Bromide

Short description: Chemical compound or ion

Bromide  |  |

|

Names
Systematic IUPAC name

Bromide[1]

Identifiers

CAS Number

* 24959-67-9 Y

3D model (JSmol)

* Interactive image

Beilstein Reference

| 3587179
ChEBI |

* CHEBI:15858 Y

ChEMBL |

* ChEMBL11685 Y

ChemSpider |

* 254 Y

Gmelin Reference

| 14908
KEGG |

* C01324 N

PubChem CID

* 259

UNII |

* 952902IX06 Y

InChI

* InChI=1S/BrH/h1H/p-1 Y

Key: CPELXLSAUQHCOX-UHFFFAOYSA-M Y

SMILES

* [Br-]

Properties

Chemical formula

| Br−
Molar mass | 79.904 g·mol−1
Conjugate acid | Hydrogen bromide
Thermochemistry

Std molar
entropy (S ~~o~~ 298)

| 82 J·mol−1·K−1[2]

Std enthalpy of
formation (ΔfH⦵298)

| −121 kJ·mol−1[2]
Pharmacology
1=ATC code }}  | N05CM11 (WHO)
Pharmacokinetics:

Biological half-life

| 12 d
Related compounds

Other anions

| Fluoride

Chloride
Iodide

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)
Infobox references

Tracking categories (test):

* PairSizeSet

A bromide ion is the negatively charged form (Br−) of the element bromine, a member of the halogens group on the periodic table. Most bromides are colorless. Bromides have many practical roles, being found in anticonvulsants, flame-retardant materials, and cell stains.[3] Although uncommon, chronic toxicity from bromide can result in bromism, a syndrome with multiple neurological symptoms. Bromide toxicity can also cause a type of skin eruption, see potassium bromide. The bromide ion has an ionic radius of 196 pm.[4]

## Contents

* 1 Natural occurrence
* 2 Formation and reactions of bromide
* 2.1 Dissociation of bromide salts
* 2.2 Hydrolysis of bromine
* 2.3 Oxidation of bromide
* 3 Applications
* 4 Medicinal and veterinary uses
* 4.1 Folk and passé medicine
* 5 Biochemistry
* 5.1 Substrate
* 5.2 Cofactor
* 6 Further reading
* 6.1 Encyclopedia articles and books
* 6.2 Peer-reviewed journal articles for bromine (Br)
* 6.3 Peer-reviewed journal articles for bromide (Br−)
* 7 References

## Natural occurrence

Bromide is present in typical seawater (35 PSU) with a concentration of around 65 mg/L, which is about 0.2% of all dissolved salts. Seafood and deep sea plants generally have higher levels than land-derived foods. Bromargyrite—natural, crystalline silver bromide—is the most common bromide mineral known but is still very rare. In addition to silver, bromine is also in minerals combined with mercury and copper.[5]

## Formation and reactions of bromide

### Dissociation of bromide salts

Bromide salts of alkali metal, alkaline earth metals, and many other metals dissolve in water (and even some alcohols and a few ethers) to give bromide ions. The classic case is sodium bromide, which fully dissociates in water:

NaBr → Na+ \+ Br−

Hydrogen bromide, which is a diatomic molecule, takes on salt-like properties upon contact with water to give an ionic solution called hydrobromic acid. The process is often described simplistically as involving formation of the hydronium salt of bromide:

HBr + H2O → H3O+ \+ Br−

### Hydrolysis of bromine

Bromine readily reacts with water, i.e. it undergoes hydrolysis:

Br2 \+ H2O → HOBr + HBr

This forms hypobromous acid (HOBr), and hydrobromic acid (HBr in water). The solution is called "bromine water". The hydrolysis of bromine is more favorable in the presence of base, for example sodium hydroxide:

Br2 \+ NaOH → NaOBr + NaBr

This reaction is analogous to the production of bleach, where chlorine is dissolved in the presence of sodium hydroxide.[6]

### Oxidation of bromide

One can test for a bromide ion by adding an oxidizer. One method uses dilute HNO3.

