Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, and also their synthetic analogues. The two main classes of corticosteroids – glucocorticoids and mineralocorticoids – are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.[1]

Some common naturally occurring steroid hormones are cortisol (C21H30O5), corticosterone (C21H30O4), cortisone (C21H28O5) and aldosterone (C21H28O5) (cortisone and aldosterone are isomers). The main corticosteroids produced by the adrenal cortex are cortisol and aldosterone.[1]

## Contents

* 1 Etymology
* 2 Classes
* 3 Medical uses
* 4 Pharmacology
* 5 Pharmacogenetics
* 5.1 Asthma
* 6 Adverse effects
* 7 Biosynthesis
* 8 Classification
* 8.1 By chemical structure
* 8.1.1 Group A – Hydrocortisone type
* 8.1.2 Group B – Acetonides (and related substances)
* 8.1.3 Group C – Betamethasone type
* 8.1.4 Group D – Esters
* 8.1.4.1 Group D1 – Halogenated (less labile)
* 8.1.4.2 Group D2 – Labile prodrug esters
* 8.2 By route of administration
* 8.2.1 Topical steroids
* 8.2.2 Inhaled steroids
* 8.2.3 Oral forms
* 8.2.4 Systemic forms
* 9 History
* 10 See also
* 11 References

## Etymology

The etymology of the cortico- part of the name refers to the adrenal cortex, which makes these steroid hormones. Thus a corticosteroid is a "cortex steroid".

## Classes

[[Image:|thumb|200px|class=skin-invert-image|Cortisol]] [[Image:|thumb|200px|class=skin-invert-image|Cortisone]] [[Image:|thumb|200px|class=skin-invert-image|Corticosterone]] [[Image:|thumb|200px|class=skin-invert-image|Aldosterone]]

* Glucocorticoids such as cortisol affect carbohydrate, fat, and protein metabolism, and have anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive effects.[2] Anti-inflammatory effects are mediated by blocking the action of inflammatory mediators (transrepression) and inducing anti-inflammatory mediators (transactivation).[2] Immunosuppressive effects are mediated by suppressing delayed hypersensitivity reactions by direct action on T-lymphocytes.[2] Anti-proliferative effects are mediated by inhibition of DNA synthesis and epidermal cell turnover.[2] Vasoconstrictive effects are mediated by inhibiting the action of inflammatory mediators such as histamine.[2]
* Mineralocorticoids such as aldosterone are primarily involved in the regulation of electrolyte and water balance by modulating ion transport in the epithelial cells of the renal tubules of the kidney.[2]

## Medical uses

Synthetic pharmaceutical drugs with corticosteroid-like effects are used in a variety of conditions, ranging from hematological neoplasms[3] to brain tumors or skin diseases. Dexamethasone and its derivatives are almost pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect. Fludrocortisone (Florinef) is a synthetic mineralocorticoid. Hydrocortisone (cortisol) is typically used for replacement therapy, e.g. for adrenal insufficiency and congenital adrenal hyperplasia.[citation needed]

Medical conditions treated with systemic corticosteroids:[2][4]

* Allergy and respirology medicine
* Asthma (severe exacerbations)
* Chronic obstructive pulmonary disease (COPD)
* Allergic rhinitis
* Atopic dermatitis
* Hives
* Angioedema
* Anaphylaxis
* Food allergies
* Drug allergies
* Nasal polyps
* Hypersensitivity pneumonitis
* Sarcoidosis
* Eosinophilic pneumonia
* Some other types of pneumonia (in addition to the traditional antibiotic treatment protocols)
* Interstitial lung disease
* Dermatology
* Pemphigus vulgaris
* Contact dermatitis
* Endocrinology (usually at physiologic doses)
* Addison's disease
* Adrenal insufficiency
* Congenital adrenal hyperplasia
* Gastroenterology
* Ulcerative colitis
* Crohn's disease
* Autoimmune hepatitis
* Hematology
* Lymphoma
* Leukemia
* Hemolytic anemia
* Idiopathic thrombocytopenic purpura
* Multiple Myeloma
* Rheumatology/Immunology
* Rheumatoid arthritis
* Systemic lupus erythematosus
* Polymyalgia rheumatica
* Polymyositis
* Dermatomyositis
* Polyarteritis
* Vasculitis
* Ophthalmology
* Uveitis
* Optic neuritis
* Keratoconjunctivitis
* Other conditions
* Multiple sclerosis relapses
* Organ transplantation
* Nephrotic syndrome
* Chronic hepatitis (flare ups)
* Cerebral edema
* IgG4-related disease
* Prostate cancer
* Tendinosis
* Lichen planus

Topical formulations are also available for the skin, eyes (uveitis), lungs (asthma), nose (rhinitis), and bowels. Corticosteroids are also used supportively to prevent nausea, often in combination with 5-HT3 antagonists (e.g., ondansetron).[citation needed]

Typical undesired effects of glucocorticoids present quite uniformly as drug-induced Cushing's syndrome. Typical mineralocorticoid side-effects are hypertension (abnormally high blood pressure), steroid induced diabetes mellitus, psychosis, poor sleep, hypokalemia (low potassium levels in the blood), hypernatremia (high sodium levels in the blood) without causing peripheral edema, metabolic alkalosis and connective tissue weakness.[5] Wound healing or ulcer formation may be inhibited by the immunosuppressive effects.[citation needed]

A variety of steroid medications, from anti-allergy nasal sprays (Nasonex, Flonase) to topical skin creams, to eye drops (Tobradex), to prednisone have been implicated in the development of central serous retinopathy (CSR).[6][7]

Corticosteroids have been widely used in treating people with traumatic brain injury.[8] A systematic review identified 20 randomised controlled trials and included 12,303 participants, then compared patients who received corticosteroids with patients who received no treatment. The authors recommended people with traumatic head injury should not be routinely treated with corticosteroids.[9]

## Pharmacology

Corticosteroids act as agonists of the glucocorticoid receptor and/or the mineralocorticoid receptor.[10]

In addition to their corticosteroid activity, some corticosteroids may have some progestogenic activity and may produce sex-related side effects.[11][12][13][14]

## Pharmacogenetics

### Asthma

Patients' response to inhaled corticosteroids has some basis in genetic variations. Two genes of interest are CHRH1 (corticotropin-releasing hormone receptor 1) and TBX21 (transcription factor T-bet). Both genes display some degree of polymorphic variation in humans, which may explain how some patients respond better to inhaled corticosteroid therapy than others.[15][16] However, not all asthma patients respond to corticosteroids and large sub groups of asthma patients are corticosteroid resistant.[17]

A study funded by the Patient-Centered Outcomes Research Institute of children and teens with mild persistent asthma found that using the control inhaler as needed worked the same as daily use in improving asthma control, number of asthma flares, how well the lungs work, and quality of life. Children and teens using the inhaler as needed used about one-fourth the amount of corticosteroid medicine as children and teens using it daily.[18][19]

## Adverse effects

Lower arm of a 47-year-old female showing skin damage caused by topical corticosteroid use.

