Frontal lobe disorder

Short description: Brain disorder

Frontal lobe disorder

Illustration of lateral view of the right side of the brain showing the frontal lobe, other lobes of the brain, and the cerebellum
Specialty| Neurology, psychiatry
Symptoms| Tremor, dystonia[1]
Causes| Closed head injuries[2]
Diagnostic method| Neuropsychological test[3]
Treatment| Speech therapy, supportive care[4]

Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury.[5] The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production. Frontal lobe syndrome can be caused by a range of conditions including head trauma, tumours, neurodegenerative diseases, neurodevelopmental disorders, neurosurgery and cerebrovascular disease. Frontal lobe impairment can be detected by recognition of typical signs and symptoms, use of simple screening tests, and specialist neurological testing.[3][6]

## Contents

* 1 Signs and symptoms
* 2 Causes
* 3 Pathogenesis
* 3.1 Anatomy and functions
* 4 Diagnosis
* 5 Treatment
* 6 History
* 7 See also
* 8 References
* 9 Further reading
* 10 External links

## Signs and symptoms

The signs and symptoms of frontal lobe disorder can be indicated by dysexecutive syndrome[7] which consists of a number of symptoms which tend to occur together.[8] Broadly speaking, these symptoms fall into three main categories; cognitive (movement and speech), emotional or behavioral. Although many of these symptoms regularly co-occur, it is common to encounter patients who have several, but not all of these symptoms. This is one reason why some researchers are beginning to argue that dysexecutive syndrome is not the best term to describe these various symptoms. The fact that many of the dysexecutive syndrome symptoms can occur alone has led some researchers[9] to suggest that the symptoms should not be labelled as a "syndrome" as such. Some of the latest imaging research[10] on frontal cortex areas suggests that executive functions may be more discrete than was previously thought. Signs and symptoms can be divided as follows:[1]

Movement

* Tremor
* Apraxia
* Dystonia
* Gait abnormality
* Dyspraxia

Emotional

* Difficulty in inhibiting emotions, anger, excitement
* Depression
* Difficulty in understanding others' points of view

Behavioral

* Utilization behavior
* Perseveration behavior
* Social disinhibition
* Compulsive eating

Language signs

* Aphasia
* Expressive aphasia

## Causes

The causes of frontal lobe disorders can be closed head injury. An example of this can be from an accident, which can cause damage to the orbitofrontal cortex area of the brain.[2]

Cerebrovascular disease may cause a stroke in the frontal lobe. Tumours such as meningiomas may present with a frontal lobe syndrome.[11] Frontal lobe impairment is also a feature of Alzheimer's disease, and frontotemporal dementia.[1]

## Pathogenesis

The pathogenesis of frontal lobe disorders entails various pathologies, some are as follows:

* Foster Kennedy syndrome[12]\- It is caused due to tumor of frontal lobe and gives rise to ipsilateral optic atrophy and contralateral papilledema.
* Frontal disinhibition syndrome, Fetal Alcohol Spectrum Disorder, Rett syndrome and attention deficit hyperactivity disorder[13]
* It is produced from frontal lobe damage due to prenatal exposure to teratogens (like ethanol), head injuries, or tumors.
* Socially disinhibited and shows severe impairment of judgment, insight and foresight.
* Antisocial behaviour is a characteristic feature of frontal disinhibition syndrome.
* Frontal abulic syndrome[14]
* Loss of initiative, creativity and curiosity
* Pervasive emotional apathy and blandness
* Akinetic mutism

OFC-Orbitofrontal cortex

### Anatomy and functions

The frontal lobe contains the precentral gyrus and prefrontal cortex and, by some conventions, the orbitofrontal cortex. These three areas are represented in both the left and the right cerebral hemispheres. The precentral gyrus or primary motor cortex is concerned with the planning, initiation and control of fine motor movements dorsolateral to each hemisphere.[15] The dorsolateral part of the frontal lobe is concerned with planning, strategy formation, and other executive functions. The prefrontal cortex in the left hemisphere is involved with verbal memory while the prefrontal cortex in the right hemisphere is involved in spatial memory. The left frontal operculum region of the prefrontal cortex, or Broca's area, is responsible for expressive language, i.e. language production. The orbitofrontal cortex is concerned with response inhibition, impulse control, and social behaviour.[4]

## Diagnosis

Frontotemporal dementia.

