Plague (disease)

This article is about the disease caused by Yersinia pestis. For other uses, see Plague.

Plague

Yersinia pestis seen at 200× magnification with a fluorescent label.
Specialty| Infectious disease
Symptoms| Fever, weakness, headache[1]
Usual onset| 1-7 days after exposure[2]
Types| Bubonic plague, septicemic plague, pneumonic plague[1]
Causes| Yersinia pestis[2]
Diagnostic method| Finding the bacterium in a lymph node, blood, sputum[2]
Prevention| Plague vaccine[2]
Treatment| Antibiotics and supportive care[2]
Medication| Gentamicin and a fluoroquinolone[3]
Prognosis| ~10% risk of death (with treatment)[4]
Frequency| ~600 cases a year[2]

bew:Ambah-ambah Plague is an infectious disease caused by the bacterium Yersinia pestis.[2] Symptoms include fever, weakness and headache.[1] Usually this begins one to seven days after exposure.[2] In the bubonic form there is also swelling of lymph nodes, while in the septicemic form tissues may turn black and die, and in the pneumonic form shortness of breath, cough and chest pain may occur.[1]

Bubonic and septicemic plague are generally spread by flea bites or handling an infected animal.[1] The pneumonic form is generally spread between people through the air via infectious droplets.[1] Diagnosis is typically by finding the bacterium in fluid from a lymph node, blood or sputum.[2]

Those at high risk may be vaccinated.[2] Those exposed to a case of pneumonic plague may be treated with preventive medication.[2] If infected, treatment is with antibiotics and supportive care.[2] Typically antibiotics include a combination of gentamicin and a fluoroquinolone.[3] The risk of death with treatment is about 10% while without it is about 70%.[4]

Globally, about 600 cases are reported a year.[2] In 2017, the countries with the most cases include the Democratic Republic of the Congo, Madagascar and Peru.[2] In the United States, infections occasionally occur in rural areas, where the bacteria are believed to circulate among rodents.[5] It has historically occurred in large outbreaks, with the best known being the Black Death in the 14th century, which resulted in more than 50 million deaths.[2]

## Contents

* 1 Signs and symptoms
* 1.1 Bubonic plague
* 1.2 Septicemic plague
* 1.3 Pneumonic plague
* 2 Cause
* 3 Diagnosis
* 4 Prevention
* 4.1 Vaccination
* 4.2 Early diagnosis
* 5 Treatments
* 6 Epidemiology
* 7 Biological weapon
* 8 References
* 9 External links

## Signs and symptoms[edit | edit source]

### Bubonic plague[edit | edit source]

Main article: Bubonic plague

Swollen inguinal lymph glands on a person infected with the bubonic plague. The swollen lymph glands are termed buboes from the Greek word for groin, swollen gland: bubo.

When a flea bites a human and contaminates the wound with regurgitated blood, the plague-causing bacteria are passed into the tissue. Y. pestis can reproduce inside cells, so even if phagocytosed, they can still survive. Once in the body, the bacteria can enter the lymphatic system, which drains interstitial fluid. Plague bacteria secrete several toxins, one of which is known to cause beta-adrenergic blockade.[6]

Y. pestis spreads through the lymphatic vessels of the infected human until it reaches a lymph node, where it causes acute lymphadenitis.[7] The swollen lymph nodes form the characteristic buboes associated with the disease,[8] and autopsies of these buboes have revealed them to be mostly hemorrhagic or necrotic.[9]

If the lymph node is overwhelmed, the infection can pass into the bloodstream, causing secondary septicemic plague and if the lungs are seeded, it can cause secondary pneumonic plague.[10]

