Copper (64Cu) oxodotreotide
INN: Copper (64Cu) oxodotreotide

Names
Trade names| Detectnet
Other names| Copper Cu 64 dotatate

IUPAC name

* 2-[4-[2-[[(2R)-1-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]-10-(carboxylatomethyl)-7-(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;copper-64(2+)

Clinical data
Drug class| Radioactive diagnostic agent[1]
Main uses| Positron emission tomography (PET) of neuroendocrine tumors (NETs)[1]
Side effects| Nausea, vomiting, flushing[1]
Pregnancy
category|

* US: N (Not classified yet)

Routes of
use| Intravenous
Legal
License data|

* US DailyMed: Detectnet

Legal status|

* US: ℞-only [1]

Chemical and physical data
Formula| C65H88CuN14O19S2
Molar mass| 1497.16 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)CN6CCN(CCN(CCN(CC6)CC(=O)[O-])CC(=O)[O-])CC(=O)O)C(=O)NC(C(C)O)C(=O)O)O.[Cu+2]

InChI

* InChI=1S/C65H90N14O19S2.Cu/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+2/p-2/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1+0

* Key:IJRLLVFQGCCPPI-NVGRTJHCSA-L

Copper (64Cu) oxodotreotide, sold under the brand name Detectnet, is a radioactive diagnostic agent used in positron emission tomography (PET) of neuroendocrine tumors (NETs).[1] Specifically it is used in adults with somatostatin receptor positive disease.[1] It is given by injection into a vein.[1]

Common side effects include nausea, vomiting, and flushing.[1] Other side effects include radiation exposure and allergic reactions.[1] It interacts with somatostatin analogs.[1] Use during pregnancy may harm the baby.[1] It works by binding to somatostatin receptor, particularly subtype 2 receptors.[1]

Copper (64Cu) oxodotreotide was approved for medical use in the United States in 2020.[1] In the United States it costs about 3,900 USD for a vial as of 2022.[2]

## Contents

* 1 Medical uses
* 1.1 Dosage
* 2 History
* 3 See also
* 4 References
* 5 External links

## Medical uses[edit | edit source]

### Dosage[edit | edit source]

It is typically used at a dose of 148 MBq (4 mCi).[1]

## History[edit | edit source]

The U.S. Food and Drug Administration (FDA) approved copper 64Cu dotatate based on data from two trials that evaluated 175 adults.[3]

Trial 1 evaluated adults, some of whom had known or suspected NETs and some of whom were healthy volunteers.[3] The trial was conducted at one site in the United States (Houston, TX).[3] Both groups received copper 64Cu dotatate and underwent PET scan imaging.[3]

Trial 2 data came from the literature-reported trial of 112 adults, all of whom had history of NETs and underwent PET scan imaging with copper 64Cu dotatate.[3] The trial was conducted at one site in Denmark.[3] In both trials, copper 64Cu dotatate images were compared to either biopsy results or other images taken by different techniques to detect the sites of a tumor.[3] The images were read as either positive or negative for presence of NETs by three independent image readers who did not know participant clinical information.[3]

## See also[edit | edit source]

* Copper-64
* DOTA-TATE

## References[edit | edit source]

1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 "Detectnet- copper cu 64 dotatate injection, solution". DailyMed. 14 September 2020. Archived from the original on 1 November 2022. Retrieved 24 September 2020.
2. ↑ "Detectnet Prices, Coupons, Copay & Patient Assistance". Drugs.com. Archived from the original on 22 May 2022. Retrieved 3 November 2022.
3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Drug Trials Snapshots: Detectnet". U.S. Food and Drug Administration (FDA). 3 September 2020. Archived from the original on 21 September 2020. Retrieved 10 September 2020. This article incorporates text from this source, which is in the public domain.

