Group 2 organometallic chemistry

thumb|right|Magnesium anthracenide with three thf ligands.[1] Group 2 organometallic chemistry refers to the chemistry of compounds containing carbon bonded to any group 2 element.[2][3] By far the most common group 2 organometallic compounds are the magnesium-containing Grignard reagents which are widely used in organic chemistry. Other organometallic group 2 compounds are rare and are typically limited to academic interests.

## Contents

* 1 Characteristics
* 2 Synthesis
* 3 Compounds
* 3.1 Organoberyllium
* 3.2 Organomagnesium
* 3.3 Organocalcium
* 3.4 Organostrontium
* 3.5 Organobarium
* 3.6 Organoradium
* 4 See also
* 5 References

## Characteristics

As the group 2 elements (also referred to as the alkaline earth metals) contain two valence electrons, their chemistries have similarities group 12 organometallic compounds. Both readily assume a +2 oxidation states with higher and lower states being rare, and are less electronegative than carbon. However, as the group two elements (with the exception of beryllium) have considerably low electronegativity the resulting C-M bonds are more highly polarized and ionic-like, if not entirely ionic for the heavier barium compounds. The lighter organoberyllium and organomagnesium compounds are often considered covalent, but with some ionic bond characteristics owing to the attached carbon bearing a negative dipole moment. This higher ionic character and bond polarization tends to produce high coordination numbers and many compounds (particularly dialklys) are polymeric in solid or liquid states with highly complex structures in solution, though in the gaseous state they are often monomeric.

Metallocene compounds with group 2 elements are rare, but some do exist. Bis(cyclopentadienyl)beryllium or beryllocene (Cp2Be), with a molecular dipole moment of 2.2 D, is so-called slipped 5η/1η sandwich. While magnesocene (Cp2Mg) is a regular metallocene, bis(pentamethylcyclopentadienyl)calcium (Cp*)2Ca is bent with an angle of 147°.

right|thumb|322 px|[[Dimethylmagnesium is a polymer built up from 3-center, 2-electron bonded bridging methyl groups.[4] Dimethylberyllium adopts the same structure.[5]]]

## Synthesis

Mixed alkyl/aryl-halide compounds, which contain a single C-M bond and a C-X bond, are typically prepared by oxidative addition. Magnesium-containing compounds of this configuration are known as the Grignard reagents, though some calcium Grignard's are known and more reactive and sensitive to decomposition. Calcium grignard's must be pre-activated prior to synthesis.[6]

There are three key reaction pathways for dialkyl and diaryl group 2 metal compounds.

* metathesis:

MX2 \+ R-Y -> MR2 \+ Y-X'

* transmetallation:

M'R2 \+ M -> MR2 \+ M'

* via the Schlenk equilibrium:

2 RMX -> MR2 \+ MX2

## Compounds

Although organomagnesium compounds are widespread in the form of Grignard reagents, the other organo-group 2 compound are almost exclusively of academic interest. Organoberyllium chemistry is limited due to the cost and toxicity of beryllium. Calcium is nontoxic and cheap but organocalcium compounds are difficult to prepare, strontium and barium compounds even more so. One use for these type of compounds is in chemical vapor deposition.

### Organoberyllium

Main article: Chemistry:Organoberyllium chemistry

Beryllium derivatives and reagents are often prepared by alkylation of beryllium chloride.[7] Examples of known organoberyllium compounds are dineopentylberyllium,[8] beryllocene (Cp2Be),[9][10][11][12] diallylberyllium (by exchange reaction of diethyl beryllium with triallyl boron),[13] bis(1,3-trimethylsilylallyl)beryllium[14] and Be(mes)2.[7][15] Ligands can also be aryls[16] and alkynyls.[17]

### Organomagnesium

See also: Grignard reagent

The distinctive feature of the Grignard reagents is their formation from the organic halide and magnesium metal. Most other group II organic compounds are generated by salt metathesis, which limits their accessibility. The formation of the Grignard reagents has received intense scrutiny. It proceeds by a SET process. For less reactive organic halides, activated forms of magnesium have been produced in the form of Rieke magnesium. Examples of Grignard reagents are phenylmagnesium bromide and ethylmagnesium bromide. These simplified formulas are deceptive: Grignard reagents generally exist as dietherates, RMgX(ether)2. As such they obey the octet rule.