### Septicemic plague[edit | edit source]

Main article: Septicemic plague

Septicemic plague resulting in necrosis

Lymphatics ultimately drain into the bloodstream, so the plague bacteria may enter the blood and travel to almost any part of the body. In septicemic plague, bacterial endotoxins cause disseminated intravascular coagulation (DIC), causing tiny clots throughout the body and possibly ischemic necrosis (tissue death due to lack of circulation/perfusion to that tissue) from the clots. DIC results in depletion of the body's clotting resources, so that it can no longer control bleeding. Consequently, there is bleeding into the skin and other organs, which can cause red and/or black patchy rash and hemoptysis/hematemesis (coughing up/ vomiting of blood). There are bumps on the skin that look somewhat like insect bites; these are usually red, and sometimes white in the center. Untreated, septicemic plague is usually fatal. Early treatment with antibiotics reduces the mortality rate to between 4 and 15 percent.[11][12][13] People who die from this form of plague often die on the same day symptoms first appear.[citation needed]

### Pneumonic plague[edit | edit source]

Main article: Pneumonic plague

The pneumonic form of plague arises from infection of the lungs. It causes coughing and thereby produces airborne droplets that contain bacterial cells and are likely to infect anyone inhaling them. The incubation period for pneumonic plague is short, usually two to four days, but sometimes just a few hours. The initial signs are indistinguishable from several other respiratory illnesses; they include headache, weakness and spitting or vomiting of blood. The course of the disease is rapid; unless diagnosed and treated soon enough, typically within a few hours, death may follow in one to six days; in untreated cases mortality is nearly 100%.[14][15]

## Cause[edit | edit source]

The Oriental rat flea (Xenopsylla cheopis) engorged with blood after a blood meal. This species of flea is the primary vector for the transmission of Yersinia pestis, the organism responsible for bubonic plague in most plague epidemics in Asia, Africa and South America. Both male and female fleas feed on blood and can transmit the infection. A child bitten by a flea infected with the bacterium Yersinia pestis. Y. pestis, a member of the family Yersiniaceae, has caused the bite to become ulcerated.

Transmission of Y. pestis to an uninfected individual is possible by any of the following means.[16]

* droplet contact – coughing or sneezing on another person
* direct physical contact – touching an infected person, including sexual contact
* indirect contact – usually by touching soil contamination or a contaminated surface
* airborne transmission – if the microorganism can remain in the air for long periods
* fecal-oral transmission – usually from contaminated food or water sources
* vector borne transmission – carried by insects or other animals.

Yersinia pestis circulates in animal reservoirs, particularly in rodents, in the natural foci of infection found on all continents except Australia. The natural foci of plague are situated in a broad belt in the tropical and sub-tropical latitudes and the warmer parts of the temperate latitudes around the globe, between the parallels 55 degrees North and 40 degrees South.[16] Contrary to popular belief, rats did not directly start the spread of the bubonic plague. It is mainly a disease in the fleas (Xenopsylla cheopis) that infested the rats, making the rats themselves the first victims of the plague. Rodent-borne infection in a human occurs when a person is bitten by a flea that has been infected by biting a rodent that itself has been infected by the bite of a flea carrying the disease. The bacteria multiply inside the flea, sticking together to form a plug that blocks its stomach and causes it to starve. The flea then bites a host and continues to feed, even though it cannot quell its hunger, and consequently the flea vomits blood tainted with the bacteria back into the bite wound. The bubonic plague bacterium then infects a new person and the flea eventually dies from starvation. Serious outbreaks of plague are usually started by other disease outbreaks in rodents, or a rise in the rodent population.[17]

A study of a 1665 outbreak of plague in the village of Eyam in England's Derbyshire Dales—which isolated itself during the outbreak, facilitating modern study—found that three-quarters of cases are likely to have been due to human-to-human transmission, especially within families, a much bigger proportion than previously thought.[18]

## Diagnosis[edit | edit source]

Symptoms of plague are usually non-specific and in order to definitively diagnose plague, laboratory testing is required.[19] Y pestis can be identified through both a microscope and by culturing a sample and this is used as a reference standard to confirm that a person has a case of plague.[19] The sample can be obtained from the blood, mucus (sputum), or aspirate extracted from inflamed lymph nodes (buboes).[19] If a person is administered antibiotics before a sample is taken or if there is a delay in transporting the person's sample to a laboratory and/or a poorly stored sample, there is a possibility for false negative results.[19]

