Ephedra

Short description: Medicinal preparation from the plant Ephedra sinica

Bottle of ephedrine, an alkaloid found in ephedra

Ephedra is a medicinal preparation from the plant Ephedra sinica.[1] Several additional species belonging to the genus Ephedra have traditionally been used for a variety of medicinal purposes, and are a possible candidate for the soma plant of Indo-Iranian religion.[2] It has been used in traditional Chinese medicine, in which it is referred to as Ma Huang, for more than 2,000 years.[3][4] Native Americans and Mormon pioneers drank a tea brewed from other Ephedra species, called "Mormon tea" and "Indian tea".

Mormon tea (Ephedra funerea) growing in the wild in the Fiery Furnace area of Arches National Park near Moab, Utah

Dietary supplements containing ephedra alkaloids have been found to be unsafe, with reports of serious side effects and ephedra-related deaths.[5][6][7][8] In response to accumulating evidence of adverse effects and deaths related to ephedra, the U.S. Food and Drug Administration (FDA) banned the sale of supplements containing ephedrine alkaloids in 2004.[9] The ban was challenged in court by ephedra manufacturers, but ultimately upheld in 2006 by the U.S. Court of Appeals for the Tenth Circuit.[10] Ephedra extracts not containing ephedrine have not been banned by the FDA and are still sold legally.[11]

## Contents

* 1 Biochemistry and effects
* 2 Purity and dosage
* 3 Regulation in the United States
* 3.1 Initial concerns and industry response
* 3.2 Additional evidence and deaths
* 3.3 Ephedrine supplement ban
* 3.4 Legal challenges
* 4 Use in sports
* 4.1 Prominent cases
* 5 Connections to Soma rituals
* 5.1 History of Soma
* 5.2 Ritual use of Ephedra
* 6 See also
* 7 References
* 8 External links

## Biochemistry and effects

A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of ephedra. Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine,[12] which are the sources of its stimulant and thermogenic effects.[3] These compounds stimulate the brain, increase heart rate, constrict blood vessels (increasing blood pressure), and expand bronchial tubes (making breathing easier). Their thermogenic properties cause an increase in metabolism, as evidenced by an increase in body heat.

Ephedra is widely used by athletes as a performance-enhancing drug,[13] despite a lack of evidence that it improves athletic performance.[14][15] Ephedra may also be used as a precursor in the illicit manufacture of methamphetamine.[16]

Ephedra has been used as a weight-loss aid, sometimes in combination with aspirin and caffeine. Some studies in regulated and supervised environments have shown that ephedra is effective for marginal short-term weight loss (0.9 kg/month more than the placebo), although it was untested whether such weight loss is maintained.[17] However, several reports have documented a number of adverse events attributable to unregulated ephedra supplements.[18]

Adverse effects of ephedra consumption may include severe skin reactions, irritability, nervousness, dizziness, trembling, headache, insomnia, profuse perspiration, dehydration, itchy scalp and skin, vomiting, and hyperthermia. More serious potential side effects include irregular heartbeat, seizures, heart attack, stroke, and death.[19]

## Purity and dosage

There are no formal requirements for standardization or quality control of dietary supplements in the United States, and the dosage of effective ingredients in supplements may vary widely from brand to brand or batch to batch.[20][21][22] Studies of ephedra supplements have found significant discrepancies between the labeled dose and the actual amount of ephedra in the product. Significant variation in ephedrine alkaloid levels, by as much as 10-fold, was seen even from lot to lot within the same brand.[23][24]

## Regulation in the United States

Escalating concerns regarding the safety of ephedra supplements led the FDA to ban the sale of supplements containing ephedrine alkaloids (specifically ephedrine, pseudoephedrine, norephedrine, and methylephedrine) in the United States in 2004. This ban was challenged by supplement manufacturers and initially overturned, but ultimately upheld.

