Epidemic typhus

Other names: Camp fever, jail fever, hospital fever, ship fever, famine fever, putrid fever, petechial fever, epidemic louse-borne typhus,[1] louse-borne typhus[2]
Rash caused by epidemic typhus[3]
Specialty| Infectious diseases
Symptoms| Fever and chills, headache, rapid breathing,rash, cough[4]
Complications| Brill-Zinsser disease[4][5]
Causes| R. prowazekii[5]
Diagnostic method| Based on clinical features, biopsy[5]
Prevention| Dusting infested people with malathion [5]
Treatment| Doxycycline[4]
Chloramphenicol[5]

Epidemic typhus, also known as louse-borne typhus, is a form of typhus which results in outbreaks following wars and natural disasters.[6][7] It spreads through contact with infected body lice, in contrast to endemic typhus which is usually transmitted by fleas.[6][7]

Typhus has been responsible for millions of deaths throughout history, though it is currently rare, mainly occurring in unhygienic conditions with extreme overcrowding.[4] Typhus is most rare in industrialized countries. It occurs primarily in the colder, mountainous regions of central and east Africa, as well as Central and South America.[8] The cause is the bacterium Rickettsia prowazekii, transmitted by the human body louse (Pediculus humanus corporis).[9][10] Untreated typhus cases have a fatality rate of approximately 40%.[8]

Epidemic typhus should not be confused with Murine typhus, which is more endemic to the United States, particularly Southern California and Texas. This form of typhus has similar symptoms, but is caused by Rickettsia typhi. It is carried primarily in rat feces and fleas, as well as other rodents, it is not as deadly as louse-born typhus.[11][12]

## Contents

* 1 Signs and symptoms
* 1.1 Complications
* 2 Cause
* 3 Transmission
* 4 Diagnosis
* 5 Prevention
* 6 Treatment
* 7 History
* 7.1 Outbreaks
* 7.1.1 Before 19th century
* 7.1.2 19th century
* 7.1.3 20th century
* 7.1.4 21st century
* 8 Society and culture
* 8.1 Biological weapon
* 8.2 Poverty and displacement
* 8.3 Literature
* 9 Research
* 9.1 Vaccines
* 10 See also
* 11 References

## Signs and symptoms[edit | edit source]

Symptoms of this disease typically begin within 2 weeks of contact with the causative organism. Signs/Symptoms may include:[4]

* Fever
* Chills
* Headache
* Confusion
* Cough
* Rapid breathing
* Body/muscle aches
* Rash
* Nausea
* Vomiting

After 5-6 days, a macular skin eruption develops: first on the upper trunk and spreading to the rest of the body (rarely to the face, palms, or soles of the feet, however).[4]

* Rash caused by epidemic typhus in Burundi

* Petechial rash

* Rash on the volar surface of the hand

### Complications[edit | edit source]

A recurrent typhus, first described by Nathan Brill in 1910 occurred in Mount Sinai Hospital in New York City. It was in 1933 that it was recognized as Brill disease and determined a recrudescent epidemic typhus, that is, a mild form of epidemic typhus that recurs in someone after a long period of latency. This recurrence often arises in times of relative immunosuppression, which is often in the context of a person suffering malnutrition and/or other illnesses. In combination with poor sanitation and hygiene in times of social chaos and upheaval, which enable a greater density of lice, this reactivation is why typhus generates epidemics in such conditions.[13][14][15][16]

Other possible complications of Epidemic typhus are as follows

* Myocarditis[17]
* Otitis media[18]
* Parotitis[18]
* Pneumonia[18]
* Acute Renal failure[18]
* Meningoencephalitis[18]
* Myelitis[18]
* Psychosis[18]

## Cause[edit | edit source]

Flying squirrel

Rickettsia prowazekii is a species of gram-negative, alphaproteobacteria, obligate intracellular parasitic, aerobic bacillus bacteria that is the etiologic agent of epidemic typhus, transmitted in the feces of lice. [19]

In North America, the main reservoir for R. prowazekii is the flying squirrel. R. prowazekii is often surrounded by a protein microcapsular layer and slime layer; the natural life cycle of the bacterium generally involves a vertebrate and an invertebrate host, usually an arthropod, typically the human body louse. A form of R. prowazekii that exists in the feces of arthropods remains stably infective for months.[19][20][21]

## Transmission[edit | edit source]

R. prowazekii bacteria in a yolk sac smear specimen

Feeding on a human who carries the bacterium infects the louse. R. prowazekii grows in the louse's gut and is excreted in its feces. The louse transmits the disease by biting an uninfected human, who scratches the louse bites and rubs the feces into the wound.[19][22]

The incubation period is one to two weeks. R. prowazekii can remain viable and virulent in the dried louse feces for many days; typhus will eventually kill the louse, though the disease will remain viable for many weeks in the dead louse.[23]

Epidemic typhus has historically occurred during times of war and deprivation. For example, typhus killed millions of prisoners in German Nazi concentration camps during World War II. The deteriorating quality of hygiene in camps such as Auschwitz created conditions where diseases such as typhus flourished. Situations in the twenty-first century with potential for a typhus epidemic would include refugee camps during a major famine or natural disaster. In the periods between outbreaks, human to human transmission occurred less often.[24][25]

In 1916, Henrique da Rocha Lima proved that the bacterium Rickettsia prowazekii was the agent responsible for typhus; he named it after H. T. Ricketts and Stanislaus von Prowazek, two zoologists who had died from typhus while investigating epidemics. Once these crucial facts were recognized, Rudolf Weigl in 1930 was able to fashion a practical and effective vaccine production method.[26]

He ground up the insides of infected lice that had been drinking blood. It was, however, very dangerous to produce, and carried a high likelihood of infection to those who were working on it.A safer mass-production-ready method using egg yolks was developed by Herald R. Cox in 1938.This vaccine was widely available and used extensively by 1943.[27][26]

## Diagnosis[edit | edit source]

In terms of the diagnosis of Epidemic typhus we find that it is evaluated clinically and then confirmed serologically.[19]

Among the methods used are:[19]

* Indirect fluorescence antibody test
* Plate microagglutination
* Latex agglutination
* Enzyme immunoassays

## Prevention[edit | edit source]

Prevention of Epidemic typhus can be done via the following:[5]

* Dusting infested individuals with malathion
* Louse-infested clothing/bedding should be washed with hot water (> 130F > 54 C)
* Non-washable clothing can be sealed/stored in plastic bag for 2 weeks
* Bedding/clothing can be treated with insecticide permethrin

