Dysentery

Other names: Bloody diarrhea
A person with dysentery in a Burmese hospital, 1943
Specialty| Infectious disease
Symptoms| Bloody diarrhea, abdominal pain, fever[1][2]
Complications| Dehydration[3]
Duration| Less than a week[4]
Causes| Usually Shigella or Entamoeba histolytica[1]
Risk factors| Contamination of food and water with feces due to poor sanitation[5]
Prevention| Hand washing, food safety[4]
Treatment| Drinking sufficient fluids, antibiotics (severe cases)[4]
Frequency| Common in the developing world[6]
Deaths| > million a year[6]

bew:Mejen Dysentery is a type of gastroenteritis that results in diarrhea with blood.[1][7] Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation.[2][8] Complications may include dehydration.[3]

The cause of dysentery is usually the bacteria Shigella, in which case it is known as shigellosis, or the amoeba Entamoeba histolytica.[1] Other causes may include certain chemicals, other bacteria, other protozoa, or parasitic worms.[2] It may spread between people.[4] Risk factors include contamination of food and water with feces due to poor sanitation.[5] The underlying mechanism involves inflammation of the intestine, especially of the colon.[2]

Efforts to prevent dysentery include hand washing and food safety measures while traveling in areas of high risk.[4] While the condition generally resolves on its own within a week, drinking sufficient fluids such as oral rehydration solution is important.[4] Antibiotics such as azithromycin or ciprofloxacin may be used to treat severe cases or cases associated with travelling in the developing world.[8][9] While medications used to decrease diarrhea such as loperamide are not recommended on their own, they may be used together with antibiotics.[8][4]

Shigella results in about 165 million cases of diarrhea and 1.1 million deaths a year with nearly all cases in the developing world.[6] In areas with poor sanitation nearly half of cases of diarrhea are due to Entamoeba histolytica.[5] Entamoeba histolytica affects millions of people and results in greater than 55,000 deaths a year.[10] It commonly occurs in less developed areas of Central and South America, Africa, and Asia.[10] Dysentery has been described at least since the time of Hippocrates.[11]

## Contents

* 1 Signs and symptoms
* 2 Cause
* 2.1 Amoebic dysentery
* 2.2 Bacillary dysentery
* 2.3 Other bacteria
* 3 Diagnosis
* 3.1 Physical exam
* 3.2 Stool and blood tests
* 4 Prevention
* 4.1 Vaccine
* 5 Treatment
* 6 Prognosis
* 7 Epidemiology
* 8 History
* 9 Notable cases
* 10 See also
* 11 References
* 12 External links

## Signs and symptoms[edit | edit source]

The most common form of dysentery is bacillary dysentery, which is typically a mild sickness, causing symptoms normally consisting of mild gut pains and frequent passage of stool or diarrhea. Symptoms normally present themselves after 1–3 days, and are usually no longer present after a week. The frequency of urges to defecate, the large volume of liquid feces ejected, and the presence of blood, mucus, or pus depends on the pathogen causing the disease. Temporary lactose intolerance can occur, as well. In some caustic occasions, severe abdominal cramps, fever, shock, and delirium can all be symptoms.[2][12][13][14]

In extreme cases, people may pass more than one liter of fluid per hour. More often, individuals will complain of diarrhea with blood, accompanied by abdominal pain, rectal pain and a low-grade fever. Rapid weight loss and muscle aches sometimes also accompany dysentery, while nausea and vomiting are rare. On rare occasions, the amoebic parasite will invade the body through the bloodstream and spread beyond the intestines. In such cases, it may more seriously infect other organs such as the brain, lungs, and most commonly the liver.[15]

## Cause[edit | edit source]

Cross-section of diseased intestines. Colored lithograph c. 1843

Dysentery results from bacterial, or parasitic infections. Viruses do not generally cause the disease.[7] These pathogens typically reach the large intestine after entering orally, through ingestion of contaminated food or water, oral contact with contaminated objects or hands, and so on. Each specific pathogen has its own mechanism or pathogenesis, but in general, the result is damage to the intestinal linings, leading to the inflammatory immune responses. This can cause elevated physical temperature, painful spasms of the intestinal muscles (cramping), swelling due to fluid leaking from capillaries of the intestine (edema) and further tissue damage by the body's immune cells and the chemicals, called cytokines, which are released to fight the infection. The result can be impaired nutrient absorption, excessive water and mineral loss through the stools due to breakdown of the control mechanisms in the intestinal tissue that normally remove water from the stools, and in severe cases, the entry of pathogenic organisms into the bloodstream. Anemia may also arise due to the blood loss through diarrhea.[citation needed]

