Altizide

Names
IUPAC name

(3R)-3-[(Allylsulfanyl)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Other names

* Althiazide
* CB 8093
* P 1779
* Altizidum

Identifiers

CAS Number

* 5588-16-9 N

3D model (JSmol)

* Interactive image
* Interactive image

ChEMBL |

* ChEMBL599870 N

ChemSpider |

* 5036613 Y

KEGG |

* D02838 Y

PubChem CID

* 6604323
* 2122

UNII |

* GI8CB72B0D Y

InChI

* InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1 Y

Key: VGLGVJVUHYTIIU-LLVKDONJSA-N Y

* InChI=1/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1

Key: VGLGVJVUHYTIIU-LLVKDONJBT

SMILES

* O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)N[C@@H](N2)CSC\C=C)N

* C=CCSCC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Properties

Chemical formula

| C11H14ClN3O4S3
Molar mass | 383.89456
Density | 1.502 g/mL
Boiling point |  625.8 °C (1,158.4 °F; 898.9 K)

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)
Infobox references

Tracking categories (test):

* SizeSet

Altizide is a thiazide diuretic. In combination with spironolactone it is sold under the brand name of Aldactacine and Aldactazine by Pfizer and other names by other companies.[1][2]

## References

1. ↑ "Altizide". https://www.drugs.com/international/altizide.html.
2. ↑ Dueymes, J. M (1990). "Clinical update: spironolactone and altizide as monotherapy in systemic hypertension". The American Journal of Cardiology 65 (23): 20K–23K. doi:10.1016/0002-9149(90)91272-8. PMID 2191585.

* v
* t
* e

Antihypertensives: diuretics (C03)

Sulfonamides
(and etacrynic acid)|

| CA inhibitors (at PT)|

* Acetazolamide

|

Loop (Na-K-Cl at AL)|

* Furosemide#
* Azosemide
* Bumetanide
* Etacrynic acid
* Etozolin
* Muzolimine
* Ozolinone
* Piretanide
* Tienilic acid
* Torasemide

[[Chemistry:ThiThiazides (Sodium-chloride Na-Cl at Distal convoluted tubule|DCT]],
Calcium-sparing)|

* Altizide
* Bendroflumethiazide
* Butizide
* Chlorothiazide
* Cyclopenthiazide
* Cyclothiazide
* Epitizide
* Hydrochlorothiazide#
* Hydroflumethiazide
* Mebutizide
* Methyclothiazide
* Polythiazide
* Trichlormethiazide

Thiazide-likes (primarily DCT)|

* Quinethazone
* Clopamide
* Chlortalidone
* Mefruside
* Clofenamide
* Metolazone
* Meticrane
* Xipamide
* Indapamide
* Clorexolone
* Fenquizone

Potassium-sparing (at CD)|

| ESC blockers|

* Amiloride#
* Triamterene
* Benzamil

|

Aldosterone antagonists|

* Spirolactones
* Spironolactone#
* Eplerenone
* Potassium canrenoate
* Canrenone

* Nonsteroidal
* Finerenone

Osmotic diuretics (PT, DL)|

* Mannitol#
* Glycerol
* Urea

Vasopressin receptor inhibitors
(DCT and CD)|

* Vaptans
* Conivaptan
* Mozavaptan
* Satavaptan
* Tolvaptan

* Others
* Demeclocycline
* Lithium carbonate

Other|

* Ethanol, Isopropanol, 2M2B
* mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
* Theobromine
* Cicletanine

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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