Immune disorder

Other names: Autoimmune disease
Child with Graves' disease \- with a goiter and protruding eyes.
Specialty| Immunology

An immune disorder is a dysfunction of the immune system.[1] These disorders can be characterized in several different ways:

* By the component(s) of the immune system affected
* By whether the immune system is overactive or underactive
* By whether the condition is congenital or acquired

According to the International Union of Immunological Societies, more than 150 primary immunodeficiency diseases (PIDs) have been characterized.[2] However, the number of acquired immunodeficiencies exceeds the number of PIDs.[3]

It has been suggested that most people have at least one primary immunodeficiency.[4] Due to redundancies in the immune system, though, many of these are never detected.

## Contents

* 1 Autoimmune diseases
* 1.1 List of some autoimmune disorders
* 2 Immunodeficiencies
* 3 Allergies
* 4 See also
* 5 References
* 6 External links

## Autoimmune diseases[edit | edit source]

Main article: Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.[5] There are at least 80 types of autoimmune diseases.[5] Nearly any body part can be involved. Common symptoms include low-grade fever and feeling tired.[5] Often symptoms come and go.[5]

### List of some autoimmune disorders[edit | edit source]

Main article: List of autoimmune diseases

* Lupus
* Scleroderma
* Certain types of hemolytic anemia
* Vasculitis
* Type 1 diabetes
* Graves' disease
* Rheumatoid arthritis
* Multiple sclerosis (although it is thought to be an immune-mediated process)
* Goodpasture syndrome
* Pernicious anemia
* Some types of myopathy
* Lyme disease (Late)
* Celiac disease
* Alopecia Areata [1]

## Immunodeficiencies[edit | edit source]

Main article: immunodeficiency

Primary immune deficiency diseases are those caused by inherited genetic mutations. Secondary or acquired immune deficiencies are caused by something outside the body such as a virus or immune suppressing drugs.[6]

Primary immune diseases are at risk to an increased susceptibility to, and often recurrent ear infections, pneumonia, bronchitis, sinusitis or skin infections. Immunodeficient patients may less frequently develop abscesses of their internal organs, autoimmune or rheumatologic and gastrointestinal problems.[7]

Primary immune deficiencies

* Severe combined immunodeficiency (SCID)
* DiGeorge syndrome
* Hyperimmunoglobulin E syndrome (also known as Job's Syndrome)
* Common variable immunodeficiency (CVID): B cell levels are normal in circulation but with decreased production of IgG throughout the years, so it is the only primary immune disorder that presents onset in the late teens years.
* Chronic granulomatous disease (CGD): a deficiency in NADPH oxidase enzyme, which causes failure to generate oxygen radicals. Classical recurrent infection from catalase positive bacteria and fungi.
* Wiskott–Aldrich syndrome (WAS)
* Autoimmune lymphoproliferative syndrome (ALPS)
* Hyper IgM syndrome: X-linked disorder that causes a deficiency in the production of CD40 ligand on activated T cells. This increases the production and release of IgM into circulation. The B cell and T cell numbers are within normal limits. Increased susceptibility to extracellular bacteria and opportunistic infections.
* Leukocyte adhesion deficiency (LAD)
* NF-κB Essential Modifier (NEMO) Mutations
* Selective immunoglobulin A deficiency: the most common defect of the humoral immunity, characterized by a deficiency of IgA. Produces repeating sino-pulmonary and gastrointestinal infections.
* X-linked agammaglobulinemia (XLA; also known as Bruton type agammaglobulinemia): characterized by a deficiency in tyrosine kinase enzyme that blocks B cell maturation in the bone marrow. No B cells are produced to circulation and thus, there are no immunoglobulin classes, although there tends to be a normal cell-mediated immunity.
* X-linked lymphoproliferative disease (XLP)
* Ataxia–telangiectasia

Secondary immune deficiencies

* AIDS

## Allergies[edit | edit source]

Main article: allergy

An allergy is an abnormal immune reaction to a harmless antigen.[citation needed]

* Seasonal allergy
* Mastocytosis
* Perennial allergy
* Anaphylaxis
* Food allergy
* Allergic rhinitis[8]
* Atopic dermatitis

## See also[edit | edit source]

* Disorders of human immunity
* Hypersplenism

## References[edit | edit source]

1. ↑ 1.0 1.1 Erjavec SO, Gelfman S, Abdelaziz AR, Lee EY, Monga I, Alkelai A, Ionita-Laza I, Petukhova L, Christiano AM (Feb 2022). "Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82". Nat Commun. 13 (1): 800. doi:10.1038/s41467-022-28343-3. PMID 35145093.
2. ↑ Geha RS, Notarangelo LD, Casanova JL, et al. (October 2007). "Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee". J. Allergy Clin. Immunol. 120 (4): 776–94. doi:10.1016/j.jaci.2007.08.053. PMC 2601718. PMID 17952897.
3. ↑ Kumar A, Teuber SS, Gershwin ME (2006). "Current perspectives on primary immunodeficiency diseases". Clin. Dev. Immunol. 13 (2–4): 223–59. doi:10.1080/17402520600800705. PMC 2270780. PMID 17162365.
4. ↑ Casanova JL, Abel L (August 2007). "Primary immunodeficiencies: a field in its infancy". Science. 317 (5838): 617–9. Bibcode:2007Sci...317..617C. doi:10.1126/science.1142963. PMID 17673650. S2CID 7287315.
5. ↑ 5.0 5.1 5.2 5.3 "Autoimmune diseases fact sheet". OWH. 16 July 2012. Archived from the original on 5 October 2016. Retrieved 5 October 2016.
6. ↑ "Primary Immune Deficiency Diseases". Department of Health and Human Services: National Institutes of Health. Archived from the original on 27 July 2011. Retrieved 31 August 2011.
7. ↑ "Primary Immunodeficiency FAQ". INFO4PI. Archived from the original on 2 October 2011. Retrieved 31 August 2011.
8. ↑ "Immune Disorders". Archived from the original on 2015-03-30. Retrieved 2023-02-13.

