Coronavirus breathalyzer

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A coronavirus breathalyzer is a diagnostic medical device enabling the user to test with 90% or greater accuracy the presence of severe acute respiratory syndrome coronavirus 2 in an exhaled breath.[1] As of the first half of 2020, the idea of a practical coronavirus breathalyzer was concomitantly developed by unrelated research groups in Australia, Canada, Finland, Germany, Indonesia, Israel, Netherlands, Poland, Singapore, United Kingdom and USA.[2][3]

People with COVID-19 have higher levels of aldehydes, compounds produced when cells or tissues are damaged by inflammation, and ketones, which fits with research suggesting that the virus may damage the pancreas and cause ketosis. Diagnostics researchers hope to find the components in exhaled air that are truly characteristic of a disease and develop more specific sensors for them, This is done by studying breath samples using sensors in parallel with mass spectrometry analyses.[4]

Different diseases may cause similar breath changes. Diet can affect the chemicals someone exhales, as can smoking, alcohol consumption and medicines.[citation needed]

## Contents

* 1 Australia
* 2 Canada
* 3 Finland
* 4 Germany
* 5 Indonesia
* 6 Israel
* 7 The Netherlands
* 8 Poland
* 9 United Kingdom
* 10 United States
* 11 References
* 12 External links

## Australia[edit | edit source]

In Australia, GreyScan CEO Samantha Ollerton and Prof. Michael Breadmore of the University of Tasmania are basing a coronavirus breathalyzer on existing technology that is used around the world to detect explosives.[5]

## Canada[edit | edit source]

Canary Health Technologies, headquartered in Toronto with offices in Cleveland, Ohio, is developing a breathalyzer with disposable nanosensors using AI-powered cloud-based analysis. According to a press release, clinical trials began in India during November 2020.[6] The stated goal is to develop an accurate, reasonably priced screening tool that can be used anywhere and deliver a result in less than a minute. The company postulates that analyzing volatile organic compounds in human breath could potentially detect diseases before the on-set of symptoms, earlier than currently available methods. Moreover, the cloud-based technology is designed to be used as a disease surveillance apparatus.[7][8]

## Finland[edit | edit source]

By the end of June 2020, Forum Virium Helsinki, in collaboration with Finnish software firm Deep Sensing Algorithms, funded by the Helsinki-Uusimaa Regional Council,[9] announced that testing of their device had begun with a control group in Kazakhstan, with plans to expand to the Netherlands, the United States, South Africa, Brazil and Finland throughout the summer.[10] The efficacy of the Forum Virium Helsinki / Deep Sensing Algorithms device hinges on its AI component.[11] "We are engaged in innovative cooperation with corporations to solve the coronavirus crisis, and we will help firms to use the city as a development platform. We are utilizing artificial intelligence and digitalization," said Forum Virium Helsinki CEO Mika Malin.[12]

## Germany[edit | edit source]

In March 2020, the Singaporean company RAM Global conducted research in Germany in hopes of developing a one-minute breathalyzer test for SARS-CoV-2 based on terahertz time-domain spectroscopy. The company attempted to develop a disposable test kit for direct detection of COVID-19 virion particles in breath, saliva and swab samples.[13] On 31 March, RAM Global completed an initial clinical study on live patients at University Hospital Saarland. In April, the company pursued a small unknown sample study in which hospital doctors provided unknown samples in order to test accuracy in differentiating positive and negative samples.[14] The company named its product platform ThEA, or Terahertz Express Analyzer.[15]

## Indonesia[edit | edit source]

Since April 2020, a team of researchers from Gadjah Mada University (UGM) has been developing an electronic nose called GeNose C19.[16] The GeNose C19 can be used as a rapid, non-invasive screening tool in less than two minutes. A profiling test was carried out at the Bhayangkara Hospital and the Covid Bambanglipuro Special Field Hospital in Yogyakarta.[17] GeNose C19 consists of gas sensors and an artificial intelligence-based pattern recognition system. The diagnostic test was carried out with the cooperation of nine multi-center hospitals.[18]

In the end of December 2020, GeNose C19 received a distribution permit from Indonesia's Health Ministry. Initially, 100 units will be released and each device will be able to perform 120 tests per day. The test is estimated to cost 15,000–25,000 Indonesian rupiah ($1–$1.8) and would take three minutes for the test and another two minutes to yield a result. Researchers hope to manufacture up to 1,000 GeNose C19 units, increasing the country's testing capabilities by 120 thousand subjects per day.[19] Moreover, they aim to manufacture 10,000 units by February 2021.[20][21]

## Israel[edit | edit source]

In Israel, it is at the photonics lab of Gabby Sarusi, professor at Ben-Gurion University of the Negev, that research is underway as of midsummer 2020.[22] Separately from Sarusi's project, in July 2020, it was reported that Israeli start-up Nanoscent in cooperation with Sheba Medical Center had devised a breathalyzer that Magen David Adom (MDA) is seeking to incorporate into existing drive-thru testing stations located throughout the country.[23]

Questionable intellectual property of Gabby Sarusi regarding this project is now under discussion in the court in Israel.[24][25][26]

## The Netherlands[edit | edit source]

A breath test with the SpiroNose device, made by the Dutch company Breathomix,[1] has been developed and tested in collaboration with the Leiden University Medical Center (LUMC), Franciscus Gasthuis & Vlietland and the GGD Amsterdam. The breath test has been validated as a pre-screening test for people who have no or mild symptoms of COVID-19. From April 2021, the device was operational in COVID-19 test drive-ins, conferences and events, i.e. Eurovision Song Contest 2021. Subjects must abstain from alcohol for eight hours prior to taking the breath test.[citation needed]

The SpiroNose contains four sets of seven different sensors that can measure the mixture of volatile organic compounds (biomarkers) in the exhaled air. These VOCs provide a picture of a person's metabolism. This 'breath profile' is forwarded to an online analysis platform. Here the breath profile is compared with other breath profiles of people with and without a COVID-19 diagnosis and analysed by algorithms. Data-analysis involves advanced signal processing and statistics based on independent t-tests followed by linear discriminant and ROC analysis. The test result is known within minutes.[citation needed]

