List of Intelligent Systems for Molecular Biology keynote speakers

ISMB is an academic conference on the subjects of bioinformatics and computational biology organised by the International Society for Computational Biology (ISCB). The conference has been held annually since 1993 and keynote talks have been presented since 1994. Keynotes are chosen to reflect outstanding research in bioinformatics. The recipients of the ISCB Overton Prize and ISCB Accomplishment by a Senior Scientist Award are invited to give keynote talks as part of the programme.

Keynote speakers include eight Nobel laureates: Richard J. Roberts (1994, 2006), John Sulston (1995), Manfred Eigen (1999), Gerald Edelman (2000), Sydney Brenner (2003), Kurt Wüthrich (2006), Robert Huber (2006) and Michael Levitt (2015).[1][2][3]

## List of Speakers

This list is incomplete; you can help by expanding it.

Conference | Keynote Speakers | Title | Notes

|
|
|

ISMB 1994[4] | Bruce Buchanan  |  |
Lawrence Hunter  |  | Plenary speaker
Richard J. Roberts  |  | Plenary speaker
ISMB 1995[5] | Douglas Brutlag  |  |
John Sulston  |  |
Janet Thornton  |  |
ISMB 1996[6] | Robert Waterston  |  |
David Haussler  |  |
Russell Doolittle  |  |
Chris Sander  |  |
ISMB 1997[5] | Richard H. Lathrop  |  |
Marcie McClure  |  |
Hans Westerhoff  |  |
ISMB 1998[7] | Robert Cedergren  |  |
Michael Waterman  |  |
Shoshana Wodak  |  |
ISMB 1999[8] | Manfred Eigen  | The Origin of Biological Information  |
Amos Bairoch  | Swiss-Prot in the 21st century!  |
Richard M. Karp  | Combinatorial Problems in Gene expression Analysis Using DNA microarrays  |
Anthony R. Kerlavage  | Computational genomics: Biological Discovery in Complete Genomes  |
Eugene Koonin  | Comparative genomics: Is it changing the paradigm of evolutionary biology?  |
David Balaban  | Genes, Chips, and Genomes  |
Matthias Mann  | Gene Function via the Mass Spectrometric Analysis of Multi-Protein Complexes
Michael Sternberg  | Exploiting Protein Structure in the Post-genome Era  |
ISMB 2000[5] | Gerald Edelman  |  |
Leroy Hood  |  |
Minoru Kanehisa  |  |
J. Andrew McCammon  |  |
Eugene Myers  |  |
Harold Scheraga  |  |
David Searls  |  |
ISMB 2001[5] | Christopher Burge  |  |
Chris Dobson  |  |
Sean Eddy  |  |
David Eisenberg  |  |
Bernardo Huberman  |  |
Chris Sander  |  |
Gunnar von Heijne  |  |
ISMB 2002[9] | Stephen Altschul  | Assessing the accuracy of database search methods, and improving the performance of PSI-BLAST  |
Michael Ashburner  |  |
Ford Doolittle  |  |
Terry Gaasterland  |  |
Barry Honig  |  |
David Baker  |  | 2002 ISCB Overton Prize winner
John Reinitz  |  |
Isidore Rigoutsos  |  |
ISMB 2003[10] | Sydney Brenner  | The Evolution of Genes and Genomes  |
David Haussler  | Identifying functional elements in the human genome by tracing the evolutionary history of the bases: a key challenge for comparative genomics  |
Yoshihide Hayashizaki  | Dynamic Eukaryotic Transcriptome  |
Jim Kent  | Patching and Painting the Human Genome  | 2003 ISCB Overton Prize winner
John Mattick  | Programming of the autopoietic development of complex organisms: the hidden layer of noncoding RNA  |
David Sankoff  | The Parameters of Genome Rearrangement  | 2003 ISCB Senior Scientist Award winner
Ron Shamir  | Reconstructing Genetic Networks  |
Michael Waterman  | Dynamic Programming Algorithms for Haplotype Block Partitioning  |
ISMB/ECCB 2004[11] | Leroy Hood  | Systems Biology: Strategies for Deciphering Life  |
Denis Noble  | Computational systems biology of the heart  |
Eric D. Green  | Decoding the Human Genome by Multi-Species Sequence Comparisons  |
Svante Pääbo  | Evolution of the primate transcriptome  |
Matthias Mann  | Organellar and time resolved proteomics  |
Anna Tramontano  | Progress, assessment and perspectives in protein structure prediction  |
Uri Alon  | Simplicity in complex biological networks  | 2004 ISCB Overton Prize winner