Balard and Löwig's method can be used to extract bromine from seawater and certain brines. For samples testing for sufficient bromide concentration, addition of chlorine produces bromine (Br2):[7]

Cl2 \+ 2 Br− → 2 Cl− \+ Br2

## Applications

Bromide's main commercial value is its use in producing organobromine compounds, which themselves are rather specialized. Organobromine compounds are commonly used as brominated flame retardants.[8] Some brominated flame retardants were identified as persistent, bioaccumulative, and toxic to both humans and the environment and were suspected of causing neurobehavioral effects and endocrine disruption.[9][10]

Many metal bromides are produced commercially, including LiBr, NaBr, NH4Br, CuBr, ZnBr2 and AlBr3. AgBr is used for the largely obsolete photographic gelatin silver process.[11]

## Medicinal and veterinary uses

Dermatitis reactions to bromide, all except lower right

### Folk and passé medicine

Lithium bromide was used as a sedative beginning in the early 1900s. However, it fell into disfavour in the 1940s due to the rising popularity of safer and more efficient sedatives (specifically, barbiturates) and when some heart patients died after using a salt substitute (see lithium chloride).[12] Like lithium carbonate and lithium chloride, it was used as a treatment for bipolar disorder.

From 1954 - 1977, the Australian biochemist Shirley Andrews was researching safe ways to use lithium for the treatment of manic depressive illnesses while working at the Royal Park Psychiatric Hospital in Victoria. While conducting this research she discovered that bromide caused symptoms of mental illness, leading to a major reduction in its usage.[13]

Further information: Chemistry:Potassium bromide

Bromide compounds, especially potassium bromide, were frequently used as sedatives in the 19th and early 20th centuries. Their use in over-the-counter sedatives and headache remedies (such as Bromo-Seltzer) in the United States extended to 1975 when bromides were withdrawn as ingredients due to chronic toxicity.[14] This use gave the word "bromide" its colloquial connotation of a comforting cliché.[15]

It has been said that during World War I, British soldiers were given bromide to curb their sexual urges.[16] Lord Dunsany mentions a soldier being given bromide as a sedative for nervous exhaustion and overwork in his play Fame and the Poet (1919).[17]

Bromide salts are used in hot tubs as mild germicidal agents to generate in situ hypobromite

The bromide ion is antiepileptic and as bromide salt, is used in veterinary medicine in the US. The kidneys excrete bromide ions. The half-life of bromide in the human body (12 days) is long compared with many pharmaceuticals, making dosing challenging to adjust. (A new dose may require several months to reach equilibrium.) Bromide ion concentrations in the cerebrospinal fluid are about 30% of those in blood and are strongly influenced by the body's chloride intake and metabolism.[18]

Since bromide is still used in veterinary medicine in the United States, veterinary diagnostic labs can routinely measure blood bromide levels. However, this is not a conventional test in human medicine in the US since there are no FDA-approved uses for the bromide. Therapeutic bromide levels are measured in European countries like Germany , where bromide is still used therapeutically in human epilepsy.

## Biochemistry

Bromide is rarely mentioned in the biochemical context. Some enzymes use bromide as substrate or as a cofactor.

### Substrate

Bromoperoxidase enzymes use bromide (typically in seawater) to generate electrophilic brominating agents Hundreds of organobromine compounds are generated by this process. Notable examples are bromoform, thousands of tons of which are produced annually in this way. The historical dye Tyrian purple is produced by similar enzymatic reactions.[19]

### Cofactor

In one specialized report, bromide is an essential cofactor in the peroxidising catalysis of sulfonimine crosslinks in collagen IV. This post-translational modification occurs in all animals and bromine is an essential trace element for humans.[20]

Eosinophils need bromide for fighting multicellular parasites. Hypobromite is produced via eosinophil peroxidase, an enzyme that can use chloride but preferentially uses bromide.[21]

The average concentration of bromide in human blood in Queensland, Australia, is 5.3±1.4 mg/L and varies with age and gender.[22] Much higher levels may indicate exposure to brominated chemicals. It is also found in seafood.

