Glucuronide

Morphine-6-glucuronide, a major metabolite of morphine

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.[1] The glucuronides belong to the glycosides.

Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.[2]

Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.

## Examples

* Miquelianin (Quercetin 3-O-glucuronide)
* Morphine-6-glucuronide
* Scutellarein-7-glucuronide

## References

1. ↑ The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company
2. ↑ "Glucuronidation: driving factors and their impact on glucuronide disposition". Drug Metabolism Reviews 49 (2): 105–138. May 2017. doi:10.1080/03602532.2017.1293682. PMID 28266877.

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