Selenium disulfide

Selenium disulfideNames

Trade names| Selsun Blue,[1] Selseb, others
Other names| Selenium sulfide

IUPAC name

* Selenium disulfide

Clinical data
Pregnancy
category|

* US: C (Risk not ruled out)

Routes of
use| Topical
Defined daily dose| not established[2]
External links
AHFS/Drugs.com| Monograph
Legal
Legal status|

* US: OTC

Chemical and physical data
Molar mass| 143.09
Density| 3 g/cm3
Melting point| 111 °C (232 °F)
Boiling point| 118 to 119 °C (244 to 246 °F) (decomposes)
Solubility in water| negligible mg/mL (20 °C)

Selenium disulfide, also known as selenium sulfide, is a chemical compound and medication used to treat pityriasis versicolor, seborrhoeic dermatitis, and dandruff.[3] It is applied to the affected area as a lotion or shampoo.[4] Dandruff frequently returns if treatment is stopped.[5]

Side effects include hair loss, irritation of the skin, weakness, and feeling tired.[3] Use is not recommended in children less than 2–5 years old.[3][5] Use in pregnancy or breastfeeding has not been studied.[6] Selenium disulfide is an inorganic compound with the chemical formula SeS2.[7]

Selenium disulfide was approved for medical use in the United States at least as early as 1951.[5] It is on the World Health Organization's List of Essential Medicines.[8] Selenium disulfide is available as a generic medication and over the counter.[4] In the United States a month of treatment costs less than 25 USD.[4] In the United Kingdom 100 ml of 2.5% shampoo costs the NHS about 1.96 pounds.[9]

## Contents

* 1 Medical uses
* 1.1 Dosage
* 2 Side effects
* 3 Chemical composition
* 4 History
* 5 Society and culture
* 6 See also
* 7 References
* 8 Further reading
* 9 External links

## Medical uses[edit | edit source]

Selenium disulfide is sold as an antifungal agent in shampoos for the treatment of dandruff and seborrheic dermatitis associated in the scalp with fungi of genus Malassezia.[10][11][12] In the United States, a 1% strength is available over-the-counter, and a 2.5% strength is also available with a prescription. In Canada, the 2.5% strength is available over-the-counter. At the 2.5% strength, selenium disulfide is also used on the body to treat Tinea versicolor, a type of fungal skin infection caused by a different species of Malassezia. It has been suggested to be effective as a treatment for hyperkeratosis.[13]

### Dosage[edit | edit source]

The defined daily dose is not established.[2]

## Side effects[edit | edit source]

Selenium disulfide can cause discoloration of the hair and alter the color of hair dyes. It may also discolor metallic jewellery.

## Chemical composition[edit | edit source]

Structure of 1,2,3-Se3S5, illustrative of selenium sulfide.

Selenium disulfide has a composition that approximates to SeS2 and is sometimes called selenium sulfide. However, as used in proprietary formulations, it is not a pure chemical compound but a mixture where the overall Se:S ratio is 1:2. The compounds are Se–S rings containing a variable number of S and Se atoms, SenS8−n.[14]

Many selenium sulfides are known as indicated by 77Se-NMR spectroscopy.[15]

## History[edit | edit source]

Selenium monosulfide, along with elemental selenium and sulfur, has been used in medicinal preparations in the past,[16] causing confusion and contradiction[17] as to exactly what form selenium is in any given topical preparation.

## Society and culture[edit | edit source]

In the film Evolution selenium was mentioned as an active ingredient of Head & Shoulders. A group of academics, therefore, tried to use this brand of shampoo to stop an alien invasion after discovering that the alien life form was sensitive to selenium. In fact, the modern shampoo from this brand no longer contains selenium sulfide and instead zinc pyrithione is used as a dandruff-reducing component.[18]

## See also[edit | edit source]

* Zinc pyrithione, an antimicrobial agent used in many off the shelf shampoos
* Selsun Blue, a shampoo with selenium disulfide as its active ingredient
* Ketoconazole, another antifungal agent used in medicated shampoos