David J. Lipman  | Message and meaning in sequence comparison: is systems biology possible?  | 2004 ISCB Senior Scientist Award winner
ISMB 2005[12] | Howard Cash  | Biology of Life and Death: Disaster, DNA and the Information Science of Human Identification  |
Gunnar von Heijne  | Membrane Proteins in vivo and in silico \- Getting the Best of Two Worlds  |
Jill Mesirov  | Gene Expression Analysis: A Knowledge-based Approach  |
Pavel A. Pevzner  | Transforming Men into Mice: Fragile versus Random Breakage Models of Chromosome Evolution  |
Peter Hunter  | Computational Physiology and the IUPS Physiome Project  |
Satoru Miyano  | Computational Challenges for Gene Networks  |
Ewan Birney  | Genomes to Systems Biology  | 2005 ISCB Overton Prize winner
Janet Thornton  | From Proteins to Life - Old and New Challenges  | 2005 ISCB Senior Scientist Award winner
ISMB 2006[13] | Robert Huber  | Molecular machines for protein degradation  |
Tom Blundell  | Structural biology, informatics and the discovery of new medicines  |
Kurt Wüthrich  | Computational Aspects of NMR Studies with Proteins in Solution  |
Mathieu Blanchette  | What mammalian genomes tell us about our ancestors, and vice versa  | 2006 ISCB Overton Prize winner
Elena Conti  | Molecular mechanisms in RNA degradation  |
Charles DeLisi  | New Approaches to Biomarker Discovery  |
Richard J. Roberts  | The need of Bioinformatics for experimental biologists  |
Michael Waterman  | Whole Genome Optical Mapping  | 2006 ISCB Senior Scientist Award winner
ISMB/ECCB 2007[14] | Eran Segal  | Quantitative Models for Chromatin and Transcription Regulation  | 2007 ISCB Overton Prize winner
Temple F. Smith  | Computational Biology: What is next?  | 2007 ISCB Senior Scientist Award winner
Søren Brunak  | Understanding interactomes by data integration  |
Stephen K. Burley  | Fragment-based discovery of BCR-ABL inhibitors for treatment of chronic myelogenous leukemia  |
Michael Eisen  | Understanding and exploiting the evolution of the sequences that control gene expression  |
Anne-Claude Gavin  | Interaction Networks Probed by Mass Spectrometry  |
John Mattick  | The majority of the genome of complex organisms is devoted to an RNA regulatory system that directs differentiation and development  |
Erin K. O'Shea  | Dissecting Transcriptional Network Structure and Function  |
Renée Schroeder  | Genomic SELEX for the identification of novel non-coding RNAs independent of their expression level  |
Terry Speed  | Genome-wide genotyping: the great classification challenge  |
ISMB 2008[15] | Aviv Regev  | Modular biology: the function and evolution of molecular networks  | 2008 ISCB Overton Prize winner
David Haussler  | 100 Million Years of Evolutionary History of the Human Genome  | 2008 ISCB Senior Scientist Award winner
Claire M. Fraser-Liggett  | Microbial Communities in Health and Disease  |
David Jaffe  | Tiny bits and pieces: new sequencing technologies and what they can do for you  |
Eugene Myers  | Imaging Bioinformatics  |
Morag Park  | Profiling the Breast Tumor Microenvironment  |
Bernhard Palsson  | Systems Biology: an era of reconstruction and interrogation  |
Hanah Margalit  | Intriguing roles for small non-coding RNAs in the cellular regulatory networks  |
ISMB/ECCB 2009[16] | Trey Ideker  | New Challenges and Opportunities in Network Biology  | 2009 ISCB Overton Prize winner
Webb Miller  | Bioinformatics Methods to Study Species Extinctions  | 2009 ISCB Senior Scientist Award winner
Pierre-Henri Gouyon  | Information and Biology  |
Daphne Koller  | Individual Genetic Variation: From Networks to Mechanisms  |
Thomas Lengauer  | Chasing the AIDS Virus  |
Eugenia María del Pino Veintimilla  | The comparative analysis reveals independence of developmental processes during early development in frogs  |
Tomaso Poggio  | Computational Neuroscience: Models of the Visual System  |
Mathias Uhlén  | A global view on protein expression based on the Human Protein Atlas  |