Use of corticosteroids has numerous side-effects, some of which may be severe:

* Severe amoebic colitis: Fulminant amoebic colitis is associated with high case fatality and can occur in patients infected with the parasite Entamoeba histolytica after exposure to corticosteroid medications.[20]
* Neuropsychiatric: steroid psychosis,[21] and anxiety,[22] depression. Therapeutic doses may cause a feeling of artificial well-being known as "steroid euphoria".[23] Rare case reports of corticosteroid misuse, addiction, and dependence due to euphoria exist.[24][25][26] The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm; if given at night, the feeling of being energized will interfere with sleep. An extensive review is provided by Flores and Gumina.[27]
* Cardiovascular: Corticosteroids can cause sodium retention through a direct action on the kidney, in a manner analogous to the mineralocorticoid aldosterone. This can result in fluid retention and hypertension.
* Metabolic: Corticosteroids cause a movement of body fat to the face and torso, resulting in "moon face", "buffalo hump", and "pot belly" or "beer belly", and cause movement of body fat away from the limbs. This has been termed corticosteroid-induced lipodystrophy. Due to the diversion of amino-acids to glucose, they are considered anti-anabolic, and long term therapy can cause muscle wasting (muscle atrophy).[28] Besides muscle atrophy, steroid myopathy includes muscle pains (myalgias), muscle weakness (typically of the proximal muscles), serum creatine kinase normal, EMG myopathic, and some have type II (fast-twitch/glycolytic) fibre atrophy.[29]
* Endocrine: By increasing the production of glucose from amino-acid breakdown and opposing the action of insulin, corticosteroids can cause hyperglycemia,[30] insulin resistance and diabetes mellitus.[31]
* Skeletal: Steroid-induced osteoporosis may be a side-effect of long-term corticosteroid use.[32][33][34] Use of inhaled corticosteroids among children with asthma may result in decreased height.[35]
* Gastro-intestinal: While cases of colitis have been reported, corticosteroids are often prescribed when the colitis, although due to suppression of the immune response to pathogens, should be considered only after ruling out infection or microbe/fungal overgrowth in the gastrointestinal tract. While the evidence for corticosteroids causing peptic ulceration is relatively poor except for high doses taken for over a month,[36] the majority of doctors as of 2010[update] still believe this is the case, and would consider protective prophylactic measures.[37]
* Eyes: chronic use may predispose to cataract and glaucoma. Clinical and experimental evidence indicates that corticosteroids can cause permanent eye damage by inducing central serous retinopathy (CSR, also known as central serous chorioretinopathy, CSC).[38] This should be borne in mind when treating patients with optic neuritis. There is experimental and clinical evidence that, at least in optic neuritis speed of treatment initiation is important.[39]
* Vulnerability to infection: By suppressing immune reactions (which is one of the main reasons for their use in allergies), steroids may cause infections to flare up, notably candidiasis.[40]
* Pregnancy: Corticosteroids have a low but significant teratogenic effect, causing a few birth defects per 1,000 pregnant women treated. Corticosteroids are therefore contraindicated in pregnancy.[41]
* Habituation: Topical steroid addiction (TSA) or red burning skin has been reported in long-term users of topical steroids (users who applied topical steroids to their skin over a period of weeks, months, or years).[42][43] TSA is characterised by uncontrollable, spreading dermatitis and worsening skin inflammation which requires a stronger topical steroid to get the same result as the first prescription. When topical steroid medication is lost, the skin experiences redness, burning, itching, hot skin, swelling, and/or oozing for a length of time. This is also called 'red skin syndrome' or 'topical steroid withdrawal' (TSW). After the withdrawal period is over the atopic dermatitis can cease or is less severe than it was before.[44]
* In children the short term use of steroids by mouth increases the risk of vomiting, behavioral changes, and sleeping problems.[45]
* Dysphonia: Inhaled corticosteroids are used for treatment of asthma as a standard treatment. This can cause local adverse effects like vocal cord dysfunction.[46]

## Biosynthesis

Steroidogenesis, including corticosteroid biosynthesis.

The corticosteroids are synthesized from cholesterol within the adrenal cortex.[1] Most steroidogenic reactions are catalysed by enzymes of the cytochrome P450 family. They are located within the mitochondria and require adrenodoxin as a cofactor (except 21-hydroxylase and 17α-hydroxylase).[citation needed]

Aldosterone and corticosterone share the first part of their biosynthetic pathway. The last part is mediated either by the aldosterone synthase (for aldosterone) or by the 11β-hydroxylase (for corticosterone). These enzymes are nearly identical (they share 11β-hydroxylation and 18-hydroxylation functions), but aldosterone synthase is also able to perform an 18-oxidation. Moreover, aldosterone synthase is found within the zona glomerulosa at the outer edge of the adrenal cortex; 11β-hydroxylase is found in the zona fasciculata and zona glomerulosa.[citation needed]

## Classification

### By chemical structure

In general, corticosteroids are grouped into four classes, based on chemical structure. Allergic reactions to one member of a class typically indicate an intolerance of all members of the class. This is known as the "Coopman classification".[47][48]

The highlighted steroids are often used in the screening of allergies to topical steroids.[49]

#### Group A – Hydrocortisone type

Hydrocortisone, hydrocortisone acetate, cortisone acetate, tixocortol pivalate, prednisolone, methylprednisolone, and prednisone.

#### Group B – Acetonides (and related substances)

Amcinonide, budesonide, desonide, fluocinolone acetonide, fluocinonide, halcinonide, triamcinolone acetonide, and Deflazacort (O-isopropylidene derivative)

#### Group C – Betamethasone type

Beclometasone, betamethasone, dexamethasone, fluocortolone, halometasone, and mometasone.

#### Group D – Esters

##### Group D1 – Halogenated (less labile)

Alclometasone dipropionate, betamethasone dipropionate, betamethasone valerate, clobetasol propionate, clobetasone butyrate, fluprednidene acetate, and mometasone furoate.

##### Group D2 – Labile prodrug esters

Ciclesonide, cortisone acetate, hydrocortisone aceponate, hydrocortisone acetate, hydrocortisone buteprate, hydrocortisone butyrate, hydrocortisone valerate, prednicarbate, and tixocortol pivalate.

### By route of administration

#### Topical steroids

Main article: Chemistry:Topical steroid

For use topically on the skin, eye, and mucous membranes.

Topical corticosteroids are divided in potency classes I to IV in most countries (A to D in Japan). Seven categories are used in the United States to determine the level of potency of any given topical corticosteroid.

#### Inhaled steroids

For nasal mucosa, sinuses, bronchi, and lungs.[50]

This group includes:

* Flunisolide[51]
* Fluticasone furoate[51]
* Fluticasone propionate[51]
* Triamcinolone acetonide[51]
* Beclomethasone dipropionate[51]
* Budesonide[51]
* Mometasone furoate
* Ciclesonide

There also exist certain combination preparations such as Advair Diskus in the United States, containing fluticasone propionate and salmeterol (a long-acting bronchodilator), and Symbicort, containing budesonide and formoterol fumarate dihydrate (another long-acting bronchodilator).[51] They are both approved for use in children over 12 years old.