### Initial concerns and industry response

In 1997, in response to mounting concern over serious side effects of ephedra, the FDA proposed a ban on products containing 8 mg or more of ephedrine alkaloids and stricter labeling of low-dose ephedra supplements. The FDA also proposed that ephedra labels be required to disclose the health risks of ephedra, such as heart attack, stroke, and death.[25]

In response, the supplement industry created a public relations group, the Ephedra Education Council, to oppose the changes, and commissioned a scientific review by a private consulting firm, which reported that ephedra was safe.[26] The Ephedra Education Council also attempted to block publication of a study confirming wide discrepancies between the labeled potency of supplements and the actual amount of ephedra in the product.[20]

Metabolife, makers of the best-selling brand of ephedra supplement, had received over 14,000 complaints of adverse events associated with its product. These reports were not initially provided to the FDA.[26][27] Co-founder of Metabolife, Michael Ellis, was sentenced in 2008 to six months in federal prison for his failure to report adverse effects from his company's products to the FDA.[28] Senators Orrin Hatch (R. Utah) and Tom Harkin (D. Iowa), authors of the Dietary Supplements Health and Education Act, questioned the scientific basis for the FDA's proposed labeling changes and suggested that the number of problems reported were insufficient to warrant regulatory action. At the time, Senator Hatch's son was working for a firm hired to lobby Congress and the FDA on behalf of ephedra manufacturers.[29]

In addition to the activities of the Ephedra Education Council, Metabolife spent more than $4 million between 1998 and 2000 lobbying against state regulation of ephedra in Texas.[30] Business Week reported that efforts to regulate ephedra and other potentially harmful supplements had been "beaten down by deep-pocketed industry lobbying."[31]

In 2000, the FDA withdrew the proposed labeling changes and restrictions.[32]

### Additional evidence and deaths

A review of ephedra-related adverse reactions, published in the New England Journal of Medicine in 2000, found a number of cases of sudden cardiac death or severe disability resulting from ephedra use, many of which occurred in young adults using ephedra in the labeled dosages.[5] Subsequently, in response to pressure from the consumer advocacy group Public Citizen,[31] Metabolife was compelled by the Department of Justice in 2002 to turn over reports of over 15,000 ephedra-related adverse events, ranging from insomnia to death, which the company had previously withheld from the FDA.[26][33] Use of ephedra was considered to have possibly contributed to the death of Minnesota Vikings offensive lineman Korey Stringer from heatstroke in 2001.[34]

Steve Bechler, a pitcher for the Baltimore Orioles, died of complications from heatstroke following a spring training workout on February 17, 2003. The medical examiner found that ephedra toxicity played a "significant role" in Bechler's sudden death.[35] Following Bechler's death, the FDA re-opened its efforts to regulate ephedra use. According to Bruce Silverglade, legal director for the Center for Science in the Public Interest, "All of a sudden [after Bechler's death] Congress dropped objections to an ephedra ban and started demanding that the FDA act."[26]

Senator Orrin Hatch (R. Utah), who in 1999 had helped block the FDA's attempts to regulate ephedra, said in March 2003 that "...it has been obvious to even the most casual observer that problems exist", and called FDA action to regulate ephedra "long overdue."[29]

### Ephedrine supplement ban

In response to renewed calls for the regulation of ephedra, the U.S. Department of Health and Human Services commissioned a large meta-analysis of ephedra's safety and efficacy by the RAND Corporation. This study found that ephedra promoted modest short-term weight loss, but there was insufficient data to determine whether it was effective for long-term weight loss or performance enhancement. The use of ephedrine alkaloids in this study was associated with significant gastrointestinal, psychiatric, and autonomic side effects.[36] Almost simultaneously, a study in Annals of Internal Medicine found that ephedrine alkaloids were 100 to 700 times more likely to cause a significant adverse reaction than other commonly used supplements such as kava or Ginkgo biloba.[6]

On December 30, 2003, the FDA issued a press release recommending that consumers stop buying and using products containing ephedrine alkaloids, and indicating its intention to ban the sale of ephedrine alkaloid-containing supplements.[37] Subsequently, on April 12, 2004, the FDA issued a final rule banning the sale of ephedrine alkaloid-containing dietary supplements. Tommy Thompson, the Secretary of Health and Human Services, stated that "...These products pose unacceptable health risks, and any consumers who are still using them should stop immediately."[9] Products containing ephedra extract remain legal to this day.[11]

### Legal challenges

Nutraceutical Corporation, a supplement manufacturer based in Park City, Utah, challenged the legality of the FDA's ban of ephedra alkaloids as exceeding the authority given the agency by the Dietary Health Supplements and Education Act. Nutraceutical Corporation stated that while they did not intend to restart marketing ephedra, they were concerned about the scope of the FDA's regulatory action. Judge Tena Campbell of the Utah Federal District Court ruled that the FDA had not proven that low doses of ephedra alkaloids were unsafe, although she also noted that studies to address the safety of low-dose ephedra would be unethical. Nevertheless, her ruling overturned the ban on the sale of ephedra alkaloids in the state of Utah, and called into question whether the ban could be enforced anywhere in the United States.[38]

