Citric acid cycle

The citric acid cycle is an ingenious series of reactions that oxidizes the acetyl group of acetyl-CoA to two molecules of CO2 in a manner that conserves the liberated free energy for utilization in ATP generation.

## Contents

* 1 Reactions of the Cycle
* 2 Historical Perspective
* 3 Metabolic Sources of Acetyl-Coenzyme A
* 3.1 Pyruvate Dehydrogenase Multienzyme Complex
* 3.2 Control of Pyruvate Dehydrogenase
* 4 Enzymes of the Citric Acid Cycle
* 4.1 Citrate Synthase
* 4.2 Aconitase
* 4.3 NAD+-Dependent Isocitrate Dehydrogenase
* 4.4 α-Ketoglutarate Dehydrogenase
* 4.5 Succinyl-CoA Synthetase
* 4.6 Succinate Dehydrogenase
* 4.7 Fumarase
* 4.8 Malate Dehydrogenase
* 4.9 Integration of the Citric Acid Cycle
* 5 Regulation of the Citric Acid Cycle
* 6 The Amphibolic Nature of the Citric Acid Cycle

### Reactions of the Cycle[edit]

### Historical Perspective[edit]

## Metabolic Sources of Acetyl-Coenzyme A[edit]

### Pyruvate Dehydrogenase Multienzyme Complex[edit]

### Control of Pyruvate Dehydrogenase[edit]

## Enzymes of the Citric Acid Cycle[edit]

### Citrate Synthase[edit]

### Aconitase[edit]

### NAD+-Dependent Isocitrate Dehydrogenase[edit]

### α-Ketoglutarate Dehydrogenase[edit]

### Succinyl-CoA Synthetase[edit]

### Succinate Dehydrogenase[edit]

### Fumarase[edit]

### Malate Dehydrogenase[edit]

### Integration of the Citric Acid Cycle[edit]

## Regulation of the Citric Acid Cycle[edit]

## The Amphibolic Nature of the Citric Acid Cycle[edit]