## Treatment[edit | edit source]

Doxycycline

The infection is treated with antibiotics. Intravenous fluids and oxygen may be needed to stabilize the patient. There is a significant disparity between the untreated mortality and treated mortality rates (that is 10-60% untreated versus close to 0% treated with antibiotics within 8 days of initial infection). Tetracycline, chloramphenicol, and doxycycline are commonly used.[28]

Some of the simplest methods of prevention and treatment focus on preventing infestation of body lice. Completely changing the clothing, washing the infested clothing in hot water, and in some cases also treating recently used bedsheets all help to prevent typhus by removing potentially infected lice. Clothes left unworn and unwashed for 7 days also result in the death of both lice and their eggs, as they have no access to a human host.[29] Another form of lice prevention requires dusting infested clothing with a powder consisting of 10% DDT, 1% malathion, or 1% permethrin, which kill lice and their eggs.[28]

Other preventive measures for individuals are to avoid unhygienic, extremely overcrowded areas where the causative organisms can jump from person to person. In addition, they are warned to keep a distance from larger rodents that carry lice, such as rats, squirrels, or opossums.[28]

## History[edit | edit source]

### Outbreaks[edit | edit source]

a,b)Tree-ring–reconstructed summer Palmer Drought Severity Index during 22 and 15 typhus epidemics in Mexico, 1665–1918[30]

#### Before 19th century[edit | edit source]

During the second year of the Peloponnesian War (430 BC), the city-state of Athens in ancient Greece suffered a devastating epidemic, known as the Plague of Athens, which killed, among others, Pericles and his two elder sons. The plague returned twice more, in 429 BC and in the winter of 427/6 BC. Epidemic typhus is proposed as a strong candidate for the cause of this disease outbreak, supported by both medical and scholarly opinions.[31][32]

The first description of typhus was probably given in 1083 at La Cava abbey near Salerno, Italy.[33][34] In 1546, Girolamo Fracastoro, a Florentine physician, described typhus in his famous treatise on viruses and contagion, De Contagione et Contagiosis Morbis.[35]

Typhus was carried to mainland Europe by soldiers who had been fighting on Cyprus. The first reliable description of the disease appears during the siege of the Emirate of Granada by the Catholic Monarchs in 1489 during the Granada War. These accounts include descriptions of fever and red spots over arms, back and chest, progressing to delirium, gangrenous sores, and the stench of rotting flesh. During the siege, the Catholics lost 3,000 men to enemy action, but an additional 17,000 died of typhus.Typhus was also common in prisons, where it was known as Gaol fever or Jail fever. Gaol fever often occurs when prisoners are frequently huddled together in dark, filthy rooms. Imprisonment until the next term of court was often equivalent to a death sentence. Typhus was so infectious that prisoners brought before the court sometimes infected the court itself. Following the Black Assize of Oxford 1577, over 300 died from epidemic typhus.[27][36][37]

During the Lent assize held at Taunton (1730), typhus caused the death of the Lord Chief Baron of the Exchequer, the High Sheriff of Somerset, the sergeant, and hundreds of other persons. During a time when there were 241 capital offences, more prisoners died from 'gaol fever' than were put to death by all the public executioners in the realm. In 1759 an English authority estimated that each year a quarter of the prisoners had died from gaol fever.[38]

#### 19th century[edit | edit source]

Epidemics occurred in the British Isles and throughout Europe, for instance, during the English Civil War, the Thirty Years' War, and the Napoleonic Wars. Many historians believe that the typhus outbreak among Napoleon's troops is the real reason why he stalled his military campaign into Russia, rather than starvation or the cold.[39] A major epidemic occurred in Ireland between 1816–19, and again in the late 1830s. Another major typhus epidemic occurred during the Great Irish Famine between 1846 and 1849. The Irish typhus spread to England, where it was sometimes called "Irish fever" and was noted for its virulence. It killed people of all social classes since lice were endemic and inescapable, but it hit particularly hard in the lower or "unwashed" social strata. It was carried to North America by the many Irish refugees who fled the famine. In Canada, the 1847 North American typhus epidemic killed more than 20,000 people, mainly Irish immigrants in fever sheds and other forms of quarantine, who had contracted the disease aboard coffin ships.[40] As many as 900,000 deaths have been attributed to the typhus fever during the Crimean War in 1853-1856.[39]

In the United States, a typhus epidemic struck Philadelphia in 1837. Several epidemics occurred in Baltimore, Memphis, and Washington, D.C. between 1865 and 1873. Typhus fever was also a significant killer during the American Civil War. Typically more men died on both sides of disease than wounds.Rudolph Carl Virchow, a physician, anthropologist, and historian attempted to control an outbreak of typhus in Upper Silesia and wrote a voluminous report about it. He concluded that the solution to the outbreak did not lie in individual treatment or by providing small changes in housing, food or clothing, but rather in widespread structural changes to directly address the issue of poverty. [41][42][43][44]

#### 20th century[edit | edit source]

DDT was used to control the spread of typhus-carrying lice during WWII. Concentration camp

Typhus was endemic in Poland and several neighboring countries prior to World War I (1914–1918).[45][46] During and shortly after the war, epidemic typhus caused up to three million deaths in Russia, and several million citizens also died in Poland and Romania.[47][48] Since 1914, many troops, prisoners and even doctors were infected, and at least 150,000 died from typhus in Serbia, 50,000 of whom were prisoners.[49][50][51] Delousing stations were established for troops on the Western Front, but the disease ravaged the armies of the Eastern Front. Fatalities were generally between 10 and 40 percent of those infected, and the disease was a major cause of death for those nursing the sick. During World War I and the Russian Civil War between the White and Red, the typhus epidemic caused 2–3 million deaths out of 20–30 million cases in Russia between 1918 and 1922.[47]

Typhus caused hundreds of thousands of deaths during World War II.[52] In 1942 and 1943 typhus hit French North Africa, Egypt and Iran particularly hard.[53]

Typhus epidemics killed inmates in the Nazi concentration camps and death camps such as Auschwitz. Anne Frank, at age 15, died of typhus in the camps.The Germans worked to develop a live vaccine from the urine of typhus victims, while developing a live vaccine, Germany used live Rickettsia prowazekii to test multiple possible vaccines' capabilities. They gave live Rickettsia prowazekii to concentration camp prisoners, using them as a control group for the vaccine tests.[24][54][55][56]