Bacterial infections that cause bloody diarrhea are typically classified as being either invasive or toxogenic. Invasive species cause damage directly by invading into the mucosa. The toxogenic species do not invade, but cause cellular damage by secreting toxins, resulting in bloody diarrhea. This is also in contrast to toxins that cause watery diarrhea, which usually do not cause cellular damage, but rather they take over cellular machinery for a portion of life of the cell.[16]

Some microorganisms – for example, bacteria of the genus Shigella – secrete substances known as cytotoxins, which kill and damage intestinal tissue on contact. Shigella is thought to cause bleeding due to invasion rather than toxin, because even non-toxogenic strains can cause dysentery, but E. coli with shiga-like toxins do not invade the intestinal mucosa, and are therefore toxin dependent.

Definitions of dysentery can vary by region and by medical specialty. The U. S. Centers for Disease Control and Prevention (CDC) limits its definition to "diarrhea with visible blood".[17] Others define the term more broadly.[18] These differences in definition must be taken into account when defining mechanisms. For example, using the CDC definition requires that intestinal tissue be so severely damaged that blood vessels have ruptured, allowing visible quantities of blood to be lost with defecation. Other definitions require less specific damage.

### Amoebic dysentery[edit | edit source]

Main article: Amoebiasis

Amoebiasis, also known as amoebic dysentery, is caused by an infection from the amoeba Entamoeba histolytica,[19] which is found mainly in tropical areas.[20] Proper treatment of the underlying infection of amoebic dysentery is important; insufficiently treated amoebiasis can lie dormant for years and subsequently lead to severe, potentially fatal, complications.

When amoebae inside the bowel of an infected person are ready to leave the body, they group together and form a shell that surrounds and protects them. This group of amoebae is known as a cyst, which is then passed out of the person's body in the feces and can survive outside the body. If hygiene standards are poor – for example, if the person does not dispose of the feces hygienically – then it can contaminate the surroundings, such as nearby food and water. If another person then eats or drinks food or water that has been contaminated with feces containing the cyst, that person will also become infected with the amoebae. Amoebic dysentery is particularly common in parts of the world where human feces are used as fertilizer. After entering the person's body through the mouth, the cyst travels down into the stomach. The amoebae inside the cyst are protected from the stomach's digestive acid. From the stomach, the cyst travels to the intestines, where it breaks open and releases the amoebae, causing the infection. The amoebae can burrow into the walls of the intestines and cause small abscesses and ulcers to form. The cycle then begins again.[citation needed]

### Bacillary dysentery[edit | edit source]

Main article: Bacillary dysentery

Dysentery may also be caused by shigellosis, an infection by bacteria of the genus Shigella, and is then known as bacillary dysentery (or Marlow syndrome). The term bacillary dysentery etymologically might seem to refer to any dysentery caused by any bacilliform bacteria, but its meaning is restricted by convention to Shigella dysentery.

### Other bacteria[edit | edit source]

Some strains of Escherichia coli cause bloody diarrhea. The typical culprits are enterohemorrhagic Escherichia coli, of which O157:H7 is the best known.

## Diagnosis[edit | edit source]

A diagnosis may be made by taking a history and doing a brief examination. Dysentery should not be confused with hematochezia, which is the passage of fresh blood through the anus, usually in or with stools.

### Physical exam[edit | edit source]

The mouth, skin, and lips may appear dry due to dehydration. Lower abdominal tenderness may also be present.[15]

### Stool and blood tests[edit | edit source]

Cultures of stool samples are examined to identify the organism causing dysentery. Usually, several samples must be obtained due to the number of amoebae, which changes daily.[15] Blood tests can be used to measure abnormalities in the levels of essential minerals and salts.[15]

## Prevention[edit | edit source]

Efforts to prevent dysentery include hand washing and food safety measures while traveling in areas of high risk.[4]