## Further reading

### Encyclopedia articles and books

* Christe, K., and S. Schneider (2020), Bromine, Encyclopædia Britannica.
* Emerson, S., and J. Hedges (2011), Chemical Oceanography and the Marine Carbon Cycle, Cambridge University Press, Cambridge.
* Glasow, R. von, and C. Hughes (2014), Biogeochemical Cycles: Bromine, Encyclopedia of Atmospheric Sciences (Second Edition).
* Knight, J., and N. Schlager (2002), Real-life chemistry, Gale Group, Detroit, MI.
* Millero, F. J. (2013), Chemical oceanography, Taylor & Francis, Boca Raton.
* Newton D. E. (2010), Bromine (Revised), Chemical Elements: From Carbon to Krypton.
* Riley, J. P., G. Skirrow, and R. Chester (1975), Chemical Oceanography, Academic Press, London
* Ross, R. (2017), Facts About Bromine, LiveScience.
* Steele, J. H., S. A. Thorpe, and K. K. Turekian (2001), Encyclopedia of Ocean Sciences, Academic Press, San Diego.
* Steele, J. H., S. A. Thorpe, and K. K. Turekian (2009), Encyclopedia of Ocean Sciences, Academic Press, Boston.
* Watkins, T. (2011), Bromine, Environmental Encyclopedia.

### Peer-reviewed journal articles for bromine (Br)

* Wisniak, J. (2002), The history of bromine from discovery to commodity, NOPR.

### Peer-reviewed journal articles for bromide (Br−)

* Anbar, A. D., Y. L. Yung, and F. P. Chavez (1996), Methyl bromide: Ocean sources, ocean sinks, and climate sensitivity, AGU Journals.
* Foti, S. C., and Naval Ordnance Lab White Oak Md (1972), Concentration of Bromide Ions in Seawater by Isotopic Exchange with Mercurous Bromide, DTIC.
* Gribble, G. W. (2000), The natural production of organobromine compounds, Environmental Science and Pollution Research, 7(1), 37–49, doi:10.1065/espr199910.002.
* Leri A. (2012), The Chemistry of Bromine in Terrestrial and Marine Environments, Science Highlight.
* Magazinovic, R. S., B. C. Nicholson, D. E. Mulcahy, and D. E. Davey (2004), Bromide levels in natural waters: its relationship to levels of both chloride and total dissolved solids and the implications for water treatment, Chemosphere, 57(4), 329–335, doi:10.1016/j.chemosphere.2004.04.056.
* Pilinis, C., D. B. King, and E. S. Saltzman (1996), The oceans: A source or a sink of methyl bromide?, Geophysical Research Letters, 23(8), 817–820, doi:10.1029/96gl00424.
* Stemmler, I., I. Hense, and B. Quack (2015), Marine sources of bromoform in the global open ocean – global patterns and emissions, Biogeosciences, 12(6), 1967–1981, doi:10.5194/bg-12-1967-2015.
* Suzuki, A., Lim, L., Hiroi, T., & Takeuchi, T. (2006, March 20). Rapid determination of bromide in seawater samples by capillary ion chromatography using monolithic silica columns modified with cetyltrimethylammonium ion.

