PiXL

PiXL (Photorefractive Intrastromal Cross-Linking) is a modern non-invasive non-surgical vision correction procedure.[1]

It is performed by applying riboflavin (vitamin B2) eye drops to the cornea and illuminating it with UVA light, which cross-links the collagen fibers within the cornea, making it stronger, changing the shape and improving the patient's vision.[2]

PiXL is a high-fluence corneal collagen cross-linking administered in a customizable pattern and intensity in order to flatten or steepen the cornea through corneal strengthening.[3] The specific application of UVA for each patient takes into account the refractive error and corneal topography.[4] The major components of the therapy are riboflavin injection and UVA irradiation, and the procedure is followed by a course of topical antibiotics and corticosteroids.[5]

PiXL is appropriate for patients with low myopia or hyperopia (mild nearsightedness or farsightedness) as a second line to conventional refractive surgeries (i.e. SMILE, LASIK, PRK, intraocular lens), and for patients who require correction of residual refractive error or refractive regression after conventional refractive surgeries.[1][4][6]

## References

1. ↑ 1.0 1.1 "PiXL Vision Correction Procedure Toronto - Clearview Vision Institute". http://www.clearviewinstitute.com/treatments/pixl/.
2. ↑ "PiXL". https://www.kingstonmedcentre.com/pixl-new/.
3. ↑ Kanellopoulos, John (1 April 2014). "Novel myopic refractive correction with transepithelial very high-fluence collagen cross-linking applied in a customized pattern: early clinical results of a feasibility study". Clinical Ophthalmology 8: 697–702. doi:10.2147/OPTH.S59934. PMID 24741289.
4. ↑ 4.0 4.1 Lim, Wee Kiak; Soh, Zhi Da; Choi, Harold Kah Yen; Theng, Julian Thiam Siew (1 June 2017). "Epithelium-on photorefractive intrastromal cross-linking (PiXL) for reduction of low myopia". Clinical Ophthalmology 11: 1205–1211. doi:10.2147/OPTH.S137712. PMID 28721004.
5. ↑ "PiXL - EyeWiki". http://eyewiki.aao.org/PiXL.
6. ↑ "Say Hello To PiXL™ — The New Non-Invasive Vision Improvement Procedure". http://www.personalhealthnews.ca/research-and-innovations/say-goodbye-to-contact-lenses-and-glasses-with-pixltm-the-new-non-invasive-vision-improvement-procedure.

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