### Vaccine[edit | edit source]

Although there is currently no vaccine which protects against Shigella infection, several are in development.[21][22] Vaccination may eventually become a part of the strategy to reduce the incidence and severity of diarrhea, particularly among children in low-resource settings. For example, Shigella is a longstanding World Health Organization (WHO) target for vaccine development, and sharp declines in age-specific diarrhea/dysentery attack rates for this pathogen indicate that natural immunity does develop following exposure; thus, vaccination to prevent this disease should be feasible. The development of vaccines against these types of infection has been hampered by technical constraints, insufficient support for coordination, and a lack of market forces for research and development. Most vaccine development efforts are taking place in the public sector or as research programs within biotechnology companies.[citation needed]

## Treatment[edit | edit source]

Dysentery is managed by maintaining fluids using oral rehydration therapy. If this treatment cannot be adequately maintained due to vomiting or the profuseness of diarrhea, hospital admission may be required for intravenous fluid replacement. In ideal situations, no antimicrobial therapy should be administered until microbiological microscopy and culture studies have established the specific infection involved. When laboratory services are not available, it may be necessary to administer a combination of drugs, including an amoebicidal drug to kill the parasite, and an antibiotic to treat any associated bacterial infection.

If shigellosis is suspected and it is not too severe, letting it run its course may be reasonable — usually less than a week. If the case is severe, antibiotics such as ciprofloxacin or TMP-SMX may be useful. However, many strains of Shigella are becoming resistant to common antibiotics, and effective medications are often in short supply in developing countries. If necessary, a doctor may have to reserve antibiotics for those at highest risk for death, including young children, people over 50, and anyone suffering from dehydration or malnutrition.

Amoebic dysentery is often treated with two antimicrobial drugs such as metronidazole and paromomycin or iodoquinol.[23]

## Prognosis[edit | edit source]

With correct treatment, most cases of amoebic and bacterial dysentery subside within 10 days, and most individuals achieve a full recovery within two to four weeks after beginning proper treatment. If the disease is left untreated, the prognosis varies with the immune status of the individual patient and the severity of disease. Extreme dehydration can delay recovery and significantly raises the risk for serious complications.[24]

## Epidemiology[edit | edit source]

Insufficient data exists, but Shigella is estimated to have caused the death of 34,000 children under the age of five in 2013, and 40,000 deaths in people over five years of age.[21] Amoebiasis infects over 50 million people each year, of whom 50,000 die.[25]

## History[edit | edit source]

The seed, leaves, and bark of the kapok tree have been used in traditional medicine by indigenous peoples of the rainforest regions in the Americas, west-central Africa, and Southeast Asia in this disease.[26][27][28] Bacillus subtilis was marketed throughout America and Europe from 1946 as an immunostimulatory aid in the treatment of gut and urinary tract diseases such as rotavirus and Shigella,[29] but declined in popularity after the introduction of consumer antibiotics.

## Notable cases[edit | edit source]

A Red Army soldier dies of dysentery after eating unwashed vegetables. This is a common way of contracting dysentery. From a health advisory pamphlet given to soldiers.

