Nitrile

| Main Article
| Discussion
| Related Articles  [?]
| Bibliography  [?]
| External Links  [?]
| Citable Version  [?]

|
|
|
|
|
|
|
|

This editable Main Article is under development and subject to a disclaimer.

[edit intro]

A nitrile is an organic compound containing a carbon triple bonded to nitrogen.

## Synthesis[edit]

* The Sandmeyer reaction employing cuprous cyanide can be used to form nitriles from diazonium compounds.
* Aryl nitriles may be formed from aryl halides in the Rosenmund-von Braun reaction.
* The reaction of cyanide with aldehydes or ketones forms a cyanohydrin (ά-hydroxynitrile).
* Amides may be dehydrated to nitriles with a variety of reagents

## Reactivity[edit]

* Nitriles are reduced to amines by hydrogen and a nickel catalyst
* Nitriles are reduced to imines, then hydrolyzed to the aldehyde in the Stephens aldehyde synthesis.
* Beta-ketoesters are formed from alpha-bromoesters and nitriles in the Blaise reaction.
* Nitriles are hydrolysed to amides by acid