Grignard reagents participate in the Schlenk equilibrium. Exploiting this reaction is a way to generate dimethylmagnesium. Beyond Grignard reagents, another organomagnesium compound is magnesium anthracene. This orange solid is used as a source of highly active magnesium. Butadiene-magnesium serves as a source for the butadiene dianion. Ate complexes of magnesium are also well known, e.g LiMgBu3.[18]

### Organocalcium

Dimethylcalcium is obtained by metathesis reaction of calcium bis(trimethylsilyl)amide and methyllithium in diethyl ether:[19]

Ca[N{Si(CH3)3}2]2+2 LiCH3⟶Ca(CH3)2+2 Li[N{Si(CH3)3}2]

A well known organocalcium compound is (Cp)calcium(I).[citation needed] Bis(allyl)calcium was described in 2009.[20] It forms in a metathesis reaction of allylpotassium and calcium iodide as a stable non-pyrophoric off-white powder:

2KCA3HA5allylpotassium+CaIA2calcium iodide→25A∘CTHF(C3H5)2Ca+2KI

The bonding mode is η3. This compound is also reported to give access to an η1 polymeric (CaCH2CHCH2)n compound.[21]

The compound [(thf)3Ca{μ-C6H3-1,3,5-Ph3}Ca(thf)3] also described in 2009[22][23] is an inverse sandwich compound with two calcium atoms at either side of an arene.

Olefins tethered to cyclopentadienyl ligands have been shown to coordinate to calcium(II), strontium(II), and barium(II):[24]

Organocalcium compounds have been investigated as catalysts.[25]

### Organostrontium

Organostrontium compounds have been reported as intermediates in Barbier-type reactions.[26][27][28]

Structure of Ba(CH(tms)2)2(thf)3 (tms = Si(CH3)3), with H atoms omitted. Even with bulky alkyl substituents, Ba coordinates to three THF ligands.

### Organobarium

Organobarium compounds[29] of the type (allyl)BaCl can be prepared by reaction of activated barium (Rieke method reduction of barium iodide with lithium biphenylide) with allyl halides.[30][31] These allylbarium compounds react with carbonyl compounds. Such reagents are more alpha-selective and more stereoselective than the related Grignards or organocalcium compounds. The metallocene (Cp*)2Ba has also been reported.[32]

### Organoradium

The only known organoradium compound is the gas-phase acetylide.