* 685 – Constantine IV, the Byzantine emperor, died of dysentery in September 685.
* 1183 – Henry the Young King died of dysentery at the castle of Martel on 11 June 1183.
* 1216 – John, King of England died of dysentery at Newark Castle on 18 October 1216.[30]
* 1270 – Saint Louis IX of France died of dysentery in Tunis while commanding his troops for the Eighth Crusade on 25 September 1270.
* 1307 – Edward I of England caught dysentery on his way to the Scottish border and died in his servants' arms on 6 July 1307.
* 1322 – Philip V of France died of dysentery at the Abbey of Longchamp (site of the present hippodrome in the Bois de Boulogne) in Paris while visiting his daughter, Blanche, who had taken her vows as a nun there in 1322. He died on January 3, 1322.
* 1376 – Edward the Black Prince son of Edward III of England and heir to the English throne. Died of apparent dysentery in June, after a months-long period of illness during which he predicted his own imminent death, in his 46th year.
* 1422 – King Henry V of England died suddenly on 31 August 1422 at the Château de Vincennes, apparently from dysentery,[31] which he had contracted during the siege of Meaux. He was 35 years old and had reigned for nine years.
* 1536 – Erasmus, Dutch renaissance humanist and theologian. At Basel.[32]
* 1596 – Sir Francis Drake, vice admiral, died of dysentery on 28 January 1596 whilst anchored off the coast of Portobelo.[33]
* 1605 – Akbar, ruler of the Mughal Empire of South Asia, died of dysentery. On 3 October 1605, he fell ill with an attack of dysentery, from which he never recovered. He is believed to have died on or about 27 October 1605, after which his body was buried at a mausoleum in Agra, present-day India.[34]
* 1675 – Jacques Marquette died of dysentery on his way north from what is today Chicago, traveling to the mission where he intended to spend the rest of his life.[35]
* 1676 – Nathaniel Bacon died of dysentery after taking control of Virginia following Bacon's Rebellion. He is believed to have died in October 1676, allowing Virginia's ruling elite to regain control.[36]
* 1680 \- Shivaji, founder and ruler of the Maratha Empire of South Asia, died of dysentery on 3 April 1680. In 1680, Shivaji fell ill with fever and dysentery, dying around 3–5 April 1680 at the age of 52 on the eve of Hanuman Jayanti. He was cremated at Raigad Fort, where his Samadhi is built in Mahad, Raigad district of Maharashtra, India.[37] [38]
* 19th century – As late as the nineteenth century, the 'bloody flux' it is estimated, killed more soldiers and sailors than did combat.[18] Typhus and dysentery decimated Napoleon's Grande Armée in Russia. More than 80,000 Union soldiers died of dysentery during the American Civil War.[39]
* 1827 – Queen Nandi kaBhebhe, (mother of Shaka Zulu) died of dysentery on October 10, 1827.[40]
* 1896 – Phan Đình Phùng, a Vietnamese revolutionary who led rebel armies against French colonial forces in Vietnam, died of dysentery as the French surrounded his forces on January 21, 1896.[41]
* 1930 – The French explorer and writer, Michel Vieuchange, died of dysentery in Agadir on 30 November 1930, on his return from the "forbidden city" of Smara. He was nursed by his brother, Doctor Jean Vieuchange, who was unable to save him. The notebooks and photographs, edited by Jean Vieuchange, went on to become bestsellers.[42][43]
* 1942 – The Selarang Barracks incident in the summer of 1942 during World War II involved the forced crowding of 17,000 Anglo-Australian prisoners-of-war (POWs) by their Japanese captors in the areas around the barracks square for nearly five days with little water and no sanitation after the Selarang Barracks POWs refused to sign a pledge not to escape. The incident ended with the surrender of the Australian commanders due to the spreading of dysentery among their men.[44]

## See also[edit | edit source]

* Cholera, a bacterial infection of the small intestine which produces severe diarrhea