## External links[edit | edit source]

Classification|

* ICD-10: D80-D89
* ICD-9-CM: 273, 279
* MeSH: D007154

|

* Immune disorder at Curlie

* v
* t
* e

Lymphoid and complement disorders causing immunodeficiency

Primary|

| Antibody/humoral
(B)|

| Hypogammaglobulinemia|

* X-linked agammaglobulinemia
* Transient hypogammaglobulinemia of infancy

|

Dysgammaglobulinemia|

* IgA deficiency
* IgG deficiency
* IgM deficiency
* Hyper IgM syndrome (1
* 2
* 3
* 4
* 5)
* Wiskott–Aldrich syndrome
* Hyper-IgE syndrome

Other|

* Common variable immunodeficiency
* ICF syndrome

T cell deficiency
(T)|

* thymic hypoplasia: hypoparathyroid (Di George's syndrome)
* euparathyroid (Nezelof syndrome
* Ataxia–telangiectasia)

peripheral: Purine nucleoside phosphorylase deficiency

* Hyper IgM syndrome (1)

Severe combined
(B+T)|

* x-linked: X-SCID
autosomal: Adenosine deaminase deficiency
* Omenn syndrome
* ZAP70 deficiency
* Bare lymphocyte syndrome

Acquired|

* HIV/AIDS

Leukopenia:
Lymphocytopenia|

* Idiopathic CD4+ lymphocytopenia

Complement
deficiency|

* C1-inhibitor (Angioedema/Hereditary angioedema)
* Complement 2 deficiency/Complement 4 deficiency
* MBL deficiency
* Properdin deficiency
* Complement 3 deficiency
* Terminal complement pathway deficiency
* Paroxysmal nocturnal hemoglobinuria
* Complement receptor deficiency

* v
* t
* e

Immunoproliferative immunoglobulin disorders

PCDs/PP|

* Plasmacytoma
* Multiple myeloma (Plasma cell leukemia)
* MGUS
* IgM (Macroglobulinemia/Waldenström's macroglobulinemia)
* heavy chain (Heavy chain disease)
* light chain (Primary amyloidosis)

Other hypergammaglobulinemia|

* Cryoglobulinemia

* v
* t
* e

Hypersensitivity and autoimmune diseases

Type I/allergy/atopy
(IgE)|

| Foreign|

* Atopic eczema
* Allergic urticaria
* Allergic rhinitis (Hay fever)
* Allergic asthma
* Anaphylaxis
* Food allergy
* common allergies include: Milk
* Egg
* Peanut
* Tree nut
* Seafood
* Soy
* Wheat
* Penicillin allergy

|

Autoimmune|

* Eosinophilic esophagitis

Type II/ADCC

*     * IgM
* IgG

| Foreign|

* Hemolytic disease of the newborn

|

Autoimmune|

| Cytotoxic|

* Autoimmune hemolytic anemia
* Immune thrombocytopenic purpura
* Bullous pemphigoid
* Pemphigus vulgaris
* Rheumatic fever
* Goodpasture syndrome
* Guillain–Barré syndrome

|

"Type V"/receptor|

* Graves' disease
* Myasthenia gravis
* Pernicious anemia

Type III
(Immune complex)|

| Foreign|

* Henoch–Schönlein purpura
* Hypersensitivity vasculitis
* Reactive arthritis
* Farmer's lung
* Post-streptococcal glomerulonephritis
* Serum sickness
* Arthus reaction

|

Autoimmune|

* Systemic lupus erythematosus
* Subacute bacterial endocarditis
* Rheumatoid arthritis

Type IV/cell-mediated
(T cells)|

| Foreign|

* Allergic contact dermatitis
* Mantoux test

|

Autoimmune|

* Diabetes mellitus type 1
* Hashimoto's thyroiditis
* Multiple sclerosis
* Coeliac disease
* Giant-cell arteritis
* Postorgasmic illness syndrome
* Reactive arthritis

GVHD|

* Transfusion-associated graft versus host disease

Unknown/
multiple|

| Foreign|

* Hypersensitivity pneumonitis
* Allergic bronchopulmonary aspergillosis
* Transplant rejection
* Latex allergy (I+IV)

|

Autoimmune|

* Sjögren syndrome
* Autoimmune hepatitis
* Autoimmune polyendocrine syndrome
* APS1
* APS2
* Autoimmune adrenalitis
* Systemic autoimmune disease

* v
* t
* e

Major Disease groups

* Infection
* Parasitic disease

* Benign tumor
* Cancer

* Endocrine disease
* Malnutrition
* Metabolic disorder
* Immune disorder

* Hematologic disease

* Mental disorder

* Neurological disorder
* Eye disease
* Ear disease

* Cardiovascular disease
* Lymphatic disease

* Respiratory disease

* Maxillofacial disorder
* Gastrointestinal disease

* Urologic disease
* Female genital disease
* Breast disease
* Male genital disease

* Complications of pregnancy
* Obstetric labor complication
* Postpartum disorder

* Skin disease

* Musculoskeletal disorder
* Soft tissue disorder
* Connective tissue disease
* Bone disease
* Chondropathy

* Congenital disorder
* Fetal disease

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