DDT was used as an effective means of killing lice, the main carrier of typhus. Even larger epidemics in the post-war chaos of Europe were averted only by the widespread use of the newly discovered DDT to kill lice on the millions of refugees and displaced persons.Following the development of a vaccine during World War II, Western Europe and North America have been able to prevent epidemics.[57][58]

In one of its first major outbreaks since World War II, epidemic typhus reemerged in 1995 in a jail in N'Gozi, Burundi. This outbreak followed the start of the Burundian Civil War in 1993, which caused the displacement of 760,000 people. Refugee camps were crowded and unsanitary, and often far from towns and medical services.[59]

#### 21st century[edit | edit source]

A 2005 study found seroprevalence of R. prowazekii antibodies in homeless populations in two shelters in Marseille, France. The study noted the “hallmarks of epidemic typhus and relapsing fever”.[60]

## Society and culture[edit | edit source]

### Biological weapon[edit | edit source]

Typhus was one of more than a dozen agents that the United States researched as potential biological weapons before President Richard Nixon suspended all non-defensive aspects of the U.S. biological weapons program in 1969.[61]

### Poverty and displacement[edit | edit source]

The CDC lists the following areas as active foci of human epidemic typhus: Andean regions of South America, some parts of Africa; on the other hand, the CDC only recognizes an active enzootic cycle in the United States involving flying squirrels (CDC). [62][63]

Though epidemic typhus is commonly thought to be restricted to areas of the developing world, serological examination of homeless persons in Houston found evidence for exposure to the bacterial pathogens that cause epidemic typhus and murine typhus. A study involving 930 homeless people in Marseille, France, found high rates of seroprevalence to R. prowazekii and a high prevalence of louse-borne infections in the homeless.Typhus has been increasingly discovered in homeless populations in developed nations. Typhus among homeless populations is especially prevalent as these populations tend to migrate across states and countries, spreading the risk of infection with their movement. The same risk applies to refugees, who travel across country lines, often living in close proximity and unable to maintain necessary hygienic standards to avoid being at risk for catching lice possibly infected with typhus.[64][65][66]

Because the typhus-infected lice live in clothing, the prevalence of typhus is also affected by weather, humidity, poverty and lack of hygiene. Lice, and therefore typhus, are more prevalent during colder months, especially winter and early spring. In these seasons, people tend to wear multiple layers of clothing, giving lice more places to go unnoticed by their hosts. This is particularly a problem for poverty-stricken populations as they often do not have multiple sets of clothing, preventing them from practicing good hygiene habits that could prevent louse infestation.[29]

Due to fear of an outbreak of epidemic typhus, the US Government put a typhus quarantine in place in 1917 across the entirety of the US-Mexican border. Sanitation plants were constructed that required immigrants to be thoroughly inspected and bathed before crossing the border. Those who routinely crossed back and forth across the border for work were required to go through the sanitation process weekly, updating their quarantine card with the date of the next week's sanitation. These sanitation border stations remained active over the next two decades, regardless of the disappearance of the typhus threat. This fear of typhus and resulting quarantine and sanitation protocols dramatically hardened the border between the US and Mexico, fostering scientific and popular prejudices against Mexicans. This ultimately intensified racial tensions and fueled efforts to ban immigrants to the US from the Southern Hemisphere because the immigrants were associated with the disease.[67]

### Literature[edit | edit source]

The following is how literature has portrayed Epidemic typhus:

* (1847) In Jane Eyre by Charlotte Brontë, an outbreak of typhus occurs in Jane's school Lowood, highlighting the unsanitary conditions the girls live in.[68][69]
* (1862) In Fathers and Sons by Ivan Turgenev, Evgeny Bazarov dissects a local peasant and dies after contracting typhus.[70]
* (1886) In the short story "Excellent People" by Anton Chekhov, typhus kills a Russian provincial.[71]
* (1886) In The Strange Adventures of Captain Dangerous by George Augustus Henry Sala: "We Convicts were all had to the Grate, for the Knight and Alderman would not venture further in, for fear of the Gaol Fever;"[72]
* (1890) In How the Other Half Lives by Jacob Riis, the effects of typhus fever and smallpox on "Jewtown" are described.[73][74]
* (1935) Hans Zinsser's Rats, Lice and History, although a touch outdated on the science, contains many useful cross-references to classical and historical impact of typhus.[55]
* (1940) in The Don Flows Home to the Sea by Mikhail Sholokhov, numerous characters contract typhus during the Russian Civil War[75]
* (1946) In Viktor Frankl's Man's Search for Meaning, Frankl, a Nazi concentration camp prisoner and trained psychiatrist, treats fellow prisoners for delirium due to typhus, whilst being an on-again, off-again sufferer himself.[76]
* (1955) In Vladimir Nabokov's Lolita, Humbert Humbert's childhood sweetheart, Annabel Leigh, dies of typhus.[77]
* (1956) In Doctor Zhivago by Boris Pasternak, the main character contracts epidemic typhus in the winter following the Russian Revolution, while living in Moscow.[78]
* (1964) In Nacht (novel) by Edgar Hilsenrath, characters imprisoned in a ghetto in Transnistria during World War II are portrayed infected with and dying of epidemic typhus.[79]
* (1978) In Patrick O'Brian's novel Desolation Island, an outbreak of "gaol-fever" strikes the crew while sailing aboard the Leopard.[80]
* (1980–1991) In Maus by Art Spiegelman, Vladek Spiegelman contracts typhus during his imprisonment at the Dachau concentration camp.[81][82]
* (1982) There is a typhus epidemic in Chile graphically described in The House of the Spirits by Isabel Allende[83]
* (1996) In Andrea Barrett's novella Ship Fever, the characters struggle with a typhus outbreak at the Canadian Grosse Isle Quarantine Station during 1847.[84][85]
* (2001) Lynn and Gilbert Morris' novel Where Two Seas Met (novel)|Where Two Seas Met portrays an outbreak of typhus on the island of Bequia in the Grenadines, in 1869[86]

## Research[edit | edit source]

Charles Nicolle received the 1928 Nobel Prize in Medicine for his identification of lice as the transmitter of epidemic typhus.