## References[edit | edit source]

1. ↑ 1.0 1.1 1.2 1.3 "Dysentery". who.int. Archived from the original on 5 December 2014. Retrieved 28 November 2014.
2. ↑ 2.0 2.1 2.2 2.3 2.4 "Dysentery" at Dorland's Medical Dictionary
3. ↑ 3.0 3.1 "WHO EMRO | Dysentery | Health topics". www.emro.who.int. Archived from the original on 15 November 2019. Retrieved 15 November 2019.
4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 "Dysentery". nhs.uk. 18 October 2017. Archived from the original on 13 January 2015. Retrieved 15 November 2019.
5. ↑ 5.0 5.1 5.2 Marie, C; Petri WA, Jr (30 August 2013). "Amoebic dysentery". BMJ Clinical Evidence. 2013. PMC 3758071. PMID 23991750.
6. ↑ 6.0 6.1 6.2 "Dysentery (Shigellosis)" (PDF). WHO. November 2016. p. 2\. Archived (PDF) from the original on 20 September 2018. Retrieved 15 November 2019.
7. ↑ 7.0 7.1 "Controlling the Spread of Infections|Health and Safety Concerns". www.cdc.gov. Archived from the original on 29 October 2019. Retrieved 15 November 2019.
8. ↑ 8.0 8.1 8.2 Tribble, DR (September 2017). "Antibiotic Therapy for Acute Watery Diarrhea and Dysentery". Military Medicine. 182 (S2): 17–25. doi:10.7205/MILMED-D-17-00068. PMC 5650106. PMID 28885920.
9. ↑ The WHO AWaRe (Access, Watch, Reserve) antibiotic book. 9 December 2022. Archived from the original on 13 August 2023. Retrieved 16 August 2023.
10. ↑ 10.0 10.1 Shirley, DT; Farr, L; Watanabe, K; Moonah, S (July 2018). "A Review of the Global Burden, New Diagnostics, and Current Therapeutics for Amebiasis". Open Forum Infectious Diseases. 5 (7): ofy161. doi:10.1093/ofid/ofy161. PMC 6055529. PMID 30046644.
11. ↑ Grove, David (2013). Tapeworms, Lice, and Prions: A compendium of unpleasant infections. OUP Oxford. p. PT517. ISBN 9780191653452. Archived from the original on 7 March 2021. Retrieved 31 July 2020.
12. ↑ DuPont, H. L. (1978). "Interventions in diarrheas of infants and young children". J. Am. Vet. Med. Assoc. 173 (5 Pt 2): 649–53. PMID 359524.
13. ↑ DeWitt, T. G. (1989). "Acute diarrhoea in children". Pediatr Rev. 11 (1): 6–13. doi:10.1542/pir.11-1-6. PMID 2664748.
14. ↑ "Dysentery symptoms". National Health Service. Archived from the original on 23 March 2010. Retrieved 22 January 2010.
15. ↑ 15.0 15.1 15.2 15.3 "Dysentery-Diagnosis". mdguidelines.com. Archived from the original on 14 July 2011. Retrieved 17 November 2010.
16. ↑ Ryan, Jason (2016). Boards and Beyond: Infectious Disease (Version 9-26-2016 ed.).
17. ↑ "Laboratory Methods for the Diagnosis of Epidemic Dysentery and Cholera" (PDF). WHO/CDS/CSR/EDC/99.8. Centers for Disease Control and Prevention. Atlanta, Georgia 1999. Archived from the original (PDF) on March 5, 2012.
18. ↑ 18.0 18.1 "Dysentery". TheFreeDictionary's Medical dictionary. Archived from the original on 3 February 2021. Retrieved 31 July 2020.
19. ↑ WHO (1969). "Amoebiasis. Report of a WHO Expert Committee". WHO Technical Report Series. 421: 1–52. PMID 4978968.
20. ↑ Amebic+Dysentery at the US National Library of Medicine Medical Subject Headings (MeSH)
21. ↑ 21.0 21.1 Mani, Sachin; Wierzba, Thomas; Walker, Richard I (2016). "Status of vaccine research and development Shigella". Vaccine. 34 (26): 2887–2894. doi:10.1016/j.vaccine.2016.02.075. PMID 26979135.
22. ↑ "WHO vaccine pipeline tracker". World Health Organization. Archived from the original on 25 July 2016. Retrieved 21 July 2016.
23. ↑ "Chapter 3 Infectious Diseases Related To Travel". CDC. 1 August 2013. Archived from the original on 14 July 2014. Retrieved 9 June 2014.
24. ↑ mdguidelines.com. "Dysentery-Prognosis". Archived from the original on 14 July 2011. Retrieved 17 November 2010.
25. ↑ Byrne, Joseph Patrick (2008). Encyclopedia of Pestilence, Pandemics, and Plagues: A-M. ABC-CLIO. pp. 175–176. ISBN 978-0-313-34102-1. Archived from the original on 26 May 2013. Retrieved 31 July 2020.
26. ↑ "Kapok Tree". Blue Planet and Biomoes. Archived from the original on 22 February 2012. Retrieved 7 February 2012.
27. ↑ "Ceiba pentandra". Human Uses and Cultural Importance. Archived from the original on 15 February 2012. Retrieved 7 February 2012.
28. ↑ "Kapok Emergent Tree Of Tropical Rain Forest Used To Treat Asthma Dysentery Fever Kidney Diseases". encyclocenter.com. Archived from the original on 10 May 2012. Retrieved 27 April 2018.
29. ↑ Mazza, P. (1994). "The use of Bacillus subtilis as an antidiarrhoeal microorganism". Boll. Chim. Farm. 133 (1): 3–18. PMID 8166962.
30. ↑ Warren, W. Lewis (1991). King John. London: Methuen. p. 253\. ISBN 978-0-413-45520-8. Archived from the original on 30 April 2021. Retrieved 31 July 2020.
31. ↑ "BBC – History – Henry V". bbc.co.uk. Archived from the original on 13 February 2018. Retrieved 27 April 2018.
32. ↑ Herbermann, Charles, ed. (1913). "Desiderius Erasmus" . Catholic Encyclopedia. New York: Robert Appleton Company.
33. ↑ "BBC – History – Sir Francis Drake". bbc.co.uk. Archived from the original on 12 February 2018. Retrieved 27 April 2018.
34. ↑ Majumdar 1984, pp. 168–169 harvnb error: no target: CITEREFMajumdar1984 (help)
35. ↑ [1] Archived March 8, 2013, at the Wayback Machine
36. ↑ Foner, Eric (2012). Give Me Liberty! An American History (brief ed.). New York, London: W. W. Norton and Company. ISBN 9780393920321.
37. ↑ * Sarkar, Jadunath (1920) [1919], Shivaji and His Times (Second ed.), London: Longmans, Green and Co.
38. ↑ Sarkar, Shivaji and His Times 1920, p. 382.
39. ↑ Tucker, Spencer C. (2009). The encyclopedia of the Spanish-American and Philippine-American wars: a political, social, and military history. ABC–CLIO. p. 189\. ISBN 978-1-85109-951-1.
40. ↑ cite Morris, Donald R. (1998). The Washing of the Spears: A History of the Rise of the Zulu Nation Under Shaka and Its Fall in the Zulu War of 1879
41. ↑ Marr, David G. (1970). Vietnamese anticolonialism, 1885–1925. Berkeley, California: University of California. p. 68\. ISBN 978-0-520-01813-6. Archived from the original on 29 April 2021. Retrieved 31 July 2020.
42. ↑ Meaux, Antoine de (2004). L'ultime désert: vie et mort de Michel Vieuchange (in French). Paris: Phébus. pp. 29, 245–249 & 253\. ISBN 978-2-85940-997-5. `{{cite book}}`: Cite has empty unknown parameter: `|1=` (help)CS1 maint: unrecognized language (link)
43. ↑ Vieuchange, Michel (1988) [1932]. Smara: The Forbidden City. Fletcher Allen, Edgar (translation); Vieuchange, Jean (editor; introduction, notes, postscript); Claudel, Paul (preface). (Reprinted ed.). New York: Ecco. ISBN 978-0-88001-146-4. `{{cite book}}`: Cite has empty unknown parameter: `|1=` (help)
44. ↑ Thompson, Peter (2005). The Battle For Singapore—The True Story of the Greatest Catastrophe of World War II. United Kingdom: Portraits Books. pp. 389–390. ISBN 978-0-7499-5085-9.

