[edit | edit source]

Other conditions can share features with hypertensive heart disease and need to be considered in the differential diagnosis. For example:[citation needed]

* Coronary artery disease or ischemic heart diseases due to atherosclerosis
* Hypertrophic cardiomyopathy
* Left ventricular hypertrophy in athletes
* Congestive heart failure or heart failure with normal ejection fraction due to other causes
* Atrial fibrillation or other disorders of cardiac rhythm due to other causes
* Sleep apnea

## Prevention[edit | edit source]

Because there are no symptoms with high blood pressure, people can have the condition without knowing it. Diagnosing high blood pressure early can help prevent heart disease, stroke, eye problems, and chronic kidney disease.[9]

The risk of cardiovascular disease and death can be reduced by lifestyle modifications, including dietary advice, promotion of weight loss and regular aerobic exercise, moderation of alcohol intake and cessation of smoking.[8] Drug treatment may also be needed to control the hypertension and reduce the risk of cardiovascular disease,[8] manage the heart failure,[10] or control cardiac arrhythmias.[11] Patients with hypertensive heart disease should avoid taking over the counter nonsteroidal anti-inflammatory drugs (NSAIDs), or cough suppressants, and decongestants containing sympathomimetics, unless otherwise advised by their physician as these can exacerbate hypertension and heart failure.[12][13]

### Blood pressure goals[edit | edit source]

According to JNC 7, BP goals should be as follows:[8]

* Less than 140/90mm Hg in patients with uncomplicated hypertension
* Less than 130/85mm Hg in patients with diabetes and those with renal disease with less than 1g/24-hour proteinuria
* Less than 125/75mm Hg in patients with renal disease and more than 1 g/24-hour proteinuria

## Treatment[edit | edit source]

The medical care of patients with hypertensive heart disease falls under 2 categories—[14]

* Treatment of hypertension
* Prevention (and, if present, treatment) of heart failure or other cardiovascular disease

## Epidemiology[edit | edit source]

Deaths due to hypertensive crisis per million persons in 2012

9–54

55–64

65–78

79–92

93–113

114–141

142–173

174–217

218–317

318–1618

Disability-adjusted life year for hypertensive heart disease per 100,000 inhabitants in 2004.[15]

no data

less than 110

110–220

220–330

330–440

440–550

550–660

660–770

770–880

880–990

990–1100

1100–1600

more than 1600

Hypertension or high blood pressure affects at least 26.4% of the world's population.[16] Hypertensive heart disease is only one of several diseases attributable to high blood pressure. Other diseases caused by high blood pressure include ischemic heart disease, cancer, stroke, peripheral arterial disease, aneurysms and kidney disease. Hypertension increases the risk of heart failure by two or three-fold[8] and probably accounts for about 25% of all cases of heart failure.[17] In addition, hypertension precedes heart failure in 90% of cases,[8] and the majority of heart failure in the elderly may be attributable to hypertension.[18] Hypertensive heart disease was estimated to be responsible for 1.0 million deaths worldwide in 2004 (or approximately 1.7% of all deaths globally), and was ranked 13th in the leading global causes of death for all ages.[19] A world map shows the estimated disability-adjusted life years per 100,000 inhabitants lost due to hypertensive heart disease in 2004.[15]

### Sex differences[edit | edit source]

There are more women than men with hypertension,[20] and, although men develop hypertension earlier in life,[21] hypertension in women is less well controlled.[22][23] The consequences of high blood pressure in women are a major public health problem and hypertension is a more important contributory factor in heart attacks in women than men.[21] Until recently women have been under-represented in clinical trials in hypertension and heart failure. Nevertheless, there is some evidence that the effectiveness of antihypertensive drugs differs between men and women[21] and that treatment for heart failure may be less effective in women.[24]

### Ethnic differences[edit | edit source]

Studies in the US indicate that a disproportionate number of African Americans have hypertension compared with non-Hispanic whites and Mexican Americans, and that they have a greater burden of hypertensive heart disease.[25] Heart failure is more common in people of African American ethnicity, mortality from heart failure is also consistently higher than in white patients, and it develops at an earlier age.[24][26] Recent data suggests that rates of hypertension are increasing more rapidly in African Americans than other ethnic groups.[27] The excess of high blood pressure and its consequences in African Americans is likely to contribute to their shorter life expectancy compared with white Americans.[25]