## External links[edit | edit source]

Identifiers:|

* ATC code:

* None

* CAS Number: 1426155-87-4
* PubChem CID: 124220636
* UNII:

* N3858377KC

* KEGG:

* D11882

|

* "Copper dotatate Cu-64". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2022-05-21. Retrieved 2022-10-20.
* "copper Cu 64 dotatate injection safety data sheet" (PDF). Curium US LLC. 15 March 2020. Archived (PDF) from the original on 27 October 2020. Retrieved 20 October 2022.

* v
* t
* e

Diagnostic radiopharmaceuticals (V09)

Central nervous system|

* 99mTc (Exametazime, Pentetic acid)
* 123I (Ioflupane (123I)
* Iofetamine (123I)
* Iolopride (123I)
* Iomazenil)
* 18F (Florbetapir (18F), Flutemetamol (18F))

Skeletal system|

* 99mTc (Medronic acid)

Renal|

* 123I (Sodium iodohippurate)
* 64Cu
* ETS2
* 99mTc (Mertiatide, Pentetic acid)

Gastrointestinal/Hepatic|

* 75Se (SeHCAT)

Respiratory system|

* 133Xe
* 81mKr
* 99mTc (99mTc-MAA, Pentetic acid)

Cardiovascular system|

* 99mTc (Sestamibi
* Tetrofosmin)
* 111In (Imciromab)
* 82Rb (Rubidium chloride)
* 125I (Iodinated human albumin)

Inflammation/infection|

* 99mTc (Exametazime
* Sulesomab
* Tilmanocept)
* 111In
* 67Ga

Tumor|

* 99mTc
* Arcitumomab
* Votumumab
* Hynic-octreotide
* 111In
* Capromab pendetide
* Satumomab pendetide
* 125I (Minretumomab)
* 123I (Iobenguane (123I))
* 131I (Iobenguane (131I))
* 18F
* Fluciclovine
* Fluorodeoxyglucose
* Fluoroethyltyrosine
* Sodium fluoride
* 64Cu
* Dotatate
* Piflufolastat F-18

Adrenal cortex|

* 123I
* 125I / 131I (Iodocholesterol)

Radionuclides
(including tracers)|

| positron (PET list)|

* 11C ([11C]ME@HAPTHI)
* 25B-NBOMe (Cimbi-36)
* Acetate
* Choline
* Carfentanil
* DASB
* DTBZ
* Flumazenil
* Methionine
* N-Methylspiperone
* Pittsburgh compound B
* Raclopride
* Verapamil)
* 13N
* Ammonia
* 64Cu
* Desmethoxyfallypride
* Fallypride
* Florbetaben (18F)
* Florbetapir (18F)
* Flortaucipir (18F)
* Flotufolastat F-18
* Flubatine
* Fluciclovine
* Fludeoxyglucose (18F) (FDG)-glucose analogue
* Flumazenil
* 18F (Altanserin)
* Fluorocholine
* Fluorodeoxysorbitol (FDS)
* Fluorodopa
* Fluoroestradiol F-18
* Fluorothymidine F-18
* Fluspidine
* Flutemetamol
* FMISO
* Gallium (68Ga) gozetotide
* 68Ga
* Mefway
* MPPF
* N-Methylspiperone
* Nifene
* FET
* 15O (Water)
* Piflufolastat F-18
* 82Rb (Rubidium chloride)
* Setoperone)

|

gamma ray/photon (SPECT/scintigraphy)|

* 51Cr
* 57Co
* 67Ga
* 111In
* 123I
* 125I
* 131I
* 81mKr
* 153Sm
* 75Se
* 99mTc
* 201Tl
* 133Xe

Isotopes used:

* carbon-11
* chromium-51
* cobalt-57
* copper-64
* fluorine-18
* gallium-67
* gallium-68
* indium-111
* iodine-123
* iodine-125
* iodine-131
* krypton-81m
* nitrogen-13
* oxygen-15
* rubidium-82
* samarium-153
* selenium-75
* technetium-99m
* thallium-201
* xenon-133

See also: Therapeutic radiopharmaceuticals (V10)

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|

* v
* t
* e

*[INN]: International nonproprietary name
*[US]: United States
*[CID]: Compound ID
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