## External links[edit | edit source]

Classification|

* ICD-10: A09.0, A03.9, A06.0, A07.9
* ICD-9-CM: 004, 007.9, 009.0
* MeSH: D004403

|

* v
* t
* e

Parasitic disease caused by Excavata protozoa (A06–A07, B55–B57, 007, 085–086)

Discicristata|

| Trypanosomatida|

| Trypanosomiasis|

* T. brucei
* African trypanosomiasis
* T. cruzi
* Chagas disease

|

Leishmaniasis|

* Leishmania major / L. mexicana / L. aethiopica / L. tropica
* Cutaneous leishmaniasis
* L. braziliensis
* Mucocutaneous leishmaniasis
* L. donovani / infantum
* Visceral leishmaniasis

Schizopyrenida|

* Naegleria fowleri
* Primary amoebic meningoencephalitis

Trichozoa|

| Diplomonadida|

* Giardia lamblia (Giardiasis)

|

Trichomonadida|

* Trichomonas vaginalis
* Trichomoniasis
* Dientamoeba fragilis
* Dientamoebiasis

* v
* t
* e

Proteobacteria-associated Gram-negative bacterial infections

| Rickettsiales|

| Rickettsiaceae/
(Rickettsioses)|

| Typhus|

* Rickettsia typhi
* Murine typhus
* Rickettsia prowazekii
* Epidemic typhus, Brill–Zinsser disease, Flying squirrel typhus

|

Spotted
fever|

| Tick-borne|

* Rickettsia rickettsii
* Rocky Mountain spotted fever
* Rickettsia conorii
* Boutonneuse fever
* Rickettsia japonica
* Japanese spotted fever
* Rickettsia sibirica
* North Asian tick typhus
* Rickettsia australis
* Queensland tick typhus
* Rickettsia honei
* Flinders Island spotted fever
* Rickettsia africae
* African tick bite fever
* Rickettsia parkeri
* American tick bite fever
* Rickettsia aeschlimannii
* Rickettsia aeschlimannii infection

|

Mite-borne|

* Rickettsia akari
* Rickettsialpox
* Orientia tsutsugamushi
* Scrub typhus

Flea-borne|

* Rickettsia felis
* Flea-borne spotted fever

Anaplasmataceae|

* Ehrlichiosis: Anaplasma phagocytophilum
* Human granulocytic anaplasmosis, Anaplasmosis
* Ehrlichia chaffeensis
* Human monocytotropic ehrlichiosis
* Ehrlichia ewingii
* Ehrlichiosis ewingii infection