## References[edit | edit source]

1. ↑ Gupta, Aditya K.; Mays, Rachel R.; Folley, Kelly A. (2019). "42. Topical antifungal agents". In Wolverton, Stephen E.; Wu, Jashin J. (eds.). Comprehensive Dermatologic Drug Therapy (4th ed.). Elsevier. p. 488\. ISBN 978-0-323-61211-1. Archived from the original on 2021-10-09. Retrieved 2021-10-07.
2. ↑ 2.0 2.1 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 September 2020. Retrieved 13 September 2020.
3. ↑ 3.0 3.1 3.2 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 297\. hdl:10665/44053. ISBN 9789241547659.
4. ↑ 4.0 4.1 4.2 Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 194\. ISBN 9781284057560.
5. ↑ 5.0 5.1 5.2 "Selenium Sulfide". The American Society of Health-System Pharmacists. Archived from the original on 18 January 2017. Retrieved 8 January 2017.
6. ↑ "Selenium sulfide topical Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 16 January 2017. Retrieved 13 January 2017.
7. ↑ Mitchell, Stephen C. (2003). Biological Interactions Of Sulfur Compounds. CRC Press. p. 174\. ISBN 9780203362525. Archived from the original on 2017-01-16.
8. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
9. ↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 829\. ISBN 9780857111562.
10. ↑ Selenium(IV) sulfide - pharmacy codes search engine Archived 2008-04-01 at the Wayback Machine
11. ↑ Chemicals of Selenium .Se Archived 2008-04-03 at the Wayback Machine
12. ↑ Accessed Dec. 24, 2007 Archived 2008-12-26 at the Wayback Machine
13. ↑ Cohen PR, Anderson CA (December 2018). "Topical Selenium Sulfide for the Treatment of Hyperkeratosis". Dermatology and therapy. 8 (4): 639–46. doi:10.1007/s13555-018-0259-9. PMC 6261123. PMID 30203232.
14. ↑ Cyclic selenium sulfides R. Steudel, R. Laitinen, Topics in Current Chemistry, (1982), 102, 177-197
15. ↑ Pekonen, Pentti.; Hiltunen, Yrjō; Laitinen, Risto S.; Pakkanen, Tapani A. (1991). "Chalcogen ring interconversion pathways. 77Se NMR spectroscopic study of the decomposition of 1,2,3,4,5-Se5S2 to 1,2,3,4,5,6-Se6S2 and 1,2,3,4-Se4S2". Inorganic Chemistry. 30 (19): 3679. doi:10.1021/ic00019a022.
16. ↑ "Definition: selenium sulfide from Online Medical Dictionary".
17. ↑ "DrugBank: DB00971 (Selenium Sulfide)". Archived from the original on 2007-04-27.
18. ↑ "Evolution (2001) - IMDb". Archived from the original on 8 November 2020. Retrieved 19 May 2020.

## Further reading[edit | edit source]

* Danby, FW; Maddin, WS; Margesson, LJ; Rosenthal, D (December 1993). "A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff". Journal of the American Academy of Dermatology. 29 (6): 1008–12. doi:10.1016/0190-9622(93)70282-x. PMID 8245236. Archived from the original on 2013-04-14. Retrieved 2012-05-31.
* Grover, R. W. (1956). "Diffuse Hair Loss Associated with Selenium (Selsun) Sulfide Shampoo". JAMA: The Journal of the American Medical Association. 160 (16): 1397. doi:10.1001/jama.1956.02960510023006.
* Givens, T. G.; Murray, M. M.; Baker, R. C. (1995). "Comparison of 1% and 2.5% Selenium Sulfide in the Treatment of Tinea Capitis". Archives of Pediatrics and Adolescent Medicine. 149 (7): 808–11. doi:10.1001/archpedi.1995.02170200098016. PMID 7795774.
* Ransone, James W.; Scott, Norman M.; Knoblock, Edward C. (1961). "Selenium Sulfide Intoxication". New England Journal of Medicine. 264 (8): 384. doi:10.1056/NEJM196102232640806. PMID 13739506.
* Laitinen, Risto S.; Pakkanen, Tapani A. (1987). "77Se NMR spectroscopic characterization of selenium sulfide ring molecules SenS8−n". Inorganic Chemistry. 26 (16): 2598. doi:10.1021/ic00263a010.

