POLK

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

DNA polymerase kappa is a DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis.[1][2][3]

## References

1. ↑ "Error-prone bypass of certain DNA lesions by the human DNA polymerase κ". Genes Dev 14 (13): 1589–94. Aug 2000. doi:10.1101/gad.14.13.1589. PMID 10887153.
2. ↑ "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily". Proc Natl Acad Sci U S A 96 (21): 11922–7. Nov 1999. doi:10.1073/pnas.96.21.11922. PMID 10518552. Bibcode: 1999PNAS...9611922G.
3. ↑ "Entrez Gene: POLK Polymerase (DNA directed) kappa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51426.

## Further reading

* "Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa". Biochimie 87 (7): 637–46. 2005. doi:10.1016/j.biochi.2005.02.007. PMID 15989980.
* "Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB". Genes Cells 4 (11): 607–18. 2000. doi:10.1046/j.1365-2443.1999.00289.x. PMID 10620008.
* "The human DINB1 gene encodes the DNA polymerase Polθ". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3838–43. 2000. doi:10.1073/pnas.97.8.3838. PMID 10760255. Bibcode: 2000PNAS...97.3838J.
* "Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene". J. Biol. Chem. 276 (1): 92–8. 2001. doi:10.1074/jbc.M004413200. PMID 11024016.
* "Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA". Mol. Cell. Biol. 22 (3): 784–91. 2002. doi:10.1128/MCB.22.3.784-791.2002. PMID 11784855.
* "Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 1910–4. 2002. doi:10.1073/pnas.032594399. PMID 11842189. Bibcode: 2002PNAS...99.1910W.
* "Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)". Biochemistry 41 (19): 6100–6. 2002. doi:10.1021/bi020049c. PMID 11994005.
* "Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides". J. Biol. Chem. 277 (40): 37604–11. 2002. doi:10.1074/jbc.M206027200. PMID 12145297.
* "Localisation of human DNA polymerase kappa to replication foci". J. Cell Sci. 115 (Pt 23): 4413–8. 2003. doi:10.1242/jcs.00162. PMID 12414988.
* "Role of human DNA polymerase κ as an extender in translesion synthesis". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16000–5. 2003. doi:10.1073/pnas.252524999. PMID 12444249.
* "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
* "Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions". Genes Dev. 17 (17): 2191–9. 2003. doi:10.1101/gad.1108603. PMID 12952891.
* "A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair". Genes Dev. 17 (22): 2777–85. 2003. doi:10.1101/gad.1146103. PMID 14630940.
* "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
* "Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa". Biochemistry 43 (20): 6304–11. 2004. doi:10.1021/bi0360298. PMID 15147214.
* "Interaction of hREV1 with three human Y-family DNA polymerases". Genes Cells 9 (6): 523–31. 2005. doi:10.1111/j.1356-9597.2004.00747.x. PMID 15189446.
* "Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ". Mol. Cell. Biol. 24 (13): 5687–93. 2004. doi:10.1128/MCB.24.13.5687-5693.2004. PMID 15199127.
* "Crystal structure of the catalytic core of human DNA polymerase kappa". Structure 12 (8): 1395–404. 2005. doi:10.1016/j.str.2004.05.011. PMID 15296733.

## External links

* Overview of all the structural information available in the PDB for UniProt: Q9UBT6 (DNA polymerase kappa) at the PDBe-KB.

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PDB gallery

* 1t94: Crystal structure of the catalytic core of human DNA polymerase kappa

* 2oh2: Ternary Complex of Human DNA Polymerase

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