The breath test has a sensitivity/specificity for SARS-CoV-2 infection of 100/78, >99/84, 98/82% in validation, replication and asymptomatic cohorts of patients. The breath test reliably detects who is not infected. Such a subject will receive a test result immediately. Other subjects must promptly conduct a subsequent test, for example a PCR test or LAMP test. The test results can be viewed by the client and are not automatically interfaced to other databases, i.e. for public health surveillance, source and contact tracing, vaccination programs.[27][28] In additional control tests in July 2021, it was not possible to obtain sufficiently reliable results specific for the GGD test drive-in setting.[29] In July 2021, the ministry stopped the tests with the SpiroNose because, according to the GGD, the device gives unusable results in some cases. Breathomix indicates that this is the result of the way in which the SpiroNose is deployed. The SpiroNose is and remains a reliable instrument for lung diseases.[citation needed]

The analysis platform is developed conform the requirements of the standard ISO 27001 (Information Security) and NEN 7510 (Information Security in Health Care). A CE marking has been requested. In the meantime, the Dutch minister has granted a CE marking exemption on 25 January 2021. The device may also be used to detect other diseases, e.g., asthma, COPD, lung cancer, interstitial lung diseases (ILD).[citation needed]

## Poland[edit | edit source]

COVID Detector, developed by ML System in Poland.

In February 2021, the President of Poland, Andrzej Duda, announced that ML System S. A., headquartered in Zaczernie, Poland, had successfully developed a means of analyzing a patient's breath to test for the presence of coronavirus.[30] According to an anonymous press release, test subjects exhale into a device in order to determine the presence of the coronavirus. The procedure, similar to that of a police breathalyzer, is said to take less than ten seconds. Independent clinical trials were begun in April 2021.[31] In the first half of May 2021, a brief text concerning partial results was published by ML System, stating that independent clinical trials were successful with specificity (97,15%) and accuracy/sensitivity (86,86%), for CT (Cycle Threshold) assumed at 25, which is in line with the guidelines set out by the World Health Organisation.[32] Moreover, ML System in partnership with Rzeszów–Jasionka Airport published a statement indicating their intention to test the device at the airport.[33] Similar plans exist between the manufacturer and the Warsaw Chopin Airport.[34] Two large networks of laboratories in Poland, "Diagnostyka" and "ALAB Laboratoria", have signed a letter of intent with ML System. In agreement with ALAB, the parties declared cooperation in the implementation of the product named "COVID DETECTOR" on the Polish, German and Ukrainian markets. In addition, the companies declared joint activities aimed at extending the diagnosis with the use of "COVID Detector" to include mutations of the SARS-CoV-2 virus, differentiate the stage of the disease and other pathogens, including tuberculosis. Cooperation with laboratories Diagnostyka, including detection of mutations of SARS-CoV-2 virus or other pathogens, also involves the diagnosis of cancer with the use of the device.[citation needed]

## United Kingdom[edit | edit source]

In January 2021, Exhalation Technology Ltd (ETL) in Cambridge announced a clinical trial study for a cohort of up to 150 patients for its CoronaCheck breath test for COVID-19.[35]

## United States[edit | edit source]

In June 2020, American researchers at UCLA and Ohio State University received grants to test coronavirus breathalyzer concepts, one of which could produce results in 15 seconds. The testing system would be able to take certain compounds from an individual breath to detect coronavirus.[36] "The goal in this research is to develop cheap, massively deployable, rapid diagnostic and sentinel systems for detecting respiratory illness and airborne viral threats," says Prof. Pirouz Kavehpour of UCLA Henry Samueli School of Engineering and Applied Science, whose research team received a one-year, $150,000 research grant from the National Science Foundation.[37]

Commercial Research Developments

In July 2019, Technology start-up Global e∙dentity™ founder Dr. Robert Adams first discussed chemosensory biometrics detection during a TEDx talk in Norwich England July 2019, and by February 2020 it had focused its chemosensory detection developments on the emerging SARS-CoV-2 (COVID-19) pandemic. The team discovered that it could distinguish between the odor of individuals with asymptomatic or mild symptomatic SARS-CoV-2 infection and uninfected individuals, essentially, they had identified the chemical odor signature of Volatile Organic Compounds (VOCs) a.k.a. smell associated with the metabolism of COVID-19 infection in a human or non-human. The team went on to tune their associated AI algorithms to achieve an almost faultless 100% detection accuracy in 5 seconds. The company was granted the first real-time Covid detection patent on 29 Dec 2020, U.S. Patent number US 10,880,303 Real-time COVID-19 outbreak identification with non-invasive, internal imaging for dual biometric authentication and biometric health monitoring its fourth patent issued in two years, on March 15, 2022, they were granted U.S. Patent number 11,277,405 Dual biometric authentication and biometric health monitoring using chemosensory and internal imaging data.[citation needed]

In April 2022, the FDA authorized for emergency use the first COVID-19 diagnostic test using breath samples.[38] "The InspectIR COVID-19 Breathalyzer uses a technique called gas chromatography gas mass-spectrometry (GC-MS) to separate and identify chemical mixtures and rapidly detect five Volatile Organic Compounds (VOCs) associated with SARS-CoV-2 infection in exhaled breath," said the FDA.