#### Oral forms

Such as prednisone, prednisolone, methylprednisolone, or dexamethasone.[52]

#### Systemic forms

Available in injectables for intravenous and parenteral routes.[52]

## History

Introduction of early corticosteroids[53][54][55] Corticosteroid | Introduced

|

Cortisone | 1948
Hydrocortisone | 1951
Fludrocortisone acetate | 1954[56]
Prednisolone | 1955
Prednisone | 1955[57]
Methylprednisolone | 1956
Triamcinolone | 1956
Dexamethasone | 1958
Betamethasone | 1958
Triamcinolone acetonide | 1958
Fluorometholone | 1959
Deflazacort | 1969[58]

Tadeusz Reichstein, Edward Calvin Kendall, and Philip Showalter Hench were awarded the Nobel Prize for Physiology and Medicine in 1950 for their work on hormones of the adrenal cortex, which culminated in the isolation of cortisone.[59]

Initially hailed as a miracle cure and liberally prescribed during the 1950s, steroid treatment brought about adverse events of such a magnitude that the next major category of anti-inflammatory drugs, the nonsteroidal anti-inflammatory drugs (NSAIDs), was so named in order to demarcate from the opprobrium.[60]

Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a 36-step process that started with deoxycholic acid, which was extracted from ox bile.[61] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US$200 per gram in 1947. Russell Marker, at Syntex, discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams. His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception.[62]

In 1952, D.H. Peterson and H.C. Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.[63] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US$6 per gram[when?], falling to $0.46 per gram by 1980. Percy Julian's research also aided progress in the field.[64] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s. Corticosteroids were voted Allergen of the Year in 2005 by the American Contact Dermatitis Society.[65]

## See also

* List of corticosteroids
* List of corticosteroid cyclic ketals
* List of corticosteroid esters
* List of steroid abbreviations