Charles Jules Henri Nicolle was a French bacteriologist who received the Nobel Prize in Medicine for his identification of lice as the transmitter of epidemic typhus.[87][88]

Nicolle found that the chimpanzee served as a suitable host for this study since it was genetically similar to humans, and in June 1909, Nicolle tested his theory by infecting a chimpanzee with typhus, retrieving the lice from it, and placing it on a healthy chimpanzee.[88][89] Within 10 days, the second chimpanzee had typhus as well.[88][39][90] After repeating his experiment, he was sure of it: lice were the carriers.[88][39]

### Vaccines[edit | edit source]

Major developments for typhus vaccines started during World War I, as typhus caused high mortality, and threatened the health and readiness for soldiers on the battlefield. [54] Vaccines for typhus, like other vaccines of the time, were classified as either living or killed vaccines.[54] Live vaccines were typically an injection of live agent, and killed vaccines are live cultures of an agent that are chemically inactivated prior to use. [54]Attempts to create a living vaccine of classical, louse-borne, typhus were attempted by French researchers but these proved unsuccessful.[54] Researchers turned to murine typhus to develop a live vaccine.[54] At the time, murine vaccine was viewed as a less severe alternative to classical typhus. Four versions of a live vaccine cultivated from murine typhus were tested, on a large scale, in 1934.[54]

While the French were making advancements with live vaccines, other European countries were working to develop killed vaccines.[54] During World War II, there were three kinds of potentially useful killed vaccines.[54] All three killed vaccines relied on the cultivation of Rickettsia prowazekii, the organism responsible for typhus.[54] The first attempt at a killed vaccine was developed by Germany, using the Rickettsia prowazekii found in louse feces.[54] The vaccine was tested extensively in Poland between the two world wars and used by the Germans for their troops during their attacks on the Soviet Union.[54]

A second method of growing Rickettsia prowazekii was discovered using the yolk sac of chick embryos. Germans tried several times to use this technique of growing Rickettsia prowazekii but no effort was pushed very far.[54]

The last technique was an extended development of the previously known method of growing murine typhus in rodents.[54] It was discovered that rabbits could be infected, by a similar process, and contract classical typhus instead of murine typhus.[54] Again, while proven to produce suitable Rickettsia prowazekii for vaccine development, this method was not used to produce wartime vaccines. [54]

During WWII, the two major vaccines available were the killed vaccine grown in lice and the live vaccine from France.[54] Neither was used much during the war.[54] The killed, louse-grown vaccine was difficult to manufacture in large enough quantities, and the French vaccine was not believed to be safe enough for use.[54]

Currently, there is no vaccine to prevent epidemic typhus per the CDC[4]