## References[edit | edit source]

1. ↑ Alegría-Ezquerra E, González-Juanatey JR, González-Maqueda I (April 2006). "Hypertensive heart disease: a proposed clinical classification". Revista Española de Cardiología (in español). 59 (4): 398–9. doi:10.1016/S1885-5857(06)60781-0. PMID 16709396. Archived from the original on 2022-06-04. Retrieved 2022-05-21.
2. ↑ Lip GY, Felmeden DC, Li-Saw-Hee FL, Beevers DG (October 2000). "Hypertensive heart disease. A complex syndrome or a hypertensive 'cardiomyopathy'?". European Heart Journal. 21 (20): 1653–65. doi:10.1053/euhj.2000.2339. PMID 11032692.
3. ↑ Gonzalez-Maqueda, I; Alegria-Ezquerra, Eduardo; Gonzalez-Juanatey, Jose Ramon; Working group of the Spanish Society of Cardiology (2009). "Hypertensive heart disease: a new clinical classification (VIA)". e-Journal of the European Society of Cardiology Council for Cardiology Practice. 7 (20): ePub. Archived from the original on 2022-03-31. Retrieved 2022-05-21.
4. ↑ GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442.
5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Grossman E, Messerli FH (August 1996). "Diabetic and hypertensive heart disease". Annals of Internal Medicine. 125 (4): 304–310. doi:10.7326/0003-4819-125-4-199608150-00009. PMID 8678395. S2CID 38947800.
6. ↑ Maeder MT, Kaye DM (March 2009). "Heart failure with normal left ventricular ejection fraction". Journal of the American College of Cardiology. 53 (11): 905–918. doi:10.1016/j.jacc.2008.12.007. PMID 19281919.
7. ↑ Tackling, Gary; Borhade, Mahesh B. (2024). "Hypertensive Heart Disease". StatPearls. StatPearls Publishing. Archived from the original on 2023-06-08. Retrieved 2024-03-09.
8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ, National Heart, Lung, and Blood Institute, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National High Blood Pressure Education Program Coordinating Committee (May 21, 2003). "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report" (PDF). JAMA. 289 (19): 2560–2572. doi:10.1001/jama.289.19.2560. PMID 12748199. Archived (PDF) from the original on 16 February 2013. Retrieved 17 February 2013.
9. ↑ "Hypertensive heart disease". Medline Plus. Archived from the original on 27 January 2013. Retrieved 17 February 2013.
10. ↑ Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW (April 2009). "2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation". Circulation. 119 (14): e391–479. doi:10.1161/CIRCULATIONAHA.109.192065. PMID 19324966.
11. ↑ Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Kay GN, Le Huezey J, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann LS (March 2011). "2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 Guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in partnership with the European Society of Cardiology and in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society". Journal of the American College of Cardiology. 57 (11): e101–98. doi:10.1016/j.jacc.2010.09.013. PMID 21392637.
12. ↑ White WB (April 2007). "Cardiovascular risk, hypertension, and NSAIDs". Current Rheumatology Reports. 9 (1): 36–43. doi:10.1007/s11926-007-0020-3. PMID 17437665. S2CID 31212856.
13. ↑ Ackman ML, Campbell JB, Buzak KA, Tsuyuki RT, Montague TJ, Teo KK (June 1999). "Use of nonprescription medications by patients with congestive heart failure". Annals of Pharmacotherapy. 33 (6): 674–679. doi:10.1345/aph.18283. PMID 10410177. S2CID 43285809.
14. ↑ Riaz, Kamran. "Hypertensive Heart Disease". Medscape Reference. Archived from the original on 26 January 2013. Retrieved 17 February 2013.
15. ↑ 15.0 15.1 "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on November 11, 2009. Retrieved Nov 11, 2009.
16. ↑ Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J (2005). "Global burden of hypertension: analysis of worldwide data". The Lancet. 365 (9455): 217–223. doi:10.1016/S0140-6736(05)17741-1. PMID 15652604. S2CID 7244386. Archived from the original on 2018-11-03. Retrieved 2022-05-21.
17. ↑ Kannel WB, Cobb J (1992). "Left ventricular hypertrophy and mortality—results from the Framingham Study". Cardiology. 81 (4–5): 291–298. doi:10.1159/000175819. PMID 1301257.
18. ↑ Yamasaki N, Kitaoka H, Matsumura Y, Furuno T, Nishinaga M, Doi Y (May 2003). "Heart failure in the elderly". Internal Medicine. 42 (5): 383–388. doi:10.2169/internalmedicine.42.383. PMID 12793706.
19. ↑ World Health Organization (2008). The Global Burden of Disease: 2004 Update. Geneva: World Health Organization. ISBN 978-92-4-156371-0.
20. ↑ Kearney, Patricia M; Whelton, Megan; Reynolds, Kristi; Whelton, Paul K; He, Jiang (2004). "Worldwide prevalence of hypertension: a systematic review". Journal of Hypertension. 22 (1): 11–19. doi:10.1097/00004872-200401000-00003. PMID 15106785. S2CID 24840738.
21. ↑ 21.0 21.1 21.2 Rabi DM, Khan N, Vallée M, Hladunewich MA, Tobe SW, Pilote L (June 2008). "Reporting on sex-based analysis in clinical trials of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker efficacy". Canadian Journal of Cardiology. 24 (6): 491–496. doi:10.1016/S0828-282X(08)70624-X. PMC 2643194. PMID 18548147.
22. ↑ Lloyd-Jones DM, Evans JC, Levy D (July 2005). "Hypertension in adults across the age spectrum: current outcomes and control in the community". JAMA. 294 (4): 466–472. doi:10.1001/jama.294.4.466. PMID 16046653.
23. ↑ Wassertheil-Smoller S, Anderson G, Psaty BM, Black HR, Manson J, Wong N, Francis J, Grimm R, Kotchen T, Langer R, Lasser N (November 2000). "Hypertension and its treatment in postmenopausal women: baseline data from the Women's Health Initiative". Hypertension. 36 (5): 780–789. doi:10.1161/01.HYP.36.5.780. PMID 11082143. Archived from the original on 2022-06-04. Retrieved 2022-05-21.
24. ↑ 24.0 24.1 Bui AL, Horwich TB, Fonarow GC (January 2011). "Epidemiology and risk profile of heart failure". Nature Reviews Cardiology. 8 (1): 30–41. doi:10.1038/nrcardio.2010.165. PMC 3033496. PMID 21060326.
25. ↑ 25.0 25.1 Ferdinand KC, Sounders E (January 2006). "Hypertension-related morbidity and mortality in African Americans—why we need to do better". Journal of Clinical Hypertension (Greenwich). 8 (1 Suppl 1): 21–30. doi:10.1111/j.1524-6175.2006.05295.x. PMID 16415637. S2CID 11034242.
26. ↑ Loehr LR, Rosamond WD, Chang PP, Folsom AR, Chambless LE (April 2008). "Heart failure incidence and survival (from the Atherosclerosis Risk in Communities study)". American Journal of Cardiology. 101 (7): 1016–1022. doi:10.1016/j.amjcard.2007.11.061. PMID 18359324.
27. ↑ Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, Hong Y (January 2009). "Heart disease and stroke statistics—2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee". Circulation. 119 (3): e21–181. doi:10.1161/CIRCULATIONAHA.108.191261. PMID 19075105. Archived from the original on 2013-02-23. Retrieved 2022-05-21.

