Nicotine withdrawal

Nicotine molecule
Specialty| Psychiatry
Symptoms| Cravings for nicotine, anger or irritability, anxiety, depression, impatience, trouble sleeping, diarrhea, restlessness, hunger or weight gain, and difficulty concentrating
Usual onset| 2-3 hours after last intake of nicotine
Duration| 2-4 weeks
Causes| Physical dependence
Diagnostic method| Based on symptoms
Treatment| Nicotine replacement therapy

Pharmacological treatment (bupropion, varenicline, cytisine, nortriptyline, clonidine)

Cognitive behavioural therapy

Nicotine withdrawal is a group of symptoms that occur in the first few weeks after stopping or decreasing use of nicotine. Symptoms include intense cravings for nicotine, anger or irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger or weight gain, and difficulty concentrating.[1][2][3] Withdrawal symptoms make it harder to quit nicotine products, and most methods for quitting smoking involve reducing nicotine withdrawal.[1] Quit smoking programs can make it easier to quit.[1] Nicotine withdrawal is recognized in both the American Psychiatric Association Diagnostic and Statistical Manual and the WHO International Classification of Diseases.

## Contents

* 1 Signs and symptoms
* 2 Causes
* 3 Diagnosis
* 3.1 Definition
* 4 Treatment
* 5 Epidemiology
* 6 See also
* 7 References
* 8 External links

## Signs and symptoms[edit | edit source]

The most documented symptoms of nicotine withdrawal are cravings for nicotine, anger or irritability, anxiety, depression, impatience, trouble sleeping, restlessness (psychomotor agitation, including indeliberate movement), hunger or weight gain, and difficulty concentrating.[1][2][3] Symptoms are usually strongest for the first few days and then dissipate over 2–4 weeks. The most common symptoms are irritability, anxiety, and difficulty concentrating. Depression and insomnia are the least common. Other withdrawal symptoms may include anhedonia, constipation, cough, decreased positive affect, dizziness, drowsiness, headache, impulsivity, fatigue, flu symptoms, mood swings, mouth ulcers, and increased dreaming.[2] Cessation of nicotine can also require changes in levels of various medications.

## Causes[edit | edit source]

Various causes have been proposed to explain the causes of nicotine withdrawal. Nicotine binds to nicotinic receptors in the brain that, in turn, cause an increase in dopamine. Dopamine is the major chemical that stimulates reward centers in the brain. The brain recruits an opposing force to dampen the effects of nicotine and this causes tolerance (the reduction in the effect of nicotine). The onset of this opposing force and the fact that the brain becomes used to and dependent on nicotine to function normally is known as physical dependence. When nicotine intake is decreased, the brain's opposing force is now unopposed and this causes withdrawal symptoms. It also appears that opiate, serotonergic, glutamic, cannabinoid, and corticotrophin receptors may play a role in nicotine withdrawal.[1][4] In addition, smoking becomes conditioned to environmental cues that can then prompt withdrawal symptoms. In the brain, the dorsal striatum may be associated with physical (motor) but not affective withdrawal sign.[5][6]

## Diagnosis[edit | edit source]

### Definition[edit | edit source]

Nicotine withdrawal refers to the effects that nicotine-dependent individuals experience after they discontinue or decrease nicotine use. Nicotine is an addictive substance found most commonly in tobacco and tobacco products including cigarettes, cigars, chewing tobacco, e-cigarette liquid, pipe tobacco, snus, snuff, and nicotine medications such as nicotine gum. Withdrawal is the body’s reaction to not having the nicotine it had become accustomed to. Withdrawal is most common and intense in cigarette smokers[2][3] and intermediate in smokeless and e-cigarette users. The symptoms of nicotine withdrawal usually appear 2–3 hours after last intake of nicotine and peak in 2–3 days.[1]In a minority of smokers, cravings may persist for years. Nicotine withdrawal itself does not cause significant physical symptoms and is not life-threatening. However, the associated cravings can be as intense as those experienced during withdrawal from other substances. Following the initial withdrawal period, many individuals experience improvements in anxiety, depression, and overall quality of life. In fact, former smokers often find themselves in a better state compared to when they were actively smoking.