## References

1. ↑ "Bromide – PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=259.
2. ↑ 2.0 2.1 Zumdahl, Steven S. (2009). Chemical Principles (6th ed.). Houghton Mifflin. ISBN 978-0-618-94690-7.
3. ↑ Rattley, Matt (2012). "Ambiguous bromine". Nature Chemistry 4 (6): 512. doi:10.1038/nchem.1361. PMID 22614389. Bibcode: 2012NatCh...4..512R.
4. ↑ Shannon, R. D. (1976). "Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides". Acta Crystallographica A 32 (5): 751–767. doi:10.1107/s0567739476001551.
5. ↑ "Mindat.org - Mines, Minerals and More". https://www.mindat.org.
6. ↑ Chemistry of the Elements, N. N. Greenwood, A. Earnshaw, Elsevier, 2012, pp 789
7. ↑ Magazinovic, Rodney S.; Nicholson, Brenton C.; Mulcahy, Dennis E.; Davey, David E. (2004). "Bromide levels in natural waters: its relationship to levels of both chloride and total dissolved solids and the implications for water treatment" (in en). Chemosphere 57 (4): 329–335. doi:10.1016/j.chemosphere.2004.04.056. PMID 15312731. Bibcode: 2004Chmsp..57..329M. https://linkinghub.elsevier.com/retrieve/pii/S0045653504003935. Retrieved 2021-03-07.
8. ↑ Michael J. Dagani, Henry J. Barda, Theodore J. Benya, David C. Sanders: Bromine Compounds, Ullmann's Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. doi:10.1002/14356007.a04_405
9. ↑ "Polybrominated Diphenyl Ethers (PBDEs) Action Plan Summary | Existing Chemicals | OPPT | US EPA". http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/pbde.html.
10. ↑ "Archived copy". http://www.cerc.usgs.gov/pubs/center/pdfdocs/pbde.pdf.
11. ↑ Weaver, Gawain (2008). "A Guide to Fiber-Base Gelatin Silver Print Condition and Deterioration". George Eastman House, International Museum of Photography and Film. http://gawainweaver.com/images/uploads/Weaver_Guide_to_Gelatin_Silver.pdf.
12. ↑ Bipolar disorder . webmd.com
13. ↑ "Papers of Shirley Andrews" (in en). https://nla.gov.au/nla.obj-233797980.
14. ↑ Adams, Samuel Hopkins (1905). The Great American fraud. Press of the American Medical Association. https://archive.org/details/greatamericanfr03adamgoog. .
15. ↑ "the definition of bromide". https://www.dictionary.com/browse/bromide.
16. ↑ Tanaka, Yuki (2002) Japan's Comfort Women: Sexual slavery and prostitution during World War II and the US Occupation, Routledge, p. 175. ISBN 0415194008.
17. ↑ Lord Dunsany (August 1919). "Fame and the Poet". The Atlantic Monthly: 175–183.
18. ↑ Goodman, L. S.; Gilman, A., eds (1970). "10. Hypnotics and Sedatives". The Biological Basis of Therapeutics (4th ed.). London: Macmillan. p. 121.
19. ↑ Gribble, Gordon W. (1999). "The diversity of naturally occurring organobromine compounds". Chemical Society Reviews 28 (5): 335–346. doi:10.1039/a900201d.
20. ↑ McCall, A. Scott; Cummings, Christopher F.; Bhave, Gautam; Vanacore, Roberto; Page-McCaw, Andrea; Hudson, Billy G. (2014). "Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture" (in en). Cell 157 (6): 1380–1392. doi:10.1016/j.cell.2014.05.009. PMID 24906154.
21. ↑ Mayeno, Arthur N.; Curran, A. Jane; Roberts, Robert L.; Foote, Christopher S. (1989-04-05). "Eosinophils Preferentially Use Bromide to Generate Halogenating Agents". Journal of Biological Chemistry 264 (10): 5660–5668. doi:10.1016/s0021-9258(18)83599-2. ISSN 0021-9258. PMID 2538427.
22. ↑ Olszowy, HA; Rossiter, J; Hegarty, J; Geoghegan, P (1998). "Background levels of bromide in human blood". Journal of Analytical Toxicology 22 (3): 225–30. doi:10.1093/jat/22.3.225. PMID 9602940.

* v
* t
* e

GABAA receptor positive modulators

Alcohols|

* Brometone
* Butanol
* Chloralodol
* Chlorobutanol (cloretone)
* Ethanol (alcohol) (alcoholic drink)
* Ethchlorvynol
* Isobutanol
* Isopropanol
* Menthol
* Methanol
* Methylpentynol
* Pentanol
* Petrichloral
* Propanol
* tert-Butanol (2M2P)
* tert-Pentanol (2M2B)
* Tribromoethanol
* Trichloroethanol
* Triclofos
* Trifluoroethanol

Barbiturates|

* (-)-DMBB
* Allobarbital
* Alphenal
* Amobarbital
* Aprobarbital
* Barbexaclone
* Barbital
* Benzobarbital
* Benzylbutylbarbiturate
* Brallobarbital
* Brophebarbital
* Butabarbital/Secbutabarbital
* Butalbital
* Buthalital
* Butobarbital
* Butallylonal
* Carbubarb
* Crotylbarbital
* Cyclobarbital
* Cyclopentobarbital
* Difebarbamate
* Enallylpropymal
* Ethallobarbital
* Eterobarb
* Febarbamate
* Heptabarb
* Heptobarbital
* Hexethal
* Hexobarbital
* Metharbital
* Methitural
* Methohexital
* Methylphenobarbital
* Narcobarbital
* Nealbarbital
* Pentobarbital
* Phenallymal
* Phenobarbital
* Phetharbital
* Primidone
* Probarbital
* Propallylonal
* Propylbarbital
* Proxibarbital
* Reposal
* Secobarbital
* Sigmodal
* Spirobarbital
* Talbutal
* Tetrabamate
* Tetrabarbital
* Thialbarbital
* Thiamylal
* Thiobarbital
* Thiobutabarbital
* Thiopental
* Thiotetrabarbital
* Valofane
* Vinbarbital
* Vinylbital