## See also[edit | edit source]

* Globalization and disease
* List of epidemics
* Weil-Felix test

## References[edit | edit source]

1. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1130\. ISBN 978-1-4160-2999-1.
2. ↑ "Diseases P-T at sedgleymanor.com". Archived from the original on 2011-07-17. Retrieved 2007-07-17.
3. ↑ Jochmann, Georg (26 December 2017). Lehrbuch der Infektionskrankheiten fur Arzte und studierende. Berlin : J. Springer - via Internet Archive.
4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 "Epidemic Typhus | Typhus Fevers | CDC". www.cdc.gov. 2020-11-13. Archived from the original on 2017-03-26. Retrieved 2020-12-10.
5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 "Epidemic Typhus - Infectious Diseases". Merck Manuals Professional Edition. Archived from the original on 26 November 2020. Retrieved 17 July 2023.
6. ↑ 6.0 6.1 "Epidemic typhus". Centers for Disease Control and Prevention. 2020-11-13. Archived from the original on 2017-03-26. Retrieved 2021-02-27.
7. ↑ 7.0 7.1 Li, Li; Li, Guiying (2015). "Epidemic and Endemic Typhus". In Li, Hongjun (ed.). Radiology of Infectious Diseases: Volume 2. Springer, Dordrecht. p. 89-94. doi:10.1007/978-94-017-9876-1_8. ISBN 978-94-017-9875-4.
8. ↑ 8.0 8.1 "WHO | Typhus fever (Epidemic louse-borne typhus)". WHO. Archived from the original on 2012-12-26. Retrieved 2020-11-06.
9. ↑ Gray MW (November 1998). "Rickettsia, typhus and the mitochondrial connection". Nature. 396 (6707): 109–10. Bibcode:1998Natur.396..109G. doi:10.1038/24030. PMID 9823885. S2CID 5477013.
10. ↑ Andersson JO, Andersson SG (March 2000). "A century of typhus, lice and Rickettsia". Res. Microbiol. 151 (2): 143–50. doi:10.1016/s0923-2508(00)00116-9. PMID 10865960.
11. ↑ Peniche Lara, Gaspar; Dzul-Rosado, Karla R.; Zavala Velázquez, Jorge Ernesto; Zavala-Castro, Jorge (April 2012). "Murine Typhus: Clinical and epidemiological aspects". Colombia Medica (Cali, Colombia). 43 (2): 175–180. ISSN 1657-9534. Archived from the original on 14 April 2023. Retrieved 19 July 2023.
12. ↑ Woodward, T. E. (1982). "Murine and epidemic typhus rickettsiae: how close is their relationship?". The Yale Journal of Biology and Medicine. 55 (3–4): 335–341. ISSN 0044-0086. Archived from the original on 21 January 2022. Retrieved 25 July 2023.
13. ↑ Lutwick, Larry (14 April 2001). "Brill-Zinsser disease". The Lancet. 357 (9263): 1198–1200. doi:10.1016/S0140-6736(00)04339-7. ISSN 0140-6736. Retrieved 19 July 2023.
14. ↑ Knoop, F. C. (1 January 2014). "Brill-Zinsser Disease☆". Reference Module in Biomedical Sciences. Elsevier. ISBN 978-0-12-801238-3. Retrieved 21 July 2023.
15. ↑ Drancourt, Michel; Raoult, Didier A. (16 July 2020). Paleomicrobiology of Humans. John Wiley & Sons. p. 85\. ISBN 978-1-55581-917-0. Archived from the original on 27 July 2023. Retrieved 25 July 2023.
16. ↑ Anstead, Gregory M. (March 2020). "History, Rats, Fleas, and Opossums: The Ascendency of Flea-Borne Typhus in the United States, 1910–1944". Tropical Medicine and Infectious Disease. 5 (1): 37. doi:10.3390/tropicalmed5010037. ISSN 2414-6366. Archived from the original on 24 October 2022. Retrieved 25 July 2023.
17. ↑ Strelkauskas, Anthony; Edwards, Angela; Fahnert, Beatrix; Pryor, Greg; Strelkauskas, Jennifer (14 July 2015). Microbiology: A Clinical Approach. Garland Science. p. 628\. ISBN 978-1-317-33419-4. Archived from the original on 24 July 2023. Retrieved 22 July 2023.
18. ↑ 18.0 18.1 18.2 18.3 18.4 18.5 18.6 Li, Hongjun (21 August 2015). Radiology of Infectious Diseases: Volume 2. Springer. p. 91\. ISBN 978-94-017-9876-1. Archived from the original on 24 July 2023. Retrieved 23 July 2023.
19. ↑ 19.0 19.1 19.2 19.3 19.4 Akram, Sami M.; Ladd, Megan; King, Kevin C. (2023). "Rickettsia Prowazekii". StatPearls. StatPearls Publishing. Archived from the original on 4 November 2022. Retrieved 17 July 2023.
20. ↑ "Taxonomy browser (Rickettsia prowazekii)". www.ncbi.nlm.nih.gov. Archived from the original on 9 July 2022. Retrieved 20 July 2023.
21. ↑ McDade, J. E. (March 1987). "Flying squirrels and their ectoparasites: disseminators of epidemic typhus". Parasitology Today (Personal Ed.). 3 (3): 85–87. doi:10.1016/0169-4758(87)90165-7. ISSN 0169-4758. Archived from the original on 27 July 2023. Retrieved 26 July 2023.
22. ↑ Sahni, A; Fang, R; Sahni, SK; Walker, DH (24 January 2019). "Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection". Annual review of pathology. 14: 127–152. doi:10.1146/annurev-pathmechdis-012418-012800. PMID 30148688. Archived from the original on 13 June 2020. Retrieved 27 July 2023.
23. ↑ "Facts about epidemic louse-borne typhus". www.ecdc.europa.eu. 19 June 2017. Archived from the original on 23 March 2023. Retrieved 22 July 2023.
24. ↑ 24.0 24.1 Stone, Lewi; He, Daihai; Lehnstaedt, Stephan; Artzy-Randrup, Yael (24 July 2020). "Extraordinary curtailment of massive typhus epidemic in the Warsaw Ghetto". Science Advances. 6 (30). doi:10.1126/sciadv.abc0927. ISSN 2375-2548. Archived from the original on 27 November 2022. Retrieved 22 July 2023.
25. ↑ Weindling, Paul (3 February 2000). Epidemics and Genocide in Eastern Europe, 1890-1945. OUP Oxford. p. 427\. ISBN 978-0-19-154263-3. Archived from the original on 27 July 2023. Retrieved 26 July 2023.
26. ↑ 26.0 26.1 "Weigl's method of intrarectal inoculation of lice in production of typhus vaccine and experimental works with Rickettsia Prowazeki". Archived from the original on 2019-08-16. Retrieved 2021-11-17.
27. ↑ 27.0 27.1 Angelakis, Emmanouil; Bechah, Yassina; Raoult, Didier (12 August 2016). "The History of Epidemic Typhus". Microbiology Spectrum. 4 (4). doi:10.1128/microbiolspec.poh-0010-2015. Archived from the original on 24 July 2023. Retrieved 24 July 2023.
28. ↑ 28.0 28.1 28.2 Brouqui, Philippe (2011-01-01). "Arthropod-Borne Diseases Associated with Political and Social Disorder". Annual Review of Entomology. 56 (1): 357–374. doi:10.1146/annurev-ento-120709-144739. PMID 20822446.
29. ↑ 29.0 29.1 Raoult, Didier; Roux, Véronique (1999-08-15). "The Body Louse as a Vector of Reemerging Human Diseases". Clinical Infectious Diseases. 29 (4): 888–911. doi:10.1086/520454. ISSN 1058-4838. PMID 10589908.
30. ↑ Burns, JN; Acuna-Soto, R; Stahle, DW (March 2014). "Drought and epidemic typhus, central Mexico, 1655-1918". Emerging infectious diseases. 20 (3): 442–7. doi:10.3201/eid2003.131366. PMID 24564928. Retrieved 17 July 2023.
31. ↑ At a January 1999 medical conference at the University of Maryland, Dr. David Durack, consulting professor of medicine at Duke University notes: "Epidemic typhus fever is the best explanation. It hits hardest in times of war and privation, it has about 20 percent mortality, it kills the victim after about seven days, and it sometimes causes a striking complication: gangrene of the tips of the fingers and toes. The Plague of Athens had all these features." see also: umm.edu Archived 2020-04-08 at the Wayback Machine
32. ↑ Gomme, A.W. (1981). "Volume 5. Book VIII". In Andrewes, A.; Dover, K.J. (eds.). An Historical Commentary on Thucydides. Oxford University Press. ISBN 978-0-19-814198-3.
33. ↑ Szybalski, Waclaw (1999). "Maintenance of human-fed live lice in the laboratory and production of Weigl's exanthematous typhus vaccine". Archived from the original on 2021-09-04. Retrieved 2021-11-17.
34. ↑ Carugo, Beppe (2006). Breve Storia della Medicina, della Diagnostica, delle Arti Sanitarie (PDF) (2nd ed.). Archived from the original (PDF) on 2013-10-05. Retrieved 2021-11-17.
35. ↑ Fracastoro, Girolamo (1546). De Contagione et Contagiosis Morbis.
36. ↑ Kohn, George C. (2007). Encyclopedia of Plague and Pestilence: From Ancient Times to the Present. Infobase Publishing. p. 290\. ISBN 978-1-4381-2923-5. Archived from the original on 2023-07-27. Retrieved 2023-07-25.
37. ↑ Smallman-Raynor, Matthew; Cliff, Andrew (17 June 2004). War Epidemics: An Historical Geography of Infectious Diseases in Military Conflict and Civil Strife, 1850-2000. OUP Oxford. p. 6\. ISBN 978-0-19-823364-0. Archived from the original on 30 July 2023. Retrieved 28 July 2023.
