Aldehyde-stabilized cryopreservation

Aldehyde-stabilized cryopreservation is a new technique for cryopreservation first demonstrated in 2016 by Robert L. McIntyre and Gregory Fahy at the cryobiology research company 21st Century Medicine, Inc. This technique uses a particular implementation of fixation and vitrification that can successfully preserve a rabbit brain in "near perfect" condition at −135 °C, with the cell membranes, synapses, and intracellular structures intact in electron micrographs.[1] In 2016, McIntyre and Fahy were awarded the first portion of the Brain Preservation Technology Prize, the Small Animal Brain Preservation Prize, by the Brain Preservation Foundation for the successful cryopreservation of a whole mouse brain.[2][3] The cryopreserved brain was rewarmed and no serious degradation was found to have occurred; the brain structure under electron microscopic evaluation after rewarming remained well-preserved.[4][5] Although this technique has not yet lead to a successful revival of a cryopreserved brain, some researchers see this technique as providing promising directions for future research.[6]

## See also

* Cryonics

## References

1. ↑ "Aldehyde-stabilized cryopreservation". Cryobiology 71 (3): 448–458. December 2015. doi:10.1016/j.cryobiol.2015.09.003. PMID 26408851.
2. ↑ Claire Maldarelli (9 February 2016). "Researchers Have Preserved an Entire Rabbit Brain". Popular Science. http://www.popsci.com/researchers-have-preserved-an-entire-rabbit-brain.
3. ↑ Michael Shermer (1 February 2016). "Can Our Minds Live Forever?". Scientific American. http://www.scientificamerican.com/article/can-our-minds-live-forever/.
4. ↑ "21st Century Medicine's Aldehyde-Stabilized Cryopreservation". Brain Preservation Foundation. 16 September 2015. https://www.brainpreservation.org/21cm-aldehyde-stabilized-cryopreservation-eval-page/.
5. ↑ "Aldehyde-Stabilized Cryopreservation Wins Final Phase of Brain Preservation Prize". PRWeb. https://www.prweb.com/releases/aldehyde_stabilized_cryopreservation_wins_final_phase_of_brain_preservation_prize/prweb15276833.htm.
6. ↑ Ekpo, Marlene Davis; Boafo, George Frimpong; Gambo, Suleiman Shafiu; Hu, Yuying; Liu, Xiangjian; Xie, Jingxian; Tan, Songwen (2022-06-09). "Cryopreservation of Animals and Cryonics: Current Technical Progress, Difficulties and Possible Research Directions". Frontiers in Veterinary Science (Frontiers) 9. doi:10.3389/fvets.2022.877163. PMID 35754544.

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