## References[edit | edit source]

1. ↑ 1.0 1.1 Anthes, E., "A Covid Test as Easy as Breathing" Archived 2022-05-11 at the Wayback Machine, The New York Times, July 11, 2021.
2. ↑ Staff, "Coronavirus-Detecting Breathing Device Could Potentially Give a Diagnosis in Less than One Minute" Archived 2020-06-29 at the Wayback Machine, HospiMedica International, April 20, 2020.
3. ↑ Anon, "New coronavirus test that is eight times faster can help locate asymptomatic carriers" Archived 2020-06-30 at the Wayback Machine, EurekAlert!, April 20, 2020.
4. ↑ "Forget throat swabs: Dutch company claims its breathalyzer can help sniff out COVID-19". Archived from the original on 2022-04-23. Retrieved 2022-11-09.
5. ↑ Hogan, M., & Woolley, S., "The world-first 'on the spot' COVID test that could detect the virus in minutes" Archived 2020-09-29 at the Wayback Machine, Seven News, June 30, 2020.
6. ↑ Anon., "Ground Breaking Human Trial for COVID-19 Ultra-Rapid Breath Test Begins in India" Archived 2020-12-31 at the Wayback Machine, PR Newswire, December 7, 2020.
7. ↑ Makoni, M., In South Africa, COVID-19 "Breath Test Trial Set for June" Archived 2020-10-06 at the Wayback Machine, The Scientist, June 15, 2020.
8. ↑ Ebrahim, Z., "Trial for Covid-19 rapid breath test – that delivers results in under 5 minutes, to start in SA" Archived 2020-10-20 at the Wayback Machine, News24, May 29, 2020.
9. ↑ Anon, "Finnish companies develop instant COVID-19 breathalyzer" Archived 2020-10-22 at the Wayback Machine, China Internet Information Center, June 29, 2020.
10. ↑ Salomaa, M., "Laakson terveysasemalla alkavat uuden laitteen puhallustestit koronaviruksen tunnistamiseksi" Archived 2020-10-01 at the Wayback Machine, Helsingin Sanomat, June 28, 2020.
11. ↑ Anon, "Helsinki to trial coronavirus breathalyser" Archived 2020-11-12 at the Wayback Machine, Yle, June 29, 2020.
12. ↑ News desk, "Finland to trial instant coronavirus breathalyzer" Archived 2020-08-13 at the Wayback Machine, Daily Finland, June 29, 2020.
13. ↑ Deters, Jannik. "Coronavirus-Schnelltest: Saarländer Firma verspricht Testergebnis in zwei Minuten". www.wiwo.de (in Deutsch). Archived from the original on 2021-01-16. Retrieved 2020-08-23.
14. ↑ Deters, Jannik. "Uniklinik im Saarland: Wie sicher ist der Zwei-Minuten-Test auf Corona?". www.wiwo.de (in Deutsch). Archived from the original on 2021-01-16. Retrieved 2020-08-23.
15. ↑ Anon., "RAM Group Germany Awarded XPRIZE for Rapid COVID Testing Using Sensors Instead of PCR Tests—Ushering in New Age of Digital Diagnostics" Archived 2022-02-17 at the Wayback Machine, Digital Journal, April 20, 2021.
16. ↑ Staff, "Genosvid Diagnostic Test for Early Detection of COVID-19" Archived 2020-11-09 at the Wayback Machine, ClinicalTrials.gov, September 22, 2020.
17. ↑ Alfarizi, Moh Khory (24 September 2020). "UGM Develops COVID-19 'Breath Detector' with 97 Percent Accuracy Claim". Tempo. Translated by Nugraha, Ricky Mohammad. Archived from the original on 27 October 2020. Retrieved 28 December 2020.
18. ↑ Permatasari, Adinda; Edi, Cahyo (27 October 2020). "Alat Deteksi COVID-19 Buatan UGM Diuji Coba dengan 9 Rumah Sakit" [UGM's COVID-19 Detection Device Trialed by 9 Hospitals]. VIVA.co.id (in Indonesian). Archived from the original on 16 January 2021. Retrieved 28 December 2020.`{{cite news}}`: CS1 maint: unrecognized language (link)
19. ↑ "Indonesia's AI-Powered Covid-19 Test GeNose Cleared for Public Use". Jakarta Globe. December 27, 2020. Archived from the original on December 31, 2020. Retrieved December 27, 2020.
20. ↑ Satria. "GeNose UGM Dapatkan Izin Edar dan Siap Dipasarkan" [UGM's Genose Receives Distribution Permit, Ready to Launch]. Gadjah Mada University (in Indonesian). December 26, 2020. Archived from the original on January 5, 2021. Retrieved December 27, 2020.`{{cite news}}`: CS1 maint: unrecognized language (link)
21. ↑ Direktorat Pengembangan Usaha dan Inkubasi Universitas Gadjah Mada. "FAQ GENOSE C19" [FAQ GENOSE C19]. Gadjah Mada University (in Indonesian). January 14, 2021. Archived from the original on February 25, 2023. Retrieved February 9, 2021.`{{cite news}}`: CS1 maint: unrecognized language (link)
22. ↑ Zeldovich, L., "Will Travel Be Safer By 2022?" Archived 2021-06-14 at the Wayback Machine, BBC News, June 22, 2020.
23. ↑ Keyser, Z., "Israeli technology that can 'sniff out' COVID-19 infections begins trials" Archived 2022-12-09 at the Wayback Machine, The Jerusalem Post, July 1, 2020.
24. ↑ Dobrovitsky, L., "One-minute Covid-19 detector at center of bitter legal battle" Archived 2022-09-26 at the Wayback Machine, Calcalist, July 20, 2020.
25. ↑ Anon., "Israeli One-Minute Coronavirus Detector At Center Of Aggressive Legal Battle" Archived 2022-09-26 at the Wayback Machine, Jewish Business News, July 20th, 2020.
26. ↑ Rutman, D., "Israeli One-Minute Coronavirus Detector at Center of Aggressive Legal Battle" Archived 2022-08-19 at the Wayback Machine, Jewish Review, July 20, 2020.
27. ↑ Vries, R. de; Vigeveno, R. M. (February 16, 2021). "Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting". medRxiv: 2021.02.14.21251712. doi:10.1101/2021.02.14.21251712. S2CID 231933501. Archived from the original on July 11, 2021. Retrieved April 22, 2021.
28. ↑ Anon. (March 18, 2021). "SpiroNose: The electronic nose that knows about Covid-19". Healthcare in Europe. Archived from the original on April 14, 2021. Retrieved April 22, 2021.
29. ↑ "Nederlandse corona-blaastest 'waar heel de wereld jaloers op is' werkt niet goed: GGD weigert gebruik". Archived from the original on 2022-09-04. Retrieved 2022-11-09.
30. ↑ Anon., "Poles have created a device that detects coronavirus from breath" Archived 2022-07-12 at the Wayback Machine, Business Insider, February 15, 2021.
31. ↑ Anon., "A breakthrough discovery of Polish scientists—their device detects coronavirus from the breath" Archived 2021-04-12 at the Wayback Machine, Poland Daily, February 12, 2021.
32. ↑ Anon., "Covid Detector firmy ML System ma specyficzność 97,15 proc. i czułość 86,86 proc." Archived 2022-12-03 at the Wayback Machine, www.bankier.pl (in Polish), May 13, 2021.
33. ↑ Anon., "Port Lotniczy Rzeszów-Jasionka jako pierwsze lotnisko regionalne przetestuje innowacyjną technologię wykrywania zakażeń wirusem SARS-CoV-2" Archived 2022-12-01 at the Wayback Machine, Rzeszów–Jasionka Airport (in Polish), May 12, 2021.
34. ↑ Anon., "Koronawirus w Polsce. Chcą testować Covid Detector na Lotnisku Chopina" Archived 2022-08-15 at the Wayback Machine, www.money.pl (in Polish), April 23, 2021.
35. ↑ "New 5-minute Covid-19 test based on breath now in clinical trials". Cambridge Independent. January 15, 2021. Archived from the original on March 1, 2021. Retrieved April 22, 2021.
36. ↑ Young, J., "Sacramento Kings exploring breathalyzer concept to detect Covid-19, team owner says" Archived 2020-11-18 at the Wayback Machine, CNBC, June 15, 2020.
37. ↑ Staff, "Team to Develop Breathalyzer-Like Diagnostic Test for COVID-19" Archived 2020-10-20 at the Wayback Machine, ScienceBlog, May 21, 2020.
38. ↑ Commissioner, Office of the (2022-04-15). "Coronavirus (COVID-19) Update: FDA Authorizes First COVID-19 Diagnostic Test Using Breath Samples". FDA. Archived from the original on 2022-04-18. Retrieved 2022-04-18.