The ruling was appealed to the U.S. Court of Appeals for the Tenth Circuit in Denver, Colorado. On August 17, 2006, the Appeals Court upheld the FDA's ban of ephedra alkaloids, finding that the 133,000 page administrative record compiled by the FDA supported the agency's finding that ephedra alkaloids posed an unreasonable risk to consumers.[10] Nutraceutical Corp. filed a petition for a writ of certiorari seeking a rehearing on the ban of ephedra alkaloids; however, on May 14, 2007 the United States Supreme Court declined to hear this petition. The sale of ephedra alkaloid-containing dietary supplements remains illegal in the United States.[8] Sales of products containing ephedra extract not containing ephedrine remain legal.[11]

## Use in sports

Ephedrine is listed as a banned substance by both the International Olympic Committee and the World Anti-Doping Agency.[39] The National Football League banned players from using ephedra as a dietary supplement in 2001 after the death of Minnesota Vikings offensive tackle Korey Stringer; ephedra was found in Stringer's locker and lawyers for the team contended that it contributed to his death.[34][40] The substance is also banned by the National Basketball Association.[38] It was also banned by Major League Baseball after the 2003 death of Steve Bechler. Nonetheless, ephedra remains widely used by athletes; a 2006 survey of collegiate hockey players found that nearly half had used ephedra believing it enhanced their athletic performance.[13]

### Prominent cases

In the 1994 FIFA World Cup, the Argentina footballer Diego Armando Maradona tested positive for ephedrine.[41] The Japanese motorcycle racer Noriyuki Haga tested positive for ephedrine in 2000, being disqualified from two races and banned from two more as a result.[42] NFL punter Todd Sauerbrun of the Denver Broncos was suspended for the first month of the 2006 season after testing positive for ephedrine.[40]

## Connections to Soma rituals

### History of Soma

Main article: Chemistry:Soma (drink)

Throughout the many hymns, prayers, and philosophy found in the Vedas (written around 1500 BC), a mysterious plant is mentioned often and with great reverence. This plant alternates from a holy substance to an actual personified god and is considered a teacher, doctor, medicine, a bringer of insight and a vector of inspiration.[43] The deity version of Soma was associated with medicinal herbs and the moon and was considered a bringer of health and prosperity.[44] The plant was an essential aspect of Vedic religion to alter one’s mind, enabling communion with the divine. The ritual drinking of Soma was also found in the ancient Zoroastrian text, the Avesta.[43] The rituals and importance of the plant were very similar to those in Vedic culture but were instead called by the name haoma.[43] It is unknown why, but eventually in both the Vedic and Zoroastrian cultures a substitute substance was used in these religious ceremonies and over time the definitive identity of Soma-Haoma has been lost.[citation needed] There is much debate over which species of plant are the sacred plant of the Vedic and Zoroastrian faiths.

### Ritual use of Ephedra

Main article: Chemistry:Botanical identity of soma–haoma

The Rigveda is one of the four oldest and most sacred collections of stories in Hinduism. In the Rigveda soma is a drink consumed by two of the main gods; Agni and Indra. In the texts the drink helped the gods in battle by strengthening them physically.[45] Because of this, soma was given and consumed by warriors before wartime or a battle. The drink was supposed to give the warriors strength and luck in the upcoming conflict.[46] Immortality is also a quality associated with soma due to it being a drink of the divine. At religious ceremonies the drink was consumed to give consumers longevity in life. At birth the drink was also given to the babies for these same reasons.[46]

In Zoroastrianism the drink is called haoma and has similar uses. Just like in Hinduism, the drink was related to immortality and long life. Haoma was the first thing newborns drank. This assured the child would be healthy and live a long life.[46] The drink was also administered to people close to death to resurrect them back into good health.[46]

The physical appearance of Ephedra is also a reason it is believed to be the soma plant. According to the Vedic text Rigveda, the plant composing soma is shaped like an arrow. Ephedra sinica is a gymnosperm that forms stalks with buds on the end. It is easy to see how this shape could be described like an arrow.[46] Another text refers to soma as a twig, which is much like Ephedra sinica when it is dried out.[43]