Polymerase chain reaction (PCR) may also be used to diagnose plague, by detecting the presence of bacterial genes such as the pla gene (plasmogen activator) and caf1 gene, (F1 capsule antigen).[19] PCR testing requires a very small sample and is effective for both alive and dead bacteria.[19] For this reason, if a person receives antibiotics before a sample is collected for laboratory testing, they may have a false negative culture and a positive PCR result.[19]

Blood tests to detect antibodies against Y. pestis can also be used to diagnose plague, however, this requires taking blood samples at different periods of time in order to detect differences between the acute and convalescent phases of F1 antibody titres.[19]

A rapid diagnostic test that detects the F1 capsule antigen (F1RDT) has been developed. This test is easy to conduct and gives a result at the person's bedside in 15 minutes.[19] F1RDT testing requires a sample of sputum or bubo aspirate and can be used for people who have suspected pneumonic and bubonic plague. F1RDT cannot be used in people who are asymptomatic.[19] F1RDT may be useful in providing a fast result for prompt treatment and fast public health response as studies suggest that F1RDT is highly sensitive for both pneumonic and bubonic plague.[19] However, when using the rapid test, both positive and negative results need to be confirmed to establish or reject the diagnosis of a confirmed case of plague and the test result needs to be interpreted within the epidemiological context.[19]

## Prevention[edit | edit source]

Main article: Plague vaccine

### Vaccination[edit | edit source]

Since human plague is rare in most parts of the world as of 2020, routine vaccination is not needed other than for those at particularly high risk of exposure, nor for people living in areas with enzootic plague, meaning it occurs at regular, predictable rates in populations and specific areas, such as the western United States. It is not even indicated for most travelers to countries with known recent reported cases, particularly if their travel is limited to urban areas with modern hotels. The CDC thus only recommends vaccination for: (1) all laboratory and field personnel who are working with Y. pestis organisms resistant to antimicrobials: (2) people engaged in aerosol experiments with Y. pestis; and (3) people engaged in field operations in areas with enzootic plague where preventing exposure is not possible (such as some disaster areas).[20] A systematic review by the Cochrane Collaboration found no studies of sufficient quality to make any statement on the efficacy of the vaccine.[21]

### Early diagnosis[edit | edit source]

Diagnosing plague early leads to a decrease in transmission or spread of the disease.[19]

## Treatments[edit | edit source]

If diagnosed in time, the various forms of plague are usually highly responsive to antibiotic therapy. The antibiotics often used are streptomycin, chloramphenicol and tetracycline. Amongst the newer generation of antibiotics, gentamicin and doxycycline have proven effective in monotherapeutic treatment of plague.[22]

The plague bacterium could develop drug resistance and again become a major health threat. One case of a drug-resistant form of the bacterium was found in Madagascar in 1995.[23] Further outbreaks in Madagascar were reported in November 2014[24] and October 2017.[25]

## Epidemiology[edit | edit source]

Main article: Epidemiology of plague

Distribution of plague infected animals 1998

Globally about 600 cases are reported a year.[2] In 2017 the countries with the most cases include the Democratic Republic of the Congo, Madagascar and Peru.[2] It has historically occurred in large outbreaks, with the best known being the Black Death in the 14th century which resulted in greater than 50 million dead.[2]

## Biological weapon[edit | edit source]

Plague has a long history as a biological weapon. Historical accounts from ancient China and medieval Europe detail the use of infected animal carcasses, such as cows or horses, and human carcasses, by the Xiongnu/Huns, Mongols, Turks and other groups, to contaminate enemy water supplies. Han Dynasty General Huo Qubing is recorded to have died of such a contamination while engaging in warfare against the Xiongnu. Plague victims were also reported to have been tossed by catapult into cities under siege.[26]

In 1347, the Genoese possession of Caffa, a great trade emporium on the Crimean peninsula, came under siege by an army of Mongol warriors of the Golden Horde under the command of Jani Beg. After a protracted siege during which the Mongol army was reportedly withering from the disease, they decided to use the infected corpses as a biological weapon. The corpses were catapulted over the city walls, infecting the inhabitants. This event might have led to the transfer of the plague (Black Death) via their ships into the south of Europe, possibly explaining its rapid spread.[27]

