List of opioids

Short description: None

Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

## Contents

* 1 Opium and poppy straw derivatives
* 1.1 Crude opiate extracts whole opium products
* 1.2 Natural opiates
* 1.2.1 Opium alkaloids
* 1.2.2 Alkaloid salts mixtures
* 1.3 Semisynthetics including Bentley compounds
* 1.3.1 Morphine family
* 1.3.2 3,6-diesters of morphine
* 1.3.3 Codeine-dionine family
* 1.3.4 Morphinones and morphols
* 1.3.5 Morphides
* 1.3.6 Dihydrocodeine series
* 1.3.7 Nitrogen morphine derivatives
* 1.3.8 Hydrazones
* 1.3.9 Halogenated morphine derivatives
* 1.4 Active opiate metabolites
* 2 Morphinans
* 2.1 Morphinan series
* 2.2 Others
* 3 Benzomorphans
* 4 4-Phenylpiperidines
* 4.1 Pethidines (meperidines)
* 4.2 Prodines
* 4.3 Ketobemidones
* 4.4 Others
* 5 Open chain opioids
* 5.1 Amidones
* 5.2 Methadols
* 5.3 Moramides
* 5.4 Thiambutenes
* 5.5 Phenalkoxams
* 5.6 Ampromides
* 5.7 Others
* 6 Anilidopiperidines
* 7 Oripavine derivatives
* 8 Phenazepanes
* 9 Pirinitramides
* 10 Benzimidazoles
* 11 Indoles
* 12 Beta-Amino Ketones
* 13 Diphenylmethylpiperazines
* 14 Opioid peptides
* 14.1 Dynorphins
* 14.2 Endomorphins
* 14.3 Endorphins
* 14.4 Enkephalins
* 14.5 Propeptides
* 14.6 Others / unknown
* 15 Others
* 16 Opioid antagonists and inverse agonists
* 17 Biased ligands
* 18 Receptor heteromer targeting ligands
* 19 Uncategorized opioids
* 20 Combination drug formulations containing opioids
* 21 See also
* 22 References
* 23 External links

## Opium and poppy straw derivatives

Seedhead of opium poppy with white latex

### Crude opiate extracts whole opium products

* B&O Supprettes
* Diascordium
* Dover's powder
* Kendal Black Drop
* Laudanum
* Mithridate
* Opium
* Polish heroin (Compote, Kompot)
* Paregoric
* Poppy straw concentrate
* Poppy tea
* Smoking opium
* Theriac

### Natural opiates

#### Opium alkaloids

* Codeine
* Morphine
* Oripavine
* Pseudomorphine
* Thebaine

Structures

Morphides

Codeine |  Morphine |  Oripavine |  Pseudomorphine |  Thebaine

#### Alkaloid salts mixtures

* Pantopon
* Papaveretum (Omnopon)
* Tetrapon

### Semisynthetics including Bentley compounds

#### Morphine family

* 14-Hydroxymorphine [1]
* 2,4-Dinitrophenylmorphine
* 6-Methyldihydromorphine [2]
* 6-Methylenedihydrodesoxymorphine
* 6-Acetyldihydromorphine [3]
* Azidomorphine
* Chlornaltrexamine
* Chloroxymorphamine [4]
* Desomorphine (dihydrodesoxymorphine)
* Dihydromorphine
* Ethyldihydromorphine [5][full citation needed]
* Hydromorphinol
* Methyldesorphine
* Morphine methylbromide
* N-Phenethylnordesomorphine
* N-Phenethyl-14-ethoxymetopon
* N-Phenethylnormorphine
* 6-Nicotinoyldihydromorphine (metabolite of nicodicodeine)
* RAM-378
* Ro-1539

Structures of Morphine family

Morphine family

14-Hydroxymorphine | 2,4-Dinitrophenylmorphine | 6-Methyldihydromorphine | 6-Methylenedihydrodesoxymorphine | 6-Acetyldihydromorphine hydrochloride
Azidomorphine |  Chlornaltrexamine |  Chloroxymorphamine | Desomorphine
(Dihydrodesoxymorphine) |  Dihydromorphine
Ethyldihydromorphine  |  Hydromorphinol |  Methyldesorphine |  N-Phenethylnormorphine | 6-nicotinoyldihydromorphine
RAM-378

#### 3,6-diesters of morphine

* Acetylpropionylmorphine
* 3,6-Dibutanoylmorphine
* Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
* Dibutyrylmorphine [1]
* Dibenzoylmorphine (first designer drug)
* Diformylmorphine
* Dipropanoylmorphine
* Heroin (diacetylmorphine)
* Nicomorphine

Structures

3,6-diesters of morphine

Acetylpropionylmorphine | 3,6-Dibutanoylmorphine  | Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Dibutyrylmorphine |  Dibenzoylmorphine |  Diformylmorphine
Dipropanoylmorphine | Heroin
(diacetylmorphine) |  Nicomorphine

#### Codeine-dionine family

* 6-Monoacetylcodeine
* Benzylmorphine
* Codeine methylbromide
* Desocodeine [2] [yes|permanent dead link|dead link}}]
* Dimethylmorphine (6-O-Methylcodeine)
* Ethyldihydromorphine [3] [yes|permanent dead link|dead link}}]
* Methyldihydromorphine (dihydroheterocodeine)
* Ethylmorphine (dionine)
* Heterocodeine
* Isocodeine [4]
* Pholcodine (morpholinylethylmorphine)
* Myrophine
* Thebacon
* Transisocodeine [5]