## References

1. ↑ 1.0 1.1 1.2 "The adrenal gland". Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers. 2001. https://www.ncbi.nlm.nih.gov/books/NBK26/.
2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy". Allergy, Asthma, and Clinical Immunology 9 (1). August 2013. doi:10.1186/1710-1492-9-30. PMID 23947590.
3. ↑ "Corticosteroids in oncology: Use, overuse, indications, contraindications. An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) multidisciplinary consensus position paper". Critical Reviews in Oncology/Hematology 180. December 2022. doi:10.1016/j.critrevonc.2022.103826. PMID 36191821.
4. ↑ "Corticosteroid Injections Give Small and Transient Pain Relief in Rotator Cuff Tendinosis: A Meta-analysis". Clinical Orthopaedics and Related Research 475 (1): 232–243. January 2017. doi:10.1007/s11999-016-5002-1. PMID 27469590.
5. ↑ A massage therapist's guide to Pathology (3rd ed.). Pennsylvania: Lippincott Williams & Wilkins. 2005.
6. ↑ "Corticosteroids and central serous chorioretinopathy". Ophthalmology 109 (10): 1834–1837. October 2002. doi:10.1016/S0161-6420(02)01117-X. PMID 12359603.
7. ↑ "The New York Times :: A Breathing Technique Offers Help for People With Asthma". buteykola.com. http://buteykola.com/2010/07/the-new-york-times-a-breathing-technique-offers-help-for-people-with-asthma.
8. ↑ "Plain Language Summary". Corticosteroids for acute traumatic brain injury. The Cochrane Collaboration. p. 2.
9. ↑ "Corticosteroids for acute traumatic brain injury". The Cochrane Database of Systematic Reviews 2005 (1). January 2005. doi:10.1002/14651858.CD000196.pub2. PMID 15674869.
10. ↑ Diego Alvarez de la Rosa, Zuleima Ramos-Hernández, Julián Weller-Pérez, Thomas A. Johnson, Gordon L. Hager, The impact of mineralocorticoid and glucocorticoid receptor interaction on corticosteroid transcriptional outcomes, Molecular and Cellular Endocrinology, Volume 594, 2024, 112389, ISSN 0303-7207
11. ↑ "A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis". The Journal of Allergy and Clinical Immunology 104 (4 Pt 1): S150–S158. October 1999. doi:10.1016/s0091-6749(99)70311-8. PMID 10518812.
12. ↑ "Corticosteroid Injections: A Review of Sex-Related Side Effects". Orthopedics 40 (2): e211–e215. March 2017. doi:10.3928/01477447-20161116-07. PMID 27874912.
13. ↑ "In vitro and ex vivo binding to uterine progestin receptors of the rat as a tool to assay progestational activity of glucocorticoids". Methods and Findings in Experimental and Clinical Pharmacology 4 (4): 237–242. 1982. PMID 7121132.
14. ↑ "The mechanism of ovulation inhibition by triamcinolone acetonide". The Journal of Clinical Endocrinology and Metabolism 46 (1): 8–14. January 1978. doi:10.1210/jcem-46-1-8. PMID 376542.
15. ↑ "Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids". Human Molecular Genetics 13 (13): 1353–1359. July 2004. doi:10.1093/hmg/ddh149. PMID 15128701.
16. ↑ "TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids". Proceedings of the National Academy of Sciences of the United States of America 101 (52): 18099–18104. December 2004. doi:10.1073/pnas.0408532102. PMID 15604153. Bibcode: 2004PNAS..10118099T.
17. ↑ "Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids". The Journal of Allergy and Clinical Immunology 143 (1): 104–113.e14. January 2019. doi:10.1016/j.jaci.2017.12.1009. PMID 29524537.
18. ↑ "A Pragmatic Trial of Symptom-Based Inhaled Corticosteroid Use in African-American Children with Mild Asthma" (in English). The Journal of Allergy and Clinical Immunology. In Practice 8 (1): 176–185.e2. January 2020. doi:10.1016/j.jaip.2019.06.030. PMID 31371165.
19. ↑ "Managing Mild Asthma in Children Age Six and Older" (in en). 2021-08-13. https://www.pcori.org/evidence-updates/managing-mild-asthma-children-age-six-and-older.
20. ↑ "Fulminant Amebic Colitis after Corticosteroid Therapy: A Systematic Review". PLOS Neglected Tropical Diseases 10 (7). July 2016. doi:10.1371/journal.pntd.0004879. PMID 27467600.
21. ↑ "Psychiatric Adverse Drug Reactions: Steroid Psychosis". Director of Research Monarch Health Corporation Marblehead, Massachusetts. http://www.drrichardhall.com/steroid.htm.
22. ↑ "Corticosteroids in relation to fear, anxiety and psychopathology". Neuroscience and Biobehavioral Reviews 25 (2): 117–142. March 2001. doi:10.1016/S0149-7634(01)00002-1. PMID 11323078. Bibcode: 2001NBRev..25..117K.
23. ↑ "Evidence of prednisolone induced mood change ('steroid euphoria') in patients with chronic obstructive airways disease". British Journal of Clinical Pharmacology 26 (6): 709–713. December 1988. doi:10.1111/j.1365-2125.1988.tb05309.x. PMID 3242575.
24. ↑ "Psychiatric complications of treatment with corticosteroids: review with case report". Psychiatry Clin Neurosci 65 (6): 549–560. October 2011. doi:10.1111/j.1440-1819.2011.02260.x. PMID 22003987. "Rarely, corticosteroids have been abused for their euphoria-producing effects, producing drug dependency.31–33".
25. ↑ "Psychiatric adverse effects of corticosteroids". Mayo Clin Proc 81 (10): 1361–1367. October 2006. doi:10.4065/81.10.1361. PMID 17036562. "CORTICOSTEROID ABUSE: Several case reports describe corticosteroid abuse or dependence driven by the euphoria these medications can induce. These cases typically involve high-dose oral or intravenous formulations, but at least 1 case of dexamethasone nasal spray abuse has been reported.33 Most cases of corticosteroid abuse have been described in patients with a premorbid history of either psychiatric illness or drug or alcohol dependence.34".
26. ↑ "Hypothalamic-pituitary-adrenocortical axis: neuropsychiatric aspects". Compr Physiol 4 (2): 715–738. April 2014. doi:10.1002/cphy.c130036. PMID 24715565. "Glucocorticoids can also have mood-elevating effects, whose loss might fit better into a model of GR-impaired depression (392). Such effects are manifested in psychiatrically normal subjects as euphoria after exogenous administration, as depression after steroid withdrawal, and in a few cases, as steroid abuse (50, 210, 394). Mood improvements after glucocorticoid treatment occur before significant amelioration of the diseases for which the steroids were prescribed (373, 394), making it unlikely that euphoric effects were due to relief of disease symptoms. [...]".
27. ↑ Benjamin H. Flores and Heather Kenna Gumina. The Neuropsychiatric Sequelae of Steroid Treatment. URL:http://www.dianafoundation.com/articles/df_04_article_01_steroids_pg01.html
28. ↑ "Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation". Current Opinion in Clinical Nutrition and Metabolic Care 13 (4): 423–428. July 2010. doi:10.1097/MCO.0b013e32833a5107. PMID 20473154.
29. ↑ "Endocrine myopathies: clinical and histopathological features of the major forms". Acta Myologica 39 (3): 130–135. September 2020. doi:10.36185/2532-1900-017. PMID 33305169.
30. ↑ "Prevalence and predictors of corticosteroid-related hyperglycemia in hospitalized patients". Endocrine Practice 12 (4): 358–362. 2006. doi:10.4158/ep.12.4.358. PMID 16901792.
31. ↑ "Quantification of the Risk of Corticosteroid-induced Diabetes Mellitus Among the Elderly". Journal of General Internal Medicine 17 (9): 717–720. September 2002. doi:10.1046/j.1525-1497.2002.10649.x. PMID 12220369.
32. ↑ "Risk of osteoporosis and fragility fractures in asthma due to oral and inhaled corticosteroids: two population-based nested case-control studies". Thorax 76 (1): 21–28. January 2021. doi:10.1136/thoraxjnl-2020-215664. PMID 33087546. https://nottingham-repository.worktribe.com/output/4983605.
33. ↑ "Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study". The European Respiratory Journal 57 (1). January 2021. doi:10.1183/13993003.01251-2020. PMID 32764111.
34. ↑ "Corticosteroids and bone health in people with asthma: A systematic review and meta-analysis". Respiratory Medicine 181. May 2021. doi:10.1016/j.rmed.2021.106374. PMID 33799052.
35. ↑ "Inhaled corticosteroids in children with persistent asthma: effects on growth". The Cochrane Database of Systematic Reviews 2014 (7). July 2014. doi:10.1002/14651858.CD009471.pub2. PMID 25030198.
36. ↑ "Corticosteroids and ulcers: is there an association?". The Annals of Pharmacotherapy 30 (7–8): 870–872. 1996. doi:10.1177/106002809603000729. PMID 8826575.
37. ↑ ""A surviving myth"--corticosteroids are still considered ulcerogenic by a majority of physicians". Scandinavian Journal of Gastroenterology 45 (10): 1156–1161. October 2010. doi:10.3109/00365521.2010.497935. PMID 20569095.
38. ↑ "Advances in the treatment of central serous chorioretinopathy". Saudi Journal of Ophthalmology 29 (4): 278–286. 2015. doi:10.1016/j.sjopt.2015.01.007. PMID 26586979.
39. ↑ "Case for a new corticosteroid treatment trial in optic neuritis: review of updated evidence". Journal of Neurology, Neurosurgery, and Psychiatry 91 (1): 9–14. January 2020. doi:10.1136/jnnp-2019-321653. PMID 31740484.
40. ↑ "Oral candidiasis associated with inhaled corticosteroid use: comparison of fluticasone and beclomethasone". Annals of Allergy, Asthma & Immunology 90 (6): 646–651. June 2003. doi:10.1016/S1081-1206(10)61870-4. PMID 12839324.
41. ↑ "Update on new developments in the study of human teratogens". Teratology 65 (4): 153–161. April 2002. doi:10.1002/tera.10032. PMID 11948561.
42. ↑ "Misuse and abuse of topical steroids: implications.". Expert Review of Dermatology 2 (1): 31–40. 2007. doi:10.1586/17469872.2.1.31. https://drive.google.com/file/d/0B1-8beVOpbT8ZWh5Q09NakxDNlk/edit. Retrieved 2014-12-18.
43. ↑ "Rational and ethical use of topical corticosteroids based on safety and efficacy". Indian Journal of Dermatology 57 (4): 251–259. July 2012. doi:10.4103/0019-5154.97655. PMID 22837556.
44. ↑ "Topical steroid addiction in atopic dermatitis". Drug, Healthcare and Patient Safety 6: 131–138. 2014. doi:10.2147/dhps.s69201. PMID 25378953.
45. ↑ "Systematic review of the toxicity of short-course oral corticosteroids in children". Archives of Disease in Childhood 101 (4): 365–370. April 2016. doi:10.1136/archdischild-2015-309522. PMID 26768830.
46. ↑ Galván, César A.; Guarderas, Juan Carlos (September 2012). "Practical Considerations for Dysphonia Caused by Inhaled Corticosteroids". Mayo Clinic Proceedings 87 (9): 901–904. doi:10.1016/j.mayocp.2012.06.022. PMID 22958993.
47. ↑ Fisher's Contact Dermatitis, 6/e. Hamilton, Ont: BC Decker Inc. 2007. p. 256. ISBN 978-1-55009-378-0.
48. ↑ "Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids". The British Journal of Dermatology 121 (1): 27–34. July 1989. doi:10.1111/j.1365-2133.1989.tb01396.x. PMID 2757954.
49. ↑ Comprehensive Dermatologic Drug Therapy. WB Saunders. 2001. p. 562.
50. ↑ "Asthma Steroids: Inhaled Steroids, Side Effects, Benefits, and More". Webmd.com. http://www.webmd.com/asthma/guide/asthma_control_with_anti-inflammatory-drugs.
51. ↑ 51.0 51.1 51.2 51.3 51.4 51.5 51.6 Mayo Clinic Staff (September 2015). "Asthma Medications: Know your options". MayoClinic.org. https://www.mayoclinic.org/diseases-conditions/asthma/in-depth/asthma-medications/art-20045557.
52. ↑ 52.0 52.1 "Systemic steroids (corticosteroids). DermNet NZ". . DermNet NZ. 2012-05-19. http://dermnetnz.org/treatments/systemic-steroids.html.
53. ↑ "Antedrugs: an approach to safer drugs". Current Medicinal Chemistry 12 (19): 2227–2239. 2005. doi:10.2174/0929867054864840. PMID 16178782.
54. ↑ "Anti-inflammatory steroids". Wisconsin Medical Journal 61: 403–404. August 1962. PMID 13875857.
55. ↑ Alberto Conde-Taboada (2012). Dermatological Treatments. Bentham Science Publishers. pp. 35–36. ISBN 978-1-60805-234-9. https://books.google.com/books?id=mZDuAQAAQBAJ&pg=PA35.
56. ↑ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1642–1643. ISBN 978-0-8155-1856-3. https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA1642.
57. ↑ Cancer Drug Discovery: Science and History. Springer. 14 November 2016. pp. 169–. ISBN 978-94-024-0844-7. https://books.google.com/books?id=BR9_DQAAQBAJ&pg=PA169.
58. ↑ Nayak, Surajit; Acharjya, Basanti (December 19, 2008). "Deflazacort versus other glucocorticoids: A comparison". Indian Journal of Dermatology 53 (4): 167–170. doi:10.4103/0019-5154.44786. PMID 19882026.
59. ↑ "The development of cortisone as a therapeutic agent". Antibiotics & Chemotherapy (Northfield, Ill.) 1 (1): 7–15. April 1951. PMID 24540604. http://nobelprize.org/nobel_prizes/medicine/laureates/1950/kendall-lecture.pdf.
60. ↑ "Origins and impact of the term 'NSAID'". Inflammopharmacology 22 (5): 263–267. October 2014. doi:10.1007/s10787-014-0211-2. PMID 25064056.
61. ↑ Sarett LH, "Process of Treating Pregnene Compounds", US patent 2462133, issued 1947
62. ↑ "Steroidal sapogenins". Journal of the American Chemical Society 69 (9): 2167–2230. September 1947. doi:10.1021/ja01201a032. PMID 20262743. Bibcode: 1947JAChS..69.2167M.
63. ↑ "Microbiological Oxygenation of Steroids at Carbon 11". J. Am. Chem. Soc. 74 (7): 1871–2. 1952. doi:10.1021/ja01127a531. Bibcode: 1952JAChS..74.1871P.
64. ↑ Julian L, Cole JW, Meyer EW, Karpel WJ, "Preparation of Cortisone", US patent 2752339, issued 1956
65. ↑ "Contact Allergen of the Year: Corticosteroids: Introduction". Medscape.com. 2005-06-13. http://www.medscape.com/viewarticle/505245.