## External links[edit | edit source]

Identifiers:|

* ATC code:

* D01AE13 (WHO)

* CAS Number: 7488-56-4  Y
* PubChem CID: 24087
* UNII:

* Z69D9E381Q

* ChEMBL:

* ChEMBL1200680

|

* "Selenium Disulfide". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2021-08-29. Retrieved 2020-05-17.

* v
* t
* e

Selenium compounds

Se(−II)|

* Se2−
* H2Se
* Al2Se3
* Sb2Se3
* As2Se3
* Bi2Se3
* CdSe
* CaSe
* CSe2
* OCSe
* CrSe
* CoSe
* CuSe
* (CH3)2Se
* GaSe
* Ga2Se3
* GeSe
* In2Se3
* FeSe
* PbSe
* MnSe
* MnSe2
* HgSe
* MoSe2
* NiSe
* NbSe2
* NbSe3
* PxSey
* ReSe2
* Sm2Se3
* Ag2Se
* Na2Se
* SnSe
* TiSe2
* WSe2
* USe2
* ZnSe

Se(0,I)|

* Se3S5

Se(I)|

* Se2S6
* Se2Cl2
* C3H7NO2Se

Se(II)|

* SeS2

Se(IV)|

* SeCl4
* SeF4
* SeO2
* SeS2
* SeOBr2
* SeOCl2
* H2SeO3

Se(VI)|

* SeF6
* SeO3
* SeO2F2
* H2SeO4

* v
* t
* e

Sulfides (S2−)

| H2S
H2S2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | He

|
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|
|
|
|
|
|
|
|
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|
|
|
|

Li2S | BeS |  |  |  |  |  |  |  |  |  |  | B2S3 | CS2
COS | (NH4)SH | O | F | Ne
Na2S
Na2Sx | MgS |  |  |  |  |  |  |  |  |  |  | Al2S3 | SiS
SiS2 | PxSy | S | Cl | Ar
K2S | CaS | Sc2S3 | TiS2 | V | CrS
Cr2S3 | MnS
MnS2 | FeS
Fe3S4 | CoS | NiS | Cu2S
CuS | ZnS | GaS
Ga2S3 | GeS
GeS2 | As2S3
As4S3 | SeS2 | Br | Kr
Rb2S | SrS | Y2S3 | ZrS2 | NbS2 | MoS2 | Tc | Ru | Rh2S3 | PdS | Ag2S | CdS | In2S3 | SnS
SnS2 | Sb2S3
Sb2S5 | TeS2 | I | Xe
Cs2S | BaS | *  | HfS2 | TaS2 | WS2
WS3 | ReS2
Re2S7 | Os | Ir2S3
IrS2 | PtS
PtS2 | Au2S
Au2S3 | HgS | Tl2S | PbS
PbS2 | Bi2S3 | Po | At | Rn
Fr | Ra | **  | Rf | Db | Sg | Bh | Hs | Mt | Ds | Rg | Cn | Nh | Fl | Mc | Lv | Ts | Og |  |  |  |  |  |  |  |
|  | ↓ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| * | La2S3 | CeS
Ce2S3 | Pr2S3 | Nd2S3 | Pm2S3 | SmS
Sm2S3 | Eu2S3 | Gd2S3 | Tb2S3 | Dy2S3 | Ho2S3 | Er2S3 | Tm2S3 | Yb2S3 | Lu2S3 |
| ** | Ac | ThS2 | Pa | US2 | Np | Pu | Am | Cm | Bk | Cf | Es | Fm | Md | No | Lr |

* v
* t
* e

Antifungals (D01 and J02)

Wall/
membrane|

| Ergosterol
inhibitors|

| Azoles (lanosterol 14α-
demethylase inhibitors)|

| Imidazoles|

* Topical: bifonazole‡
* butoconazole
* chlormidazole‡
* climbazole
* clotrimazole#
* croconazole‡
* eberconazole
* econazole
* fenticonazole‡
* flutrimazole
* isoconazole
* ketoconazole
* luliconazole
* miconazole#
* neticonazole‡
* omoconazole‡
* oxiconazole
* sertaconazole
* sulconazole
* tioconazole