During World War II, the Japanese Army developed weaponised plague, based on the breeding and release of large numbers of fleas. During the Japanese occupation of Manchuria, Unit 731 deliberately infected Chinese, Korean and Manchurian civilians and prisoners of war with the plague bacterium. These subjects, termed "maruta" or "logs", were then studied by dissection, others by vivisection while still conscious. Members of the unit such as Shiro Ishii were exonerated from the Tokyo tribunal by Douglas MacArthur but 12 of them were prosecuted in the Khabarovsk War Crime Trials in 1949 during which some admitted having spread bubonic plague within a 36-kilometre (22 mi) radius around the city of Changde.[28]

Ishii innovated bombs containing live mice and fleas, with very small explosive loads, to deliver the weaponized microbes, overcoming the problem of the explosive killing the infected animal and insect by the use of a ceramic, rather than metal, casing for the warhead. While no records survive of the actual usage of the ceramic shells, prototypes exist and are believed to have been used in experiments during WWII.[citation needed]

After World War II, both the United States and the Soviet Union developed means of weaponising pneumonic plague. Experiments included various delivery methods, vacuum drying, sizing the bacterium, developing strains resistant to antibiotics, combining the bacterium with other diseases (such as diphtheria), and genetic engineering. Scientists who worked in USSR bio-weapons programs have stated that the Soviet effort was formidable and that large stocks of weaponised plague bacteria were produced. Information on many of the Soviet and US projects are largely unavailable. Aerosolized pneumonic plague remains the most significant threat.[citation needed]

The plague can be easily treated with antibiotics. Some countries, such as the United States, have large supplies on hand if such an attack should occur, thus making the threat less severe.[29]

