Kairine

Names
Preferred IUPAC name

1-Methyl-1,2,3,4-tetrahydroquinolin-8-ol

Identifiers

CAS Number

* 5080-60-4 Y

3D model (JSmol)

* Interactive image

ChemSpider |

* 15544231 N

PubChem CID

* 12945981

UNII |

* L2F6AD5R4V Y

InChI

* InChI=1S/C10H13NO/c1-11-7-3-5-8-4-2-6-9(12)10(8)11/h2,4,6,12H,3,5,7H2,1H3 N

Key: AXONCVPTTFHNOI-UHFFFAOYSA-N N

* InChI=1/C10H13NO/c1-11-7-3-5-8-4-2-6-9(12)10(8)11/h2,4,6,12H,3,5,7H2,1H3

Key: AXONCVPTTFHNOI-UHFFFAOYAE

SMILES

* CN1CCCC2=C1C(=CC=C2)O

Properties

Chemical formula

| C10H13NO
Molar mass | 163.220 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)
Infobox references

Tracking categories (test):

* SizeSet

Kairine is a derivative of tetrahydroquinoline which was first described by Wilhelm Fischer in 1883. Its name comes from the Greek kairos, meaning "the right time".[1] It is an antipyretic, formerly used against typhoid fever, but now largely obsolete due to severe side effects. Both kairine and its N-ethyl homolog show similar antipyretic activity.[2][3][4][5]

## See also

* 8-Hydroxyquinoline

## References

1. ↑ W.E.Flood (1963). The Origins of Chemical Names. Oldbourne Book Co Ltd. pp. 126.
2. ↑ Fischer, Wilhelm (1883). "On Kairine and Kairoline". New Remedies 12 (2): 41. https://books.google.com/books?id=UVBHAQAAMAAJ&pg=PA41.
3. ↑ Fruitnight, J. Henry (1886). "Kairine and Antipyrine". Medical Record 29 (23): 646–648. https://books.google.com/books?id=xNM-AQAAMAAJ&pg=PA646.
4. ↑ Bockmuhl M, Dorzbach E. Antipyretics of the tetrahydroquinoline series. Med. u. Chem. (1942) 4: 179-212.
5. ↑ Slater, Leo Barney (2009). War and Disease: Biomedical Research on Malaria in the Twentieth Century. Rutgers University Press. p. 26. ISBN 978-0-8135-4438-0.

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*[CID]: Compound ID