## External links[edit | edit source]

* COVID-19 Diagnostics & testing of FIND Archived 2022-11-08 at the Wayback Machine
* SpiroNose Archived 2022-12-09 at the Wayback Machine

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* Sabah
* Sarawak
* Selangor

Philippines|

* timeline
* 2020
* 2021
* 2022
* government response
* community quarantines
* Luzon
* evacuations
* testing controversy
* vaccination
* Bangsamoro
* Bicol Region
* Cagayan Valley
* Calabarzon
* Caraga
* Central Luzon
* Central Visayas
* Cordillera
* Davao Region
* Eastern Visayas
* Ilocos Region
* Metro Manila
* Mimaropa
* Northern Mindanao
* Soccsksargen
* Western Visayas
* Zamboanga Peninsula
* Overseas Filipinos

West|

* Armenia
* Azerbaijan
* Artsakh
* Bahrain
* Cyprus
* Northern Cyprus
* Egypt
* Georgia
* Abkhazia
* South Ossetia
* Iran
* Iraq
* Kurdistan Region
* Israel
* Jordan
* Kuwait
* Lebanon
* Oman
* Palestine
* Qatar
* Saudi Arabia
* vaccination
* Syria
* Turkey
* timeline
* United Arab Emirates
* Yemen

Europe|

| United Kingdom|

* history
* timeline
* January–June 2020
* July–December 2020
* January–June 2021
* July–December 2021
* January–June 2022
* July–December 2022
* 2023
* responses
* government response
* response
* Operation Rescript
* contracts
* impact
* social
* economic
* education

By location|

* England
* timeline
* 2020
* January–June
* July–December
* 2021
* 2022
* London
* local lockdown regulations
* first tier regulations
* Northern Ireland
* timeline
* 2020
* 2021
* 2022
* Scotland
* timeline
* 2020
* 2021
* 2022
* Wales
* timeline
* 2020
* 2021
* 2022
* Crown Dependencies
* Isle of Man
* Jersey
* Guernsey
* Overseas territories
* Akrotiri and Dhekelia
* British Indian Ocean Territory
* Gibraltar

Eastern|

* Belarus
* timeline
* 2020
* 2021
* 2022
* Kazakhstan
* Moldova
* Gagauzia
* Transnistria
* Russia
* timeline
* January–June 2020
* July–December 2020
* government responses
* political impact
* Turkey
* timeline
* Ukraine
* Crimea
* Sevastopol

Western Balkans|

* Albania
* Bosnia and Herzegovina
* Kosovo
* Montenegro
* North Macedonia
* Serbia
* statistics

European Union|

* Austria
* Belgium
* Bulgaria
* Croatia
* timeline
* Cyprus
* Northern Cyprus
* Czech Republic
* Denmark
* Faroe Islands
* Estonia
* Finland
* Åland
* France
* Guadeloupe
* French Guiana
* Réunion
* Martinique
* Mayotte
* Normandy
* Saint Martin
* Germany
* North Rhine-Westphalia
* government response
* Greece
* Hungary
* Ireland
* timeline
* 2020
* 2021
* 2022
* economic impact
* social impact
* vaccination
* Italy
* lockdowns
* timeline
* Latvia
* Lithuania
* Luxembourg
* Malta
* Netherlands
* government response
* Poland
* Portugal
* Romania
* timeline
* Slovakia
* Slovenia
* Spain
* timeline
* Asturias
* Canary Islands
* Ceuta
* Community of Madrid
* Melilla
* Sweden
* government response
* Operation Gloria

EFTA countries|

* Iceland
* Liechtenstein
* Norway
* Svalbard
* Switzerland

Microstates|

* Andorra
* Monaco
* San Marino
* Vatican City

North
America|

| Atlantic|

* Bermuda
* Greenland
* Saint Pierre and Miquelon

|

Canada|

* timeline
* economic impact
* federal aid
* vaccination
* by province
* military response
* Atlantic Bubble
* Alberta
* timeline
* British Columbia
* Manitoba
* New Brunswick
* Newfoundland and Labrador
* Northwest Territories
* Nova Scotia
* Nunavut
* Ontario
* timeline
* 2020
* 2021
* 2022
* Ottawa
* Peel Region
* Toronto
* York Region
* Provincial government response
* Vaccination
* Prince Edward Island
* Quebec
* Montreal
* boroughs
* Saskatchewan
* timeline
* Yukon

Caribbean|

| Countries|

* Antigua and Barbuda
* Bahamas
* Barbados
* Cuba
* Guantanamo Bay Naval Base
* Dominica
* Dominican Republic
* Grenada
* Haiti
* Jamaica
* Saint Kitts and Nevis
* Saint Lucia
* Saint Vincent and the Grenadines
* Trinidad and Tobago
* timeline

|

British Overseas Territories|

* Anguilla
* British Virgin Islands
* Cayman Islands
* Montserrat
* Turks and Caicos Islands
* response