## Treatment[edit | edit source]

Gradually reducing nicotine intake causes less withdrawal than abruptly stopping.[2][3] Another way to reduce nicotine withdrawal symptoms is to provide the body with an alternative source of nicotine (nicotine replacement therapy) for a temporary period and then taper this new nicotine intake. Other medication used for quitting smoking include bupropion, varenicline, cytisine, nortriptyline, and clonidine and psychedelics. Treatments other than medication, such as increased exercise, can also reduce nicotine withdrawal symptoms. Many behavior changes such as avoiding situations where one usually smoked, planning ahead to deal with temptations, and seeking the support of friends and family are effective in helping people quit smoking, but whether this is due to reduced withdrawal is unclear.

## Epidemiology[edit | edit source]

Most nicotine users have at least one of the above withdrawal symptoms when they try to stop. These effects are much milder to those who use isolated nicotine over tobacco.[4]

Withdrawal can occur in less frequent users, but heavier users and those with a past or current psychiatric disorder tend to have more severe withdrawal. Genetics also influence the severity of withdrawal.[7]

## See also[edit | edit source]

* Withdrawal
* Smoking cessation
* Nicotine dependence

## References[edit | edit source]

1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Linda J. Vorvick (2013-08-29). "Nicotine and Tobacco". Medline Plus. Archived from the original on 2016-07-05. Retrieved 2015-05-21.
2. ↑ 2.0 2.1 2.2 2.3 2.4 Hughes, John R. (2007). "Effects of abstinence from tobacco: valid symptoms and time course". Nicotine & Tobacco Research. 9 (3): 315–327. doi:10.1080/14622200701188919. PMID 17365764.
3. ↑ 3.0 3.1 3.2 3.3 Piper, Megan E. (2015). "Withdrawal: Expanding a Key Addiction Construct". Nicotine & Tobacco Research. 17 (12): 1405–1415. doi:10.1093/ntr/ntv048. PMC 4654762. PMID 25744958.
4. ↑ 4.0 4.1 Hughes, JR (2007). "Review: Effects of abstinence from tobacco: Etiology, animal models, epidemiology, and significance: A subjective review". Nicotine & Tobacco Research. 9 (3): 329–339. doi:10.1080/14622200701188927. PMID 17365765.
5. ↑ Becker JA, Kieffer BL, Le Merrer J (2017). "Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol". Addiction Biology. 22 (5): 1205–1217. doi:10.1111/adb.12405. PMC 5085894. PMID 27126842.
6. ↑ Kim B, Im HI (2020). "Chronic nicotine impairs sparse motor learning via striatal fast‐spiking parvalbumin interneurons". Addiction Biology. Early View (3): e12956. doi:10.1111/adb.12956. PMC 8243919. PMID 32767546.
7. ↑ Quaak, M.; van Schayck, C. P.; Knaapen, A. M.; van Schooten, F. J. (2009-03-01). "Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?". European Respiratory Journal. 33 (3): 468–480. doi:10.1183/09031936.00056908. ISSN 0903-1936. PMID 19251795. S2CID 9379591. Archived from the original on 2023-10-26. Retrieved 2023-08-19.

## External links[edit | edit source]

Classification|

* ICD-10: F17.2
* ICD-9-CM: 292.0

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External resources|

* MedlinePlus: 000953

* v
* t
* e

Psychoactive substance-related disorder

General|

* SID
* Substance intoxication / Drug overdose
* Substance-induced psychosis
* Withdrawal:
* Craving
* Neonatal withdrawal
* Post-acute-withdrawal syndrome (PAWS)
* SUD
* Substance abuse / Substance-related disorders
* Physical dependence / Psychological dependence / Substance dependence

Combined
substance use|

* SUD
* Polysubstance dependence
* SID
* Combined drug intoxication (CDI)

Alcohol|

| SID|

| Cardiovascular diseases|

* Alcoholic cardiomyopathy
* Alcohol flush reaction (AFR)

|

Gastrointestinal diseases|

* Alcoholic liver disease (ALD):
* Alcoholic hepatitis
* Auto-brewery syndrome (ABS)

Endocrine diseases|

* Alcoholic ketoacidosis (AKA)

Nervous
system diseases|

* Alcohol-related dementia (ARD)
* Alcohol intoxication
* Hangover

Neurological
disorders|

* Alcoholic hallucinosis
* Alcoholic polyneuropathy
* Alcohol-related brain damage
* Alcohol withdrawal syndrome (AWS):
* Alcoholic hallucinosis
* Delirium tremens (DTs)
* Fetal alcohol spectrum disorder (FASD)
* Fetal alcohol syndrome (FAS)
* Korsakoff syndrome
* Positional alcohol nystagmus (PAN)
* Wernicke–Korsakoff syndrome (WKS, Korsakoff psychosis)
* Wernicke encephalopathy (WE)