* v
* t
* e

Pharmacology: major drug groups

Gastrointestinal tract/
metabolism (A)|

* stomach acid
* Antacids
* H2 antagonists
* Proton pump inhibitors
* Antiemetics
* Laxatives
* Antidiarrhoeals/Antipropulsives
* Anti-obesity drugs
* Anti-diabetics
* Vitamins
* Dietary minerals

Blood and blood
forming organs (B)|

* Antithrombotics
* Antiplatelets
* Anticoagulants
* Thrombolytics/fibrinolytics
* Antihemorrhagics
* Platelets
* Coagulants
* Antifibrinolytics

Cardiovascular
system (C)|

* cardiac therapy/antianginals
* Cardiac glycosides
* Antiarrhythmics
* Cardiac stimulants
* Antihypertensives
* Diuretics
* Vasodilators
* Beta blockers
* Calcium channel blockers
* renin–angiotensin system
* ACE inhibitors
* Angiotensin II receptor antagonists
* Renin inhibitors
* Antihyperlipidemics
* Statins
* Fibrates
* Bile acid sequestrants

Skin (D)|

* Emollients
* Cicatrizants
* Antipruritics
* Antipsoriatics
* Medicated dressings

Genitourinary
system (G)|

* Hormonal contraception
* Fertility agents
* SERMs
* Sex hormones

Endocrine
system (H)|

* Hypothalamic–pituitary hormones
* Corticosteroids
* Glucocorticoids
* Mineralocorticoids
* Sex hormones
* Thyroid hormones/Antithyroid agents

Infections and
infestations (J, P, QI)|

* Antimicrobials: Antibacterials (Antimycobacterials)
* Antifungals
* Antivirals
* Antiparasitics
* Antiprotozoals
* Anthelmintics
* Ectoparasiticides
* IVIG
* Vaccines

Malignant disease
(L01–L02)|

* Anticancer agents
* Antimetabolites
* Alkylating
* Spindle poisons
* Antineoplastic
* Topoisomerase inhibitors

Immune disease
(L03–L04)|

* Immunomodulators
* Immunostimulants
* Immunosuppressants

Muscles, bones,
and joints (M)|

* Anabolic steroids
* Anti-inflammatories
* NSAIDs
* Antirheumatics
* Corticosteroids
* Muscle relaxants
* Bisphosphonates

Brain and
nervous system (N)|

* Analgesics
* Anesthetics
* General
* Local
* Anorectics
* Anti-ADHD agents
* Antiaddictives
* Anticonvulsants
* Antidementia agents
* Antidepressants
* Antimigraine agents
* Antiparkinson agents
* Antipsychotics
* Anxiolytics
* Aphrodisiacs
* Depressants
* Entactogens
* Entheogens
* Euphoriants
* Hallucinogens
* Psychedelics
* Dissociatives
* Deliriants
* Hypnotics/Sedatives
* Mood Stabilizers
* Neuroprotectives
* Nootropics
* Neurotoxins
* Orexigenics
* Serenics
* Stimulants
* Wakefulness-promoting agents

Respiratory
system (R)|

* Decongestants
* Bronchodilators
* Cough medicines
* H1 antagonists

Sensory organs (S)|

* Ophthalmologicals
* Otologicals

Other ATC (V)|

* Antidotes
* Contrast media
* Radiopharmaceuticals
* Dressings
* Senotherapeutics

* v
* t
* e

Endogenous steroids

Precursors|

* Cholesterol
* 22R-Hydroxycholesterol
* 20α,22R-Dihydroxycholesterol
* Pregnenolone
* 11β-Hydroxypregnenolone
* 17α-Hydroxypregnenolone
* 21-Hydroxypregnenolone
* 17α,21-Dihydroxypregnenolone
* 11β,17α,21-Trihydroxypregnenolone

