EHNA

Short description: Chemical compound

EHNA

Identifiers

IUPAC name

* 3-(6-aminopurin-9-yl)nonan-2-ol

CAS Number|

* 59262-86-1

PubChem CID|

* 3206

ChemSpider|

* 3094

ChEMBL|

* ChEMBL50378 Y

Chemical and physical data
Formula| C14H23N5O
Molar mass| 277.372 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CCCCCCC(C(C)O)n1cnc2c1ncnc2N

InChI

* InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)

* Key:IOSAAWHGJUZBOG-UHFFFAOYSA-N

(verify)

EHNA (erythro-9-(2-hydroxy-3-nonly)adenine) is a potent adenosine deaminase inhibitor,[1] which also acts as a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type 2 (PDE2).[2][3]

## References

1. ↑ "Sigma Aldrich". http://www.sigmaaldrich.com/catalog/product/sigma/e114?lang=en&region=US.
2. ↑ "Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine". Cellular Signalling 7 (7): 733–8. September 1995. doi:10.1016/0898-6568(95)00042-N. PMID 8519602.
3. ↑ "Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes". Molecular Pharmacology 48 (1): 121–30. July 1995. PMID 7623766.

* v
* t
* e

Phosphodiesterase inhibitors

PDE1|

* MMPX
* SCH-51866
* Vinpocetine

PDE2|

* BAY 60-7550
* Carbazeran
* EHNA
* Oxindole
* PDP

PDE3|

* Adibendan
* Amrinone (inamrinone)
* Anagrelide
* Benafentrine
* Bucladesine
* Carbazeran
* Cilostamide
* Cilostazol
* Enoximone
* Imazodan
* KMUP-1
* Meribendan
* Milrinone
* Olprinone
* Parogrelil
* Pimobendan
* Pumafentrine
* Quazinone
* RPL-554
* Siguazodan
* Trequinsin
* Vesnarinone
* Zardaverine

PDE4|

* Apremilast
* Arofylline
* Atizoram
* Benafentrine
* Catramilast
* CC-1088
* CDP-840
* CGH-2466
* Cilomilast
* Cipamfylline
* Crisaborole
* Denbutylline
* Difamilast
* Drotaverine
* Etazolate
* Filaminast
* Glaucine
* HT-0712
* ICI-63197
* Indimilast
* Irsogladine
* Lavamilast
* Lirimilast
* Lotamilast
* Luteolin
* Mesembrenone
* Mesembrine
* Mesopram
* Oglemilast
* Piclamilast
* Pumafentrine
* Revamilast
* Ro 20-1724
* Roflumilast
* Rolipram
* Ronomilast
* RPL-554
* RS-25344
* Tetomilast
* Tofimilast
* YM-976
* Zardaverine

PDE5|

* Acetildenafil
* Aildenafil
* Avanafil
* Beminafil
* Benzamidenafil
* Dasantafil
* Icariin
* Gisadenafil
* Homosildenafil
* Lodenafil
* Mirodenafil
* MY-5445
* Nitrosoprodenafil
* Norcarbodenafil
* SCH-51866
* Sildenafil
* Sulfoaildenafil
* T-0156
* Tadalafil
* Udenafil
* Vardenafil

PDE7|

* BRL-50481

PDE9|

* BAY 73-6691
* PF-04447943
* Paraxanthine

PDE10|

* Balipodect
* Mardepodect
* Papaverine
* TC-E 5005
* Tofisopam

PDE11|

BC11-38

Non-selective|

* Aminophylline
* Caffeine
* Choline theophyllinate
* CPX
* Dipyridamole
* Doxofylline
* Enprofylline
* Ibudilast
* IBMX
* Luteolin
* Pentoxifylline
* Propentofylline
* Theobromine
* Theophylline
* Zaprinast

Unsorted|

* Diazepam
* Diprophylline
* DPCPX
* Furafylline
* Lisofylline
* MDL-12330A
* Moxaverine
* Oxagrelate
* Pentifylline
* Proxyphylline
* Quercetin
* Satigrel
* Tolafentrine
* Trapidil

See also: Receptor/signaling modulators

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