Leucovorin rescue

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Leucovorin rescue is a type of cancer chemotherapy, sometimes called effective heroic medicine, in which a lethal dose of methotrexate is administered, and then an antidote, leucovorin, given at a delayed time calculated to kill a maximum number of malignant cells without killing the patient.[1]

## References[edit]

1. ↑ Sirotnak FM, Moccio DM, Dorick DM (February 1978), "Optimization of High-Dose Methotrexate with Leucovorin Rescue Therapy in the L1210 Leukemia and Sarcoma 180 Murine Tumor Models1", Cancer Research 38: 345