The diagnosis of frontal lobe disorder can be divided into the following three categories:

* Clinical history

Frontal lobe disorders may be recognized through a sudden and dramatic change in a person's personality, for example with loss of social awareness, disinhibition, emotional instability, irritability or impulsiveness. Alternatively, the disorder may become apparent because of mood changes such as depression, anxiety or apathy.[1]

* Examination

On mental state examination a person with frontal lobe damage may show speech problems, with reduced verbal fluency.[4] Typically the person is lacking in insight and judgment, but does not have marked cognitive abnormalities or memory impairment (as measured for example by the mini-mental state examination).[16] With more severe impairment there may be echolalia or mutism.[17] Neurological examination may show primitive reflexes (also known as frontal release signs) such as the grasp reflex.[18] Akinesia (lack of spontaneous movement) will be present in more severe and advanced cases.[19]

* Further investigation

A range of neuropsychological tests are available for clarifying the nature and extent of frontal lobe dysfunction. For example, concept formation and ability to shift mental sets can be measured with the Wisconsin Card Sorting Test, planning can be assessed with the Mazes subtest of the WISC.[3] Frontotemporal dementia shows up as atrophy of the frontal cortex on MRI.[20] Frontal impairment due to head injuries, tumours or cerebrovascular disease will also appear on brain imaging.[4]

## Treatment

In terms of treatment for frontal lobe disorder, there is none, general supportive care is given, also some level of supervision could be needed. The prognosis will depend on the cause of the disorder, of course. A possible complication is that individuals with severe injuries may be disabled, such that, a caregiver may be unrecognizable to the person.[5] Another aspect of treatment of frontal lobe disorder is speech therapy. This type of therapy might help individuals with symptoms that are associated with aphasia and dysarthria.[4]

## History

Phineas Gage, who sustained a severe frontal lobe injury in 1848, has been called a case of dysexecutive syndrome. Gage's psychological changes are almost always exaggerated - of the symptoms listed, the only ones Gage can be said to have exhibited are "anger and frustration", slight memory impairment, and "difficulty in planning".[21]

In December 2005, at his Dover Road flat in Singapore, 44-year-old caretaker Mohammad Zam Abdul Rashid attacked and battered his 38-year-old wife Ramona Johari (a production operator) to death after he accused her of getting close to a colleague. Mohammad Zam was originally charged with murder but after he was found to be suffering from frontal lobe syndrome, which went undiagnosed prior to the murder and had affected his mental responsibility at the time of the killing, Mohammad Zam was convicted of a reduced charge of manslaughter and hence sentenced to life imprisonment.[22] The diagnosis of frontal lobe syndrome in this homicide case generated public discussions about the disorder.[23]

## See also

* Attention
* Cognitive neuropsychology
* Dysexecutive syndrome
* Executive functions
* Frontal lobe
* Gourmand syndrome
* Klüver–Bucy syndrome
* Phineas Gage
* Working memory