* Aruba
* Curaçao
* Sint Maarten

Caribbean Netherlands|

* Bonaire
* Saba
* Sint Eustatius

French West Indies|

* Guadeloupe
* Martinique
* Saint Barthélemy
* Saint Martin

US insular areas|

* Puerto Rico
* U.S. Virgin Islands

Central America|

* Belize
* Costa Rica
* El Salvador
* Guatemala
* Honduras
* Mexico
* timeline
* vaccination
* Nicaragua
* Panama

United States|

* Trump administration communication
* timeline
* 2020
* 2021
* social impact
* economic impact
* 2021 hospital crisis

responses|

* federal government
* state and local governments
* California government response
* New York government response
* Texas government response
* Eastern States Multi-state Council
* Midwest Governors Regional Pact
* Western States Pact

By location|

* Alabama
* Alaska
* American Samoa
* Arizona
* Navajo Nation
* Arkansas
* California
* timeline
* S.F. Bay Area
* Colorado
* Connecticut
* Delaware
* Florida
* Georgia
* Guam
* Hawaii
* Idaho
* Illinois
* Indiana
* Iowa
* Kansas
* Kentucky
* Louisiana
* Maine
* Maryland
* timeline
* Massachusetts
* timeline
* Boston
* timeline
* Michigan
* Minnesota
* Mississippi
* Missouri
* Montana
* Nebraska
* Nevada
* timeline
* New Hampshire
* New Jersey
* New Mexico
* New York
* New York City
* timeline
* North Carolina
* North Dakota
* Northern Mariana Islands
* Ohio
* Columbus
* Oklahoma
* Oregon
* Portland
* Pennsylvania
* Philadelphia
* Puerto Rico
* Rhode Island
* South Carolina
* South Dakota
* Tennessee
* Texas
* timeline
* Austin
* U.S. Virgin Islands
* Utah
* Vermont
* Virginia
* Washington
* Washington, D.C.
* White House
* West Virginia
* Wisconsin
* Wyoming

Oceania|

* American Samoa
* Cook Islands
* Easter Island
* Federated States of Micronesia
* Fiji
* French Polynesia
* Guam
* Hawaii
* Kiribati
* Marshall Islands
* Nauru
* New Caledonia
* Niue
* Northern Mariana Islands
* Palau
* Papua New Guinea
* Bougainville
* Pitcairn Islands
* Samoa
* Solomon Islands
* Tokelau
* Tonga
* Tuvalu
* Vanuatu
* Wallis and Futuna

Australia|

* timeline
* 2020
* 2021
* January–June
* July–December
* 2022
* Australian Capital Territory
* Christmas Island
* Cocos (Keeling) Islands
* New South Wales
* Norfolk Island
* Northern Territory
* Queensland
* South Australia
* Tasmania
* Victoria
* Western Australia

New Zealand|

* timeline
* 2020
* 2021
* 2022
* 2023
* economic impact
* government response
* Alert levels
* Traffic light system
* social impact
* managed isolation

South
America|

* Argentina
* statistics
* human rights
* Bolivia
* Brazil
* São Paulo
* Chile
* statistics
* Easter Island
* Colombia
* timeline
* Ecuador
* Falkland Islands
* French Guiana
* Guyana
* Paraguay
* Peru
* statistics
* Cusco
* Suriname
* Uruguay
* Venezuela

Others|

* Antarctica
* Cruise ships
* Diamond Princess
* Grand Princess
* Naval ships
* Charles de Gaulle
* USS Theodore Roosevelt

Impact

| Culture and
entertainment|

| Arts and
cultural heritage|

* References in popular culture
* Cinema
* films affected
* Corona-chan
* Disney
* Fashion industry
* Music industry
* Performing arts
* Television
* U.S.
* U.S. sports
* programs affected
* Video games

|

Education|

* Female education
* Homeschooling

By country|

* Ghana
* Ireland
* United Kingdom
* exam grading controversy
* United States

Sports|

* Bio-secure bubble

By country|

* Ireland
* Philippines

By sport|

* Association football
* Baseball
* Basketball
* NBA
* Combat sports
* Cricket
* Disc golf
* Gaelic games
* Gridirion football (NCAAF, NFL, and CFL)
* Ice hockey
* Motorsport
* Rugby league

Society
and rights|

| Social impact|

* Social media
* Stigma
* COVID-19 parties
* Children
* foster care in the U.S.

|

Labor|

* Healthcare workers
* Indian migrant workers
* Great Resignation
* Strikes

Human rights|

* Argentina
* Hong Kong
* Myanmar
* North Korea
* Turkmenistan

Legal|

* Abortion in the U.S.
* Crime
* Domestic violence
* Prisons
* U.S. immigration detention

Minority|

* Gender
* LGBT community
* African communities
* Disability community
* Native American communities
* Xenophobia and racism

Religion|

* Catholic Church
* Hajj

Economic|

* Charitable activity
* COVID-19 scams
* Travel restrictions

By country|

* Canada
* India
* Ireland
* COVID-19 Pandemic Unemployment Payment
* Malaysia
* New Zealand
* Russia
* U.K.
* U.S.

By industry|

* Aviation
* Airlines
* Cannabis industry
* Food industry
* meat industry in Canada
* meat industry in the U.S.
* restaurant industry in the U.S.
* Hospitals
* ICU capacity
* Long-term care facilities
* Mink farming
* Public transport
* Retail
* Tourism

Supply and trade|

* Shortages
* Chip supply
* Energy
* Global supply chain
* Oil price war
* Food security

Financial markets|

* Global stock market crash
* COVID-19 recession
* Inflation

Information|

* Journalism
* Media coverage
* Wikipedia's response

Misinformation|

* Governments
* China
* United States
* By country
* Canada
* Philippines
* Ivermectin
* Plandemic

Politics|

* National responses
* Legislation
* European Union

Political impact|

* Ireland
* Malaysia
* Russia

Protests|

* Canada
* convoy protest
* China
* Italy
* Germany
* Idar-Oberstein shooting
* the Netherlands
* New Zealand
* Serbia
* United Kingdom
* United States
* Open the States

International relations|

* Aid
* Italy
* Moldovan–Romanian collaboration
* Nicaragua–Taiwan relations
* Respirator diplomacy of Taiwan
* Vaccine diplomacy

Language|

* Anthropause
* Doomscrolling
* Flattening the curve
* Green recovery
* Long COVID
* Quarantini
* Social distancing
* Superspreader
* Twindemic
* Zero-COVID
* Zoom
* Zoom towns