* Systemic: ketoconazole

|

Triazoles|

* Topical: efinaconazole
* fluconazole#
* terconazole

* Systemic: fluconazole#
* hexaconazole‡
* fosfluconazole
* fosravuconazole
* isavuconazonium
* itraconazole#
* posaconazole
* voriconazole#

* Unknown: albaconazole‡
* ravuconazole†

Thiazoles|

* Topical: abafungin‡

Polyene antimycotics
(ergosterol binding)|

* Topical: hamycin‡
* natamycin
* nystatin#
Systemic: amphotericin B#, hamycin‡

Squalene monooxygenase
inhibitors|

| Allylamines|

* Topical: naftifine
* terbinafine
Systemic: terbinafine

|

Benzylamines|

* Topical: butenafine

Others|

* Topical: amorolfine

β-glucan synthase
inhibitors|

* Systemic: echinocandins (anidulafungin
* biafungin
* caspofungin
* cilofungin
* micafungin)

Intracellular|

| Pyrimidine analogues/
thymidylate synthase inhibitors|

* Systemic: flucytosine#

|

Mitotic inhibitors|

* Systemic: griseofulvin#

Aminoacyl tRNA synthetase inhibitors|

* Topical: tavaborole

Others|

* bromochlorosalicylanilide
* chlorophetanol
* chlorphenesin
* ciclopirox
* crystal violet
* dimazole
* ethylparaben
* haloprogin‡
* polynoxylin
* potassium iodide#
* salicylic acid
* selenium disulfide#
* sodium thiosulfate#
* sulbentine
* taurolidine
* ticlatone
* tolciclate
* tolnaftate
* tribromometacresol
* undecylenic acid
* Whitfield's ointment#

* citronella oil
* lemon grass
* lemon myrtle
* orange oil
* patchouli
* tea tree oil
* PCP: atovaquone
* dapsone
* pentamidine

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
* t
* e

Prostanoid signaling modulators

Receptor
(ligands)|

| DP (D2)|

| DP1|

* Agonists: Prostaglandin D2
* Treprostinil

* Antagonists: Asapiprant
* Laropiprant
* Vidupiprant

|

DP2|

* Agonists: Indometacin
* Prostaglandin D2

* Antagonists: ADC-3680
* AZD-1981
* Bay U3405
* Fevipiprant
* MK-1029
* MK-7246
* QAV-680
* Ramatroban
* Setipiprant
* Timapiprant
* TM30089
* Vidupiprant

EP (E2)|

| EP1|

* Agonists: Beraprost
* Enprostil
* Iloprost (ciloprost)
* Latanoprost
* Lubiprostone
* Misoprostol
* Prostaglandin E1 (alprostadil)
* Prostaglandin E2 (dinoprostone)
* Sulprostone

* Antagonists: AH-6809
* ONO-8130
* SC-19220
* SC-51089
* SC-51322

|

EP2|

* Agonists: Butaprost
* Misoprostol
* Prostaglandin E1 (alprostadil)
* Prostaglandin E2 (dinoprostone)
* Treprostinil

* Antagonists: AH-6809
* PF-04418948
* TG 4-155

EP3|

* Agonists: Beraprost
* Carbacyclin
* Cicaprost
* Enprostil
* Iloprost (ciloprost)
* Isocarbacyclin
* Latanoprost
* Misoprostol
* Prostaglandin D2
* Prostaglandin E1 (alprostadil)
* Prostaglandin E2 (dinoprostone)
* Remiprostol
* Ricinoleic acid
* Sulprostone

* Antagonists: L-798106

EP4|

* Agonists: Lubiprostone
* Misoprostol
* Prostaglandin E1 (alprostadil)
* Prostaglandin E2 (dinoprostone)
* TCS-2510

* Antagonists: Grapiprant
* GW-627368
* L-161982
* ONO-AE3-208

Unsorted|

* Agonists: 16,16-Dimethyl Prostaglandin E2
* Aganepag
* Carboprost
* Evatanepag
* Gemeprost
* Nocloprost
* Omidenepag
* Prostaglandin F2α (dinoprost)
* Simenepag
* Taprenepag