38. ↑ Ralph D. Smith, "Comment, Criminal Law – Arrest – The Right to Resist Unlawful Arrest," 7 Nat. Resources J. 119, 122 n.16 (1967) (hereinafter Comment) (citing John Howard, The State of Prisons 6-7 (1929)) (Howard's observations are from 1773 to 1775). Copied from State v. Valentine, May 1997 132 Wn.2d 1, 935 P.2d 1294
39. ↑ 39.0 39.1 39.2 39.3 "Typhus- Biological Weapons". www.globalsecurity.org. Archived from the original on 2020-10-16. Retrieved 2020-10-09.
40. ↑ "The government inspector's office". McCord Museum. Montreal. M993X.5.1529.1. Archived from the original on 8 April 2011. Retrieved 22 January 2012.
41. ↑ Magazine, Smithsonian; Holliday, Timothy Kent. "What an 1836 Typhus Outbreak Taught the Medical World About Epidemics". Smithsonian Magazine. Archived from the original on 22 March 2023. Retrieved 24 July 2023.
42. ↑ Humphreys, Margaret (2006). "A stranger to our camps: Typhus in American history". Bulletin of the History of Medicine. 80 (2): 269–290. doi:10.1353/bhm.2006.0058. ISSN 0007-5140. Archived from the original on 30 July 2023. Retrieved 29 July 2023.
43. ↑ Taylor, R; Rieger, A (1985). "Medicine as social science: Rudolf Virchow on the typhus epidemic in Upper Silesia". International Journal of Health Services. 15 (4): 547–559. doi:10.2190/xx9v-acd4-kuxd-c0e5. PMID 3908347. S2CID 44723532.
44. ↑ Azar, HA (1997). "Rudolf Virchow, not just a pathologist: a re-examination of the report on the typhus epidemic in Upper Silesia". Annals of Diagnostic Pathology. 1 (1): 65–71. doi:10.1016/S1092-9134(97)80010-X. PMID 9869827.
45. ↑ "Health, Disease, Mortality; Demographic Effects | International Encyclopedia of the First World War (WW1)". encyclopedia.1914-1918-online.net. Archived from the original on 2020-11-18. Retrieved 2021-02-26.
46. ↑ Goodall, E. W. (April 23, 1920). "Typhus Fever in Poland, 1916 to 1919". Section of Epidemiology and State Medicine. Archived from the original on December 11, 2021. Retrieved November 17, 2021.
47. ↑ 47.0 47.1 Patterson KD (1993). "Typhus and its control in Russia, 1870–1940". Med Hist. 37 (4): 361–381 [378]. doi:10.1017/s0025727300058725. PMC 1036775. PMID 8246643.
48. ↑ "Typhus, War, and Vaccines". History of Vaccines. Archived from the original on 2021-02-28. Retrieved 2021-02-26.
49. ↑ Pennington, Hugh (2019-01-10). "The impact of infectious disease in war time: a look back at WW1". Future Microbiology. 14 (3): 165–168. doi:10.2217/fmb-2018-0323. ISSN 1746-0913. Archived from the original on 2021-12-11. Retrieved 2021-11-17.
50. ↑ "Typhus in World War I". Microbiology Society. Archived from the original on 2021-03-08. Retrieved 2021-02-26.
51. ↑ SOUBBOTITCH, V. (November 30, 1917). "A Pandemic of Typhus in Serbia in 1914 and 1915". Section of Epidemiology and State Medicine. Archived from the original on March 30, 2020. Retrieved November 17, 2021.
52. ↑ Zinsser, Hans (1996) [1935]. Rats, Lice and History: A Chronicle of Pestilence and Plagues. New York: Black Dog & Leventhal. ISBN 978-1-884822-47-6.
53. ↑ Zarafonetis, Chris J. D. Internal Medicine in World War II, Volume II, Chapter 7 Archived 2018-07-07 at the Wayback Machine
54. ↑ 54.00 54.01 54.02 54.03 54.04 54.05 54.06 54.07 54.08 54.09 54.10 54.11 54.12 54.13 54.14 54.15 54.16 54.17 54.18 Lindenmann, Jean (2002). "Typhus Vaccine Developments from the First to the Second World War (On Paul Weindling's 'Between Bacteriology and Virology...')". History and Philosophy of the Life Sciences. Stazione Zoologica Anton Dohrn - Napoli. 24: 467–485 - via JSTOR.
55. ↑ 55.0 55.1 Weissmann, Gerald (March 2005). "Rats, Lice, and Zinsser". Emerging Infectious Diseases. 11 (3): 492–496. doi:10.3201/eid1103.AD1103. PMID 15789497. Archived from the original on 21 July 2023. Retrieved 20 July 2023.
56. ↑ Zilinskas, RA (31 December 1992). "Confronting biological threats to international security: a biological hazards early warning program". Annals of the New York Academy of Sciences. 666: 146–76. doi:10.1111/j.1749-6632.1992.tb38028.x. PMID 1297275. Retrieved 30 July 2023.
57. ↑ US EPA, OCSPP (7 January 2014). "DDT - A Brief History and Status". www.epa.gov. Archived from the original on 2 August 2023. Retrieved 30 July 2023.
58. ↑ Lindenmann, Jean (2002). "Typhus vaccine developments from the First to the Second World War (on Paul Weindling's 'between bacteriology and virology...')". History and Philosophy of the Life Sciences. 24 (3–4): 467–485. doi:10.1080/03919710210001714513. ISSN 0391-9714. Archived from the original on 23 May 2023. Retrieved 30 July 2023.
59. ↑ Raoult, D; Ndihokubwayo, JB; Tissot-Dupont, H; Roux, V; Faugere, B; Abegbinni, R; Birtles, RJ (1998-08-01). "Outbreak of epidemic typhus associated with trench fever in Burundi". The Lancet. 352 (9125): 353–358. doi:10.1016/S0140-6736(97)12433-3. ISSN 0140-6736. PMID 9717922. S2CID 25814472. Archived from the original on 2021-12-11. Retrieved 2021-11-17.
60. ↑ Brouqui, Philippe; Stein, Andreas; Dupont, Hervé Tissot; Gallian, Pierre; Badiaga, Sekene; Rolain, Jean Marc; Mege, Jean Louis; Scola, Bernard La; Berbis, Philippe (2005). "Ectoparasitism and Vector-Borne Diseases in 930 Homeless People From Marseilles". Medicine. 84 (1): 61–68. doi:10.1097/01.md.0000152373.07500.6e. PMID 15643300. S2CID 24934110.
61. ↑ "Chemical and Biological Weapons: Possession and Programs Past and Present". Middlebury College: James Martin Center for Nonproliferation Studies. 9 April 2002. Archived from the original on 2 October 2001. Retrieved 2008-11-14.
62. ↑ Breedlove, Byron (April 2023). "Specter of Epidemic Typhus". Emerging Infectious Diseases. 29 (4). doi:10.3201/eid2904.ac2904. Archived from the original on 29 July 2023. Retrieved 27 July 2023.
63. ↑ Reynolds, MG; Krebs, JS; Comer, JA; Sumner, JW; Rushton, TC; Lopez, CE; Nicholson, WL; Rooney, JA; Lance-Parker, SE; McQuiston, JH; Paddock, CD; Childs, JE (October 2003). "Flying squirrel-associated typhus, United States". Emerging infectious diseases. 9 (10): 1341–3. doi:10.3201/eid0910.030278. PMID 14609478. Archived from the original on 23 March 2022. Retrieved 27 July 2023.
64. ↑ Badiaga, S.; Brouqui, P. (April 2012). "Human louse-transmitted infectious diseases". Clinical Microbiology and Infection. 18 (4): 332–337. doi:10.1111/j.1469-0691.2012.03778.x. Archived from the original on 9 April 2023. Retrieved 22 July 2023.
65. ↑ Kollipara, Ramya; Tyring, Stephen K. (1 January 2017). "23 - Rickettsial Infections". Tropical Dermatology (Second Edition). Elsevier. pp. 280–296. ISBN 978-0-323-29634-2. Retrieved 25 July 2023.
66. ↑ Badiaga, Sékéné; Raoult, Didier; Brouqui, Philippe. "Preventing and Controlling Emerging and Reemerging Transmissible Diseases in the Homeless - Volume 14, Number 9—September 2008 - Emerging Infectious Diseases journal - CDC". doi:10.3201/eid1409.080204. Archived from the original on 28 March 2023. Retrieved 27 July 2023. `{{cite journal}}`: Cite journal requires `|journal=` (help)
67. ↑ Stern, Alexandra Minna (2005). Eugenic Nation: Faults and Frontier of Better Breeding in Modern America. ProQuest ebrary: University of California Press. ISBN 9780520285064.
68. ↑ Roberts, Jack (2002). "Was It Really Typhus?". Brontë Studies. 27 (1): 49–53. doi:10.1179/bst.2002.27.1.49.
69. ↑ Sorkin, Amy Davidson (2020). "The Fever Room: Epidemics and Social Distancing in 'Bleak House' and 'Jane Eyre'". The New Yorker. Archived from the original on 2021-05-13. Retrieved 2021-11-17.
70. ↑ Patterson, K David (1993). "Typhus and its control in Russia, 1870–1940". Medical History. 37 (4): 361–381. doi:10.1017/S0025727300058725.
71. ↑ Coulehan, Jack (2003). "Comments on Chekhov's Doctors". Chekhov's Doctors: A Collection of Chekhov's Medical Tales. By Chekhov, Anton Pavlovich. Coulehan, Jack (ed.). Kent, Ohio: Kent State University Press. p. 185\. ISBN 0-87338-780-5.
72. ↑ Sala, George Augustus (11 July 2015). "The Strange Adventures of Captain Dangerous - Volume III". CreateSpace Independent Publishing Platform. Archived from the original on 21 July 2023. Retrieved 20 July 2023.
73. ↑ Markel, Howard (1999). "The City Responds to the Threat of Typhus". Quarantine!: East European Jewish Immigrants and the New York City Epidemics of 1892. Baltimore: Johns Hopkins University Press. p. 48\. ISBN 0-8018-6180-2.
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Classification|