## See also

* Chinese medicine
* Sida cordifolia
* Pinellia
* Synephrine

## References

1. ↑ "Ephedrine-type alkaloid content of nutritional supplements containing Ephedra sinica (Ma-huang) as determined by high performance liquid chromatography". J Pharm Sci 87 (12): 1547–53. 1998. doi:10.1021/js9801844. PMID 10189265.
2. ↑ Botany of Haoma , from Encyclopædia Iranica. Accessed March 15, 2007.
3. ↑ 3.0 3.1 "Ephedra in perspective--a current review". Phytother Res 17 (7): 703–12. 2003. doi:10.1002/ptr.1337. PMID 12916063.
4. ↑ Kee C. Huang (12 December 2010). The Pharmacology of Chinese Herbs, Second Edition. CRC Press. p. 9. ISBN 978-1-4200-4826-1. https://books.google.com/books?id=xKGxTcF8u-sC&pg=PR3.
5. ↑ 5.0 5.1 "Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids". N Engl J Med 343 (25): 1833–38. 2000. doi:10.1056/NEJM200012213432502. PMID 11117974.
6. ↑ 6.0 6.1 "The relative safety of ephedra compared with other herbal products". Ann Intern Med 138 (6): 468–71. 2003. doi:10.7326/0003-4819-138-6-200303180-00010. PMID 12639079.
7. ↑ "National Center for Complementary and Alternative Medicine Consumer Advisory on ephedra". 2004-10-01. http://nccih.nih.gov/health/alerts/ephedra/consumeradvisory.htm. [yes|permanent dead link|dead link}}]
8. ↑ 8.0 8.1 "Food and Drug Administration summary of actions regarding sale of ephedra supplements". https://www.fda.gov/oc/initiatives/ephedra/february2004/.
9. ↑ 9.0 9.1 "FDA Final Rule Banning Dietary Supplements With Ephedrine Alkaloids Becomes Effective". U.S. Food and Drug Administration. https://www.fda.gov/bbs/topics/NEWS/2004/NEW01050.html.
10. ↑ 10.0 10.1 "FDA Statement on Tenth Circuit's Ruling to Uphold FDA Decision Banning Dietary Supplements Containing Ephedrine Alkaloids". U.S. Food and Drug Administration. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108715.htm.
11. ↑ 11.0 11.1 11.2 "Is Ephedra legal? Consumer Reports Investigates". http://www.consumerreports.org/cro/magazine-archive/2010/march/health/ephedra/overview/ephedra-ov.htm.
12. ↑ Abourashed, Ehab A.; Abir T. El-Alfy; Ikhlas A. Khan; Larry Walker (2003). "Ephedra in perspective – a current review". Phytotherapy Research 17 (7): 703–712. doi:10.1002/ptr.1337. PMID 12916063. http://weightlosster.com/ephedra_in_perspective_a_current_review.pdf.
13. ↑ 13.0 13.1 "Patterns of ephedra and other stimulant use in collegiate hockey athletes". Int J Sport Nutr Exerc Metab 16 (6): 636–43. 2006. doi:10.1123/ijsnem.16.6.636. PMID 17342884.
14. ↑ "Ephedrine and other stimulants as ergogenic aids". Curr Sports Med Rep 2 (4): 220–5. 2003. doi:10.1249/00149619-200308000-00009. PMID 12834578.
15. ↑ "Popular ergogenic drugs and supplements in young athletes". Pediatrics 117 (3): e577–89. 2006. doi:10.1542/peds.2005-1429. PMID 16510635.
16. ↑ "A study of the use of Ephedra in the manufacture of methamphetamine". Forensic Sci Int 166 (2–3): 102–9. 2007. doi:10.1016/j.forsciint.2006.04.005. PMID 16707238.
17. ↑ "Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial". Int J Obes Relat Metab Disord 26 (5): 593–604. 2002. doi:10.1038/sj.ijo.0802023. PMID 12032741.
18. ↑ "The severity of toxic reactions to ephedra: comparisons to other botanical products and national trends from 1993–2002". Clin Toxicol 43 (5): 347–55. 2005. doi:10.1081/CLT-200066075. PMID 16235509.
19. ↑ "Ephedra information". Memorial Sloan-Kettering Cancer Center. http://www.mskcc.org/mskcc/html/69213.cfm.
20. ↑ 20.0 20.1 "Swallowing Ephedra" , by Sharon Brownlee. Published online at Salon.com on June 7, 2000. Accessed 8 February 2007.
21. ↑ Dietary Supplements: Background Information . From the Office of Dietary Supplements at the National Institutes of Health. Accessed 7 February 2007.
22. ↑ Herbal Rx: the promise and pitfalls. Consumer Reports, 1999, pp 44–48.