Others|

* Animals
* Cluster 5
* Environment
* Military
* Pregnant women
* Science and technology

Health issues

| Medical topics|

* Transmission
* Symptoms
* Cancer
* Endemic COVID-19
* Skin manifestations
* Long COVID
* Mental health
* neurological, psychological and other mental health outcomes
* Pregnancy
* Non-COVID-19–related health issues
* Shortages
* Raise the line
* Rehabilitation
* Unproven medical methods

|

Testing and
epidemiology|

* Datasets
* Death rates by country
* Disease testing
* Breathalyzer
* Operation Moonshot
* Test to Release
* UK Rapid Test Consortium
* AbC-19 rapid antibody test
* investigations into the origins
* lab leak theory
* Rapid antigen test
* Software
* Surveillance
* Undercounting COVID-19 deaths

Apps|

* Aarogya Setu
* BlueTrace
* careFIJI
* Coronavirus Australia
* Corona-Warn-App
* COVID-19 Contact-Confirming Application
* COVID Alert (Canada)
* COVID AlertSA (South Africa)
* COVIDSafe
* COVID Tracker Ireland
* Covid Watch
* Decentralized Privacy-Preserving Proximity Tracing
* Exposure Notification
* Health Code
* Healthy Together
* Immuni
* Koronavilkku
* LeaveHomeSafe
* MySejahtera
* NHS COVID-19
* NZ COVID Tracer
* NZ Pass Verifier
* PathCheck
* PeduliLindungi
* SafeEntry
* SafePass
* StaySafe.ph
* SwissCovid
* TCN Protocol
* Test, Trace, Protect
* Thai Chana
* TousAntiCovid
* TraceTogether
* Valtrace
* Zoe Health Study

Prevention|

* Air purifier (Corsi–Rosenthal Box)
* Chloroquine and hydroxychloroquine
* COVID fatigue
* Evacuations
* Face masks
* Anti-mask sentiment
* United States
* Flattening the curve
* Great Barrington Declaration
* International aid
* Lockdowns
* Public health mitigation
* Safe Hands Challenge
* Social distancing
* Workplace hazard controls
* Zero-COVID

Vaccines|

| Topics|

* Authorizations
* Clinical research
* Deployment
* Development
* EU Certificate
* Misinformation and hesitancy
* Deaths of anti-vaccine advocates
* US
* Operation Warp Speed (U.S.)
* Post-vaccination complications
* Vaccine card
* Vaccine passports

|

Authorized|

| DNA|

* ZyCoV-D

|

Inactivated|

* Chinese Academy of Medical Sciences
* CoronaVac
* Covaxin
* COVIran Barekat
* CoviVac (Russia)
* FAKHRAVAC
* Minhai
* QazCovid-in
* Sinopharm BIBP
* Sinopharm WIBP
* Turkovac
* Valneva

mRNA|

* Moderna
* Pfizer–BioNTech

Subunit|

* Abdala
* Corbevax (Bio E COVID-19)
* COVAX-19
* EpiVacCorona
* IndoVac
* MVC
* Noora
* Novavax
* Razi Cov Pars
* Sinopharm CNBG
* Soberana 02
* Soberana Plus
* ZF2001 (Zifivax)

Viral vector|

* Convidecia
* Janssen
* Oxford–AstraZeneca
* Sputnik V
* Sputnik Light

Virus-like particles|

* CoVLP

In trials|

| Attenuated|

* COVI-VAC (United States)

|

DNA|

* AG0302-COVID‑19
* GX-19
* Inovio

Inactivated|

* KD-414
* NDV-HXP-S

RNA|

* ARCT-021
* ARCT-154
* Bangavax
* CureVac (terminated)
* HGC019
* mRNA-1283
* PTX-COVID19-B
* Sanofi–Translate Bio (terminated)
* Stemirna COVID-19 vaccine
* Walvax

Subunit|

* 202-CoV
* AKS-452
* EuCorVac-19
* IVX-411
* Nanocovax
* ReCOV
* Sanofi–GSK
* S-268019
* SCB-2019
* SCTV01C
* Skycovione
* UB-612
* V-01
* V451 (terminated)
* Vabiotech
* West China Hospital
* Zhongyianke Biotech–Liaoning Maokangyuan Biotech

Viral vector|

* AdCLD-CoV19
* BriLife
* COH04S1
* DelNS1-2019-nCoV-RBD-OPT
* GRAd-COV2
* ImmunityBio
* iNCOVACC
* INNA-051
* NDV-HXP-S
* Vaxart COVID-19 vaccine

Virus-like particles|

* ABNCoV2
* LYB001
* MigVax-101
* VBI-2902

Deployment
by location|

| Africa|

* Algeria
* Angola
* Benin
* Botswana
* Burkina Faso
* Burundi
* Cameroon
* Cape Verde
* Cameroon
* Chad
* Comoros
* Democratic Republic of the Congo
* Djibouti
* Egypt
* Equatorial Guinea
* Eswatini
* Ghana
* Morocco
* Nigeria
* Senegal
* South Africa
* Zimbabwe

|

Asia|

* Bangladesh
* Bhutan
* Mainland China
* India
* Indonesia
* Iran
* Israel
* Japan
* Kazakhstan
* Malaysia
* Nepal
* Philippines
* Russia
* Singapore
* South Korea
* Sri Lanka
* Taiwan
* Thailand
* Turkey
* United Arab Emirates
* Vietnam

Europe|

* Albania
* Bosnia and Herzegovina
* Bulgaria
* Croatia
* Denmark
* France
* Germany
* Greece
* Hungary
* Iceland
* Ireland
* Italy
* Moldova
* Norway
* Portugal
* Romania
* Russia
* Spain
* Sweden
* Switzerland
* Ukraine
* United Kingdom

North America|

* Canada
* Ontario
* Quebec
* Cuba
* Haiti
* Mexico
* United States
* mandates

Oceania|

* Australia
* Fiji
* New Zealand

South America|

* Argentina
* Brazil
* Colombia
* Peru

Others|

* Antarctica

Treatment|

* Drug development
* Drug repurposing research
* Baricitinib
* Dexamethasone
* Extracorporeal membrane oxygenation
* Open-source ventilator
* PANORAMIC trial (UK)
* RECOVERY Trial (UK)
* Solidarity trial (WHO)