Structures

Codeine-dionine family

6-Monoacetylcodeine |  Benzylmorphine | Codeine methylbromide |  Desocodeine |  Dimethylmorphine
(6-O-Methylcodeine)
Ethyldihydromorphine  |  Methyldihydromorphine
(dihydroheterocodeine) | Ethylmorphine |  Heterocodeine |  Isocodeine
Pholcodine |  Myrophine |  Transisocodeine

#### Morphinones and morphols

* 14-Cinnamoyloxycodeinone
* 14-Ethoxymetopon
* 14-Methoxymetopon
* 14-Phenylpropoxymetopon
* 3-Acetyloxymorphone
* 3,14-Diacetyloxymorphone
* 7-Spiroindanyloxymorphone
* 8,14-Dihydroxydihydromorphinone [6]
* Acetylcodone
* Acetylmorphone
* α-hydrocodol (=dihydrocodeine, )
* Benzhydrocodone
* Bromoisopropropyldihydromorphinone cas?
* Codeinone
* Codoxime
* Conorfone (codorphone)
* IBNtxA
* Thebacon (acetyldihydrocodeinone, dihydrocodeinone enol acetate)
* Hydrocodone
* Hydromorphone
* Hydroxycodeine [7]
* Metopon (=methyldihydromorphinone)
* Morphenol [8]
* Morphinone
* Morphol [9]
* N-Phenethyl-14-ethoxymetopon
* Noroxymorphone
* Oxycodone
* Oxymorphol
* Oxymorphone
* Pentamorphone
* Semorphone

Structures

Morphinones and morphols

14-Cinnamoyloxycodeinone |  14-Ethoxymetopon |  14-Methoxymetopon |  14-Phenylpropoxymetopon |  7-Spiroindanyloxymorphone
8,14-Dihydroxydihydromorphinone  |  Acetylcodone  |  Acetylmorphone |  α-hydrocodol
(Dihydrocodeine) |  Bromoisopropropyldihydromorphinone
Codeinone |  Codorphone  |  Codol
(Codeine Phosphate)  |  Codoxime |  IBNtxA
Thebacon |  Hydrocodone |  Hydromorphone |  Hydroxycodeine  | Metopon
(methyldihydromorphinone)
Morphenol  |  Morphinone |  Morphol  |  N-Phenethyl-14-ethoxymetopon |  Oxycodone
Oxymorphol |  Oxymorphone |  Pentamorphone |  Semorphone |

#### Morphides

* α-Chlorocodide (= chlorocodide) [10]
* β-Chlorocodide [11]
* α-Chloromorphide (= chloromorphide)
* Bromocodide [12]
* Bromomorphide [13]
* Chlorodihydrocodide [14]
* Chloromorphide
* Codide [15]

Structures

Morphides

α-chlorocodide  |  β-chlorocodide  |  Bromomorphide
Chlorodihydrocodide.  |  Chloromorphide |  Codide

#### Dihydrocodeine series

* 14-Hydroxydihydrocodeine
* Acetyldihydrocodeine
* Dihydrocodeine
* Dihydrodesoxycodeine (desocodeine)
* Dihydroisocodeine
* Nicocodeine
* Nicodicodeine

Structures

Morphides

14-Hydroxydihydrocodeine |  Acetyldihydrocodeine |  Dihydrocodeine |  Dihydrodesoxycodeine
Dihydroisocodeine |  Nicocodeine |  Nicodicodeine |

#### Nitrogen morphine derivatives

* 1-Nitrocodeine cas? [16]
* Codeine-N-oxide [17]
* Morphine-N-oxide

Structures

Morphides

1-Nitrocodeine  |  Codeine-N-oxide |  Morphine-N-oxide

#### Hydrazones

* Oxymorphazone

Structures

Hydrazones

Oxymorphazone

#### Halogenated morphine derivatives

* 1-Bromocodeine
* 1-Chlorocodeine
* 1-Iodomorphine

Structures

Other open chain opioids

1-Bromocodeine

1-Chlorocodeine

1-Iodomorphine

### Active opiate metabolites

* Codeine-6-glucuronide
* Codeine-N-oxide (genocodeine)[18]
* Heroin-7,8-oxide [19]
* Morphine-6-glucuronide
* 3-Monoacetylmorphine
* 6-Monoacetylmorphine
* Morphine-N-oxide (genomorphine)
* Naltrexol [20]
* Norcodeine
* Normorphine

Structures

Active opiate metabolites

Codeine-N-oxide | Heroin-7,8-oxide | Morphine-6-glucuronide | 6-Monoacetylmorphine
Morphine-N-oxide |  Naltrexol  |  Norcodeine |  Normorphine

## Morphinans

Levomethorphan

### Morphinan series

* 3-Hydroxymorphinan
* 4-Chlorophenylpyridomorphinan [21]
* Cyclorphan
* Levargorphan [22]
* Levorphanol
* Levophenacylmorphan
* Levomethorphan
* Methorphan (racemethorphan)
* Morphanol (racemorphanol)
* Norlevorphanol
* N-Methylmorphinan [23]
* Oxilorphan
* Phenomorphan
* Proxorphan
* Ro4-1539
* Stephodeline [24] [yes|permanent dead link|dead link}}]Xorphanol

Structures

Other morphinans

4-chlorophenylpyridomorphinan  |  Cyclorphan |  Dextrallorphan |  Levargorphan  |  Levophenacylmorphan
Levomethorphan |  Norlevorphanol |  N-Methylmorphinan  |  Oxilorphan |  Phenomorphan
Dextromethorphan 70 px|Chemical structure of Levomethorphan. levomethorphan |  Morphanol  |  Ro4-1539 |  Stephodeline  |  Xorphanol

