Tuberculosis elimination

Tuberculosis elimination is the effort to reduce the number of tuberculosis (TB) cases to less than one per 1 million population, contrasted with the effort to completely eradicate infection in humans worldwide.[1] The goal of tuberculosis elimination is hampered by the lack of rapid testing, short and effective treatment courses, and completely effective vaccine.[2] The WHO as well as the Stop TB Partnership aim for the full elimination of TB by 2050—requiring a 1000-fold reduction in tuberculosis incidence.[3] As of 2017, tuberculosis has not been eliminated from any country.[4]

## Contents

* 1 Feasibility
* 2 Elimination strategies
* 2.1 Globally
* 2.2 India
* 3 References

## Feasibility[edit | edit source]

Prospects for tuberculosis control and elimination in a hypothetical high-burden country, starting in 2015

Tuberculosis has been a curable illness since the 1940s when the first drugs became available, although multidrug-resistant and extensively drug-resistant TB present an increasing challenge.[5] According to a 2017 article in International Journal of Infectious Diseases, tuberculosis eradication is possible if enough technology, funding, and political will were available, but the characteristics of the disease do not make it easy to eradicate. So far, tuberculosis has not been eliminated from any country.[4] According to European Respiratory Review, tuberculosis eradication is not considered possible due to the lack of a completely effective vaccine and large reservoir of people infected with latent tuberculosis.[1]

According to a 2013 review, tuberculosis elimination will require not just treating active tuberculosis but also latent cases, and eliminating tuberculosis by 2050 worldwide is not possible, although great reductions in infections and deaths are possible.[3] Addressing poverty is a further requirement for eliminating tuberculosis. People who are poor are disproportionately affected by tuberculosis because the disease is made worse by inadequate housing and malnutrition, and poverty can make it difficult to get treatment. The WHO has estimated that eliminating poverty would reduce tuberculosis incidence by 84 percent.[6][7][8][9]

## Elimination strategies[edit | edit source]

### Globally[edit | edit source]

In 2014, the World Health Organization launched the End TB Strategy with the goal of reducing tuberculosis deaths by 95% and incidence by 90% before 2035.[2] As of 2020, the world was not on track to meet those goals.[10] The WHO, as well as the Stop TB Partnership, are now aiming for the full elimination of TB by the year 2050, which will require a 1000-fold reduction in the incidence of the disease.[3]

### India[edit | edit source]

Further information: National TB Elimination Program (India)

In 2017, the Indian government announced its intention to eliminate tuberculosis in the country by 2025. The previous year, it accounted for 27 percent of tuberculosis cases and 29 percent of deaths worldwide, making it the highest burden country for both tuberculosis and multidrug-resistant tuberculosis.[11][12]

## References[edit | edit source]

1. ↑ 1.0 1.1 Matteelli, Alberto; Rendon, Adrian; Tiberi, Simon; Al-Abri, Seif; Voniatis, Constantia; Carvalho, Anna Cristina C.; Centis, Rosella; D'Ambrosio, Lia; Visca, Dina; Spanevello, Antonio; Migliori, Giovanni Battista (2018). "Tuberculosis elimination: where are we now?". European Respiratory Review. 27 (148): 180035. doi:10.1183/16000617.0035-2018. ISSN 0905-9180. PMC 9488456. PMID 29898905. S2CID 49189423. Archived from the original on 2023-03-31. Retrieved 2023-09-13.
2. ↑ 2.0 2.1 Uplekar, Mukund; Weil, Diana; Lonnroth, Knut; Jaramillo, Ernesto; Lienhardt, Christian; Dias, Hannah Monica; Falzon, Dennis; Floyd, Katherine; Gargioni, Giuliano; Getahun, Haileyesus; Gilpin, Christopher; Glaziou, Philippe; Grzemska, Malgorzata; Mirzayev, Fuad; Nakatani, Hiroki; Raviglione, Mario (2015). "WHO's new End TB Strategy". The Lancet. 385 (9979): 1799–1801. doi:10.1016/S0140-6736(15)60570-0. PMID 25814376. S2CID 39379915.
3. ↑ 3.0 3.1 3.2 Dye, Christopher; Glaziou, Philippe; Floyd, Katherine; Raviglione, Mario (2013). "Prospects for Tuberculosis Elimination". Annual Review of Public Health. 34 (1): 271–286. doi:10.1146/annurev-publhealth-031912-114431. ISSN 0163-7525. PMID 23244049. S2CID 40664687.
4. ↑ 4.0 4.1 Schito, Marco; Hanna, Debra; Zumla, Alimuddin (2017). "Tuberculosis eradication versus control". International Journal of Infectious Diseases. 56: 10–13. doi:10.1016/j.ijid.2016.11.007. ISSN 1201-9712. PMID 27872016.
5. ↑ Sharma, Surendra K.; Mohan, Alladi (2013). "Tuberculosis: From an incurable scourge to a curable disease - journey over a millennium". The Indian Journal of Medical Research. 137 (3): 455–493. ISSN 0971-5916. PMC 3705655. PMID 23640554.
6. ↑ Shete, Priya B.; Reid, Michael; Goosby, Eric (2018). "Message to world leaders: we cannot end tuberculosis without addressing the social and economic burden of the disease". The Lancet Global Health. 6 (12): e1272–e1273. doi:10.1016/S2214-109X(18)30378-4. ISSN 2214-109X. PMID 30224288. S2CID 52286416.
7. ↑ Bhargava, Anurag; Bhargava, Madhavi; Juneja, Anika (2021). "Social determinants of tuberculosis: context, framework, and the way forward to ending TB in India". Expert Review of Respiratory Medicine. 15 (7): 867–883. doi:10.1080/17476348.2021.1832469. PMID 33016808. S2CID 222148768.
8. ↑ Carter, Daniel J; Glaziou, Philippe; Lönnroth, Knut; Siroka, Andrew; Floyd, Katherine; Weil, Diana; Raviglione, Mario; Houben, Rein M G J; Boccia, Delia (2018). "The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1". The Lancet Global Health. 6 (5): e514–e522. doi:10.1016/S2214-109X(18)30195-5. PMC 5968370. PMID 29580761.
9. ↑ Adu, Prince A.; Spiegel, Jerry M.; Yassi, Annalee (2021). "Towards TB elimination: how are macro-level factors perceived and addressed in policy initiatives in a high burden country?". Globalization and Health. 17 (1): 11. doi:10.1186/s12992-020-00657-1. ISSN 1744-8603. PMC 7802197. PMID 33430902.
10. ↑ Harding, Emilia (2020). "WHO global progress report on tuberculosis elimination". The Lancet Respiratory Medicine. 8 (1): 19. doi:10.1016/S2213-2600(19)30418-7. PMID 31706931. S2CID 207943921.
11. ↑ Pai, Madhukar; Bhaumik, Soumyadeep; Bhuyan, Soumitra S (2017). "India's plan to eliminate tuberculosis by 2025: converting rhetoric into reality". BMJ Global Health. 2 (2): e000326. doi:10.1136/bmjgh-2017-000326. PMC 5435272. PMID 28589035.
12. ↑ Singh, Sakshi; Kumar, Sandeep (2019). "Tuberculosis in India: Road to elimination". International Journal of Preventive Medicine. 10 (1): 114. doi:10.4103/ijpvm.IJPVM_492_17. ISSN 2008-7802. PMC 6592106. PMID 31360361.