* ICD-10: A75.0
* ICD-9-CM: 080-083
* MeSH: D014438
* DiseasesDB: 29240

|

External resources|

* MedlinePlus: 001363
* eMedicine: med/2332

* v
* t
* e

Proteobacteria-associated Gram-negative bacterial infections

| Rickettsiales|

| Rickettsiaceae/
(Rickettsioses)|

| Typhus|

* Rickettsia typhi
* Murine typhus
* Rickettsia prowazekii
* Epidemic typhus, Brill–Zinsser disease, Flying squirrel typhus

|

Spotted
fever|

| Tick-borne|

* Rickettsia rickettsii
* Rocky Mountain spotted fever
* Rickettsia conorii
* Boutonneuse fever
* Rickettsia japonica
* Japanese spotted fever
* Rickettsia sibirica
* North Asian tick typhus
* Rickettsia australis
* Queensland tick typhus
* Rickettsia honei
* Flinders Island spotted fever
* Rickettsia africae
* African tick bite fever
* Rickettsia parkeri
* American tick bite fever
* Rickettsia aeschlimannii
* Rickettsia aeschlimannii infection

|

Mite-borne|

* Rickettsia akari
* Rickettsialpox
* Orientia tsutsugamushi
* Scrub typhus

Flea-borne|

* Rickettsia felis
* Flea-borne spotted fever

Anaplasmataceae|

* Ehrlichiosis: Anaplasma phagocytophilum
* Human granulocytic anaplasmosis, Anaplasmosis
* Ehrlichia chaffeensis
* Human monocytotropic ehrlichiosis
* Ehrlichia ewingii
* Ehrlichiosis ewingii infection

Rhizobiales|

| Brucellaceae|

* Brucella abortus
* Brucellosis

|

Bartonellaceae|

* Bartonellosis: Bartonella henselae
* Cat-scratch disease
* Bartonella quintana
* Trench fever
* Either B. henselae or B. quintana
* Bacillary angiomatosis
* Bartonella bacilliformis
* Carrion's disease, Verruga peruana

| Neisseriales|

| M+|

* Neisseria meningitidis/meningococcus
* Meningococcal disease, Waterhouse–Friderichsen syndrome, Meningococcal septicaemia

|

M−|

* Neisseria gonorrhoeae/gonococcus
* Gonorrhea

ungrouped:|

* Eikenella corrodens/Kingella kingae
* HACEK
* Chromobacterium violaceum
* Chromobacteriosis infection

Burkholderiales|

* Burkholderia pseudomallei
* Melioidosis
* Burkholderia mallei
* Glanders
* Burkholderia cepacia complex
* Bordetella pertussis/Bordetella parapertussis
* Pertussis

| Enterobacteriales
(OX−)|

| Lac+|

* Klebsiella pneumoniae
* Rhinoscleroma, Pneumonia
* Klebsiella granulomatis
* Granuloma inguinale
* Klebsiella oxytoca

* Escherichia coli: Enterotoxigenic
* Enteroinvasive
* Enterohemorrhagic
* O157:H7
* O104:H4
* Hemolytic-uremic syndrome

* Enterobacter aerogenes/Enterobacter cloacae

|

Slow/weak|

* Serratia marcescens
* Serratia infection
* Citrobacter koseri/Citrobacter freundii