### Others

* 1-Nitroaknadinine * 14-episinomenine
* 5,6-Dihydronorsalutaridine
* 6-Keto Nalbuphine
* Aknadinine
* Butorphanol
* Cephakicine
* Cephasamine
* Cyprodime
* Drotebanol
* Fenfangjine G
* Ketorfanol
* Nalbuphine
* Nalbuphone
* Tannagine

Structures

Other Morphinans

1-Nitroaknadinine  |  14-episinomenine  |  5,6-Dihydronorsalutaridine  |  6-Keto Nalbuphine  |  Aknadinine
Butorphanol |  Cephakicine  |  Cephasamine  |  Cyprodime |  Drotebanol
Fenfangjine G  |  Nalbuphine |  Sinococuline |  Sinomenine |  Tannagine

## Benzomorphans

* 5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB) [25]
* 8-Carboxamidocyclazocine (8-CAC)
* Alazocine
* Anazocine [26]
* Bremazocine
* Butinazocine [27]
* Carbazocine [28]
* Cogazocine
* Cyclazocine
* Dezocine
* Eptazocine
* Etazocine [29] [yes|permanent dead link|dead link}}]
* Ethylketazocine [30]
* Fedotozine
* Fluorophen [31]
* Gemazocine [32] [yes|permanent dead link|dead link}}]
* Ibazocine [33] [yes|permanent dead link|dead link}}]
* Ketazocine
* Metazocine
* Moxazocine [34]
* Pentazocine
* Phenazocine
* Quadazocine [35]
* SKF-10047

[36]\-->

* Tonazocine
* Volazocine
* Zenazocine[37]

Structures

Benzomorphans

5,9 alpha-diethyl-2-hydroxybenzomorphan
(5,9-DEHB) |  8-Carboxamidocyclazocine |  Alazocine |  Anazocine |  Bremazocine
Butinazocine |  Carbazocine |  Cogazocine |  Cyclazocine |  Dezocine
Eptazocine |  Etazocine |  Ethylketocyclazocine  |  Fedotozine |  Fluorophen
Gemazocine |  Ibazocine |  Ketazocine |  Metazocine |  Moxazocine
Pentazocine |  Phenazocine |  Quadazocine |  Thiazocine  |  Tonazocine
Volazocine |  Zenazocine |

## 4-Phenylpiperidines

Pethidine

### Pethidines (meperidines)

* 4-Fluoropethidine
* Allylnorpethidine
* Anileridine
* Benzethidine
* Carperidine
* Difenoxin
* Diphenoxylate
* Etoxeridine (carbetidine)
* Furethidine
* Hydroxypethidine (bemidone)
* Morpheridine
* Meperidine-N-oxide
* Oxpheneridine (carbamethidine)
* Pethidine (meperidine)
* Pethidine intermediate A
* Pethidine intermediate B (norpethidine)
* Pethidine intermediate C (pethidinic acid)
* Pheneridine
* Phenoperidine
* Piminodine
* Properidine (ipropethidine)
* Sameridine

Structures

Pethidines (meperidines)

4-Fluoropethidine |  8-Carboxamidocyclazocine |  Allylnorpethidine |  Anileridine |  Benzethidine
Carperidine |  Difenoxin |  Diphenoxylate |  Etoxeridine |  Furethidine
Hydroxypethidine |  Morpheridine |  Meperidine-N-oxide  |  Oxpheneridine |  Pethidine
Pethidine intermediate A |  Pethidine intermediate B  |  Pethidine intermediate C  |  Pheneridine |  Phenoperidine
Piminodine | Properidine |  Sameridine |

### Prodines

* Allylprodine
* (α/β)-Meprodine
* Desmethylprodine (MPPP)
* PEPAP
* (α/β)-Prodine
* Prosidol
* Trimeperidine (promedol)

Structures

Prodines

Allylprodine |  (α/β)-Meprodine |  Desmethylprodine (MPPP) |  PEPAP |  Prodine
Prosidol |  Prosidol |

### Ketobemidones

* Acetoxyketobemidone
* Droxypropine
* Ketobemidone
* Methylketobemidone
* Propylketobemidone

Structures

Ketobemidones

Acetoxyketobemidone |  Droxypropine |  Ketobemidone |  Methylketobemidone |  Propylketobemidone |

### Others

* Alvimopan
* Loperamide
* LS-115509
* Picenadol

Structures

Other phenylpiperidines

Alvimopan |  Loperamide |  LS-115509 |  Picenadol

## Open chain opioids

Methadone

### Amidones

* Dextromethadone
* Dipipanone
* Isomethadone=
* Levoisomethadone
* Levomethadone
* Methadone
* Methadone intermediate [38]
* Normethadone
* Norpipanone [39]
* Phenadoxone (heptazone)

Structures

Amidones

Dextromethadone

Dipipanone

Isomethadone

|  Levoisomethadone
Noracetylmethadol  |  Levomethadone |  Methadone | Methadone intermediate
Normethadone |  Norpipanone |  Phenadoxone |  Pipidone

### Methadols

* Acetylmethadol
* Alphaacetylmethadol
* Alphamethadol
* Betacetylmethadol
* Betamethadol
* Dimepheptanol (racemethadol)
* Isomethadol
* Levacetylmethadol
* Noracymethadol

Structures

Other open chain opioids

Alphaacetylmethadol

Dimepheptanol

Levacetylmethadol

Noracetylmethadol

### Moramides

* Desmethylmoramide
* Dextromoramide
* Levomoramide
* Moramide intermediate [40]
* Racemoramide