23. ↑ "Concentrations of ephedra alkaloids and caffeine in commercial dietary supplements". J Anal Toxicol 28 (3): 145–51. 2004. doi:10.1093/jat/28.3.145. PMID 15107143.
24. ↑ "Content versus label claims in ephedra-containing dietary supplements". Am J Health Syst Pharm 57 (10): 963–9. 2000. doi:10.1093/ajhp/57.10.963. PMID 10832496.
25. ↑ "Dietary Supplements Containing Ephedrine Alkaloids; Proposed Rule" , from the Federal Register, June 4, 1997. Accessed 7 February 2007.
26. ↑ 26.0 26.1 26.2 26.3 "Dangerous supplements: Still at large", from Consumer Reports magazine. Published May 2004, accessed 7 February 2007.
27. ↑ Criminal investigation sought for diet supplement seller, published in USA Today on August 15, 2002. Accessed April 10, 2007.
28. ↑ Metabolife Founder Sentenced For Lying To FDA
29. ↑ 29.0 29.1 "Senator, His Son Get Boosts From Makers of Ephedra" , published in the Los Angeles Times on March 5, 2003. Purchase required to view full text. Accessed 7 February 2007.
30. ↑ Wolfe S (2003). "Medicine. Ephedra--scientific evidence versus money/politics". Science 300 (5618): 437. doi:10.1126/science.1081910. PMID 12702860.
31. ↑ 31.0 31.1 "Diet Pills and Pols: A Dangerous Mix" , by Arlene Weintraub and John Carey. Published in Business Week on September 2, 2002. Accessed March 31, 2007.
32. ↑ "Dietary Supplements Containing Ephedrine Alkaloids; Withdrawal in Part" , from the Federal Register, April 3, 2000. Accessed 7 February 2007.
33. ↑ "The Secret of Ephedra's Questionable Success". A report on "All Things Considered", National Public Radio, November 22, 2002. Accessed 7 February 2007.
34. ↑ 34.0 34.1 Vikings: Stringer's use of ephedra contributed to death, published online by Sports Illustrated on February 25, 2003. Accessed March 15, 2007.
35. ↑ "Medical examiner: Ephedra a factor in Bechler death", from USA Today, published March 13, 2003. Accessed 7 February 2007.
36. ↑ "Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis". JAMA 289 (12): 1537–45. 2003. doi:10.1001/jama.289.12.1470. PMID 12672771.
37. ↑ "FDA Announces Plans to Prohibit Sales of Dietary Supplements Containing Ephedra": Press release from the FDA website, issued December 30, 2003, accessed 7 February 2007.
38. ↑ 38.0 38.1 "Judge's Decision Lifts Ban On Sale of Ephedra in Utah", from The New York Times , published April 15, 2005. Accessed 7 February 2007.
39. ↑ "World Anti-Doping Agency Prohibited List, 2006". http://www.wada-ama.org/rtecontent/document/Prohibited_List_2006_EN_FR_SP.pdf. . (1.50 MiB) Accessed March 15, 2007.
40. ↑ 40.0 40.1 Sauerbrun fails test: Broncos punter faces suspension for use of ephedra, by Bill Williamson. Published in the Denver Post on July 6, 2006. Accessed March 15, 2007.
41. ↑ "Maradona's fall from grace", by John May. From the BBC, published April 19, 2004. Accessed March 15, 2007.
42. ↑ "Haga Saga" , by Dirck Edge. From motorcycledaily.com, May 24, 2000. Accessed March 15, 2007.
43. ↑ 43.0 43.1 43.2 43.3 Houben, Jan. “The Soma-Haoma problem : Introductory overview and observations on the discussion.” Electronic Journal of Vedic Studies, 2003.
44. ↑ Cartwright, Mark. "Soma." Ancient History Encyclopedia. Ancient History Encyclopedia, 30 Jan 2016. Web. 17 Apr 2020.
45. ↑ Shah, N.C. “Soma, an Enigmatic, Mysterious Plant of the Vedic Aryas: An Appraisal” Indian Journal of History of Science, vol. 50.1, (2015): 26-4
46. ↑ 46.0 46.1 46.2 46.3 46.4 Mahdihassan, S. “Ephedra, the oldest medicinal plant with the history of an uninterrupted use.” Ancient science of life vol. 7,2 (1987): 105-9.

## External links

* United States FDA links to actions
* United States NIH Factsheet regarding weight loss and athletic performance
* Dietary Supplements: Balancing Consumer Choice and Safety. A report of the New York State Task Force on Life & the Law.
* The history of Ephedra (ma-huang).

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