## See also

* Organometallic chemistry

## References

1. ↑ Borislav Bogdanovic (1988). "Magnesium Anthracene Systems and their Application in Synthesis and Catalysis". Accounts of Chemical Research 21 (7): 261–267. doi:10.1021/ar00151a002.
2. ↑ Comprehensive Organometallic Chemistry by Mike Mingos, Robert Crabtree 2007 ISBN 978-0-08-044590-8
3. ↑ C. Elschenbroich, A. Salzer Organometallics : A Concise Introduction (2nd Ed) (1992) from Wiley-VCH: Weinheim. ISBN 3-527-28165-7
4. ↑ Weiss, E. (1964). "Die Kristallstruktur des Dimethylmagnesiums". J. Organomet. Chem. 2 (4): 314–321. doi:10.1016/S0022-328X(00)82217-2.
5. ↑ Snow, A.I.; Rundle, R.E. (1951). "Structure of Dimethylberyllium". Acta Crystallographica 4 (4): 348–52. doi:10.1107/S0365110X51001100.
6. ↑ Reuben D. Rieke; Tse-Chong Wu; Loretta I. Rieke (1995). "Highly Reactive Calcium for the Preparation of Organocalcium Reagents: 1-Adamantyl Calcium Halides and Their Addition to Ketones: 1-(1-Adamantyl)cyclohexanol". Org. Synth. 72: 147. doi:10.15227/orgsyn.072.0147.
7. ↑ 7.0 7.1 Off the Beaten Track—A Hitchhiker's Guide to Beryllium Chemistry D. Naglav, M. R. Buchner, G. Bendt, F. Kraus, S. Schulz, Angew. Chem. Int. Ed. 2016, 55, 10562. doi:10.1002/anie.201601809
8. ↑ Coates, G. E.; Francis, B. R. (1971). "Preparation of base-free beryllium alkyls from trialkylboranes. Dineopentylberyllium, bis(trimethylsilylmethyl)beryllium, and an ethylberyllium hydride". Journal of the Chemical Society A: Inorganic, Physical, Theoretical: 1308. doi:10.1039/J19710001308.
9. ↑ Fischer, Ernst Otto; Hofmann, Hermann P. (1959). "Über Aromatenkomplexe von Metallen, XXV. Di-cyclopentadienyl-beryllium". Chemische Berichte 92 (2): 482. doi:10.1002/cber.19590920233.
10. ↑ Nugent, KW; Beattie, JK; Hambley, TW; Snow, MR (1984). "A precise low-temperature crystal structure of Bis(cyclopentadienyl)beryllium". Australian Journal of Chemistry 37 (8): 1601. doi:10.1071/CH9841601.
11. ↑ Almenningen, A; Haaland, Arne; Lusztyk, Janusz (1979). "The molecular structure of beryllocene, (C5H5)2Be. A reinvestigation by gas phase electron diffraction". Journal of Organometallic Chemistry 170 (3): 271. doi:10.1016/S0022-328X(00)92065-5.
12. ↑ Wong, C. H.; Lee, T. Y.; Chao, K. J.; Lee, S. (1972). "Crystal structure of bis(cyclopentadienyl)beryllium at −120 °C". Acta Crystallographica Section B 28 (6): 1662. doi:10.1107/S0567740872004820.
13. ↑ Wiegand, G.; Thiele, K.-H. (1974). "Ein Beitrag zur Existenz von Allylberyllium- und Allylaluminiumverbindungen". Zeitschrift für anorganische und allgemeine Chemie 405: 101–108. doi:10.1002/zaac.19744050111.
14. ↑ Chmely, Stephen C.; Hanusa, Timothy P.; Brennessel, William W. (2010). "Bis(1,3-trimethylsilylallyl)beryllium". Angewandte Chemie International Edition 49 (34): 5870–4. doi:10.1002/anie.201001866. PMID 20575128.
15. ↑ Synthesis and structural characterization of the beryllium compounds [Be(2,4,6-Me3C6H2)2(OEt2)], [Be{O(2,4,6-tert-Bu3C6H2)}2(OEt2)], and [Be{S(2,4,6-tert-Bu3C6H2)}2(THF)].cntdot.PhMe and determination of the structure of [BeCl2(OEt2)2] Karin Ruhlandt-Senge, Ruth A. Bartlett, Marilyn M. Olmstead, and Philip P. Power Inorganic Chemistry 1993 32 (9), 1724-1728 doi:10.1021/ic00061a031
16. ↑ Ruhlandt-Senge, Karin; Bartlett, Ruth A.; Olmstead, Marilyn M.; Power, Philip P. (1993). "Synthesis and structural characterization of the beryllium compounds [Be(2,4,6-Me3C6H2)2(OEt2)], [Be{O(2,4,6-tert-Bu3C6H2)}2(OEt2)], and [Be{S(2,4,6-tert-Bu3C6H2)}2(THF)].cntdot.PhMe and determination of the structure of [BeCl2(OEt2)2]". Inorganic Chemistry 32: 1724. doi:10.1021/ic00061a031.
17. ↑ Morosin, B; Howatson, J. (1971). "The crystal structure of dimeric methyl-1-propynyl- beryllium-كس امك trimethylamine". Journal of Organometallic Chemistry 29: 7. doi:10.1016/S0022-328X(00)87485-9.
18. ↑ Arredondo, Juan D.; Li, Hongmei; Balsells, Jaume (2012). "Preparation of t-Butyl-3-Bromo-5-Formylbenzoate Through Selective Metal-Halogen Exchange Reactions". Organic Syntheses 89: 460. doi:10.15227/orgsyn.089.0460.
19. ↑ "Dimethylcalcium" Benjamin M. Wolf, Christoph Stuhl, Cäcilia Maichle-Mössmer, and Reiner Anwander J. Am. Chem. Soc. 2018, Volume 140, Issue 6, Pages 2373–2383 doi:10.1021/jacs.7b12984
20. ↑ "Bis(allyl)calcium" Phillip Jochmann, Thomas S. Dols, Thomas P. Spaniol, Lionel Perrin, Laurent Maron, Jun Okuda Angewandte Chemie International Edition Volume 48 Issue 31, Pages 5715–5719 2009 doi:10.1002/anie.200901743
21. ↑ Lichtenberg, C., Jochmann, P., Spaniol, T. P. and Okuda, J. (2011), "The Allylcalcium Monocation: A Bridging Allyl Ligand with a Non-Bent Coordination Geometry". Angewandte Chemie International Edition, 50: 5753–5756. doi:10.1002/anie.201100073
22. ↑ "Stable 'Inverse' Sandwich Complex with Unprecedented Organocalcium(I): Crystal Structures of [(thf)2Mg(Br)-C6H2-2,4,6-Ph3] and [(thf)3Ca{μ-C6H3-1,3,5-Ph3}Ca(thf)3]" Sven Krieck, Helmar Görls, Lian Yu, Markus Reiher and Matthias Westerhausen J. Am. Chem. Soc., 2009, 131 (8), pp 2977–2985 doi:10.1021/ja808524y
23. ↑ "Organometallic Compounds of the Heavier s-Block Elements—What Next?" J. David Smith Angew. Chem. Int. Ed. 2009, 48, 6597–6599 doi:10.1002/anie.200901506
24. ↑ 24.0 24.1 H. Schumann; S. Schutte; H.-J. Kroth; D. Lentz (2004). "Butenyl-Substituted Alkaline-Earth Metallocenes: A First Step towards Olefin Complexes of the Alkaline-Earth Metals". Angew. Chem. Int. Ed. 43 (45): 6208–6211. doi:10.1002/anie.200460927. PMID 15549740.
25. ↑ Arrowsmith, Merle; Crimmin, Mark R.; Barrett, Anthony G. M.; Hill, Michael S.; Kociok-KöHn, Gabriele; Procopiou, Panayiotis A. (2011). "Cation Charge Density and Precatalyst Selection in Group 2-Catalyzed Aminoalkene Hydroamination". Organometallics 30 (6): 1493–1506. doi:10.1021/om101063m.
26. ↑ Miyoshi, N.; Kamiura, K.; Oka, H.; Kita, A.; Kuwata, R.; Ikehara, D.; Wada, M. (2004). "The Barbier-Type Alkylation of Aldehydes with Alkyl Halides in the Presence of Metallic Strontium". Bulletin of the Chemical Society of Japan 77 (2): 341. doi:10.1246/bcsj.77.341.
27. ↑ Miyoshi, N.; Ikehara, D.; Kohno, T.; Matsui, A.; Wada, M. (2005). "The Chemistry of Alkylstrontium Halide Analogues: Barbier-type Alkylation of Imines with Alkyl Halides". Chemistry Letters 34 (6): 760. doi:10.1246/cl.2005.760.
28. ↑ Miyoshi, N.; Matsuo, T.; Wada, M. (2005). "The Chemistry of Alkylstrontium Halide Analogues, Part 2: Barbier-Type Dialkylation of Esters with Alkyl Halides". European Journal of Organic Chemistry 2005 (20): 4253. doi:10.1002/ejoc.200500484.
29. ↑ Comprehensive organic functional group transformations Alan R. Katritzky, Otto Meth-Cohn, Charles Wayne Rees
30. ↑ Yanagisawa, A.; Habaue, S.; Yamamoto, H. (1991). "Allylbarium in organic synthesis: unprecedented .alpha.-selective and stereospecific allylation of carbonyl compounds". Journal of the American Chemical Society 113 (23): 8955. doi:10.1021/ja00023a058.
31. ↑ Yanagisawa, A.; Habaue, S.; Yasue, K.; Yamamoto, H. (1994). "Allylbarium Reagents: Unprecedented Regio- and Stereoselective Allylation Reactions of Carbonyl Compounds". Journal of the American Chemical Society 116 (14): 6130. doi:10.1021/ja00093a010.
32. ↑ Williams, R. A.; Hanusa, T. P.; Huffman, J. C. (1988). "Solid state structure of bis(pentamethylcyclopentadienyl)barium, (Me5C5)2Ba; the first X-ray crystal structure of an organobarium complex". Journal of the Chemical Society, Chemical Communications (15): 1045. doi:10.1039/C39880001045.