Structures

Other open chain opioids

Desmethylmoramide

Dextromoramide

Levomoramide

Moramide intermediate

Racemoramide

### Thiambutenes

* Diethylthiambutene
* Dimethylthiambutene
* Ethylmethylthiambutene
* Piperidylthiambutene
* Pyrrolidinylthiambutene
* Thiambutene

Structures

Thiambutenes

Diethylthiambutene

Dimethylthiambutene

Ethylmethylthiambutene

Piperidylthiambutene

Thiambutene

Tipepidine

### Phenalkoxams

* Dextropropoxyphene (propoxyphene)
* Dimenoxadol
* Dioxaphetyl butyrate
* Levopropoxyphene
* Norpropoxyphene
* Pyrroliphene

Structures

Phenalkoxams

Error creating thumbnail: Unable to save thumbnail to destination

Dextropropoxyphene
(propoxyphene)

Dimenoxadol

Dioxaphetyl butyrate

Levopropoxyphene

Norpropoxyphene

### Ampromides

* Diampromide
* Phenampromide
* Propiram

Structures

Ampromides

Diampromide

Phenampromide

Propiram

### Others

* Embutramide
* IC-26
* Isoaminile
* Lefetamine
* R-4066

Structures

Other open chain opioids

Embutramide

IC-26

Isoaminile

Lefetamine

R-4066

## Anilidopiperidines

Fentanyl

* 3-Allylfentanyl
* 3-Methylfentanyl
* 3-Methylthiofentanyl
* 4-Phenylfentanyl
* Alfentanil
* α-Methylacetylfentanyl
* α-Methylfentanyl
* α-Methylthiofentanyl
* Benzylfentanyl [41]
* β-hydroxyfentanyl
* β-hydroxythiofentanyl
* β-Methylfentanyl
* Brifentanil
* Butyrfentanyl
* Carfentanil
* Fentanyl
* Lofentanil
* N-Methylcarfentanil
* Mirfentanil
* Ocfentanil
* Ohmefentanyl
* Parafluorofentanyl
* Phenaridine
* R-30490
* Remifentanil
* Sufentanil
* Thenylfentanyl [42]
*   * Thiofentanyl
* Trefentanil

Structures

Anilidopiperidines

3-Allylfentanyl | 3-Methylfentanyl | 3-Methylthiofentanyl | 4-Phenylfentanyl |  Alfentanil
Alphamethylacetylfentanyl  |  Alphamethylfentanyl  |  Alphamethylthiofentanyl |  Benzylfentanyl |  Betahydroxyfentanyl
Betahydroxythiofentanyl |  Betamethylfentanyl  |  Brifentanil |  Carfentanil |  Fentanyl
Lofentanil |  Mirfentanil |  Ocfentanil |  Ohmefentanyl |  Parafluorofentanyl
Phenaridine |  Remifentanil |  Sufentanil |  Thenylfentanyl |  Thiofentanyl
Trefentanil

## Oripavine derivatives

Thienorphine

* 7-PET
* Acetorphine
* Alletorphine (N-allyl-noretorphine)
* BU-48
* Buprenorphine
* Buprenorphine-3-glucuronide
* Cyprenorphine
* Dihydroetorphine
* Etorphine
* Homprenorphine
* 18,19-Dehydrobuprenorphine (HS-599) [43] [44]
* N-cyclopropylmethylnoretorphine [45]
* Nepenthone [46] [47]
* Norbuprenorphine
* Norbuprenorphine-3-glucuronide
* Thevinone [48]
* Thienorphine [49]

Structures

Oripavine derivatives

7-PET |  Acetorphine |  Alletorphine |  BU-48 |  Buprenorphine
Cyprenorphine |  Dihydroetorphine |  Etorphine |  Homprenorphine | 18,19-Dehydrobuprenorphine
N-cyclopropylmethylnoretorphine |  Nepenthone  |  Norbuprenorphine |  Thevinone |  Thienorphine

## Phenazepanes

* Ethoheptazine
* Meptazinol
* Metheptazine
* Metethoheptazine
* Proheptazine

Structures

Phenazepanes

Ethoheptazine

Meptazinol

Metheptazine

Metethoheptazine

Proheptazine

## Pirinitramides

* Bezitramide
* Piritramide

Structures

Pirinitramides

Bezitramide

Piritramide

## Benzimidazoles

* Clonitazene
* Etonitazene
* Isotonitazene
* Metonitazene

Structures

Benzimidazoles

Clonitazene

Etonitazene

Isotonitazene

Metonitazene

Nitazene: R = hydrogen

## Indoles

* 18-Methoxycoronaridine
* 7-Acetoxymitragynine
* 7-Hydroxymitragynine
* ψ-Akuammigine
* Akuammidine
* Akuammine
* Coronaridine
* Eseroline
* Hodgkinsine
* Ibogaine
* Mitragynine
* Mitragynine pseudoindoxyl
* Noribogaine
* Pericine
* Pseudoakuammigine

Structures

Indoles

18-Methoxycoronaridine

7-Acetoxymitragynine

7-Hydroxymitragynine

Akuammidine

Akuammine

Eseroline

Hodgkinsine

Mitragynine

Pericine

Pseudoakuammigine

## Beta-Amino Ketones

* 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one

Structures

| Indoles

|

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

## Diphenylmethylpiperazines

* BW373U86
* DPI-221
* DPI-287
* DPI-3290
* SNC-80
* AZD-2327

Structures

Diphenylmethylpiperazines

BW373U86

DPI-221

DPI-287

DPI-3290

SNC-80

## Opioid peptides

β-neoendorphin

### Dynorphins

* Big dynorphin
* Dynorphin A
* Dynorphin B
* Leumorphin

Structures

Dynorphins

Big dynorphin |  Dynorphin A | Error creating thumbnail: Unable to save thumbnail to destination Dynorphin B