Lac−|

| H2S+|

* Salmonella enterica
* Typhoid fever, Paratyphoid fever, Salmonellosis

|

H2S−|

* Shigella dysenteriae/sonnei/flexneri/boydii
* Shigellosis, Bacillary dysentery
* Proteus mirabilis/Proteus vulgaris
* Yersinia pestis
* Plague/Bubonic plague
* Yersinia enterocolitica
* Yersiniosis
* Yersinia pseudotuberculosis
* Far East scarlet-like fever

Pasteurellales|

| Haemophilus:|

* H. influenzae
* Haemophilus meningitis
* Brazilian purpuric fever
* H. ducreyi
* Chancroid
* H. parainfluenzae
* HACEK

|

Pasteurella multocida|

* Pasteurellosis
* Actinobacillus
* Actinobacillosis

Aggregatibacter actinomycetemcomitans|

* HACEK

Legionellales|

* Legionella pneumophila/Legionella longbeachae
* Legionnaires' disease
* Coxiella burnetii
* Q fever

Thiotrichales|

* Francisella tularensis
* Tularemia

Vibrionaceae|

* Vibrio cholerae
* Cholera
* Vibrio vulnificus
* Vibrio parahaemolyticus
* Vibrio alginolyticus
* Plesiomonas shigelloides

Pseudomonadales|

* Pseudomonas aeruginosa
* Pseudomonas infection
* Moraxella catarrhalis
* Acinetobacter baumannii

Xanthomonadaceae|

* Stenotrophomonas maltophilia

Cardiobacteriaceae|

* Cardiobacterium hominis
* HACEK

Aeromonadales|

* Aeromonas hydrophila/Aeromonas veronii
* Aeromonas infection

| Campylobacterales|

* Campylobacter jejuni
* Campylobacteriosis, Guillain–Barré syndrome
* Helicobacter pylori
* Peptic ulcer, MALT lymphoma, Gastric cancer
* Helicobacter cinaedi
* Helicobacter cellulitis

|

* v
* t
* e

Bacterial skin disease

Gram +ve|

| Firmicutes|

* Staphylococcus
* Staphylococcal scalded skin syndrome
* Impetigo
* Toxic shock syndrome
* Streptococcus
* Impetigo
* Cutaneous group B streptococcal infection
* Streptococcal intertrigo
* Cutaneous Streptococcus iniae infection
* Erysipelas / Chronic recurrent erysipelas
* Scarlet fever
* Corynebacterium
* Erythrasma

* Listeriosis

* Clostridium
* Gas gangrene
* Dermatitis gangrenosa
* Mycoplasma
* Erysipeloid of Rosenbach

|

Actinobacteria|

* Mycobacterium-related: Aquarium granuloma
* Borderline lepromatous leprosy
* Borderline leprosy
* Borderline tuberculoid leprosy
* Buruli ulcer
* Erythema induratum
* Histoid leprosy
* Lepromatous leprosy
* Leprosy
* Lichen scrofulosorum
* Lupus vulgaris
* Miliary tuberculosis
* Mycobacterium avium-intracellulare complex infection
* Mycobacterium haemophilum infection
* Mycobacterium kansasii infection
* Papulonecrotic tuberculid
* Primary inoculation tuberculosis
* Rapid growing mycobacterium infection
* Scrofuloderma
* Tuberculosis cutis orificialis
* Tuberculosis verrucosa cutis
* Tuberculous cellulitis
* Tuberculous gumma
* Tuberculoid leprosy

* Cutaneous actinomycosis
* Nocardiosis
* Cutaneous diphtheria infection
* Arcanobacterium haemolyticum infection
* Group JK corynebacterium sepsis

Gram -ve|

| Proteobacteria|

* α: Endemic typhus
* Epidemic typhus
* Scrub typhus
* North Asian tick typhus
* Queensland tick typhus
* Flying squirrel typhus
* Trench fever
* Bacillary angiomatosis
* African tick bite fever
* American tick bite fever
* Rickettsia aeschlimannii infection
* Rickettsialpox
* Rocky Mountain spotted fever
* Human granulocytotropic anaplasmosis
* Human monocytotropic ehrlichiosis
* Flea-borne spotted fever
* Japanese spotted fever
* Mediterranean spotted fever
* Flinders Island spotted fever
* Verruga peruana
* Brill–Zinsser disease
* Brucellosis
* Cat-scratch disease
* Oroya fever
* Ehrlichiosis ewingii infection

* β: Gonococcemia/Gonorrhea/Primary gonococcal dermatitis
* Melioidosis
* Cutaneous Pasteurella hemolytica infection
* Meningococcemia
* Glanders
* Chromobacteriosis infection

* γ: Pasteurellosis
* Tularemia
* Vibrio vulnificus
* Rhinoscleroma
* Haemophilus influenzae cellulitis
* Pseudomonal pyoderma / Pseudomonas hot-foot syndrome / Hot tub folliculitis / Ecthyma gangrenosum / Green nail syndrome
* Q fever
* Salmonellosis
* Shigellosis
* Plague
* Granuloma inguinale
* Chancroid
* Aeromonas infection

* ε: Helicobacter cellulitis

|

Other|

* Syphilid
* Syphilis
* Chancre
* Yaws
* Pinta
* Bejel
* Chlamydia infection
* Leptospirosis
* Rat-bite fever
* Lyme disease
* Lymphogranuloma venereum

Unspecified
pathogen|

* Abscess
* Periapical abscess
* Boil/furuncle
* Hospital furunculosis
* Carbuncle
* Cellulitis
* Paronychia / Pyogenic paronychia
* Perianal cellulitis
* Acute lymphadenitis
* Pilonidal cyst
* Pyoderma

* Folliculitis
* Superficial pustular folliculitis
* Sycosis vulgaris
* Pimple
* Ecthyma
* Pitted keratolysis
* Trichomycosis axillaris
* Necrotizing fascitis
* Gangrene
* Chronic undermining burrowing ulcers
* Fournier gangrene
* Elephantiasis nostras
* Blistering distal dactylitis
* Botryomycosis
* Malakoplakia
* Gram-negative folliculitis
* Gram-negative toe web infection
* Pyomyositis
* Blastomycosis-like pyoderma
* Bullous impetigo
* Chronic lymphangitis
* Recurrent toxin-mediated perineal erythema
* Tick-borne lymphadenopathy
* Tropical ulcer

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