* v
* t
* e

Tuberculosis

Symptoms, signs and
associated conditions|

* Pulmonary tuberculosis
* Ghon focus / Ghon's complex
* Extrapulmonary tuberculosis
* Caseous necrosis
* Pott disease
* Canga's bead symptom
* Prosector's wart
* Lupus vulgaris
* Tuberculous lymphadenitis
* Tuberculous meningitis
* Miliary tuberculosis
* Latent tuberculosis
* Paronychia
* Giant multinucleated cell

Mycobacterium species|

* Mycobacterium africanum
* Mycobacterium bovis
* Mycobacterium caprae
* Mycobacterium tuberculosis

Tuberculosis diagnosis|

* Ziehl–Neelsen stain
* Auramine phenol stain
* Culture on Löwenstein–Jensen medium and/or MGIT
* Chest photofluorography
* GeneXpert MTB/RIF
* Interferon gamma release assay
* QuantiFERON
* T-SPOT.TB
* Microscopic Observation Drug Susceptibility assay
* Tuberculin
* Heaf test
* Mantoux test
* Tine test

Management|

* ATC code J04
* Isoniazid
* 4-Aminosalicylic acid
* Ethambutol
* Capreomycin
* Cycloserine
* Rifampicin
* Thioacetazone
* Streptomycin
* Bedaquiline
* RBCG30
* Pyrazinamide
* MVA85A
* Rifater
* vaccines
* BCG vaccine

Resistance|

* Multi-drug-resistant tuberculosis
* Extensively drug-resistant tuberculosis
* Totally drug-resistant tuberculosis

History of tuberculosis|

* Manuel de Abreu
* Hermann Brehmer
* Albert Calmette
* Christopher Dye
* Marcos Espinal
* Friedrich Franz Friedmann
* Max Gerson
* Philip D'Arcy Hart
* F. R. G. Heaf
* George M. Heath
* Robert Koch
* Charles Mantoux
* Richard Morton
* Mario Raviglione
* Carl Rüedi
* Lucius Rüedi
* Madonna Swan
* Edward Livingston Trudeau

Organizations|

* Adirondack Cottage Sanitarium
* Campaign for Access to Essential Medicines
* Center for Infectious Disease Research
* Cure Cottages of Saranac Lake
* European and Developing Countries Clinical Trials Partnership
* Glen Lake Children's Camp
* Glen Lake Sanatorium
* Glenn Dale Hospital
* The Global Fund to Fight AIDS, Tuberculosis and Malaria
* Global Plan to Stop Tuberculosis
* International Congress on Tuberculosis
* International Union Against Tuberculosis and Lung Disease
* Millennium Foundation
* Mycobacterium Tuberculosis Structural Genomics Consortium
* National Jewish Health
* Phipps Institute for the Study, Treatment and Prevention of Tuberculosis
* Stop TB Partnership
* TB Alliance
* Unitaid

Other|

* 2007 tuberculosis scare
* 72F fusion protein vaccine
* Baumgarten-Tangl law
* CFP-10
* ESAT-6
* Iowa Cow War
* List of tuberculosis cases
* Plombage
* Preventorium
* Sanatorium
* Sunshine Way
* Tuberculosis classification
* Tuberculosis in China
* Tuberculosis in popular culture
* Tuberculosis radiology
* Tygerberg score
* World Tuberculosis Day

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