## External links[edit | edit source]

Classification|

* ICD-10: I11, I13
* ICD-9-CM: 402

|

External resources|

* MedlinePlus: 000163
* eMedicine: article/162449

* v
* t
* e

Cardiovascular disease (vessels)

Arteries, arterioles
and capillaries|

| Inflammation|

* Arteritis
* Aortitis
* Buerger's disease

|

Peripheral artery disease|

| Arteriosclerosis|

* Atherosclerosis
* Foam cell
* Fatty streak
* Atheroma
* Intermittent claudication
* Critical limb ischemia

* Monckeberg's arteriosclerosis
* Arteriolosclerosis
* Hyaline
* Hyperplastic
* Cholesterol
* LDL
* Oxycholesterol
* Trans fat

|

Stenosis|

* Carotid artery stenosis
* Renal artery stenosis

Other|

* Aortoiliac occlusive disease
* Degos disease
* Erythromelalgia
* Fibromuscular dysplasia
* Raynaud's phenomenon

Aneurysm / dissection /
pseudoaneurysm|

* torso: Aortic aneurysm
* Abdominal aortic aneurysm
* Thoracic aortic aneurysm
* Aneurysm of sinus of Valsalva
* Aortic dissection
* Aortic rupture
* Coronary artery aneurysm
* head / neck
* Intracranial aneurysm
* Intracranial berry aneurysm
* Carotid artery dissection
* Vertebral artery dissection
* Familial aortic dissection

Vascular malformation|

* Arteriovenous fistula
* Arteriovenous malformation
* Telangiectasia
* Hereditary hemorrhagic telangiectasia

Vascular nevus|

* Cherry hemangioma
* Halo nevus
* Spider angioma

Veins|

| Inflammation|

* Phlebitis

|

Venous thrombosis /
Thrombophlebitis|

* primarily lower limb
* Deep vein thrombosis
* abdomen
* Hepatic veno-occlusive disease
* Budd–Chiari syndrome
* May–Thurner syndrome
* Portal vein thrombosis
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* upper limb / torso
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* head
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Varicose veins|

* Gastric varices
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Other|

* Chronic venous insufficiency
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Arteries or veins|

* Angiopathy
* Macroangiopathy
* Microangiopathy
* Embolism
* Pulmonary embolism
* Cholesterol embolism
* Paradoxical embolism
* Thrombosis
* Hepatic artery thrombosis
* Vasculitis

Blood pressure|

| Hypertension|

* Hypertensive heart disease
* Hypertensive emergency
* Hypertensive nephropathy
* Essential hypertension
* Secondary hypertension
* Renovascular hypertension
* Benign hypertension
* Pulmonary hypertension
* Systolic hypertension
* White coat hypertension

|

Hypotension|

* Orthostatic hypotension

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