ISMB 2010[17] | Steven E. Brenner  | Ultraconserved nonsense: gene regulation by splicing & RNA surveillance  | 2010 ISCB Overton Prize winner
Susan Lindquist  | Protein Folding and Environmental Stress REDRAW the Relationship between Genotype and Phenotype  |
Svante Pääbo  | Analyses of Pleistocene Genomes  |
Chris Sander  | Systems Biology of Cancer Cells  | 2010 ISCB Senior Scientist Award winner
David Altshuler  | Genomic Variation and the Inherited Basis of Common Disease  |
George M. Church  | BI/O: Reading and Writing Genomes  |
Robert Weinberg  | Cancer Stem Cells and the Evolution of Malignancy  | Special Public Lecture
ISMB/ECCB 2011[18] | Bonnie Berger  | Computational biology in the 21st century: making sense out of massive data  |
Olga Troyanskaya  | Integrating computation and experiments for a molecular-level understanding of human disease  | 2011 ISCB Overton Prize winner
Janet Thornton  | The Evolution of Enzyme Mechanisms and Functional Diversity  | ECCB 10th Anniversary Keynote
Alfonso Valencia  | Challenges for Bioinformatics in Personalized Cancer Medicine  | 2011 ISCB Fellow
Luis Serrano  | M. pneumoniae (Towards a full quantitative understanding of a free-living system)  |
Michael Ashburner  | From sequences to ontologies - adventures in informatics  | 2011 ISCB Senior Scientist Award winner
ISMB 2012[19] | Richard H. Lathrop & Lawrence Hunter  | Seeing forward by looking back  | ISMB 20th Anniversary Keynote
Ziv Bar-Joseph  | Data integration for understanding dynamic biological systems  | 2012 ISCB Overton Prize winner
Barbara Wold  | Analysis of transcriptome structure and chromatin landscapes  |
Richard M. Durbin  | Progress, challenges and opportunities in population genome sequencing  | 2012 ISCB Fellow
Andrej Šali  | Integrative Structural Biology  |
Gunnar von Heijne  | The other Third: Coming to grips with membrane proteins  | 2012 ISCB Senior Scientist Award winner
ISMB/ECCB 2013[20] | Gil Ast  | How Chromatin organization and epigenetics talk with alternative splicing  |
Gonçalo Abecasis  | Insights from Sequencing Thousands of Human Genomes  | 2013 ISCB Overton Prize winner
Lior Pachter  | Sequencing based functional genomics (analysis)  |
Gary Stormo  | Searching for Signals in Sequences  | 2013 ISCB Fellow
Carole Goble  | Results may vary: what is reproducible? why do open science and who gets the credit?  |
David Eisenberg  | Protein Interactions in Health and Disease  | 2013 ISCB Senior Scientist Award winner
ISMB 2014[21] | Isaac Kohane  | Biomedical Quants of the World Unite! We only have our disease burden to lose  |
Eugene Myers  | DNA Assembly: Past, Present, and Future  | 2014 ISCB Senior Scientist Award winner
Michal Linial  | Good Things Come in Small Packages – Replicators and Innovators  |
Dana Pe'er  | A multidimensional single cell approach to understand cellular behavior  | 2014 ISCB Overton Prize winner
Robert S. Langer  | Biomaterials and biotechnology: From the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering  |
Russ Altman  | Informatics for understanding drug response at all scales  | 2014 ISCB Fellow
ISMB 2015[3] | Michael Levitt  | Birth & Future of Multiscale Modeling of Macromolecules  |
Curtis Huttenhower  | Understanding microbial community function and the human microbiome in health and disease  | 2015 ISCB Overton Prize winner
Eileen Furlong  | Genome regulation during embryonic development  |
Kenneth H Wolfe  | TBA  |
Cyrus Chothia  | TBA  | 2015 ISCB Senior Scientist Award winner
Amos Bairoch  | TBA  | 2015 ISCB Fellow
ISMB 2016[22] | Ruth Nussinov  | Ras signaling: a challenge to the biological sciences  | 2016 ISCB Fellow
Debora Marks  |  | 2016 ISCB Overton Prize winner
Sandrine Dudoit  | Identification of Novel Cell Types in the Brain Using Single-Cell Transcriptome Sequencing  |
Sarah Teichmann  | Understanding Cellular Heterogeneity  |
Serafim Batzoglou  |  | 2016 ISCB Innovator Award winner
Søren Brunak  |  | 2016 ISCB Senior Scientist Award winner