## References

1. ↑ 1.0 1.1 1.2 1.3 "Frontotemporal Dementia and Other Frontotemporal Disorders". https://www.ninds.nih.gov/health-information/disorders/frontotemporal-dementia-and-other-frontotemporal-disorders.
2. ↑ 2.0 2.1 Walz, Roger (September 2008). "Psychiatric disorders and traumatic brain injury". Neuropsychiatric Disease and Treatment 4 (4): 797–816. doi:10.2147/ndt.s2653. PMID 19043523.
3. ↑ 3.0 3.1 3.2 Eling, Paul; Derckx, Kristianne; Maes, Roald (August 2008). "On the historical and conceptual background of the Wisconsin Card Sorting Test". Brain and Cognition 67 (3): 247–253. doi:10.1016/j.bandc.2008.01.006. PMID 18328609.
4. ↑ 4.0 4.1 4.2 4.3 4.4 Frontal Lobe Syndromes at eMedicine
5. ↑ 5.0 5.1 "Frontal Lobe Syndrome. FLS information. Frontal Lobe Lesions | Patient" (in en-GB). 6 November 2014. http://patient.info/doctor/frontal-lobe-syndrome.
6. ↑ Ruiz-Barrio, Iñigo; Horta-Barba, Andrea; Aracil-Bolaños, Ignacio; Martinez-Horta, Saül; Kulisevsky, Jaime; Pagonabarraga, Javier (March 2024). "Predicting Disability in Progressive Supranuclear Palsy Using Bedside Frontal-Lobe Signs". Movement Disorders Clinical Practice 11 (3): 248–256. doi:10.1002/mdc3.13958. PMID 38164060.
7. ↑ M.D, Larry E. Davis; Richardson, Sarah Pirio (2015). Fundamentals of Neurologic Disease. Springer. p. 139. ISBN 978-1-4939-2359-5.
8. ↑ Marshall, John (2010). The Handbook of Clinical Neuropsychology. doi:10.1093/acprof:oso/9780199234110.001.0001. ISBN 978-0-19-923411-0. [page needed]
9. ↑ Stuss D.T., Alexander M.P. (2007). "Is there a Dysexecutive Syndrome? Philosophical transactions of the Royal Society of London". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 362 (1481): 901–15. doi:10.1098/rstb.2007.2096. PMID 17412679.
10. ↑ Gilbert S.J., Burgess P.W. (2008). "Executive Function". Current Biology 18 (3): 110–114. doi:10.1016/j.cub.2007.12.014. PMID 18269902. Bibcode: 2008CBio...18.R110G.
11. ↑ Miller, Bruce L.; Cummings, Jeffrey L. (2007). The Human Frontal Lobes: Functions and Disorders. Guilford Publications. pp. 19, 450. ISBN 978-1-59385-329-7.
12. ↑ "Foster Kennedy's Syndrome. FKS information. Patient | Patient" (in en-GB). http://patient.info/doctor/Foster-Kennedy-Syndrome.htm.
13. ↑ Niedermeyer, E (Jan 2001). "Frontal lobe disinhibition, Rett syndrome and attention deficit hyperactivity disorder". Clinical Electroencephalography 32 (1): 20–3. doi:10.1177/155005940103200106. PMID 11202137.
14. ↑ Leadership, Donald T. Stuss Reva James Leeds Chair in Neuroscience and Research; Berkeley, Helen Wills Neuroscience Institute Robert T. Knight Evan Rauch Professor of Neuroscience and Director, Department of Psychology University of California (20 June 2002). Principles of Frontal Lobe Function. Oxford University Press. p. 13. ISBN 978-0-19-803083-6. https://books.google.com/books?id=ntOEPvcGoiYC&pg=PA13.
15. ↑ Kalat, James (2007). Biological Psychology (9 ed.). Belmont, CA, USA: Thomas Wadsworth. pp. 100. ISBN 978-0-495-09079-3. https://archive.org/details/biologicalpsycho00ka/page/100.
16. ↑ Pangman, Verna C.; Sloan, Jeff; Guse, Lorna (2000). "An examination of psychometric properties of the Mini-Mental State Examination and the Standardized Mini-Mental State Examination: Implications for clinical practice". Applied Nursing Research 13 (4): 209–13. doi:10.1053/apnr.2000.9231. PMID 11078787.
17. ↑ Nagaratnam, Nages (2005). "Mutism in the Older Adult". Geriatrics and Aging 8 (8): 61–68. https://www.medscape.com/viewarticle/512923.
18. ↑ Schott, J M (May 2003). "The grasp and other primitive reflexes". Journal of Neurology, Neurosurgery & Psychiatry 74 (5): 558–560. doi:10.1136/jnnp.74.5.558. PMID 12700289.
19. ↑ Bradley, Walter George (2004). Neurology in Clinical Practice. Taylor & Francis. p. 122. ISBN 978-0-7506-7469-0.
20. ↑ Pick Disease~workup at eMedicine
21. ↑ Macmillan, Malcolm (2008). "Phineas Gage – Unravelling the myth". The Psychologist 21 (9): 828–831. https://www.bps.org.uk/psychologist/phineas-gage-unravelling-myth.
22. ↑ "'Unstable' wife-killer escapes the gallows". Today. 12 September 2006. https://eresources.nlb.gov.sg/newspapers/digitised/article/today20060912-1.2.8.5.
23. ↑ "Wife-killer case: Questions about syndrome". The Straits Times. 22 September 2006.