Corticosteroids|

| Glucocorticoids|

* 3α,5α-Tetrahydrocorticosterone
* 5α-Dihydrocorticosterone
* 11-Deoxycorticosterone
* 11-Deoxycortisol
* 11-Ketoprogesterone
* 21-Deoxycortisol
* 21-Deoxycortisone
* Corticosterone
* Cortisol
* Cortisone
* 17α-Hydroxypregnenolone
* 17α-Hydroxyprogesterone
* Pregnenolone
* Progesterone

* Metabolites: 5α-Dihydrocortisol
* 3α,5α-Tetrahydrocortisol

|

Mineralocorticoids|

* 5α-Dihydroaldosterone
* 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
* 11-Deoxycortisol
* 11-Deoxycorticosterone
* 11β-Hydroxyprogesterone (21-deoxycorticosterone)
* 18-Hydroxy-11-deoxycorticosterone
* 18-Hydroxycorticosterone
* 18-Hydroxyprogesterone
* Aldosterone
* Corticosterone
* Cortisol

Sex steroids|

| Androgens|

* 11-Ketodihydrotestosterone
* 11-Ketotestosterone
* 7β-Hydroxyepiandrosterone
* 11β-Hydroxyandrostenedione
* Adrenosterone (11-ketoandrostenedione)
* Androstenediol
* Androstenedione
* Androsterone
* Dehydroandrosterone
* DHEA
* DHEA sulfate
* Dihydrotestosterone
* Epiandrosterone
* Epitestosterone
* 16α-Hydroxyandrostenedione
* 16α-Hydroxy-DHEA
* 16α-Hydroxy-DHEA sulfate
* Testosterone

* Metabolites: 3α-Androstanediol
* 3α-Androstanediol glucuronide
* 3β-Androstanediol
* 5β-Dihydrotestosterone
* 3α-Etiocholanediol
* 3β-Etiocholanediol
* Androstanetriols
* Androstenediol sulfate
* Androsterone glucuronide
* Androsterone sulfate
* Dihydrotestosterone glucuronide
* Dihydrotestosterone sulfate
* Etiocholanedione
* Etiocholanolone
* Etiocholanolone glucuronide
* Epietiocholanolone
* Testosterone glucuronide
* Testosterone sulfate

|

Estrogens|

* Estranes: Estetrol
* Estradiol
* Estrone
* Estriol
* 17α-Estradiol
* 16β-Epiestriol (16β-hydroxyestradiol)
* 17α-Epiestriol (16α-hydroxy-17α-estradiol)
* 16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
* 2-Hydroxyestradiol
* 2-Hydroxyestriol
* 2-Hydroxyestrone
* 4-Hydroxyestradiol
* 4-Hydroxyestriol
* 4-Hydroxyestrone
* 4-Methoxyestradiol
* 16α-Hydroxyestrone

* Others: 27-Hydroxycholesterol
* 3α-Androstanediol
* 3β-Androstanediol
* 4-Androstenedione
* 5-Androstenediol
* DHEA
* DHEA sulfate
* 7-Keto-DHEA
* 7α-Hydroxy-DHEA
* 16α-Hydroxy-DHEA

* Metabolites: 2-Methoxyestradiol
* 2-Methoxyestrone
* 4-Methoxyestrone
* Estradiol glucuronide
* Estradiol 3-glucuronide
* Estradiol sulfate
* Estradiol 17β-sulfate
* Estrone glucuronide
* Estrone sulfate
* Estriol glucuronide
* Estriol sulfate
* Lipoidal estradiol (e.g., estradiol stearate, estradiol palmitate)

Progestogens|

* Progesterone
* 16α-Hydroxyprogesterone
* 17α-Hydroxyprogesterone
* 20α-Dihydroprogesterone
* 20β-Dihydroprogesterone
* 5α-Dihydroprogesterone
* 11-Deoxycorticosterone
* 5α-DHDOC

* Metabolites: Allopregnanediol
* Pregnanediol
* Pregnanediol glucuronide
* Pregnanetriol

Neurosteroids|

* Cholestanes: 24S-Hydroxycholesterol
* Cholesterol

* Pregnanes: 3α-Dihydroprogesterone
* 3β-Dihydroprogesterone
* 5α-Dihydrocorticosterone
* 5α-Dihydroprogesterone
* 5β-Dihydroprogesterone
* Allopregnanolone
* Corticosterone
* DHC
* DHDOC
* 11-Deoxycorticosterone
* Epipregnanolone
* Isopregnanolone
* Pregnanolone
* Pregnenolone
* Pregnenolone sulfate
* Progesterone
* THB
* THDOC

* Androstanes: 3α-Androstanediol
* 3α-Androstenol
* 7-Keto-DHEA
* 7α-Hydroxy-DHEA
* 7β-Hydroxy-DHEA
* 7α-Hydroxyepiandrosterone
* 7β-Hydroxyepiandrosterone
* Androsterone
* DHEA
* DHEA sulfate
* Etiocholanolone

* Pheromones: 3α-Androstenol
* 3β-Androstenol
* Androstadienol
* Androstadienone
* Androstenone
* Androsterone
* Estratetraenol

Others|

* Vitamin D: 7-Dehydrocholesterol
* Calcidiol/Calcifediol
* Calcitriol
* Cholecalciferol

* Others: 7α-Hydroxycholesterol
* 11α-Hydroxyprogesterone
* 11β-Hydroxyprogesterone
* Cholesterol sulfate

Corticosteroids and anticorticosteroids

* v
* t
* e

Glucocorticoids and antiglucocorticoids (H02)

Glucocorticoids|

| Natural|

* Cortisone
* Cortisone acetate
* Cortodoxone (cortexolone, 11-deoxycortisol)
* Desoxycortone (deoxycortone, cortexone, 11-deoxycorticosterone)
* Desoxycortone esters
* Hydrocortisone (cortisol)#
* Hydrocortisone esters
* Prebediolone acetate
* Pregnenolone
* Pregnenolone acetate
* Pregnenolone succinate

|

Synthetic|

* Cortisol-like and related (16-unsubstituted): Chloroprednisone
* Cloprednol
* Difluprednate
* Fludrocortisone
* Flugestone acetate (flurogestone acetate)
* Fluocinolone
* Fluorometholone
* Fluorometholone acetate
* Fluperolone
* Fluperolone acetate
* Fluprednisolone
* Fluprednisolone esters
* Loteprednol
* Medrysone
* Methylprednisolone
* Methylprednisolone esters
* Prednicarbate
* Prednisolone#
* Prednisone
* Tixocortol
* Tixocortol pivalate