## References

1. ↑ "About ISMB". www.iscb.org. ISCB. http://www.iscb.org/about-ismb. Retrieved 29 October 2013.
2. ↑ Neshich, Goran; Bourne, Philip E.; Brunak, Søren (1 January 2006). "ISMB 2006". PLoS Computational Biology 2 (2): e11. doi:10.1371/journal.pcbi.0020011.
3. ↑ 3.0 3.1 "Keynotes". ISMB/ECCB 2015. ISCB. http://www.iscb.org/ismbeccb2015-program/ismbeccb2015-keynotes. Retrieved 18 May 2015.
4. ↑ "ISMB-94". International Society for Computational Biology. http://www.iscb.org/cms_addon/conferences/ismb1994/. Retrieved 27 October 2013.
5. ↑ 5.0 5.1 5.2 5.3 "ISMB". International Society for Computational Biology. http://www.iscb.org/high-quality-meetings/121. Retrieved 27 October 2013.
6. ↑ "ISMB-96 Home Page". Archived from the original on June 6, 1997. https://web.archive.org/web/19970606232955/http://www.ibc.wustl.edu/ismb96/#KeynoteSpeakers. Retrieved 27 October 2013.
7. ↑ "Intelligent Systems on Molecular Biology". Archived from the original on 8 May 2012. https://web.archive.org/web/20120508203531/http://www-lbit.iro.umontreal.ca/ISMB98/anglais/invites_en.html. Retrieved 27 October 2013.
8. ↑ "ISMB 99 - Keynotes Abstracts". http://bioinf.mpi-inf.mpg.de/conferences/ismb99/WWW/key_abs.html. Retrieved 27 October 2013.
9. ↑ "ISMB 2002 Agenda". http://www.iscb.org/cms_addon/conferences/ismb2002/agenda.htm. Retrieved 27 October 2013.
10. ↑ "ISMB 2003 - Brisbane Australia". http://www.iscb.org/cms_addon/conferences/ismb2003/detailed_agenda.shtml. Retrieved 27 October 2013.
11. ↑ "ISMB/ECCB 2004". ISCB. http://www.iscb.org/cms_addon/conferences/ismbeccb2004/detailed.html. Retrieved 29 October 2013.
12. ↑ "ISMB 2005: Michigan , June 25-29". ISCB. http://www.iscb.org/cms_addon/conferences/ismb2005/detailed1.html. Retrieved 29 October 2013.
13. ↑ "ISMB2006 Agenda". http://www.iscb.org/cms_addon/conferences/ismb2006/archive/ismb2006.cbi.cnptia.embrapa.br/pdfs/ISMB2006_Agenda.pdf. Retrieved 29 October 2013.
14. ↑ "ISMB/ECCB 2007 Keynotes". http://www.iscb.org/cms_addon/conferences/ismbeccb2007/keynotes.html. Retrieved 29 October 2013.
15. ↑ "Keynotes". ISMB 2008. ISCB. http://www.iscb.org/cms_addon/conferences/ismb2008/keynotes.php. Retrieved 27 October 2013.
16. ↑ "ISMB/ECCB 2009 Keynotes". ISMB/ECCB 2009. ISCB. http://www.iscb.org/cms_addon/conferences/ismbeccb2009/keynotes.php. Retrieved 15 September 2013.
17. ↑ "ISMB2010 - Keynotes". ISMB 2010. ISCB. http://www.iscb.org/archive/conferences/iscb/ismb2010-program/ismb2010-keynotes.html. Retrieved 14 September 2013.
18. ↑ "Keynotes". ISMB/ECCB 2011. ISCB. http://www.iscb.org/archive/conferences/iscb/ismbeccb2011-program/keynotes.html. Retrieved 26 August 2013.
19. ↑ "Keynotes". ISMB 2012. ISCB. http://www.iscb.org/ismb2012-program/ismb2012-keynotes. Retrieved 26 August 2013.
20. ↑ "All Keynotes". ISMB/ECCB 2013. ISCB. http://www.iscb.org/ismbeccb2013-program/ismbeccb2013-keynotes/ismbeccb2013-all-keynotes. Retrieved 26 August 2013.
21. ↑ "Keynotes". ISMB2014. ISCB. http://www.iscb.org/ismb2014-program/ismb2014-keynotes. Retrieved 9 February 2014.
22. ↑ "Keynotes". https://www.iscb.org/ismb2016program/keynotes. Retrieved 11 April 2016.

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