Rhizobiales|

| Brucellaceae|

* Brucella abortus
* Brucellosis

|

Bartonellaceae|

* Bartonellosis: Bartonella henselae
* Cat-scratch disease
* Bartonella quintana
* Trench fever
* Either B. henselae or B. quintana
* Bacillary angiomatosis
* Bartonella bacilliformis
* Carrion's disease, Verruga peruana

| Neisseriales|

| M+|

* Neisseria meningitidis/meningococcus
* Meningococcal disease, Waterhouse–Friderichsen syndrome, Meningococcal septicaemia

|

M−|

* Neisseria gonorrhoeae/gonococcus
* Gonorrhea

ungrouped:|

* Eikenella corrodens/Kingella kingae
* HACEK
* Chromobacterium violaceum
* Chromobacteriosis infection

Burkholderiales|

* Burkholderia pseudomallei
* Melioidosis
* Burkholderia mallei
* Glanders
* Burkholderia cepacia complex
* Bordetella pertussis/Bordetella parapertussis
* Pertussis

| Enterobacteriales
(OX−)|

| Lac+|

* Klebsiella pneumoniae
* Rhinoscleroma, Pneumonia
* Klebsiella granulomatis
* Granuloma inguinale
* Klebsiella oxytoca

* Escherichia coli: Enterotoxigenic
* Enteroinvasive
* Enterohemorrhagic
* O157:H7
* O104:H4
* Hemolytic-uremic syndrome

* Enterobacter aerogenes/Enterobacter cloacae

|

Slow/weak|

* Serratia marcescens
* Serratia infection
* Citrobacter koseri/Citrobacter freundii

Lac−|

| H2S+|

* Salmonella enterica
* Typhoid fever, Paratyphoid fever, Salmonellosis

|

H2S−|

* Shigella dysenteriae/sonnei/flexneri/boydii
* Shigellosis, Bacillary dysentery
* Proteus mirabilis/Proteus vulgaris
* Yersinia pestis
* Plague/Bubonic plague
* Yersinia enterocolitica
* Yersiniosis
* Yersinia pseudotuberculosis
* Far East scarlet-like fever

Pasteurellales|

| Haemophilus:|

* H. influenzae
* Haemophilus meningitis
* Brazilian purpuric fever
* H. ducreyi
* Chancroid
* H. parainfluenzae
* HACEK

|

Pasteurella multocida|

* Pasteurellosis
* Actinobacillus
* Actinobacillosis

Aggregatibacter actinomycetemcomitans|

* HACEK

Legionellales|

* Legionella pneumophila/Legionella longbeachae
* Legionnaires' disease
* Coxiella burnetii
* Q fever

Thiotrichales|

* Francisella tularensis
* Tularemia

Vibrionaceae|

* Vibrio cholerae
* Cholera
* Vibrio vulnificus
* Vibrio parahaemolyticus
* Vibrio alginolyticus
* Plesiomonas shigelloides

Pseudomonadales|

* Pseudomonas aeruginosa
* Pseudomonas infection
* Moraxella catarrhalis
* Acinetobacter baumannii

Xanthomonadaceae|

* Stenotrophomonas maltophilia

Cardiobacteriaceae|

* Cardiobacterium hominis
* HACEK

Aeromonadales|

* Aeromonas hydrophila/Aeromonas veronii
* Aeromonas infection

| Campylobacterales|

* Campylobacter jejuni
* Campylobacteriosis, Guillain–Barré syndrome
* Helicobacter pylori
* Peptic ulcer, MALT lymphoma, Gastric cancer
* Helicobacter cinaedi
* Helicobacter cellulitis

|

* v
* t
* e

Diseases of the digestive system

Upper GI tract|

| Esophagus|

* Esophagitis
* Candidal
* Eosinophilic
* Herpetiform
* Rupture
* Boerhaave syndrome
* Mallory–Weiss syndrome
* UES
* Zenker's diverticulum
* LES
* Barrett's esophagus
* Esophageal motility disorder
* Nutcracker esophagus
* Achalasia
* Esophagogastric junction outflow obstruction
* Diffuse esophageal spasm
* Gastroesophageal reflux disease (GERD)
* Laryngopharyngeal reflux (LPR)
* Esophageal stricture
* Megaesophagus
* Esophageal intramural pseudodiverticulosis
* Acute esophageal necrosis