Monoclonal antibodies|

* Bamlanivimab/etesevimab
* Bamlanivimab
* Etesevimab
* Bebtelovimab
* Casirivimab/imdevimab
* Regdanvimab
* Sarilumab
* Sotrovimab
* Tixagevimab/cilgavimab
* Tocilizumab

Small molecule antivirals|

* Broad-spectrum
* Ensitrelvir
* Molnupiravir
* Remdesivir
* Co-packaged
* Nirmatrelvir
* ritonavir

Variants

| Specific|

* Alpha
* Beta
* Gamma
* Delta
* Epsilon
* Zeta
* Eta
* Theta
* Iota
* Kappa
* Lambda
* Mu
* Omicron
* timeline

|

General|

* Cluster 5
* Lineage B.1.617
* Lineage B.1.640.2
* Variant of concern

Institutions

| Hospitals and
medical clinics|

| Mainland China|

* Central Hospital of Wuhan
* Dabie Mountain Regional Medical Centre
* Fangcang hospitals
* Huoshenshan Hospital
* Leishenshan Hospital
* Xinjia Express Hotel
* Wuhan Jinyintan Hospital

|

Others|

* Hospital ships
* Garran Surge Centre (Australia)
* Hospital El Salvador
* SevenHills Hospital (India)
* Kemayoran Athletes Village (Indonesia)
* Pyongyang General Hospital (North Korea)
* Malaysia Agro Exposition Park Serdang (Malaysia)
* Mega Ligtas COVID Centers (Philippines)
* Kandakadu Treatment and Rehabilitation Centre (Sri Lanka)
* Sancaktepe Prof. Dr. Feriha Öz Emergency Hospital (Turkey)
* Yeşilköy Prof. Dr. Murat Dilmener Emergency Hospital (Turkey)
* COVID-19 hospitals in the United Kingdom
* NHS Nightingale Hospitals (England)
* Birmingham
* London
* North East
* North West
* Yorkshire and the Humber
* NHS Louisa Jordan (Scotland)
* Dragon's Heart Hospital (Wales)

Organizations|

| Global|

|

By location|

* National Cabinet (Australia)
* ScienceUpFirst (Canada)
* Wuhan Institute of Virology (China)
* Independent SAGE (United Kingdom)

Health
institutes|

* Africa Centres for Disease Control and Prevention (African Union)
* Ghana Infectious Disease Centre (Ghana)
* Department of Health (Hong Kong)
* Korea Disease Control and Prevention Agency (South Korea)
* National Institute for Communicable Diseases (South Africa)
* Taiwan Centers for Disease Control (Taiwan)

Pandemic
institutes|

* National COVID-19 Commission Advisory Board (Australia)
* COVID-19 Immunity Task Force (Canada)
* COVID-19 Supply Council (Canada)
* PREPARE (European Union)
* National Expert Group on Vaccine Administration for COVID-19 (India)
* COVID-19 Response Acceleration Task Force (Indonesia)
* National Public Health Emergency Team (Ireland)
* Novel Coronavirus Expert Meeting (Japan)
* Crisis Preparedness and Response Centre (Malaysia)
* Defeat COVID-19 Ad Hoc Committee (Philippines)
* Inter-Agency Task Force for the Management of Emerging Infectious Diseases (Philippines)
* Central Epidemic Command Center (Taiwan)
* Coronavirus Scientific Advisory Board (Turkey)
* COVID-19 Genomics UK Consortium (United Kingdom)
* Imperial College COVID-19 Response Team (United Kingdom)
* Joint Biosecurity Centre (United Kingdom)
* Vaccine Taskforce (United Kingdom)
* COVID-19 Advisory Board (United States)
* Great American Economic Revival Industry Groups (United States)
* White House Coronavirus Task Force (United States)
* White House COVID-19 Response Team (United States)
* GACH (Uruguay)

Relief funds|

* PM CARES Fund (India)
* SAARC COVID-19 Emergency Fund (India)
* Artist Relief (United States)

People

| Medical
professionals|

* Ai Fen
* Corona Rintawan
* Li Wenliang
* Liu Wen
* Xie Linka
* Zhang Wenhong

|

Researchers|

* Awang Bulgiba Awang Mahmud
* Roberto Burioni
* Chen Wei
* Kizzmekia Corbett
* Andrea Crisanti
* Peter Daszak
* Christian Drosten
* Neil Ferguson
* Dale Fisher
* George F. Gao
* Azra Ghani
* Sarah Gilbert
* Guan Yi
* Kentaro Iwata
* Katalin Karikó
* Matt Keeling
* Trudie Lang
* Li Lanjuan
* W. Ian Lipkin
* Ma Xiaowei
* Shabir Madhi
* Allison McGeer
* Camilla Rothe
* Shi Zhengli
* Moncef Slaoui
* Mike Tildesley
* John Todd
* Wang Chen
* Wang Guangfa
* Drew Weissman
* Yuen Kwok-yung
* Zeng Guang
* Zhang Jixian
* Zhang Yongzhen
* Zhong Nanshan

Officials|

| WHO|

* Tedros Adhanom
(Director-General of the WHO)
* Bruce Aylward
(Team lead of WHO-China COVID-19 mission)
* Maria Van Kerkhove
(Technical Lead for COVID-19 response)
* Michael J. Ryan
(Executive Director of the WHO Health Emergencies Programme)

