Cytokine redundancy

Cytokine redundancy is a term in immunology referring to the phenomenon in which, and the ability of, multiple cytokines to exert similar actions. This phenomenon is largely due to multiple cytokines utilizing common receptor subunits and common intracellular cell signalling molecules/pathways.[1][2] For instance, a pair of redundant cytokines are interleukin 4 and interleukin 13.[3] Cytokine redundancy is associated with the term cytokine pleiotropy, which refers to the ability of cytokines to exert multiple actions.[2][4][5]

## References

1. ↑ Casssatella, M. A. (2003.) The Neutrophil: An Emerging Regulator of Inflammatory and Immune Response, Karger Publishers, p. 66.
2. ↑ 2.0 2.1 Kelso, A (February 1994). "The enigma of cytokine redundancy.". Immunology and Cell Biology 72 (1): 97–101. doi:10.1038/icb.1994.14. PMID 8157291.
3. ↑ LaPorte, S. L.; Juo, Z. S.; Vaclavikova, J.; Colf, L. A.; Qi, X.; Heller, N. M.; Keegan, A. D.; Garcia, K. C. (2008.) "Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system", Cell, 132(2):259-72.
4. ↑ Ozaki, K; Leonard, WJ (16 August 2002). "Cytokine and cytokine receptor pleiotropy and redundancy.". The Journal of Biological Chemistry 277 (33): 29355–8. doi:10.1074/jbc.R200003200. PMID 12072446.
5. ↑ Nicola, NA (1994). "Cytokine pleiotropy and redundancy: a view from the receptor.". Stem Cells 12 Suppl 1: 3-12; discussion 12-4. PMID 7696967.

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