Leukocyte receptor tyrosine kinase

Generic protein structure example

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.[1][2]

## Contents

* 1 Function
* 2 Interactions
* 3 References
* 4 Further reading

## Function

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]

## Interactions

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.[4][5]

## References

1. ↑ "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res 5 (3): 199–204. May 1990. PMID 2320375.
2. ↑ 2.0 2.1 "Entrez Gene: LTK leukocyte tyrosine kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4058.
3. ↑ "Leukocyte tyrosine kinase functions in pigment cell development". PLOS Genet. 4 (3): e1000026. 2008. doi:10.1371/journal.pgen.1000026. PMID 18369445.
4. ↑ "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene 9 (10): 2991–8. October 1994. PMID 8084603.
5. ↑ "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene 14 (25): 3067–72. June 1997. doi:10.1038/sj.onc.1201153. PMID 9223670.

## Further reading

* "The ltk gene encodes a novel receptor-type protein tyrosine kinase.". EMBO J. 10 (10): 2911–9. 1991. doi:10.1002/j.1460-2075.1991.tb07841.x. PMID 1655406.
* "Identification and chromosomal mapping of new human tyrosine kinase genes.". Oncogene 5 (3): 277–82. 1990. PMID 2156206.
* "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.". Nature 333 (6174): 672–6. 1988. doi:10.1038/333672a0. PMID 2836739. Bibcode: 1988Natur.333..672B.
* "Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5404–8. 1993. doi:10.1073/pnas.90.12.5404. PMID 7685902. Bibcode: 1993PNAS...90.5404T.
* "Regional localization of human chromosome 15 loci.". Genomics 23 (3): 619–27. 1995. doi:10.1006/geno.1994.1550. PMID 7851890.
* "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo.". Oncogene 9 (10): 2991–8. 1994. PMID 8084603.
* "Identification of the human ltk gene product in placenta and hematopoietic cell lines.". Biochem. Biophys. Res. Commun. 190 (2): 674–9. 1993. doi:10.1006/bbrc.1993.1101. PMID 8427607.
* "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.". J. Biol. Chem. 271 (44): 27707–14. 1996. doi:10.1074/jbc.271.44.27707. PMID 8910363.
* "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin.". J. Biol. Chem. 272 (2): 1297–301. 1997. doi:10.1074/jbc.272.2.1297. PMID 8995435.
* "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.". Oncogene 14 (25): 3067–72. 1997. doi:10.1038/sj.onc.1201153. PMID 9223670.
* "The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.". Protein Sci. 11 (10): 2326–34. 2003. doi:10.1110/ps.0213402. PMID 12237455.
* "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.". Hum. Mol. Genet. 13 (2): 171–9. 2004. doi:10.1093/hmg/ddh020. PMID 14695357.

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Protein kinases: tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

| Growth factor receptors|

| EGF receptor family|

* EGFR
* ERBB2
* ERBB3
* ERBB4

|

Insulin receptor family|

* IGF1R
* INSR
* INSRR

PDGF receptor family|

* CSF1R
* FLT3
* KIT
* PDGFR (PDGFRA
* PDGFRB)

FGF receptor family|

* FGFR1
* FGFR2
* FGFR3
* FGFR4

VEGF receptors family|

* VEGFR1
* VEGFR2
* VEGFR3

HGF receptor family|

* MET
* RON

Trk receptor family|

* NTRK1
* NTRK2
* NTRK3

EPH receptor family|

* EPHA1
* EPHA2
* EPHA3
* EPHA4
* EPHA5
* EPHA6
* EPHA7
* EPHA8
* EPHB1
* EPHB2
* EPHB3
* EPHB4
* EPHB5
* EPHB6
* EPHX

LTK receptor family|

* LTK
* ALK

TIE receptor family|

* TIE
* TEK

ROR receptor family|

* ROR1
* ROR2

DDR receptor family|

* DDR1
* DDR2

PTK7 receptor family|

* PTK7

RYK receptor family|

* RYK

MuSK receptor family|

* MUSK

ROS receptor family|

* ROS1

AATYK receptor family|

* AATYK
* AATYK2

AXL receptor family|

* AXL
* MER
* TYRO3

RET receptor family|

* RET

uncategorised|

* STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

| ABL family|

* ABL1
* ARG

|

ACK family|

* ACK1
* TNK1

CSK family|

* CSK
* MATK

FAK family|

* FAK
* PYK2

FES family|

* FES
* FER

FRK family|

* FRK
* BRK
* SRMS

JAK family|

* JAK1
* JAK2
* JAK3
* TYK2

SRC-A family|

* SRC
* FGR
* FYN
* YES1

SRC-B family|

* BLK
* HCK
* LCK
* LYN

TEC family|

* TEC
* BMX
* BTK
* ITK
* TXK

SYK family|

* SYK
* ZAP70

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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