## References[edit | edit source]

1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Symptoms Plague". CDC. September 2015. Archived from the original on 19 August 2015. Retrieved 8 November 2017.
2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 "Plague". World Health Organization. October 2017. Archived from the original on 24 April 2015. Retrieved 8 November 2017.
3. ↑ 3.0 3.1 "Resources for Clinicians Plague". CDC. October 2015. Archived from the original on 21 August 2015. Retrieved 8 November 2017.
4. ↑ 4.0 4.1 "FAQ Plague". CDC. September 2015. Archived from the original on 20 June 2012. Retrieved 8 November 2017.
5. ↑ "Transmission Plague". CDC. September 2015. Archived from the original on 22 August 2015. Retrieved 8 November 2017.
6. ↑ Brown, SD; Montie, TC (1977). "Beta-adrenergic blocking activity of Yersinia pestis murine toxin". Infection and Immunity. 18 (1): 85–93. PMC 421197. PMID 198377. Archived from the original on 2021-08-28. Retrieved 2020-08-01.
7. ↑ Sebbane, F; Jarret, C.O.; Gardner, D; Long, D; Hinnebusch, B.J. (2006). "Role of Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague". Proc Natl Acad Sci U S A. 103 (14): 5526–5530. doi:10.1073/pnas.0509544103. PMC 1414629. PMID 16567636.
8. ↑ "Symptoms | Plague". Centers for Disease Control and Prevention. 14 September 2015. Archived from the original on 15 August 2019. Retrieved 18 April 2017.
9. ↑ Sebbane, F; Gardner, D; Long, D; Gowen, B.B.; Hinnebusch, B.J. (2005). "Kinetics of Disease Progression and Host Response in a Rat Model of Bubonic Plague". Am J Pathol. 166 (5): 1427–1439. doi:10.1016/S0002-9440(10)62360-7. PMC 1606397. PMID 15855643.
10. ↑ "Plague". Centers for Disease Control and Prevention. Archived from the original on 2015-08-21. Retrieved 2014-08-05.
11. ↑ Wagle PM (1948). "Recent advances in the treatment of bubonic plague". Indian J Med Sci. 2: 489–94.
12. ↑ Meyer KF (1950). "Modern therapy of plague". J Am Med Assoc. 144 (12): 982–85. doi:10.1001/jama.1950.02920120006003. PMID 14774219.
13. ↑ Datt Gupta AK (1948). "A short note on plague cases treated at Campbell Hospital". Ind Med Gaz. 83: 150–51.
14. ↑ Ryan, K. J.; Ray, C. G., eds. (2004). Sherris Medical Microbiology: An Introduction to Infectious Diseases (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-8529-0.
15. ↑ Hoffman SL (1980). "Plague in the United States: the "Black Death" is still alive". Annals of Emergency Medicine. 9 (6): 319–22. doi:10.1016/S0196-0644(80)80068-0. PMID 7386958.
16. ↑ 16.0 16.1 Plague Manual: Epidemiology, Distribution, Surveillance and Control, pp. 9, 11. WHO/CDS/CSR/EDC/99.2
17. ↑ Yersin, Alexandre (1894). "La peste bubonique à Hong-Kong". Annales de l'Institut Pasteur. 8: 662–67. Archived from the original on 2019-12-10. Retrieved 2020-08-01.
18. ↑ Greig Watson (22 April 2020). "Coronavirus: What can the 'plague village' of Eyam teach us?". BBC News. Archived from the original on 8 July 2020. Retrieved 1 August 2020.
19. ↑ 19.00 19.01 19.02 19.03 19.04 19.05 19.06 19.07 19.08 19.09 19.10 19.11 19.12 Jullien, Sophie; Dissanayake, Harsha A; Chaplin, Marty (2020-06-26). Cochrane Infectious Diseases Group (ed.). "Rapid diagnostic tests for plague". Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD013459.pub2. PMID 32597510. Archived from the original on 2021-08-28. Retrieved 2020-09-24.
20. ↑ "Plague Vaccine". CDC. June 11, 1982. Archived from the original on July 14, 2018. Retrieved Apr 30, 2015.
21. ↑ Jefferson T, Demicheli V, Pratt M (2000). Jefferson T (ed.). "Vaccines for preventing plague". Cochrane Database Syst Rev (2): CD000976. doi:10.1002/14651858.CD000976. PMC 6532692. PMID 10796565.
22. ↑ Mwengee W; Butler, Thomas; Mgema, Samuel; Mhina, George; Almasi, Yusuf; Bradley, Charles; Formanik, James B.; Rochester, C. George (2006). "Treatment of Plague with Genamicin or Doxycycline in a Randomized Clinical Trial in Tanzania". Clin Infect Dis. 42 (5): 614–21. doi:10.1086/500137. PMID 16447105.
23. ↑ Drug-resistant plague a 'major threat', say scientists Archived 2012-07-19 at the Wayback Machine, SciDev.Net.
24. ↑ "Plague – Madagascar". World Health Organisation. 21 November 2014. Archived from the original on 2 May 2019. Retrieved 26 November 2014.
25. ↑ "WHO scales up response to plague in Madagascar". World Health Organization (WHO). 1 October 2017. Archived from the original on 23 April 2018. Retrieved 5 October 2017.
26. ↑ Schama, S. (2000). A History of Britain: At the Edge of the World? 3000BC–AD1603, First Edition, BBC Worldwide, London, p226.
27. ↑ Wheelis M. (2002). "Biological warfare at the 1346 siege of Caffa". Emerg Infect Dis. 8 (9): 971–75. doi:10.3201/eid0809.010536. PMC 2732530. PMID 12194776. Archived from the original on 2008-05-21. Retrieved 2020-08-01.
28. ↑ Daniel Barenblatt, A plague upon Humanity, HarperCollns, 2004, pp. 220–21
29. ↑ Tamparo, Carol; Lewis, Marcia (2011). Diseases of the Human Body. Philadelphia, PA: F.A. Davis Company. p. 70\. ISBN 9780803625051.

## External links[edit | edit source]

* WHO Health topic Archived 2016-09-24 at the Wayback Machine
* CDC Plague Archived 2020-07-24 at the Wayback Machine map world distribution, publications, information on bioterrorism preparedness and response regarding plague
* Symptoms, causes, pictures of bubonic plague Archived 2008-12-01 at the Wayback Machine

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