## Further reading

* Paradiso, S (1999). "Frontal lobe syndrome reassessed: comparison of patients with lateral or medial frontal brain damage". Journal of Neurology, Neurosurgery, and Psychiatry 67 (5): 664–7. doi:10.1136/jnnp.67.5.664. PMID 10519877.
* Paradiso, S.; Chemerinski, E.; Yazici, K. M; Tartaro, A.; Robinson, R. G (November 1999). "Frontal lobe syndrome reassessed: comparison of patients with lateral or medial frontal brain damage". Journal of Neurology, Neurosurgery & Psychiatry 67 (5): 664–667. doi:10.1136/jnnp.67.5.664. PMID 10519877.

## External links

Classification|

* ICD-10: F07

|

External resources|

* eMedicine: article/1135866

| Wikimedia Commons has media related to Frontal lobe disorder.

|

| Scholia has a topic profile for Frontal lobe disorder.

|

Template:Prosencephalon

* v
* t
* e

Medicine

Specialties
and
subspecialties|

Surgery

* Cardiac surgery
* Cardiothoracic surgery
* Colorectal surgery
* Eye surgery
* General surgery
* Neurosurgery
* Oral and maxillofacial surgery
* [[[Medicine:Orthopedic surgery|Orthopedic surgery]]
* Hand surgery
* Otolaryngology
* ENT
* Pediatric surgery
* Plastic surgery
* Reproductive surgery
* Surgical oncology
* Thoracic surgery
* Transplant surgery
* Trauma surgery
* Urology
* Andrology
* Vascular surgery

Internal medicine

* Allergy / Immunology
* Angiology
* Cardiology
* Endocrinology
* Gastroenterology
* Hepatology
* Geriatrics
* Hematology
* Hospital medicine|
* Infectious disease
* Nephrology
* Oncology
* Pulmonology
* Rheumatology

Obstetrics and gynaecology

* Gynaecology
* Gynecologic oncology
* Maternal–fetal medicine
* Obstetrics
* Reproductive endocrinology and infertility
* Urogynecology

Diagnostic

* Radiology
* Interventional radiology
* Nuclear medicine
* Pathology
* Anatomical
* Clinical pathology
* Clinical chemistry
* Clinical immunology
* Cytopathology
* Medical microbiology
* Transfusion medicine

Other specialties

* Addiction medicine
* Adolescent medicine
* Anesthesiology
* Dermatology
* Disaster medicine
* Diving medicine
* Emergency medicine
* Mass gathering medicine
* Family medicine
* General practice
* Hospital medicine
* Intensive care medicine
* Medical genetics
* Narcology
* Neurology
* Clinical neurophysiology
* Occupational medicine
* Ophthalmology
* Oral medicine
* Pain management
* Palliative care
* Pediatrics
* Neonatology
* Physical medicine and rehabilitation
* PM&R
* Preventive medicine
* Psychiatry
* Addiction psychiatry
* Radiation oncology
* Reproductive medicine
* Sexual medicine
* Sleep medicine
* Sports medicine
* Transplantation medicine
* Tropical medicine
* Travel medicine
* Venereology

Medical education|

* Medical school
* Bachelor of Medicine, Bachelor of Surgery
* Bachelor of Medical Sciences
* Master of Medicine
* Master of Surgery
* Doctor of Medicine
* Doctor of Osteopathic Medicine
* MD–PhD

Related topics|

* Alternative medicine
* Allied health
* Dentistry
* Podiatry
* Physiotherapy
* Molecular oncology
* Nanomedicine
* Personalized medicine
* Public health
* Traditional medicine
* Veterinary medicine
* Physician
* Chief physician
* History of medicine

* Book
* Category
* Commons
* Wikiproject
* Portal
* Outline

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Frontal lobe disorder. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Medicine:Frontal_lobe_disorder&oldid=4171038"
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template