### Endomorphins

* Endomorphin-1
* Endomorphin-2

### Endorphins

* α-Endorphin
* β-Endorphin
* γ-Endorphin
* α-Neoendorphin
* β-Neoendorphin

Structures

Dynorphins

Beta-endorphin  |  Alpha-endorphin  |  Gamma-endorphin  |  α-neoendorphin  |  β-neoendorphin

### Enkephalins

* DADLE
* DAMGO
* Deltorphin
* Met-enkephalin
* Leu-enkephalin

Structures

Enkephalins

DADLE |  DAMGO |  Deltorphin |  Met-enkephalin |  Leu-enkephalin

### Propeptides

* Proenkephalin
* Proendorphin
* Proopiomelanocortin

### Others / unknown

* Adrenorphin
* Amidorphin
* Biphalin
* Casokefamide
* Casomorphins
* Cytochrophin-4
* DALDA (Tyr-D-Arg-Phe-Lys-NH2)[50]
* Deltorphin I
* Deltorphin II
* Deprolorphin
* Dermorphin
* DPDPE
* Frakefamide
* Gliadorphin
* Gluten exorphins
* Hemorphin-4
* Metkefamide
* Morphiceptin
* Nociceptin
* Octreotide
* Opiorphin
* Rubiscolin
* Soymorphins
* Spinorphin
* TRIMU 5
* Tynorphin
* Valorphin
* Zyklophin

Structures

Other or unknown opioid peptides

Adrenorphin |  Amidorphin |  Casomorphin |  DALDA  |  Deltorphin
Dermorphin |  DPDPE |  Endomorphin-1
135 px|Chemical structure of Endomorphin-2. Endomorphin-2 |  Gliadorphin  |  Morphiceptin
Nociceptin |  Octreotide |  Opiorphin |  Rubiscolin  |  TRIMU 5

## Others

* 3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane
* AD-1211
* AH-7921
* Axomadol
* Azaprocin
* BDPC
* Bisnortilidine [51] [52]
* BRL-52537
* Bromadol
* Bromadoline
* Ciprefadol
* Ciramadol
* Doxpicomine
* Enadoline
* Faxeladol
* GR-89696
* Herkinorin
* ICI-199,441
* ICI-204,448
* Ketamine
* KNT-42
* LPK-26
* Lufuradom
* Metofoline
* MT-45
* Desmethylclozapine
* Nexeridine
* NNC 63-0532
* Nortilidine
* O-Desmethyltramadol
* Phenadone
* Phencyclidine
* Prodilidine
* Profadol
* Ro64-6198
* Salvinorin A
* Salvinorin B ethoxymethyl ether
* Salvinorin B methoxymethyl ether
* SB-612,111
* SC-17599
* RWJ-394,674
* TAN-67
* Tapentadol
* Thiobromadol (C-8813)
* Tifluadom
* Tilidine
* Tramadol
* Trimebutine
* U-47700
* U-50,488
* U-69,593
* Viminol
* 1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18)

## Opioid antagonists and inverse agonists

* 4-Caffeoyl-1,5-quinide
* 5'-Guanidinonaltrindole
* β-Funaltrexamine
* 6β-Naltrexol
* 6β-Naltrexol-d4
* Alvimopan
* AT-076
* Binaltorphimine
* BU09059
* Buprenorphine
* Chlornaltrexamine
* Clocinnamox
* Cyclazocine
* Cyprodime
* Diacetylnalorphine [53]
* Diprenorphine (M5050)
* Fedotozine
* ICI-174864
* J-113,397
* JDTic
* JTC-801
* Levallorphan
* LY-2456302
* LY-255582
* Methocinnamox
* Methylnaltrexone
* ML350
* Naldemedine
* Nalfurafine
* Nalmefene
* Nalmexone [54]
* Nalodeine (N-allylnorcodeine) [55]
* Naloxazone
* Naloxegol
* Naloxol
* Naloxonazine
* Naloxone
* Naloxone benzoylhydrazone
* Nalorphine
* Naltrexone
* Naltriben
* Naltrindole
* Norbinaltorphimine
* Oxilorphan
* PF-4455242
* S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)[56]
* Samidorphan
* SR-16430

## Biased ligands

* 6'-Guanidinonaltrindole
* 7-Hydroxymitragynine
* Herkinorin
* ICI-199,441
* Noribogaine
* Oliceridine
* RB-64
* TRV734

## Receptor heteromer targeting ligands

* 6'-GNTI (δ-κ)
* CYM-51010 (δ-μ)[6]
* NNTA (κ-μ)[7]
* IBNtxA (μ1G-NOP)

## Uncategorized opioids

* ADL-5859
* Alimadol
* Amentoflavone
* Anilopam +HCl
* Asimadoline
* Cyproterone acetate
* FE 200665
* Fedotozine
* HZ-2
* Kolokol-1
* Matrine
* MCOPPB
* Menthol
* MT-7716
* Nalfurafine
* Nalorphine
* Nalorphine dinicotinate
* PZM21
* Proglumide
* Ro65-6570
* SoRI-9409
* Spiradoline
* SR-8993
* SR-16435