|

Stomach|

* Gastritis
* Atrophic
* Ménétrier's disease
* Gastroenteritis
* Peptic (gastric) ulcer
* Cushing ulcer
* Dieulafoy's lesion
* Dyspepsia
* Pyloric stenosis
* Achlorhydria
* Gastroparesis
* Gastroptosis
* Portal hypertensive gastropathy
* Gastric antral vascular ectasia
* Gastric dumping syndrome
* Gastric volvulus
* Buried bumper syndrome
* Gastrinoma
* Zollinger–Ellison syndrome

Lower GI tract
Enteropathy|

| Small intestine
(Duodenum/Jejunum/Ileum)|

* Enteritis
* Duodenitis
* Jejunitis
* Ileitis
* Peptic (duodenal) ulcer
* Curling's ulcer
* Malabsorption: Coeliac
* Tropical sprue
* Blind loop syndrome
* Small intestinal bacterial overgrowth
* Whipple's
* Short bowel syndrome
* Steatorrhea
* Milroy disease
* Bile acid malabsorption

|

Large intestine
(Appendix/Colon)|

* Appendicitis
* Colitis
* Pseudomembranous
* Ulcerative
* Ischemic
* Microscopic
* Collagenous
* Lymphocytic
* Functional colonic disease
* IBS
* Intestinal pseudoobstruction / Ogilvie syndrome
* Megacolon / Toxic megacolon
* Diverticulitis/Diverticulosis/SCAD

Large and/or small|

* Enterocolitis
* Necrotizing
* Gastroenterocolitis
* IBD
* Crohn's disease
* Vascular: Abdominal angina
* Mesenteric ischemia
* Angiodysplasia
* Bowel obstruction: Ileus
* Intussusception
* Volvulus
* Fecal impaction
* Constipation
* Diarrhea
* Infectious
* Intestinal adhesions

Rectum|

* Proctitis
* Radiation proctitis
* Proctalgia fugax
* Rectal prolapse
* Anismus

Anal canal|

* Anal fissure/Anal fistula
* Anal abscess
* Hemorrhoid
* Anal dysplasia
* Pruritus ani

GI bleeding|

* Blood in stool
* Upper
* Hematemesis
* Melena
* Lower
* Hematochezia

Accessory|

| Liver|

* Hepatitis
* Viral hepatitis
* Autoimmune hepatitis
* Alcoholic hepatitis
* Cirrhosis
* PBC
* Fatty liver
* NASH
* Vascular
* Budd–Chiari syndrome
* Hepatic veno-occlusive disease
* Portal hypertension
* Nutmeg liver
* Alcoholic liver disease
* Liver failure
* Hepatic encephalopathy
* Acute liver failure
* Liver abscess
* Pyogenic
* Amoebic
* Hepatorenal syndrome
* Peliosis hepatis
* Metabolic disorders
* Wilson's disease
* Hemochromatosis

|

Gallbladder|

* Cholecystitis
* Gallstone / Cholelithiasis
* Cholesterolosis
* Adenomyomatosis
* Postcholecystectomy syndrome
* Porcelain gallbladder

Bile duct/
Other biliary tree|

* Cholangitis
* Primary sclerosing cholangitis
* Secondary sclerosing cholangitis
* Ascending
* Cholestasis/Mirizzi's syndrome
* Biliary fistula
* Haemobilia

* Common bile duct
* Choledocholithiasis
* Biliary dyskinesia
* Sphincter of Oddi dysfunction

Pancreatic|

* Pancreatitis
* Acute
* Chronic
* Hereditary
* Pancreatic abscess
* Pancreatic pseudocyst
* Exocrine pancreatic insufficiency
* Pancreatic fistula

Other|

| Hernia|

* Diaphragmatic
* Congenital
* Hiatus

* Inguinal
* Indirect
* Direct
* Umbilical
* Femoral
* Obturator
* Spigelian

* Lumbar
* Petit's
* Grynfeltt-Lesshaft

* Undefined location
* Incisional
* Internal hernia
* Richter's

|

Peritoneal|

* Peritonitis
* Spontaneous bacterial peritonitis
* Hemoperitoneum
* Pneumoperitoneum

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