Benzodiazepines|

* 2-Oxoquazepam
* 3-Hydroxyphenazepam
* Adinazolam
* Alprazolam
* Arfendazam
* Avizafone
* Bentazepam
* Bretazenil
* Bromazepam
* Brotizolam
* Camazepam
* Carburazepam
* Chlordiazepoxide
* Ciclotizolam
* Cinazepam
* Cinolazepam
* Clazolam
* Climazolam
* Clobazam
* Clonazepam
* Clonazolam
* Cloniprazepam
* Clorazepate
* Clotiazepam
* Cloxazolam
* CP-1414S
* Cyprazepam
* Delorazepam
* Demoxepam
* Diazepam
* Diclazepam
* Doxefazepam
* Elfazepam
* Estazolam
* Ethyl carfluzepate
* Ethyl dirazepate
* Ethyl loflazepate
* Etizolam
* EVT-201
* FG-8205
* Fletazepam
* Flubromazepam
* Flubromazolam
* Fludiazepam
* Flunitrazepam
* Flunitrazolam
* Flurazepam
* Flutazolam
* Flutemazepam
* Flutoprazepam
* Fosazepam
* Gidazepam
* Halazepam
* Haloxazolam
* Iclazepam
* Imidazenil
* Irazepine
* Ketazolam
* Lofendazam
* Lopirazepam
* Loprazolam
* Lorazepam
* Lormetazepam
* Meclonazepam
* Medazepam
* Menitrazepam
* Metaclazepam
* Mexazolam
* Midazolam
* Motrazepam
* N-Desalkylflurazepam
* Nifoxipam
* Nimetazepam
* Nitrazepam
* Nitrazepate
* Nitrazolam
* Nordazepam
* Nortetrazepam
* Oxazepam
* Oxazolam
* Phenazepam
* Pinazepam
* Pivoxazepam
* Prazepam
* Premazepam
* Proflazepam
* Pyrazolam
* QH-II-66
* Quazepam
* Reclazepam
* Remimazolam
* Rilmazafone
* Ripazepam
* Ro48-6791
* Ro48-8684
* SH-053-R-CH3-2′F
* Sulazepam
* Temazepam
* Tetrazepam
* Tolufazepam
* Triazolam
* Triflubazam
* Triflunordazepam (Ro5-2904)
* Tuclazepam
* Uldazepam
* Zapizolam
* Zolazepam
* Zomebazam

Carbamates|

* Carisbamate
* Carisoprodol
* Clocental
* Cyclarbamate
* Difebarbamate
* Emylcamate
* Ethinamate
* Febarbamate
* Felbamate
* Hexapropymate
* Lorbamate
* Mebutamate
* Meprobamate
* Nisobamate
* Pentabamate
* Phenprobamate
* Procymate
* Styramate
* Tetrabamate
* Tybamate

Flavonoids|

* 6-Methylapigenin
* Ampelopsin (dihydromyricetin)
* Apigenin
* Baicalein
* Baicalin
* Catechin
* EGC
* EGCG
* Hispidulin
* Linarin
* Luteolin
* Rc-OMe
* Skullcap constituents (e.g., baicalin)
* Wogonin

Imidazoles|

* Etomidate
* Metomidate
* Propoxate

Kava constituents|

* 10-Methoxyyangonin
* 11-Methoxyyangonin
* 11-Hydroxyyangonin
* Desmethoxyyangonin
* 11-Methoxy-12-hydroxydehydrokavain
* 7,8-Dihydroyangonin
* Kavain
* 5-Hydroxykavain
* 5,6-Dihydroyangonin
* 7,8-Dihydrokavain
* 5,6,7,8-Tetrahydroyangonin
* 5,6-Dehydromethysticin
* Methysticin
* 7,8-Dihydromethysticin
* Yangonin

Monoureides|

* Acecarbromal
* Apronal (apronalide)
* Bromisoval
* Carbromal
* Capuride
* Ectylurea