Structures

Uncategorized opioids

Alimadol

Anilopam

Asimadoline

FE 200665

Fedotozine

MCOPPB

Nalfurafine

|  Nalodeine |

Nalorphine

Nalorphine dinicotinate

SoRI-9409

|  |

## Combination drug formulations containing opioids

* Buprenorphine/naloxone
* Buprenorphine/samidorphan (ALKS-5461)
* Co-codamol (codeine phosphate/paracetamol)
* Co-codaprin (codeine phosphate/aspirin)
* Co-dydramol (dihydrocodeine tartrate/paracetamol)
* Co-proxamol (dextropropoxyphene/paracetamol)
* Fentanyl/fluanisone
* Hydrocodone/ibuprofen
* Hydrocodone/paracetamol
* Loperamide/simethicone
* Morphine/naltrexone
* Naltrexone/bupropion
* Oxycodone/aspirin
* Oxycodone/naloxone
* Oxycodone/paracetamol

## See also

* List of opioids by visual 2D molecular skeletal renderings (bundled remotely, click "show" after following link)
* List of Schedule I drugs (US)
* Gray death

## References

1. ↑ ChemIndex CAS Registry Number 3371-56-0
2. ↑ ChemIndex CAS Registry Number 509-56-8
3. ↑ ChemIndex CAS Registry Number 63715-94-6
4. ↑ NCBI PubChem SID 750205
5. ↑ chembase [yes|permanent dead link|dead link}}] cbid_346222
6. ↑ "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. 2013. doi:10.1073/pnas.1222044110. PMID 23818586. Bibcode: 2013PNAS..11012072G.
7. ↑ "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. 2011. doi:10.1073/pnas.1016277108. PMID 21385944. Bibcode: 2011PNAS..108.5098Y.

## External links

* Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740

* v
* t
* e

Opioid receptor modulators

MOR|

* Agonists (abridged; see here for a full list): 3-HO-PCP
* 7-Acetoxymitragynine
* 7-Hydroxymitragynine
* ψ-Akuammigine
* α-Chlornaltrexamine
* α-Narcotine
* Acetyldihydrocodeine
* Acetylfentanyl
* Acrylfentanyl
* Adrenorphin (metorphamide)
* AH-7921
* Akuammicine
* Akuammidine
* Alfentanil
* Anileridine
* Apparicine
* β-Endorphin
* BAM-12P
* BAM-18P
* BAM-22P
* Benzhydrocodone
* Benzylmorphine
* Bezitramide
* Biphalin
* BU08070
* Buprenorphine
* Butorphan
* Butorphanol
* Butyrfentanyl
* BW373U86
* Carfentanil
* Casokefamide
* Cebranopadol
* Chloroxymorphamine
* Codeine
* DADLE
* DAMGO (DAGO)
* Dermorphin
* Desmetramadol (desmethyltramadol)
* Desomorphine
* Dextromoramide
* Dextropropoxyphene (propoxyphene)
* Dezocine
* Dimenoxadol
* Dimethylaminopivalophenone
* Eluxadoline
* Diamorphine (heroin)
* Dihydrocodeine
* Dihydroetorphine
* Dihydromorphine
* Dinalbuphine sebacate
* Diphenoxylate
* Dipipanone
* Dynorphin A
* Embutramide
* Endomorphin-1
* Endomorphin-2
* Eseroline
* Ethylmorphine
* Etorphine
* Fentanyl
* Fluorophen
* Frakefamide
* Furanylfentanyl
* Hemorphin-4
* Herkinorin
* Hodgkinsine
* Hydrocodone
* Hydromorphinol
* Hydromorphone
* IBNtxA
* Ketamine
* Ketobemidone
* Kratom
* Laudanosine
* Lefetamine
* Leu-enkephalin
* Levacetylmethadol
* Levomethorphan
* Levorphanol
* Lexanopadol
* Loperamide
* Loxicodegol
* Matrine
* Meptazinol
* Met-enkephalin (metenkefalin)
* Methadone
* Metkefamide
* Metopon
* Mitragynine
* Mitragynine pseudoindoxyl
* Morphiceptin
* Morphine
* Nalbuphine
* NalBzOH
* Nalmexone
* Naltalimide
* Neopine
* NFEPP
* Nicocodeine
* Nicodicodine
* Nicomorphine
* NKTR-181
* Norketamine
* Octreotide
* Oliceridine
* OM-3-MNZ
* Oripavine
* Oxycodone
* Oxymorphazone
* Oxymorphonazine
* Oxymorphone
* Oxymorphone phenylhydrazone
* OxyPNPH
* Papaver somniferum (opium)
* Pentazocine
* Pericine
* Pethidine (meperidine)
* Phenazocine
* Phencyclidine
* Piminodine
* Piritramide
* PL-017
* Prodine
* Propiram
* PZM21
* Racemethorphan
* Racemorphan
* Remifentanil
* Salsolinol
* SC-17599
* Sinomenine
* Sufentanil
* Tapentadol
* Tetrahydropapaveroline
* TH-030418
* Thebaine
* Thienorphine
* Tianeptine
* Tilidine
* Tramadol
* Trimebutine
* TRIMU 5
* TRV734
* Tubotaiwine
* U-47700
* Valorphin
* Viminol
* Xorphanol

