Strychnos nux-vomica

Short description: Species of plant

"Nux vomica" redirects here. For other uses, see Nux vomica (disambiguation).

Strychnos nux-vomica

Illustration from Köhler's Medizinal-Pflanzen
Habitus
Scientific classification
Kingdom:  | Plantae
Clade:  | Tracheophytes
Clade:  | Angiosperms
Clade:  | Eudicots
Clade:  | Asterids
Order:  | Gentianales
Family:  | Loganiaceae
Genus:  | Strychnos
Species:  |

S. nux-vomica

Binomial name
Strychnos nux-vomica

Synonyms[1]

* Strychnos nux-vomica var. oligosperma Dop
* Strychnos spireana Dop

Strychnos nux-vomica, the strychnine tree,[2] also known as nux vomica, poison fruit, semen strychnos, and quaker buttons, is a deciduous tree native to India and to southeast Asia. It is a medium-sized tree in the family Loganiaceae that grows in open habitats. Its leaves are ovate and 5–9 centimetres (2–3.5 in) in size.[3] It is known for being the natural source of the extremely poisonous compound strychnine.

## Contents

* 1 Description and properties
* 2 Ecology
* 3 Toxicity
* 4 Uses
* 4.1 Herbalism
* 5 References

## Description and properties

Seeds of S. nux-vomica

Strychnos nux-vomica is a medium-sized tree with a potential height of 20 metres (66 feet).[4] Its trunk is short and thick. The wood is dense, hard, white, and close-grained. The branches are irregular and are covered with a smooth ashen bark. The young shoots are a deep green colour with a shiny coat. The leaves have an opposite decussate arrangement (each opposing pair of leaves at right angles to the next pair along the stem), are short stalked and oval shaped, have a shiny coat, and are smooth on both sides. The leaves are about 10 centimetres (4 inches) long and 7.6 cm (3 in) wide. The flowers are small with a pale green colour and a funnel shape. They bloom in the cold season and have a foul smell. The fruit are about the size of a large apple with a smooth and hard shell that when ripened is a mild shade of orange in colour. The flesh of the fruit is soft and white with a jelly-like pulp containing five seeds covered with a soft, woolly substance.

The seeds have the shape of a flattened disk completely covered with hairs radiating from the center of the sides. This gives the seeds a very characteristic sheen. The seeds are very hard, with a dark gray horny endosperm where the small embryo is housed that gives off no odor but possesses a very bitter taste.

Seedling of nux vomica

## Ecology

The pulp of the fruit is eaten by monkeys and birds.[5] It is also eaten by at least one species of Hornbill, the Malabar pied hornbill[6]

## Toxicity

The seeds within the round, green to orange fruit of the tree are a major source of the highly poisonous, intensely bitter alkaloids strychnine and brucine.[7] The seeds contain approximately 1.5% strychnine, and the dried blossoms contain 1.0%.[3] However, the bark of the tree also contains brucine and other poisonous compounds.

## Uses

The strychnine-containing seeds have been used in arrow poison.[5] The use of strychnine is highly regulated in many countries, and it is mostly used in baits to kill feral mammals. Most accidental poisoning is caused by breathing in the powder or by absorption through the skin.[8]

### Herbalism

Bark of Strychnos nux-vomica

Strychnos is promoted within herbal medicine as being a treatment for a wide range of maladies, including cancer and heart disease,[9] as an alternative to digitalis.[5] There is, however, no evidence it is useful for treating any condition.[9] Indeed, these seeds contain strychnine. The plant appears on the Commission E list of unapproved herbs because it has not been proven to be safe or effective and thus is not recommended for use. Use of strychnine seeds for such purposes may prove fatal, as it has no safe limit for consumption.

In Unani medicine (Perso-Arabic traditional medicine), hudar is a mixture containing Strychnos nux-vomica. The seeds are first immersed in water for five days and then in milk for two days followed by their boiling in milk.[10]

The level of toxic alkaloids in the unprocessed Strychnos seeds used in traditional medicines can be determined using established HPLC methods and HPLC-UV methods.[11]

## References

1. ↑ "Strychnos nux-vomica L.". The Plant List. http://www.theplantlist.org/tpl/record/tro-19000204.
2. ↑ "Strychnos nux-vomica". Natural Resources Conservation Service PLANTS Database. USDA. https://plants.usda.gov/core/profile?symbol=STNU4. Retrieved 4 December 2015.
3. ↑ 3.0 3.1 Harry L. Arnold (1968). Poisonous Plants of Hawaii. Tokyo, Japan: Charles E. Tuttle. p. 20. ISBN 0-8048-0474-5. https://archive.org/details/poisonousplantso0000arno/page/20.
4. ↑ "Strychnos nux-vomica L.". https://indiabiodiversity.org/species/show/31812.
5. ↑ 5.0 5.1 5.2 Hargreaves, Dorothy; Hargreaves, Bob (1970). Tropical Trees of the Pacific. Kailua, Hawaii: Hargreaves. p. 59.
6. ↑ Balasubramanian, P.; R. Saravanan and B. Maheswaran (2004). "Fruit preferences of Malabar Pied Hornbill Anthracoceros coronatus in Western Ghats, India". Bird Conservation International 14: pp. 69-79 doi:10.1017/S095927090500024 9
7. ↑ Oudhia, P., 2008. Strychnos nux-vomica L. [Internet] Record from PROTA4U. Schmelzer, G.H. & Gurib-Fakim, A. (Editors). PROTA (Plant Resources of Tropical Africa / Ressources végétales de l’Afrique tropicale), Wageningen, Netherlands.
8. ↑ "Drugs and Poisons Fact Sheet: Strychnine Permits - What you need to know". Queensland Health. December 1, 2011. http://www.health.qld.gov.au/ph/documents/ehu/strychnine-what.pdf.
9. ↑ 9.0 9.1 Ades TB, ed (2009). "Strychnos nux-vomica". American Cancer Society Complete Guide to Complementary and Alternative Cancer Therapies (2nd ed.). American Cancer Society. pp. 504–507. ISBN 9780944235713. https://archive.org/details/americancancerso0000unse/page/504.
10. ↑ Seema Akbar; Shamshad A Khan; Akbar Masood; M Iqbal (2010). "Use of Strychnos nux-vomica (azraqi) seeds in Unani system of medicine:after detoxification it is used as stimulant of nerves ,anti-inflammatory also act as a antitode.". African Journal of Traditional, Complementary and Alternative Medicines 7 (4): 286–290. doi:10.4314/ajtcam.v7i4.56689. PMID 21731158. PMC 3005396. https://journals.sfu.ca/africanem/index.php/ajtcam/article/view/487.
11. ↑ Q. B. Han; S. L. Li; C. F. Qiao; J. Z. Song; Z. W. Cai; P. Pui-Hay But; P. C. Shaw; H. X. Xu (2008). "A simple method to identify the unprocessed Strychnos seeds used in herbal medicinal products". Planta Medica 74 (4): 458–463. doi:10.1055/s-2008-1034359. PMID 18484543.

Wikidata ☰ Q272945 entry

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