* Methasones and related (16-substituted): Alclometasone
* Beclometasone
* Beclometasone esters
* Betamethasone#
* Betamethasone esters
* Clobetasol
* Clobetasol propionate
* Clobetasone
* Clocortolone
* Clocortolone esters
* Cortivazol
* Desoximetasone
* Dexamethasone
* Dexamethasone esters
* Diflorasone
* Diflucortolone
* Diflucortolone valerate
* Fluclorolone
* Flumetasone
* Fluocortin
* Fluocortolone
* Fluocortolone esters
* Fluprednidene acetate
* Fluticasone
* Fluticasone furoate
* Fluticasone propionate
* Halometasone
* Meprednisone
* Mometasone
* Mometasone furoate
* Paramethasone
* Prednylidene
* Rimexolone
* Triamcinolone
* Ulobetasol (halobetasol)

* Cyclic ketals (16,17-cyclized): Amcinonide
* Budesonide
* Ciclesonide
* Deflazacort
* Desonide
* Fluclorolone acetonide (flucloronide)
* Fludroxycortide (flurandrenolone, flurandrenolide)
* Flunisolide
* Fluocinolone acetonide
* Fluocinonide
* Formocortal (fluoroformylone)
* Halcinonide
* Triamcinolone acetonide
* Triamcinolone acetonide esters

Antiglucocorticoids|

* Antagonists: Aglepristone
* Ketoconazole
* Mifepristone
* Ulipristal acetate

Synthesis modifiers|

* Acetoxolone
* Aminoglutethimide
* Carbenoxolone
* Enoxolone
* Ketoconazole
* Metyrapone
* Mitotane
* Trilostane

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids

* v
* t
* e

Mineralocorticoids and antimineralocorticoids (H02)

Mineralocorticoids|

* Desoxycortone (desoxycorticosterone)
* Desoxycortone esters
* Hydrocortisone (cortisol)
* Hydrocortisone esters
* Fludrocortisone
* Fludrocortisone acetate
* Methylprednisolone
* Methylprednisolone esters
* Prednisolone
* Prednisolone esters
* Prednisone
* Prednisone esters

Antimineralocorticoids|

* Steroidal: Canrenoate potassium (potassium canrenoate)
* Canrenone
* Drospirenone
* Dydrogesterone
* Eplerenone
* Gestodene
* Medrogestone
* Progesterone
* Spironolactone
* Trimegestone

* Nonsteroidal: Amlodipine
* Apararenone§
* Benidipine
* Esaxerenone†
* Felodipine
* Finerenone†
* Nifedipine
* Nimodipine
* Nitrendipine

Synthesis modifiers|

* Acetoxolone
* Aminoglutethimide
* Carbenoxolone
* Enoxolone
* Ketoconazole
* Metyrapone
* Mitotane
* Trilostane

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

See also
Mineralocorticoid receptor modulators
Glucocorticoids and antiglucocorticoids
List of corticosteroids

Corticosteroid receptor modulators

* v
* t
* e

Glucocorticoid receptor modulators

GR|

| Agonists|

* Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone
* 5α-Dihydrocorticosterone
* 9α-Fluorocortisone (alfluorone)
* 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
* 11-Dehydrocorticosterone acetate
* 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
* Desoxycortone esters
* 11-Deoxycortisol (cortodoxone, cortexolone)
* Cortifen (cortiphen, kortifen)
* Cortodoxone acetate
* 21-Deoxycortisol
* Δ7-Prednisolone
* Δ7-Prednisolone 21-acetate
* Amebucort
* Chloroprednisone
* Chloroprednisone acetate
* Cloprednol
* Cloprednol acetate
* Corticosterone
* Corticosterone acetate
* Corticosterone benzoate
* Cortisol (hydrocortisone)
* Benzodrocortisone (hydrocortisone benzoate)
* Hydrocortamate (hydrocortisone diethylaminoacetate)
* Hydrocortisone esters
* Cortisone
* Cortisone acetate
* Deprodone
* Deprodone propionate
* Dichlorisone
* Dichlorisone acetate
* Dichlorisone diacetate
* Difluprednate
* Endrisone (endrysone)
* Etiprednol
* Etiprednol dicloacetate (etiprednol dichloroacetate)
* Fludrocortisone (fludrocortone)
* Fludrocortisone acetate
* Fluorometholone
* Fluorometholone acetate
* Fluperolone
* Fluperolone acetate
* Fluprednisolone
* Fluprednisolone esters
* Halopredone
* Halopredone acetate (halopredone diacetate)
* Isoflupredone (9α-fluoroprednisolone)
* Isoflupredone acetate
* Loteprednol
* Mazipredone (depersolone)
* Medrysone
* Methylprednisolone
* Methylprednisolone esters
* Prebediolone
* Prebediolone acetate
* Prednisolone
* Prednazate
* Prednazoline
* Prednicarbate (prednisolone ethylcarbonate propionate)
* Prednimustine
* Prednisolamate (prednisolone diethylaminoacetate)
* Prednisolone esters
* Prednisone
* Prednisone esters
* Pregnenolone
* Pregnenolone acetate
* Pregnenolone succinate (pregnenolone hemisuccinate)
* Resocortol
* Tipredane
* Tixocortol
* Butixocort (tixocortol butyrate)
* Butixocort propionate
* Tixocortol pivalate

* Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone
* Alclometasone
* Alclometasone dipropionate
* Amelometasone
* Beclometasone (beclomethasone)
* Beclometasone esters
* Betamethasone (betametasone)
* Betamethasone esters
* Cortobenzolone (betamethasone salicylate)
* Ciclometasone (ciclomethasone, cyclomethasone)
* Clobetasol
* Clobetasol propionate
* Clobetasone
* Clobetasone butyrate
* Clocortolone
* Clocortolone esters
* Cloticasone
* Cloticasone propionate
* Cormetasone (cormethasone)
* Cormetasone acetate
* Descinolone
* Desoximetasone (desoxymethasone)
* Dexamethasone (dexametasone)
* Dexamethasone esters
* Diflorasone
* Diflorasone diacetate
* Diflucortolone
* Diflucortolone pivalate
* Diflucortolone valerate
* Dimesone
* Dimesone acetate
* Doxibetasol (doxybetasol)
* Fluclorolone
* Flumetasone (flumethasone)
* Flumetasone acetate
* Flumetasone pivalate
* Fluocinolone
* Fluocortin
* Fluocortin butyl (fluocortin butylate)
* Fluocortolone
* Fluocortolone esters
* Fluprednidene (fluprednylidene)
* Fluprednidene acetate
* Fluticasone
* Fluticasone furoate
* Fluticasone propionate
* Halocortolone
* Halometasone
* Icometasone
* Icometasone enbutate (icometasone butyrate acetate)
* Isoprednidene
* Locicortolone (locicortone)
* Locicortolone dicibate (locicortone dicibate)
* Meclorisone
* Meclorisone dibutyrate
* Meprednisone (methylprednisone)
* Meprednisone acetate
* Meprednisone hydrogen succinate (methylprednisone hemisuccinate)
* Mometasone
* Mometasone furoate
* Paramethasone
* Paramethasone acetate
* Paramethasone disodium phosphate
* Paramethasone phosphate
* Prednylidene
* Prednylidene diethylaminoacetate
* Rimexolone
* Ticabesone
* Ticabesone propionate
* Timobesone
* Timobesone acetate
* Triamcinolone
* Triamcinolone diacetate
* Ulobetasol (halobetasol)
* Ulobetasol propionate
* Vamorolone

* Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide)
* Amcinafal (triamcinolone pentanonide)
* Amcinafide (triamcinolone acetophenide)
* Amcinonide (triamcinolone acetate cyclopentanonide)
* Budesonide
* Ciclesonide
* Cicortonide
* Deflazacort (azacort)
* Descinolone acetonide
* Desonide (hydroxyprednisolone acetonide)
* Desonide disodium phosphate
* Desonide pivalate
* Dexbudesonide
* Drocinonide
* Drocinonide phosphate
* Fluazacort
* Fluclorolone acetonide (flucloronide)
* Fludroxycortide (flurandrenolone, flurandrenolide)
* Flumoxonide
* Flunisolide
* Flunisolide acetate
* Fluocinolone acetonide
* Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate)
* Fluocinonide (fluocinolide, fluocinolone acetonide acetate)
* Procinonide (fluocinolone acetonide propionate)
* Formocortal
* Halcinonide
* Itrocinonide
* Rofleponide
* Rofleponide palmitate
* Tralonide
* Triamcinolone acetonide
* Flupamesone (triamcinolone acetonide metembonate)
* Triamcinolone acetonide esters
* Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB)
* Triclonide

* Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol
* Cortivazol
* Domoprednate
* Naflocort
* Nicocortonide
* Nicocortonide acetate
* Nivacortol (nivazol)
* Oxisopred
* RU-26988
* RU-28362

* Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate
* 17α-Hydroxyprogesterone
* Bromoketoprogesterone
* Chlormadinone acetate
* Cyproterone
* Cyproterone acetate
* Danazol
* Delmadinone acetate
* Desogestrel
* DU-41165
* Etonogestrel
* Flugestone
* Flugestone acetate (flurogestone acetate)
* Fluoromedroxyprogesterone acetate
* Fluoxymesterone
* Gestodene
* Medrogestone
* Medroxyprogesterone acetate
* Megestrol acetate
* Metribolone
* Norgestomet
* Osaterone acetate
* Progesterone
* Promegestone
* RU-2309
* Quingestrone
* Segesterone acetate (nestorone)
* Tetrahydrogestrinone

* Nonsteroidal glucocorticoids: AZD-5423
* GSK-9027

|

Mixed
(SEGRMs)|

* Dagrocorat
* Fosdagrocorat
* Mapracorat

Antagonists|

* 7α-Hydroxy-DHEA
* 17α-Methylprogesterone
* Aglepristone
* Asoprisnil
* Asoprisnil ecamate
* C108297
* C113176
* CORT-108297
* Cyproterone acetate
* Exicorilant (CORT-125281)
* Guggulsterone
* Ketoconazole
* Lilopristone
* LLY-2707
* Metapristone (RU-42633)
* Miconazole
* Mifepristone (RU-486)
* Miricorilant (CORT-118335)
* Onapristone
* ORG-34116
* ORG-34517 (SCH-900636)
* ORG-34850
* Pregnenolone 16α-carbonitrile
* Relacorilant (CORT-125134)
* RTI 3021–012
* RTI 3021–022
* Telapristone
* Tibolone
* Toripristone
* Ulipristal acetate

Others|

* Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)

See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids

* v
* t
* e

Mineralocorticoid receptor modulators

MR|

| Agonists|

* 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
* 11-Dehydrocorticosterone acetate
* 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
* Desoxycortone esters
* 11-Deoxycortisol (cortodoxone, cortexolone)
* Cortifen (cortiphen, kortifen)
* Cortodoxone acetate
* 11β-Hydroxyprogesterone
* 16α,18-Dihydroxy-11-deoxycorticosterone
* 17α-Hydroxyaldosterone
* 18-Hydroxy-11-deoxycorticosterone
* 19-Norprogesterone
* Aldosterone
* Corticosterone
* Corticosterone acetate
* Corticosterone benzoate
* Cortisol (hydrocortisone)
* Benzodrocortisone (hydrocortisone benzoate)
* Hydrocortamate (hydrocortisone diethylaminoacetate)
* Hydrocortisone esters
* Cortisone
* Cortisone acetate
* Fludrocortisone (fludrocortone)
* Fludrocortisone acetate
* Mometasone
* Mometasone furoate
* Prednisolone
* Prednazate
* Prednazoline
* Prednicarbate (prednisolone ethylcarbonate propionate)
* Prednimustine
* Prednisolamate (prednisolone diethylaminoacetate)
* Prednisolone esters
* Prednisone
* Prednisone esters

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Antagonists|

* Steroidal: 6β-Hydroxy-7α-thiomethylspironolactone
* 7α-Acetylthio-17α-hydroxyprogesterone
* 7α-Thiomethylspironolactone (SC-26519)
* 7α-Thioprogesterone (SC-8365)
* 7α-Thiospironolactone (SC-24813)
* 16α-Hydroxyprogesterone
* 17α-Hydroxyprogesterone (hydroxyprogesterone)
* 18-Deoxyaldosterone
* 18,19-Dinorprogesterone
* Canrenoate potassium (potassium canrenoate)
* Canrenoic acid (canrenoate)
* Canrenone (canrenoate y-lactone)
* Dicirenone
* Dimethisterone
* Drospirenone
* Dydrogesterone
* Eplerenone
* Gestodene
* Guggulsterone
* Hydroxyprogesterone caproate
* Medrogestone
* Mespirenone
* Metribolone
* Mexrenoate potassium
* Mexrenoic acid (mexrenoate)
* Mexrenone
* Oxprenoic acid (oxprenoate)
* Oxprenoate potassium (RU-28318)
* Pregnenolone
* Progesterone
* Prorenoate potassium
* Prorenoic acid (prorenoate)
* Prorenone
* RO-14-9012
* RU-26752
* SC-5233 (spirolactone)
* SC-8109
* SC-11927 (CS-1)
* SC-19886
* SC-27169
* Spirorenone
* Spironolactone
* Spiroxasone
* Tibolone
* Trimegestone
* ZK-91587
* ZK-97894

* Nonsteroidal: Amlodipine
* Apararenone
* Benidipine
* BR-4628
* Esaxerenone
* Felodipine
* Finerenone
* Miricorilant (CORT-118335)
* Nifedipine
* Nimodipine
* Nitrendipine
* PF-03882845
* SM-368229

See also
Receptor/signaling modulators
Mineralocorticoids and antimineralocorticoids
Glucocorticoid receptor modulators
List of corticosteroids

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Original source: https://en.wikipedia.org/wiki/Corticosteroid. Read more

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*[GR]: Glucocorticoid receptor
*[SEGRMs]: Selective glucocorticoid receptor agonists
*[MR]: Mineralocorticoid receptor