|

By location|

* Frank Atherton
(Wales)
* Ashley Bloomfield
(New Zealand)
* Catherine Calderwood
(Scotland)
* Chang Shan-chwen
(Taiwan)
* Anutin Charnvirakul
(Thailand)
* Chen Shih-chung
(Taiwan)
* Kenneth Chuang Yin-ching
(Taiwan)
* Victor Costache
(Romania)
* Fabrizio Curcio
(Italy)
* Carmen Deseda
(Puerto Rico)
* Jaap van Dissel
(the Netherlands)
* Christian Drosten
(Germany)
* Francisco Duque III
(Philippines)
* Anthony Fauci
(United States)
* Francesco Paolo Figliuolo
(Italy)
* Graça Freitas
(Portugal)
* Henrique Gouveia e Melo
(Portugal)
* Matt Hancock
(United Kingdom)
* Hamad Hasan
(Lebanon)
* Greg Hunt
(Australia)
* Tony Holohan
(Ireland)
* Jeong Eun-kyeong
(South Korea)
* Fahrettin Koca
(Turkey)
* Li Keqiang
(China)
* Hugo López-Gatell Ramírez
(Mexico)
* Michael McBride
(Northern Ireland)
* Oriol Mitjà
(Andorra)
* Zweli Mkhize
(South Africa)
* Doni Monardo
(Indonesia)
* Alma Möller
(Iceland)
* Saeed Namaki
(Iran)
* Ala Nemerenco
(Moldova)
* Nguyễn Thanh Long
(Vietnam)
* Noor Hisham Abdullah
(Malaysia)
* Ali Pilli
(Northern Cyprus)
* Daniel Salinas
(Uruguay)
* Jérôme Salomon
(France)
* Fernando Simón
(Spain)
* Gregor Smith
(Scotland)
* Su Ih-jen
(Taiwan)
* Łukasz Szumowski
(Poland)
* Theresa Tam
(Canada)
* Anders Tegnell
(Sweden)
* Þórólfur Guðnason
(Iceland)
* Sotiris Tsiodras
(Greece)
* Harsh Vardhan
(India)
* Víðir Reynisson
(Iceland)
* Carla Vizzotti
(Argentina)
* Vlad Voiculescu
(Romania)
* Chris Whitty
(United Kingdom)
* Lawrence Wong
(Singapore)
* Jeff Zients
(United States)

Others|

* Chen Qiushi
* Brett Crozier
* Fang Bin
* Fang Fang
* Joseph Ashitey Hammond
* Li Zehua
* Captain Tom Moore
* Qiu Menghuang
* Ren Zhiqiang

Deaths|

* List

Data (templates)

| Global|

* Cases, deaths, recoveries by country
* Tests, cases, tests per capita, cases per capita by country
* Tests, cases, tests per capita, cases per capita by country subdivision
* WHO situation reports
* cases
* January 2020
* February 2020
* March 2020
* April 2020
* May 2020
* June 2020
* July 2020
* August 2020
* September 2020
* October 2020
* November 2020
* December 2020
* January 2021
* February 2021
* March 2021
* April 2021
* May 2021
* June 2021
* July 2021
* August 2021
* deaths
* World map by countries: confirmed per capita
* China
* Hospital beds by country
* Lockdowns

|

Africa|

* Algeria
* Angola
* Benin
* Botswana
* Burkina Faso
* Burundi
* Cameroon
* Comoros
* Egypt
* Eswatini
* Ethiopia
* Ghana
* cases chart
* Ivory Coast
* Kenya
* Libya
* Malawi
* Mali
* Mauritania
* Mauritius
* Morocco (including occupied Western Sahara)
* Mozambique
* Namibia
* Nigera
* cases chart
* São Tomé and Príncipe
* Senegal
* Seychelles
* Sierra Leone
* South Africa
* cases chart
* South Sudan
* Sudan
* Tanzania
* Togo
* Tunisia
* Uganda
* Zambia
* Zimbabwe
* cases chart

Americas|

* Argentina
* Bolivia
* Brazil
* Canada
* by province
* vaccinations by province
* Chile
* by commune
* Colombia
* Costa Rica
* cases chart
* Cuba
* Dominican Republic
* Ecuador
* El Salvador
* Guatemala
* Haiti
* Honduras
* Mexico
* cases chart
* Nicaragua
* Panama
* Paraguay
* Peru
* United States
* by state
* Uruguay
* Venezuela

Asia|

* Afghanistan
* Armenia
* Artsakh
* Azerbaijan
* Bahrain
* Bangladesh
* by division
* Bhutan
* cases chart
* Brunei
* Cambodia
* cases chart
* summary
* China
* cases chart
* confirmed per capita
* lockdowns
* by province
* Hong Kong
* Macau
* Cyprus
* East Timor
* Egypt
* Georgia
* India
* Indonesia
* cases chart
* Iran
* cases chart
* Iraq
* Israel
* cases chart
* Japan
* cases chart
* Jordan
* Kazakhstan
* Kuwait
* cases chart
* Kyrgyzstan
* Laos
* Lebanon
* Malaysia
* cases chart
* charts
* Myanmar
* cases chart
* summary
* Nepal
* cases chart
* Oman
* cases chart
* Pakistan
* cases chart
* Philippines
* cases chart
* areas of quarantine
* vaccinations chart
* Qatar
* Russia
* cases chart
* by federal subject
* North Asia
* Saudi Arabia
* Singapore
* South Korea
* cases chart
* vaccinations charts
* Sri Lanka
* Syria
* Taiwan
* vaccination charts
* Tajikistan
* Thailand
* cases chart
* Turkey
* cases chart
* United Arab Emirates
* cases chart
* Uzbekistan
* cases chart
* Vietnam
* statistics charts
* Yemen

Europe|

* Albania
* Austria
* cases chart
* Belarus
* Belgium
* cases chart
* Bosnia and Herzegovina
* Bulgaria
* cases chart
* Croatia
* Cyprus
* Czech Republic
* Denmark
* cases chart
* Faroe Islands
* Estonia
* cases chart
* Finland
* France
* cases chart
* Germany
* cases chart
* Greece
* Hungary
* Iceland
* cases chart
* Ireland
* cases chart
* Italy
* cases chart
* statistics charts
* vaccinations chart
* Kosovo
* Latvia
* cases chart
* Lithuania
* cases chart
* Luxembourg
* Malta
* Moldova
* Monaco
* Montenegro
* Netherlands
* North Macedonia
* Norway
* cases chart
* Poland
* cases chart
* by voivodeship
* Portugal
* cases chart
* Romania
* cases chart
* Russia
* cases chart
* by federal subject
* North Asia
* San Marino
* Serbia
* Slovakia
* cases chart
* by region
* Slovenia
* cases chart
* Spain
* cases chart
* Sweden
* cases chart
* Switzerland
* cases chart
* Turkey
* cases chart
* Ukraine
* United Kingdom
* Scotland
* 2020
* 2021
* Gibraltar
* vaccinations chart
* daily
* by nation
* Vatican City

Oceania|

* Australia
* by state/territory
* Fiji
* French Polynesia
* New Caledonia
* New Zealand
* Papua New Guinea
* Solomon Islands

Others|

* Cruise ships
* Diamond Princess

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