FP (F2α)|

* Agonists: Alfaprostol
* Bimatoprost
* Carboprost
* Cloprostenol
* Enprostil
* Fluprostenol
* Latanoprost
* Prostaglandin D2
* Prostaglandin F2α (dinoprost)
* Sulotroban
* Tafluprost
* Travoprost
* Unoprostone

IP (I2)|

* Agonists: ACT-333679
* AFP-07
* Beraprost
* BMY-45778
* Carbacyclin
* Cicaprost
* Iloprost (ciloprost)
* Isocarbacyclin
* MRE-269
* NS-304
* Prostacyclin (prostaglandin I2, epoprostenol)
* Prostaglandin E1 (alprostadil)
* Ralinepag
* Selexipag
* Taprostene
* TRA-418
* Treprostinil

* Antagonists: RO1138452

TP (TXA2)|

* Agonists: Carbocyclic thromboxane A2
* I-BOP
* Thromboxane A2
* U-46619
* Vapiprost

* Antagonists: 12-HETE
* 13-APA
* AA-2414
* Argatroban
* Bay U3405
* BMS-180,291
* Daltroban
* Domitroban
* EP-045
* GR-32191
* ICI-185282
* ICI-192605
* Ifetroban
* Imitrodast
* L-655240
* L-670596
* Linotroban
* Mipitroban
* ONO-3708
* ONO-11120
* Picotamide
* Pinane thromboxane A2
* Ramatroban
* Ridogrel
* S-145
* Samixogrel
* Seratrodast
* SQ-28,668
* SQ-29,548
* Sulotroban
* Terbogrel
* Terutroban
* TRA-418

Unsorted|

* Arbaprostil
* Ataprost
* Ciprostene
* Clinprost
* Cobiprostone
* Delprostenate
* Deprostil
* Dimoxaprost
* Doxaprost
* Ecraprost
* Eganoprost
* Enisoprost
* Eptaloprost
* Esuberaprost
* Etiproston
* Fenprostalene
* Flunoprost
* Froxiprost
* Lanproston
* Limaprost
* Luprostiol
* Meteneprost
* Mexiprostil
* Naxaprostene
* Nileprost
* Nocloprost
* Ornoprostil
* Oxoprostol
* Penprostene
* Pimilprost
* Piriprost
* Posaraprost
* Prostalene
* Rioprostil
* Rivenprost
* Rosaprostol
* Spiriprostil
* Tiaprost
* Tilsuprost
* Tiprostanide
* Trimoprostil
* Viprostol