* PAMs: BMS-986121
* BMS-986122

* Antagonists: (3S,4S)-Picenadol
* 2-(S)-N,N-(R)-Viminol
* 3CS-nalmefene
* 4-Caffeoyl-1,5-quinide
* 4′-Hydroxyflavanone
* 4',7-Dihydroxyflavone
* 6β-Naltrexol
* 6β-Naltrexol-d4
* 18-MC
* α-Gliadin
* β-Chlornaltrexamine
* β-Funaltrexamine
* Akuammine
* Alvimopan
* AM-251
* Apigenin
* AT-076
* Axelopran
* Bevenopran
* Catechin
* Catechin gallate
* Clocinnamox
* CTAP
* CTOP
* Cyclofoxy
* Cyprodime
* Diacetylnalorphine
* Diprenorphine
* ECG
* EGC
* Epicatechin
* Eptazocine
* Gemazocine
* Ginsenoside R
* Hyperoside
* Ibogaine
* Levallorphan
* Lobeline
* LY-255582
* LY-2196044
* Methocinnamox
* Methylnaltrexone
* Methylsamidorphan chloride
* Naldemedine
* Nalmefene
* Nalodeine (N-allylnorcodeine)
* Nalorphine
* Nalorphine dinicotinate
* Naloxazone
* Naloxegol
* Naloxol
* Naloxonazine
* Naloxone
* Naltrexazone
* Naltrexonazine
* Naltrexone
* Naltrindole
* Naringenin
* Noribogaine
* Oxilorphan
* Pawhuskin A
* Rimonabant
* Quadazocine
* Samidorphan
* Taxifolin

* Unknown/unsorted: Cannabidiol
* Coronaridine
* Cyproterone acetate
* Dihydroakuuamine
* Tabernanthine
* Tetrahydrocannabinol

DOR|

* Agonists: 3CS-nalmefene
* 6'-GNTI
* 7-SIOM
* ADL-5747 (PF-04856881)
* ADL-5859
* Alazocine (SKF-10047)
* Amoxapine
* AR-M100390 (ARM390)
* AZD2327
* β-Endorphin
* BAM-18P
* Biphalin
* BU-48
* Butorphan
* Butorphanol
* BW373U86
* Casokefamide
* Cebranopadol
* Codeine
* Cyclazocine
* DADLE
* Deltorphin A
* Deltorphin I
* Deltorphin II
* Desmethylclozapine
* Desmetramadol (desmethyltramadol)
* Dezocine
* Diamorphine (heroin)
* Dihydroetorphine
* Dihydromorphine
* DPDPE
* DPI-221
* DPI-3290
* DSLET
* Ethylketazocine
* Etorphine
* Fentanyl
* FIT
* Fluorophen
* Hemorphin-4
* Hydrocodone
* Hydromorphone
* Ibogaine
* Isomethadone
* JNJ-20788560
* KNT-127
* Kratom
* Laudanosine
* Leu-enkephalin
* Levomethorphan
* Levorphanol
* Lexanopadol
* Lofentanil
* Met-enkephalin (metenkefalin)
* Metazocine
* Metkefamide
* Mitragynine
* Mitragynine pseudoindoxyl
* Morphine
* N-Phenethyl-14-ethoxymetopon
* Norbuprenorphine
* NalBzOH
* Oripavine
* Oxycodone
* Oxymorphone
* Pethidine (meperidine)
* Proglumide
* Racemethorphan
* Racemorphan
* RWJ-394674
* Samidorphan
* SB-235863
* SNC-80
* SNC-162
* TAN-67 (SB-205,607)
* TH-030418
* Thebaine
* Thiobromadol (C-8813)
* Tonazocine
* Tramadol
* TRV250
* Xorphanol
* Zenazocine

* Antagonists: 4',7-Dihydroxyflavone
* 5'-NTII
* 6β-Naltrexol
* 6β-Naltrexol-d4
* α-Santolol
* β-Chlornaltrexamine
* Apigenin
* AT-076
* Axelopran
* Bevenopran
* BNTX
* Catechin
* Catechin gallate
* Clocinnamox
* Diacetylnalorphine
* Diprenorphine
* ECG
* EGC
* Eluxadoline
* Epicatechin
* ICI-154129
* ICI-174864
* LY-255582
* LY-2196044
* Methylnaltrexone
* Methylnaltrindole
* N-Benzylnaltrindole
* Nalmefene
* Nalorphine
* Naltrexone
* Naltriben
* Naltrindole
* Naloxone
* Naringenin
* Noribogaine
* Pawhuskin A
* Quadazocine
* SDM25N
* SoRI-9409
* Taxifolin
* Thienorphine

* Unknown/unsorted: 18-MC
* Cannabidiol
* Coronaridine
* Cyproterone acetate
* Tabernanthine
* Tetrahydrocannabinol