Respiratory tract diseases|

* Alcohol-induced respiratory reactions
* Alcoholic lung disease

SUD|

* Alcoholism (alcohol use disorder (AUD))
* Binge drinking

Caffeine|

* SID
* Caffeine-induced anxiety disorder
* Caffeine-induced sleep disorder
* Caffeinism
* SUD
* Caffeine dependence

Cannabis|

* SID
* Cannabis arteritis
* Cannabinoid hyperemesis syndrome (CHS)
* Intravenous marijuana syndrome
* SUD
* Amotivational syndrome
* Cannabis use disorder (CUD)
* Synthetic cannabinoid use disorder

Cocaine|

* SID
* Cocaine intoxication
* Prenatal cocaine exposure (PCE)
* SUD
* Cocaine dependence

Hallucinogen|

* SID
* Acute intoxication from hallucinogens (bad trip)
* Hallucinogen persisting perception disorder (HPPD)

Nicotine|

* SID
* Green Tobacco Sickness (GTS)
* Nicotine poisoning
* Nicotine withdrawal
* SUD
* Nicotine dependence

Opioids|

* SID
* Opioid overdose
* SUD
* Opioid use disorder (OUD)

Sedative /
hypnotic|

* SID
* Kindling (sedative–hypnotic withdrawal)
* benzodiazepine: SID
* Benzodiazepine overdose
* Benzodiazepine withdrawal
* SUD
* Benzodiazepine use disorder (BUD)
* Benzodiazepine dependence
* barbiturate: SID
* Barbiturate overdose
* SUD
* Barbiturate dependence

Stimulants|

* SID
* Stimulant psychosis
* amphetamine: SUD
* Amphetamine dependence

Volatile
solvent|

* SID
* Sudden sniffing death syndrome (SSDS)
* Toluene toxicity
* SUD
* Inhalant abuse

Related
non-psychoactive
substances|

* Anabolic-androgenic steroids: SUD
* Anabolic-androgenic steroids abuse

* v
* t
* e

Tobacco smoking

Country
and region|

| Africa|

* Egypt
* Nigeria
* South Africa

|

Asia|

* Afghanistan
* China
* Macau
* Hong Kong
* East Timor
* India
* Indonesia
* Iran
* Iraq
* Japan
* North Korea
* Malaysia
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* Philippines
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* Singapore
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* Syria
* Taiwan
* Turkey
* Vietnam

Oceania|

* Australia
* New Zealand
* Tokelau

Europe|

* Albania
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* Iceland
* Ireland
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South America|

* Argentina
* Brazil
* Colombia
* Ecuador
* Uruguay

North America|

* Canada
* United States

Religion|

* Smoking in Jewish law
* Islamic views on tobacco
* Tobacco fatwa
* Ceremonial pipe
* Chanunpa
* Kinnikinnick
* Pipe bag

Health|

* Health effects of tobacco (Nicotine poisoning
* Nicotine withdrawal)
* Passive smoking
* Third-hand smoke
* Prevalence of tobacco use
* Schizophrenia and smoking
* Sidestream smoke
* Smokeless tobacco keratosis
* Smoker's face
* Smoker's melanosis
* Stomatitis nicotina
* Smoking age
* Smoking and male infertility
* Smoking cessation
* Tobacco-free pharmacies
* Tobacco packaging warning messages
* WHO Framework Convention on Tobacco Control
* MPOWER
* Protocol to Eliminate Illicit Trade in Tobacco Products
* World No Tobacco Day
* Youth smoking

Women and smoking|

* Breastfeeding difficulties
* Breast cancer
* Cervical cancer
* Menopause
* Ptosis of the breast
* Smoking and female infertility
* Smoking and pregnancy

Smoking ban|

* Inflight smoking
* List of smoking bans
* Smoking bans in private vehicles
* Tobacco-free college campuses

Country and region|

* Australia
* England
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* United States

Other|

* Chain smoking
* Tobacco consumption by country
* History of smoking
* Smoking cap
* Smokeasy
* Smoking fetishism
* Smoking in association football
* Smoking jacket
* Tobacco pipe
* Smoking room
* Nicotine marketing
* Tobacco bowdlerization
* Tobacco industry

* Category
* Cigarettes
* Electronic cigarettes

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