Enzyme
(inhibitors)|

| COX
(PTGS)|

* Salicylic acids: Aloxiprin
* Aspirin (acetylsalicylic acid)
* Benorilate (benorylate)
* Carbasalate calcium
* Diflusinal
* Dipyrocetyl
* Ethenzamide
* Guacetisal
* Magnesium salicylate
* Mesalazine (5-aminosalicylic acid)
* Methyl salicylate
* Salacetamide
* Salicin
* Salicylamide
* Salicylate (salicylic acid)
* Salsalate
* Sodium salicylate
* Triflusal; Acetic acids: Aceclofenac
* Acemetacin
* Aclofenac
* Amfenac
* Alclofenac
* Bendazac
* Bromfenac
* Bufexamac
* Bumadizone
* Cinmetacin
* Clometacin
* Diclofenac
* Difenpiramide
* Etodolac
* Felbinac
* Fenclofenac
* Fentiazac
* Glucametacin
* Indometacin (indomethacin)
* Indometacin farnesil
* Ketorolac
* Lonazolac
* Mofezolac
* Nabumetone
* Oxametacin
* Oxindanac
* Proglumetacin
* Sulindac
* Sulindac sulfide
* Tolmetin
* Zidometacin
* Zomepirac; Propionic acids: Alminoprofen
* Benoxaprofen
* Bucloxic acid (blucloxate)
* Butibufen
* Carprofen
* Dexibuprofen
* Dexindoprofen
* Dexketoprofen
* Fenbufen
* Fenoprofen
* Flunoxaprofen
* Flurbiprofen
* Ibuprofen
* Ibuproxam
* Indoprofen
* Ketoprofen
* Loxoprofen
* Miroprofen
* Naproxen
* Naproxcinod
* Oxaprozin
* Pirprofen
* Pranoprofen
* Suprofen
* Tarenflurbil
* Tepoxalin
* Tiaprofenic acid (tiaprofenate)
* Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate)
* Floctafenic acid (floctafenate)
* Flufenamic acid (flufenamate)
* Meclofenamic acid (meclofenamate)
* Mefenamic acid (mefenamate)
* Morniflumic acid (morniflumate)
* Niflumic acid (niflumate)
* Talinflumic acid (talinflumate)
* Tolfenamic acid (tolfenamate); Pyrazolones: Azapropazone
* Dipyrone
* Isopyrin
* Oxyphenbutazone
* Phenylbutazone; Enolic acids (oxicams): Ampiroxicam
* Droxicam
* Enolicam
* Isoxicam
* Lornoxicam
* Meloxicam
* Piroxicam
* Tenoxicam; 4-Aminoquinolines: Antrafenine
* Floctafenine
* Glafenine; Quinazolines: Fluproquazone
* Proquazone; Aminonicotinic acids: Clonixeril
* Clonixin
* Flunixin; Sulfonanilides: Flosulide
* Nimesulide; Aminophenols (anilines): Acetanilide
* AM-404 (N-arachidonoylaminophenol)
* Bucetin
* Paracetamol (acetaminophen)
* Parapropamol
* Phenacetin
* Propacetamol; Selective COX-2 inhibitors (coxibs): Apricoxib
* Celecoxib
* Cimicoxib
* Deracoxib
* Etoricoxib
* Firocoxib
* Lumiracoxib
* Mavacoxib
* Parecoxib
* Polmacoxib
* Robenacoxib
* Rofecoxib
* Tilmacoxib
* Valdecoxib; Others/unsorted: Anitrazafen
* Clobuzarit
* Curcumin
* DuP-697
* FK-3311
* Flumizole
* FR-122047
* Glimepiride
* Hyperforin
* Itazigrel
* L-655240
* L-670596
* Licofelone
* Menatetrenone (vitamin K2)
* NCX-466
* NCX-4040
* NS-398
* Pamicogrel
* Resveratrol
* Romazarit
* Rosmarinic acid
* Rutecarpine
* Satigrel
* SC-236
* SC-560
* SC-58125
* Tenidap
* Tiflamizole
* Timegadine
* Trifenagrel
* Tropesin

|

PGD2S|

* Retinoids
* Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)

PGES|

HQL-79

PGFS|

Bimatoprost

PGI2S|

Tranylcypromine

TXAS|

* Camonagrel
* Dazmegrel
* Dazoxiben
* Furegrelate
* Isbogrel
* Midazogrel
* Nafagrel
* Nicogrelate
* Ozagrel
* Picotamide
* Pirmagrel
* Ridogrel
* Rolafagrel
* Samixogrel
* Terbogrel
* U63557A

Others|

* Precursors: Linoleic acid
* γ-Linolenic acid (gamolenic acid)
* Dihomo-γ-linolenic acid
* Diacylglycerol
* Arachidonic acid
* Prostaglandin G2
* Prostaglandin H2

See also
Receptor/signaling modulators
Leukotriene signaling modulators
*[US]: United States
*[CID]: Compound ID
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[DP (D2)]: Prostaglandin D2 receptor
*[DP1]: Prostaglandin D2 receptor 1
*[DP2]: Prostaglandin D2 receptor 2
*[EP (E2)]: Prostaglandin E2 receptor
*[EP1]: Prostaglandin EP1 receptor
*[EP2]: Prostaglandin EP2 receptor
*[EP3]: Prostaglandin EP3 receptor
*[EP4]: Prostaglandin EP4 receptor
*[FP (F2α)]: Prostaglandin F receptor
*[IP (I2)]: Prostacyclin receptor
*[TP (TXA2)]: Thromboxane receptor
*[COX]: Cyclooxygenase
*[PTGS]: prostaglandin G/H synthase
*[PGD2S]: Prostaglandin D synthase
*[PGES]: Prostaglandin E synthase
*[PGFS]: Prostaglandin F synthase
*[PGI2S]: Prostacyclin synthase
*[TXAS]: Thromboxane A synthase