Neuroactive steroids|

* Acebrochol
* Allopregnanolone (brexanolone)
* Alfadolone
* Alfaxalone
* 3α-Androstanediol
* Androstenol
* Androsterone
* Certain anabolic-androgenic steroids
* Cholesterol
* DHDOC
* 3α-DHP
* 5α-DHP
* 5β-DHP
* DHT
* Etiocholanolone
* Ganaxolone
* Hydroxydione
* Minaxolone
* ORG-20599
* ORG-21465
* P1-185
* Pregnanolone (eltanolone)
* Progesterone
* Renanolone
* SAGE-105
* SAGE-324
* SAGE-516
* SAGE-689
* SAGE-872
* Testosterone
* THDOC
* Zuranolone

Nonbenzodiazepines|

* Cyclopyrrolones: Eszopiclone
* Pagoclone
* Pazinaclone
* Suproclone
* Suriclone
* Zopiclone

* Imidazopyridines: Alpidem
* DS-1
* Necopidem
* Saripidem
* Zolpidem

* Pyrazolopyrimidines: Divaplon
* Fasiplon
* Indiplon
* Lorediplon
* Ocinaplon
* Panadiplon
* Taniplon
* Zaleplon

* Others: Adipiplon
* CGS-8216
* CGS-9896
* CGS-13767
* CGS-20625
* CL-218,872
* CP-615,003
* CTP-354
* ELB-139
* GBLD-345
* Imepitoin
* JM-1232
* L-838,417
* Lirequinil (Ro41-3696)
* NS-2664
* NS-2710
* NS-11394
* Pipequaline
* ROD-188
* RWJ-51204
* SB-205,384
* SX-3228
* TGSC01AA
* TP-003
* TPA-023
* TP-13
* U-89843A
* U-90042
* Viqualine
* Y-23684

Phenols|

* Fospropofol
* Propofol
* Thymol

Piperidinediones|

* Glutethimide
* Methyprylon
* Piperidione
* Pyrithyldione

Pyrazolopyridines|

* Cartazolate
* Etazolate
* ICI-190,622
* Tracazolate

Quinazolinones|

* Afloqualone
* Cloroqualone
* Diproqualone
* Etaqualone
* Mebroqualone
* Mecloqualone
* Methaqualone
* Methylmethaqualone
* Nitromethaqualone
* SL-164

Volatiles/gases|

* Acetone
* Acetophenone
* Acetylglycinamide chloral hydrate
* Aliflurane
* Benzene
* Butane
* Butylene
* Centalun
* Chloral
* Chloral betaine
* Chloral hydrate
* Chloroform
* Cryofluorane
* Desflurane
* Dichloralphenazone
* Dichloromethane
* Diethyl ether
* Enflurane
* Ethyl chloride
* Ethylene
* Fluroxene
* Gasoline
* Halopropane
* Halothane
* Isoflurane
* Kerosine
* Methoxyflurane
* Methoxypropane
* Nitric oxide
* Nitrogen
* Nitrous oxide
* Norflurane
* Paraldehyde
* Propane
* Propylene
* Roflurane
* Sevoflurane
* Synthane
* Teflurane
* Toluene
* Trichloroethane (methyl chloroform)
* Trichloroethylene
* Vinyl ether

Others/unsorted|

* 3-Hydroxybutanal
* α-EMTBL
* AA-29504
* Avermectins (e.g., ivermectin)
* Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
* Carbamazepine
* Chloralose
* Chlormezanone
* Clomethiazole
* DEABL
* Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
* DS2
* Efavirenz
* Etazepine
* Etifoxine
* Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
* Fluoxetine
* Flupirtine
* Hopantenic acid
* Lanthanum
* Lavender oil
* Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
* Loreclezole
* Menthyl isovalerate (validolum)
* Monastrol
* Niacin
* Nicotinamide (niacinamide)
* Org 25,435
* Phenytoin
* Propanidid
* Retigabine (ezogabine)
* Safranal
* Seproxetine
* Stiripentol
* Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
* Terpenoids (e.g., borneol)
* Topiramate
* Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)

* Unsorted benzodiazepine site positive modulators: α-Pinene
* MRK-409 (MK-0343)
* TCS-1105
* TCS-1205

See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators

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