KOR|

* Agonists: 3CS-nalmefene
* 6'-GNTI
* 8-CAC
* 18-MC
* 14-Methoxymetopon
* β-Chlornaltrexamine
* β-Funaltrexamine
* Adrenorphin (metorphamide)
* Akuuamicine
* Alazocine (SKF-10047)
* Allomatrine
* Apadoline
* Asimadoline
* BAM-12P
* BAM-18P
* BAM-22P
* Big dynorphin
* Bremazocine
* BRL-52537
* Butorphan
* Butorphanol
* BW373U86
* Cebranopadol
* Ciprefadol
* CR665
* Cyclazocine
* Cyclorphan
* Cyprenorphine
* Desmetramadol (desmethyltramadol)
* Diamorphine (heroin)
* Diacetylnalorphine
* Difelikefalin
* Dihydroetorphine
* Dihydromorphine
* Dinalbuphine sebacate
* Diprenorphine
* Dynorphin A
* Dynorphin B (rimorphin)
* Eluxadoline
* Enadoline
* Eptazocine
* Erinacine E
* Ethylketazocine
* Etorphine
* Fedotozine
* Fentanyl
* Gemazocine
* GR-89696
* GR-103545
* Hemorphin-4
* Herkinorin
* HS665
* Hydromorphone
* HZ-2
* Ibogaine
* ICI-199,441
* ICI-204,448
* Ketamine
* Ketazocine
* Laudanosine
* Leumorphin (dynorphin B-29)
* Levallorphan
* Levomethorphan
* Levorphanol
* Lexanopadol
* Lofentanil
* LPK-26
* Lufuradom
* Matrine
* MB-1C-OH
* Menthol
* Metazocine
* Metkefamide
* Mianserin
* Mirtazapine
* Morphine
* Moxazocine
* MR-2034
* N-MPPP
* Nalbuphine
* NalBzOH
* Nalfurafine
* Nalmefene
* Nalodeine (N-allylnorcodeine)
* Nalorphine
* Naltriben
* Niravoline
* Norbuprenorphine
* Norbuprenorphine-3-glucuronide
* Noribogaine
* Norketamine
* Oripavine
* Oxilorphan
* Oxycodone
* Pentazocine
* Pethidine (meperidine)
* Phenazocine
* Proxorphan
* Racemethorphan
* Racemorphan
* RB-64
* Salvinorin A (salvia)
* Salvinorin B ethoxymethyl ether
* Salvinorin B methoxymethyl ether
* Samidorphan
* Spiradoline (U-62,066)
* TH-030418
* Thienorphine
* Tifluadom
* Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)
* U-50488
* U-54,494A
* U-69,593
* Xorphanol

* Antagonists: 4′-Hydroxyflavanone
* 4',7-Dihydroxyflavone
* 5'-GNTI
* 6'-GNTI
* 6β-Naltrexol
* 6β-Naltrexol-d4
* β-Chlornaltrexamine
* Buprenorphine/samidorphan
* Amentoflavone
* ANTI
* Apigenin
* Arodyne
* AT-076
* Aticaprant
* Axelopran
* AZ-MTAB
* Binaltorphimine
* BU09059
* Buprenorphine
* Catechin
* Catechin gallate
* CERC-501 (LY-2456302)
* Clocinnamox
* Cyclofoxy
* Dezocine
* DIPPA
* EGC
* ECG
* Epicatechin
* Hyperoside
* JDTic
* LY-255582
* LY-2196044
* LY-2444296
* LY-2459989
* LY-2795050
* MeJDTic
* Methylnaltrexone
* ML190
* ML350
* MR-2266
* N-Fluoropropyl-JDTic
* Naloxone
* Naltrexone
* Naltrindole
* Naringenin
* Norbinaltorphimine
* Noribogaine
* Pawhuskin A
* PF-4455242
* RB-64
* Quadazocine
* Taxifolin
* UPHIT
* Zyklophin

* Unknown/unsorted: Akuammicine
* Akuammine
* Coronaridine
* Cyproterone acetate
* Dihydroakuuamine
* Ibogamine
* Tabernanthine

NOP|

* Agonists: (Arg14,Lys15)Nociceptin
* ((pF)Phe4)Nociceptin(1-13)NH2
* (Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2
* Ac-RYYRWK-NH2
* Ac-RYYRIK-NH2
* BU08070
* Buprenorphine
* Cebranopadol
* Dihydroetorphine
* Etorphine
* JNJ-19385899
* Levomethorphan
* Levorphanol
* Levorphanol
* Lexanopadol
* MCOPPB
* MT-7716
* NNC 63-0532
* Nociceptin (orphanin FQ)
* Nociceptin (1-11)
* Nociceptin (1-13)NH2
* Norbuprenorphine
* Racemethorphan
* Racemorphan
* Ro64-6198
* Ro65-6570
* SCH-221510
* SCH-486757
* SR-8993
* SR-16435
* TH-030418

* Antagonists: (Nphe1)Nociceptin(1-13)NH2
* AT-076
* BAN-ORL-24
* BTRX-246040 (LY-2940094)
* J-113,397
* JTC-801
* NalBzOH
* Nociceptin (1-7)
* Nocistatin
* SB-612,111
* SR-16430
* Thienorphine
* Trap-101
* UFP-101

Unsorted|

* β-Casomorphins
* Amidorphin
* BAM-20P
* Cytochrophin-4
* Deprolorphin
* Gliadorphin (gluteomorphin)
* Gluten exorphins
* Hemorphins
* Kava constituents
* MEAGL
* MEAP
* NEM
* Neoendorphins
* Nepetalactone (catnip)
* Peptide B
* Peptide E
* Peptide F
* Peptide I
* Rubiscolins
* Soymorphins

Others|

* Enkephalinase inhibitors: Amastatin
* BL-2401
* Candoxatril
* D -Phenylalanine
* Dexecadotril (retorphan)
* Ecadotril (sinorphan)
* Kelatorphan
* Racecadotril (acetorphan)
* RB-101
* RB-120
* RB-3007
* Opiorphan
* Selank
* Semax
* Spinorphin
* Thiorphan
* Tynorphin
* Ubenimex (bestatin)

* Propeptides: β-Lipotropin (proendorphin)
* Prodynorphin
* Proenkephalin
* Pronociceptin
* Proopiomelanocortin (POMC)

* Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)

See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators

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*[MOR]: μ-opioid receptor
*[DOR]: δ-opioid receptor
*[KOR]: κ-opioid receptor
*[NOP]: Nociceptin receptor