Run-in period

Run-in period is a period between the recruitment and randomization phases of a clinical trial,[1][2] when all participants receive the same treatment, which may be active treatment, a placebo or no treatment at all. The clinical data from this stage of a trial are only occasionally of value but can serve a valuable role in screening out ineligible or non-compliant participants, in ensuring that participants are in a stable condition, and in providing baseline observations.[3] A run-in period is sometimes called a washout period if treatments that participants were using before entering the clinical trial are discontinued.[citation needed]

## See also

* Data management
* Randomized controlled trial
* Safety monitoring
* Serious adverse event
* Standard operating procedures
* Standard treatment
* Study population

## References

1. ↑ Laursen, David Ruben Teindl; Paludan-Müller, Asger Sand; Hróbjartsson, Asbjørn (2019). "Randomized clinical trials with run-in periods: frequency, characteristics and reporting". Clinical Epidemiology (Informa UK Limited) 11: 169–184. doi:10.2147/clep.s188752. ISSN 1179-1349. PMID 30809104.
2. ↑ "run-in period". Stedman's Medical Dictionary. Lippincott Williams & Wilkins. 2006. http://www.medilexicon.com/medicaldictionary.php?t=67147.
3. ↑ Bapat, Manasi (September 13, 2021). "Run-in periods in clinical trials: What can we ACHIEVE?". NephJC. http://www.nephjc.com/news/run-in-period.

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