* v
* t
* e

Compounds of carbon with other elements in the periodic table

| CH |  |  |  | He

|
|
|
|

CLi | CBe | CB | CC | CN | CO | CF | Ne
CNa | CMg | CAl | CSi | CP | CS | CCl | CAr
CK | CCa | CSc |  | CTi | CV | CCr | CMn | CFe | CCo | CNi | CCu | CZn | CGa | CGe | CAs | CSe | CBr | CKr
CRb | CSr | CY |  | CZr | CNb | CMo | CTc | CRu | CRh | CPd | CAg | CCd | CIn | CSn | CSb | CTe | CI | CXe
CCs | CBa | CLa |  | CHf | CTa | CW | CRe | COs | CIr | CPt | CAu | CHg | CTl | CPb | CBi | CPo  | CAt  | Rn
Fr  | CRa | Ac |  | Rf  | Db  | CSg  | Bh  | Hs  | Mt  | Ds  | Rg  | Cn  | Nh  | Fl  | Mc  | Lv  | Ts  | Og
|  | CCe | CPr | CNd | CPm | CSm | CEu | CGd | CTb | CDy | CHo | CEr | CTm | CYb | CLu
|  | CTh | CPa | CU | CNp | CPu | CAm | CCm | CBk | CCf | CEs | Fm | Md | No | Lr

Legend|

* Chemical bonds to carbon
* Core organic chemistry
* Many uses in chemistry
* Academic research, no widespread use
* Bond unknown

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